Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, This compound has unique chemical properties. The synthetic route is as follows., Formula: C4H6F3I

250g water, 18.9g (purity 93%, 440mmol) sodium hydroxide, and 95.2g (400mmol) 4,4,4-trifluorobutyliodide were placed in a 500ml four-necked flask equipped with a stirrer, a reflux cooler, and a thermometer. By heating, the mixture was maintained at 90C for 36 hours while being stirred. As the reaction proceeds, generation of gas was observed. Upon completion of the reaction, concentrated hydrochloric acid was added to the reaction mixture and the mixture was extracted 3 times with 200ml chloroform. The results of a gas chromatography analysis performed on the extract and the collected gas indicated that 4,4,4-trifluorobutyliodide was converted at 86.8% conversion rate, and the selectivity for 4,4,4-trifluorobutanol, 4,4,4-trifluoro-1-butene, and bis(4,4,4-trifluorobutyl)ether were 44.9%, 50.2%, and 4.9%, respectively.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 461-17-6.

Reference:
Patent; Tosoh F-Tech, Inc.; EP1403238; (2004); A1;,
Iodide – Wikipedia,
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Some common heterocyclic compound, 4387-36-4, name is 2-Iodobenzonitrile, molecular formula is C7H4IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Iodobenzonitrile

Example VI; tert.butyl[[1-(2-cyano-phenyl)-1H-indol-5-yl]-(3,5-dichloro-phenylsulphonyl)-amino]-acetate; 300 mg tert.butyl[(3,5-dichloro-phenylsulphonyl)-(1H-indol-5-yl)-amino]-acetate, 12 mg copper iodide and 307 mg potassium phosphate are placed in a flask. It is evacuated twice and filled with argon. Then 1 ml of toluene and 166 mg 2-iodo-benzonitrile are added. After the addition of 21 mul N,N’-dimethyl-trans-cyclohexanediamine the mixture is heated to 110¡ã C. for 8 hours. Then it is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate. The solvents are eliminated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 10:1 to 1:2).Yield: 266 mg (73percent of theory)Mass spectrum (ESI+): m/z=573 [M+NH4]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4387-36-4, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/93703; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 52548-63-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52548-63-7 as follows.

To a 500 mL round- bottomed flask was added 5-fluoro-2-iodo-benzoic acid (23 g, 86.5 mmol) in methanol (230 mL). To the resulting solution was added cone, sulfuric acid (2.3 mL, 43.2 mmol). The reaction mixture was warmed to 65 oC and stirred for 15 h. The resulting mixture was concentrated under reduced pressure to give crude producte which was then was partitioned between EtOAc (250 mL) and a half sat. Na2CO3(ac?) solution (250 mL). The layers were thoroughly mixed and then separated. The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give a yellow oil (23 g, 95% yield). 1 H NMR (400 MHz, CDCI3): 7.94 (dd, J = 8.7, 5.4 Hz, 1 H), 7.54 (dd, J = 9.0, 3.1 Hz, 1 H), 6.93 (m, 1 H), 3.94 (s, 3H).

According to the analysis of related databases, 52548-63-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHAI, Wenying; LETAVIC, Michael, A.; LY, Kiev, S.; PIPPEL, Daniel, J.; RUDOLPH, Dale, A.; SAPPEY, Kathleen, C.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; SOYODE-JOHNSON, Akinola; STOCKING, Emily, M.; SWANSON, Devin, M.; WO2011/50198; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 869500-07-2 as follows. Formula: C7H6BrI

29.7 g of 1-bromo-2-iodo-3-toluene was dissolved in 300 ml of 1,4-dioxane solvent.Stirring under nitrogen, adding 20.2 g of o-bromobenzeneboronic acid,34.5 g of K2CO3, 1.15 g of tetrakis(triphenylphosphine)palladium, and the temperature was raised to reflux.After 5 hours, the basic reaction of the raw materials was determined by HPLC, and the reaction solution was dried under reduced pressure.The residue was subjected to column chromatography to give Intermediate 22-1 as 22.1 g (0.068 mol). (Yield: 81%)

According to the analysis of related databases, 869500-07-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Feng Yu; Jia Xueyi; (40 pag.)CN108409773; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 5326-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5326-47-6, name is 2-Amino-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-amino-5-iodobenzoicacid (17) (15 mmol, 4.0 g) in methanol(16 mL) was added concentrated H2SO4 (3.0 mL). Thereaction mixture was refluxed for 6 h and stirred at room temperature for additional12h. After removal of the solvent, the residue was poured into 100 mL saturatedNaHCO3 solution and extracted with ethyl acetate(3¡Á15 mL). The organic layer was separated, washed with brine (3¡Á15 mL), driedover anhydrous Na2SO4, filteredand concentrated to give the product methyl 2-amino-5-iodobenzoate (18) as yellow solid, Yield: 94%, mp:70-73C. 1H NMR (400 MHz, DMSO-d6, ppm) delta: 8.13 (1H,d, J = 2.16 Hz), 7.47 (1H, dd, J = 8.68, 2.16 Hz), 6.45 (1H, d, J = 8.72 Hz), 5.42 (2H, s, NH2),3.86 (3H, s, O-CH3). C8H8INO2.

The synthetic route of 2-Amino-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kang, Dongwei; Zhang, Heng; Zhou, Zhongxia; Huang, Boshi; Naesens, Lieve; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 21; (2016); p. 5182 – 5186;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 460-37-7,Some common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a tubular reactor, evacuated and replaced twice with nitrogen, and 10 ml of methyl tert-butyl ether solvent was added under a nitrogen atmosphere.1 mmol of the compound of the above formula (II),2mmol of the above formula iodide compound,2.5 mmol of azide trimethylsilane,2mmol tert-butyl peroxybenzoateAnd 0.02 mmol of a copper hexafluorophosphate tetraacetonitrile catalyst is dissolved in the above solvent,The reaction was stirred at a temperature of 30 C for 2 hours. After the reaction was completed, the reaction liquid was cooled to room temperature, filtered, and the solvent was evaporated under reduced pressure.Purification of the compound of formula III by column chromatography,The yield was 92.7%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-3-iodopropane, its application will become more common.

Reference:
Patent; Zhang Haiying; Zhou Lanlan; (12 pag.)CN108440503; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 4-iodo-3-methylbenzoate

(c) Synthesis of methyl 3-methyl-4-[3-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]benzoate Following the basic procedure of Example 11(d), by reacting 2.4 g (10 mmol) of alpha-ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol with 2.7 g (10 mmol) of methyl 3-methyl-4-iodobenzoate, 3.2 g (83%) of the expected ester, with a melting point of 130-131 C., were obtained.

The synthetic route of Methyl 4-iodo-3-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; C.I.R.D. Galderma; US5716624; (1998); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 13421-13-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13421-13-1 as follows.

General procedure: To a solution of imidazole carbaldehyde (1a-d) (100 mg, 1 equiv) in methanol (3 mL) were added successively Na2SO4 (0.2 g), amine 2a-d (1.2 equiv), alkynoic acid 3a-c (1.2 equiv) and isonitrile 4a-c (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at room temperature for 24-48 h in closed vial. After completion of the reaction, the mixture was diluted with dichloromethane (100 mL) and was extracted with water (50 mL). Organic layer was washed with brine (50 mL), dried over magnesium sulfate and evaporated under reduced pressure to obtained residue which was subjected to silica gel column chromatography (1-5 % methanol in dichloromethane) to afford the desired product 5a-r as solid.

According to the analysis of related databases, 13421-13-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Li, Zhenghua; Legras, Laetitia; Kumar, Amit; Vachhani, Dipak D.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2070 – 2074;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-99-4, name is 1-Ethynyl-4-iodobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Ethynyl-4-iodobenzene

General procedure: (3-Methoxypent-1-yne-1,5-diyl)dibenzene (10a) A 10 mL test tube equipped with a magnetic stirring bar was charged with IPrAu(BTZ-H) OTf (1.7 mg, 1.99 mumol, 2 mol%) and THF (200 muL, 0.5 M). To the solution were added acetal 8a (18.0 mg, 0.100 mmol) and alkyne 2a (55.0 muL, 0.500 mmol, 5.0 eq) at room temperature. The mixture was heated at 100C and the solution was stirred until TLC (hexanes-Et2O = 10 : 1) indicated a complete consumption of acetal 8a. The reaction was quenched with saturated aqueous NaHCO3 and the mixture was extracted with AcOEt three times. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel (hexanes-Et2O = 60 : 1) to afford propargyl ether 10a (21.9 mg, 87.5 mumol, 87%).

The synthetic route of 766-99-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Furuta, Miyu; Sugiyama, Kyoko; Yamaguchi, Minami; Ueda, Hirofumi; Tokuyama, Hidetoshi; Chemical and Pharmaceutical Bulletin; vol. 67; 8; (2019); p. 872 – 876;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 116632-39-4,Some common heterocyclic compound, 116632-39-4, name is 5-Bromo-2-iodotoluene, molecular formula is C7H6BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION EXAMPLE 36 To a mixture of 4-bromo-1-iodo-2-methylbenzene (87.5 g) and THF (400 mL) was added dropwise n-BuLi (1.55 M in hexane, 200 mL) over 50 min with dry ice-acetone bath cooling under Ar atmosphere. Then the mixture was stirred at the same temperature for 10 min. To the mixture was added a mixture of 2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (56.8 g) and THF (40 mL) dropwise over 30 min at the same temperature. Then the mixture was stirred at the same temperature for 1 hour. The mixture was diluted with sat. aq. NH4Cl (200 mL) at the same temperature, and brine (100 mL) was added, and stirred at room temperature for 30 min. Then organic layer was separated, concentrated, and diluted with EtOAc (300 mL). Aqueous layer was extracted with EtOAc (300 mL), and combined organic layers were washed with brine twice, and dried over MgSO4, filtered, and concentrated under reduced pressure. To the residue was added IPE (150 mL), and the mixture was stirred at room temperature for 15 min and under ice bath cooling for 30 min. The precipitate was collected, and washed with IPE to give N-[3-(4-bromo-2-methylphenyl)oxetan-3-yl]-2-methylpropane-2-sulfinamide (48.07 g) as a solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-iodotoluene, its application will become more common.

Reference:
Patent; Astellas Pharma Inc.; Cytokinetics, Incorporated; SATO, Ippei; KAMIKUBO, Takashi; MIURA, Masanori; MATSUSHIMA, Yuji; TANAKA, Hiroaki; SHllNA, Yasuhiro; YAMAKI, Susumu; SAITO, Tomoyuki; KIYOHARA, Hiroshi; OHE, Munemichi; MIHARA, Kayoko; MORGAN, Bradley Paul; MALIK, Fady; COLLIBEE, Scott Emile; ASHCRAFT, Luke; LU, Pu-Ping; WARRINGTON, Jeffrey Michael; GARARD, Marc; (100 pag.)US2017/233402; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com