Tag: M.W=200-250

Prakash, G. K. Surya; Mathew, Thomas; Hoole, Dushyanthi; Esteves, Pierre M.; Wang, Qi; Rasul, Golam; Olah, George A. published the artcile< N-Halosuccinimide/BF3-H2O, Efficient Electrophilic Halogenating Systems for Aromatics>, SDS of cas: 2265-92-1, the main research area is halosuccinimide trifluoroborane monohydrate electrophile halogenation aromatic.

N-Halosuccinimides (NXS, 1) are efficiently activated in trifluoromethanesulfonic acid and BF3-H2O, allowing the halogenations of deactivated aromatics Because BF3-H2O is more economic, easy to prepare, nonoxidizing, and offers sufficiently high acidity (-H0 ≈ 12, only slightly lower than that of trifluoromethanesulfonic acid), an efficient new electrophilic reagent combination of NXS/BF3-H2O has been developed. DFT calculations at the B3LYP/6-311++G**//B3LYP/6-31G* level suggest that protonated N-halosuccinimides undergo further protosolvation at higher acidities to reactive superelectrophilic species capable either in the transfer of X+ from the protonated forms of NXS to the aromatic substrate or in forming a highly reactive and solvated X+ which would readily react with the aromatic substrates. Structural aspects of the BF3-H2O complex have also been investigated.

Journal of the American Chemical Society published new progress about Acid catalysis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, SDS of cas: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Waldvogel, S. R.; Wehming, K. M. published the artcile< Product subclass 2: iodoarenes>, HPLC of Formula: 2265-92-1, the main research area is review iodoarene preparation iodination organic synthesis.

A review of methods to prepare iodoarenes.

Science of Synthesis published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation) (iodo). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lin, Wenwei; Chen, Ling; Knochel, Paul published the artcile< Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates>, Name: 4-Iodopyridin-3-ol, the main research area is pyridyne preparation Diels Alder cycloaddition furan nucleophilic addition; pyridine arylsulfonyloxy halo preparation magnesiation elimination; oxaazatricycloundecatetraene preparation.

The preparation of functionalized 3,4-pyridynes as highly reactive intermediates has been achieved by the controlled elimination of readily generated magnesiated diaryl sulfonates obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halopyridines I (Ar = 4-ClC6H4; X = Br, iodo; R1 = H, Br, Me; R2 = Cl, iodo, MeO, H2C:CHCH2, PhS, 4-ClC6H4S, 4-EtO2CC6H4). After trapping with furan, moderate to good yields of the desired functionalized cycloadducts II were obtained. The addition of an (arylthio)magnesium chloride or (arylselenyl)magnesium chloride to 3,4-pyridyne followed by quenching with an electrophile is also described.

Tetrahedron published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Name: 4-Iodopyridin-3-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Lulu; Dong, Yanan; Xia, Qiangqiang; Bai, Jianfei; Li, Yuehui published the artcile< Zn-Catalyzed Cyanation of Aryl Iodides>, Application In Synthesis of 2265-92-1, the main research area is aryl cyanide preparation; formamide aryl iodide cyanation zinc catalyst.

An efficient method for the synthesis of cyanides such as ArCN [Ar = 4-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.] via zinc-catalyzed cyanation of aryl iodides with formamide as cyanogen source was reported. The transformation was promoted by bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into the nitrile products ArCN in good to excellent yields. This approach was an exceedingly simple and benign method for the synthesis of aryl nitriles ArCN and was likely to proceed via a dinuclear-Zn concerted catalysis.

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Bing; Yang, Zhan; Gong, Wenqi; Chen, Xinhui; Bruce, Duncan W.; Wang, Shengyue; Ma, Huili; Liu, Yu; Zhu, Weiguo; Chi, Zhenguo; Wang, Yafei published the artcile< Intramolecular Through-Space Charge Transfer Based TADF-Active Multifunctional Emitters for High Efficiency Solution-Processed OLED>, Application In Synthesis of 2265-92-1, the main research area is thermally activated delayed fluorescence emitter organic light emitting diode.

Thermally activated delayed fluorescence (TADF) has been explored actively in luminescent organic materials. Yet, realizing such TADF-active, multifunctional emitters with high emission efficiency still remains hugely challenging. In this context, a series of twist-conjugated organic mols. bearing diphenylsulfone and 9,9-dimethylacridine moieties are designed and prepared, and are found to show, in one mol., TADF, room-temperature phosphorescence, triboluminescence, and aggregation-induced emission enhancement. In addition, remarkably high photoluminescence quantum efficiency, up to ≈100%, is achieved for these novel mols. Single-crystal anal. and theor. calculations reveal that the through-space charge transfer (TSCT) effect in these mols. is responsible for both the multifunctional emission and high emission efficiency. A maximum external quantum efficiency of 20.1% is achieved, which is among the highest recorded in a solution-processable device containing TSCT-based TADF materials. These results illustrate a new approach to achieving highly efficient TADF-active, multifunctional emitters.

Advanced Optical Materials published new progress about Absorption spectroscopy. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lakshmi, Balagopal; Kung, Mei-Ping; Lieberman, Brian; Zhao, Jun; Waterhouse, Rikki; Kung, Hank F. published the artcile< (R)-N-Methyl-3-(3-125I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters>, Application In Synthesis of 188057-20-7, the main research area is radioiodinated iodonisoxetine derivative preparation biodistribution norepinephrine transporter PET imaging.

Alterations in serotonin and norepinephrine neuronal functions have been observed in patients with major depression. Several antidepressants bind to both serotonin transporters and norepinephrine transporters (NET). The ability to image NET in the human brain would be a useful step toward understanding how alterations in NET relate to disease. In this study, we report the synthesis and characterization of a new series of derivatives of iodonisoxetine, a known radioiodinated probe. The most promising, (R)-N-methyl-3-(3-iodopyridin-2-yloxy)-3-phenylpropylamine (PYINXT), displayed a high and saturable binding to NET, with a Kd value of 0.53 ± 0.03 nM. Biodistribution studies of (R)-N-methyl-3-(3-125I-pyridin-2-yloxy)-3-phenylpropan-1-amine in rats showed moderate initial brain uptake (0.54% dose/organ at 2 min) with a relatively fast washout from the brain (0.16% dose/organ at 2 h) as compared to [125I]INXT. The hypothalamus (a NET-rich region)-to-striatum (a region devoid of NET) ratio was found to be 2.14 at 4 h after i.v. injection. Preliminary results suggest that this improved iodinated ligand, when labeled with 123I, may be useful for mapping NET-binding sites with single photon emission computed tomog. in the living human brain.

Nuclear Medicine and Biology published new progress about Brain (uptake). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Application In Synthesis of 188057-20-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Namkung, Moses J.; Fletcher, T. Lloyd published the artcile< Derivatives of fluorene. XXV. Fluorofluorenes. 6>, Application In Synthesis of 2265-92-1, the main research area is FLUORINATION FLUORENES; FLUORENES FLUORO.

The synthesis of 5,6,7,8-tetrafluoro-2-acetamidofluorene, 1,4,7-trifluoro-2-acetamidofluorene (I), and 5,8-difluoro-2-acetamidofluorene, of a 1,2,3,4,7-penta-, a 1,2,3,4-tetra-, a 1,2,4,7-tetra-, a 1,4,7-tri-, and a 1,4-difluorofluorenone, and of related derivatives is reported together with their ir absorption data. Nitration of polyfluorofluorenones which have an unsubstituted 2 (or 7) position occurs at that position. An unexpected directive effect was observed in the nitration of 4,7-difluoro-2-acetamidofluorene.

Canadian Journal of Chemistry published new progress about 2265-92-1. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jia, Shiqi; Chen, Zhili; Zhang, Nan; Tan, Yu; Liu, Yidong; Deng, Jun; Yan, Hailong published the artcile< Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes>, SDS of cas: 2265-92-1, the main research area is alkynylnaphthol sulfinate organocatalytic addition; styrene sulfone enantioselective preparation.

Described herein is an organocatalytic enantioselective approach for the construction of axially chiral sulfone-containing styrenes, e.g., I. Various axially chiral sulfone-containing styrene compounds were prepared with excellent enantioselectivities (up to >99% ee) and almost complete E/Z selectivities (>99% E/Z). Furthermore, the axially chiral sulfone-containing styrenes could be easily converted into phosphonic acid and S/P ligands, which could be potentially used as organocatalysts or ligands in asym. catalysis.

Journal of the American Chemical Society published new progress about Addition reaction catalysts, stereoselective. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, SDS of cas: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cabrita, Ivania; Fernandes, Ana C. published the artcile< A novel efficient and chemoselective method for the reduction of nitriles using the system silane/oxo-rhenium complexes>, Application In Synthesis of 887266-99-1, the main research area is rhenium catalyzed reduction nitrile reactant primary amine preparation; oxo rhenium catalyzed reduction nitrile reactant amine preparation.

This work reports the reduction of nitriles to the corresponding primary amines, e.g. 4-I-3-FC6H3CH2NH2 and 4-MeSC6H4CH2NH2, with silanes catalyzed by oxo-rhenium complexes. The catalytic system PhSiH3/ReIO2(PPh3)2 (10 mol %) reduced efficiently a series of nitriles in the presence of a wide range of functional groups such as -Cl, -F, -Br, -I, -CF3, -OCH3, -SCH3, -SO2CH3 and -NHTs.

Tetrahedron published new progress about Nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 887266-99-1 belongs to class iodides-buliding-blocks, and the molecular formula is C7H3FIN, Application In Synthesis of 887266-99-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Le, Thuy G.; Kundu, Abhijit; Ghoshal, Atanu; Nguyen, Nghi H.; Preston, Sarah; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Keiser, Jennifer; Hofmann, Andreas; Chang, Bill C. H.; Garcia-Bustos, Jose; Wells, Timothy N. C.; Palmer, Michael J.; Jabbar, Abdul; Gasser, Robin B.; Baell, Jonathan B. published the artcile< Novel 1-Methyl-1H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity>, Recommanded Product: 3-Fluoro-4-iodobenzonitrile, the main research area is anthelmintic resistance phenotypic screen Haemonchus SAR hookworms whipworms.

A phenotypic screen of two different libraries of small mols. against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1H-pyrazole-5-carboxamide derivatives Medicinal chem. optimization targeted modifications of the left-hand side, middle section, and right-hand side of the hybrid structure of these two hits to elucidate the structure-activity relationship (SAR). Initial SAR around these hits allowed for the iterative and directed assembly of a focused set of 30 analogs of their hybrid structure. Compounds 10, 17, 20, and 22 were identified as the most potent compounds, inhibiting the development of the fourth larval (L4) stage of H. contortus at sub-nanomolar potencies while displaying strong selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic nematodes, including hookworms and whipworms.

Journal of Medicinal Chemistry published new progress about Anthelmintics. 887266-99-1 belongs to class iodides-buliding-blocks, and the molecular formula is C7H3FIN, Recommanded Product: 3-Fluoro-4-iodobenzonitrile.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com