Tag: M.W=200-300

Related Products of 124700-41-0,Some common heterocyclic compound, 124700-41-0, name is 2-Fluoro-5-iodobenzoic acid, molecular formula is C7H4FIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1 (20.0 g, 75.2 mmol, 1 eq) was dissolved in 70 mL of EtOH.Then gradually add H2SO4 (7.37g, 75.1mmol, 4.01mL, 1eq).The mixture was stirred at 100 C for 5 h.And use TLC (Dichloromethane/Methanol=10/1, Rf=0.87) The progress of the reaction was detected.When the reaction is complete,The reactants were concentrated under reduced pressure.The concentrated product was extracted (EOtOH 200 mL, NaHCO 3 saturated solution (100.0 mL x 2), and then the organic layer was taken.It was dried by adding anhydrous Na2SO4.After further evaporation to dryness the title product 2 (21.0 g, 71.4 mmol, 94.9% yield).Figure 3 shows the results of TLC chromatography for this reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Fluoro-5-iodobenzoic acid, its application will become more common.

Reference:
Patent; Shanghai Health Medical School; Tang Dewei; Huang Gang; Huang Chen; Wu Xingyu; Yu Meicen; Li Yanjiao; (18 pag.)CN109942582; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 3210-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3210-08-0, name is 4-Iodobutan-1-ol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Method B: Compound 3(68.9 mg, 0.074 mmol) was allowed to stir overnight in THF(10 mL) at 55 C. The solvent was removed from the product toafford pure 4 as a pale orange solid (65 mg, 87% yield). Yellow crystalssuitable for X-ray crystallography were grown from a concentratedCH2Cl2 solution of compound 4. 1H NMR (400 MHz, CD2Cl2):d 7.74 (m, 4H, Ar-H), 7.59 (m, 2H, Ar-H), 7.46 (m, 2H, Ar-H), 7.41(m, 8H, Ar-H), 7.27 (m, 2H, Ar-H), 7.18 (m, 2H, Ar-H), 7.07 (m,8H, Ar-H), 4.01 (m, 2H, O-CH2CH2CH2CH2-I), 3.88 (br, 2H, CH2),2.96 (m, 2H, O-CH2CH2CH2CH2-I), 2.54 (br, 2H, CH2), 1.67 (m, 2H,O-CH2CH2CH2CH2-I), 1.39 (m, 2H, O-CH2CH2CH2CH2-I). 31P NMR(161.8 MHz, CD2Cl2): d 93.1 (br, 1P), 10.7 (br, 2P). 13C NMR(100.5 MHz, C6D6): d 147.0, 135.6, 135.3, 134.1, 131.5, 130.0,129.6, 128.6, 124.3, 123.5, 66.8, 47.6, 33.2, 30.3, 7.0. Anal. Calc.for C42H40N2OP3CuI2: C, 50.49; H, 4.04; N, 2.80. Found: C, 50.22;H, 3.99; N, 2.77%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Knight, Sadie E.; Bezpalko, Mark W.; Foxman, Bruce M.; Thomas, Christine M.; Inorganica Chimica Acta; vol. 422; (2014); p. 181 – 187;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 13421-13-1

General procedure: To an oven dried three neck RB containing 2-Iodobenzoic acid (1) (2mmol), benzyl amine (2) (4mmol) and CuI(0.4mmol) in DMSO(3ml) was added 0.55g of K2CO3. Then, the reaction mixture was allowed to stir at 90C under air atmosphere for 12h.The completion of the reaction was monitored by TLC. After being cooled at room temperature the reaction mixture was poured in to ice cooled water and extracted with ethyl acetate two times. The combined organic layer was washed with brine and then dried over anhydrous Na2SO4. The solvent was evaporated and the crude product was purified by column chromatography (hexane(80)/ ethyl acetate (20)) on silica gel to afford 2-phenyl-4H-benzo[d][1,3]oxazine-4-one.

According to the analysis of related databases, 13421-13-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Munusamy, Sathishkumar; Venkatesan, Sathesh; Sathiyanarayanan, Kulathu Iyer; Tetrahedron Letters; vol. 56; 1; (2015); p. 203 – 205;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19099-54-8, name is 1-Iodo-2-isopropylbenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Iodo-2-isopropylbenzene

General procedure: To a mixture of the catalyst 3 (20mg containing 0.05mol% Pd for aryl iodides and 40mg containing 0.1mol% Pd for aryl bromides and chlorides), aryl halide (1mmol), alkyne (1.5mmol), and K2CO3 (1.5mmol, 207mg) was added PEG 200 (2mL) under argon atmosphere. The reaction mixture was stirred for the appropriate reaction time at 85 or 130C (see, Table 2). The progress of the reaction was monitored by using gas chromatography. After completion of the reaction, pure products were obtained by using column chromatography with hexane and ethyl acetate as eluents.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Gholinejad, Mohammad; Dasvarz, Neda; Najera, Carmen; Inorganica Chimica Acta; vol. 483; (2018); p. 262 – 270;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 103962-05-6, The chemical industry reduces the impact on the environment during synthesis 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, I believe this compound will play a more active role in future production and life.

CuI (0.26 g, 1.378 mmol), 2-picolinic acid (0.24 g, 1.969 mmol), and cesium carbonate (19.24 g, 59.061 mmol) were combined, evacuated and filled with argon (3 times). 1,4-Dioxane was then added followed by diethylmalonate (6 mL, 39.374 mmol) and 1-iodo-4-(trifluoromethoxy)benzene (3 mL, 19.687 mmol). The resulting yellow suspension was stirred at room temperature for 48 hours and quenched with saturated NH4Cl. The mixture was extracted with EtOAc (2¡Á). The combined organic extracts were dried over Na2SO4, filtered, and concentrated to provide the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-4-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Mirzadegan, Taraneh; Ganamet, Kelly; US2014/107097; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 42861-71-2, The chemical industry reduces the impact on the environment during synthesis 42861-71-2, name is 3-Iodophenyl acetate, I believe this compound will play a more active role in future production and life.

Intermediate- 17: 3-(Trimethylsilanylethynyl)-phenylacetate; To a solution of 3-acetoxy iodobenzene (6.0 g, 22.89 mmoles) in DMSO (25 mL) was added trimethylsilyl acetylene (1.1 eq) followed by triethylamine (3 eq), CuI (0.05 eq) and tetrakis (triphenylphosphine) palladium(O) (0.03 eq) and the reaction’ mixture was stirred at room temperature for 6 h. The reaction mixture was then diluted with water and extracted with ethyl acetate. The organic layer was then dried over Na2SO4, concentrated and purified by column chromatography to get 4.3 g of the desired product. 1H NMR (CDCl3) delta 7.30-7.25 (m, 2H), 7.18 (s, IH), 7.05-6.95 (m, IH), 2.28 (s, 3H), 0.24 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodophenyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant, Atmaram; NARAYANA, Lakshminarayana; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy, Manish; WO2010/7482; (2010); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 63069-48-7, name is 4-Chloro-2-iodoaniline, molecular formula is C6H5ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 63069-48-7

Step A: Preparation of l -Bromo-4-chloro-2-iodobcnzenc; |0892 ] A stirred mixture of coppcr(l l) bromide ( 1 1 mL, 237 mmol) in250 mL ACN at O0C was slowly treated with tert-butyl nitrite (33 mL, 276 mmol). The mixture was then warmed to 65C. and stirred for 30 minutes. The mixture was next treated dropwise with a mixture of 4-chloro-2-iodoaniline (50 g, 197 mmol) in 100 mL ACN. The resulting mixture was stirred for 1 hour. The mixture was cooled to room temperature and poured over 200 mL ice/10%HCl. The mixture was extracted with ether (3 x 100 mL). The combined organic layers were washed with I hO (2 100 m l .). 1 % ammonia water (2 x 100 niL), brine ( 100 ml), dried over anhydrous Na2SOi. and concentrated in vacuo to give 63 g brown oil as crude product. The crude product was purified by running it through a short silica plug eluting with 5% ether / hexane to give 54.2 g of the title compound as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63069-48-7, its application will become more common.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, molecular formula is C7H9IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

A mixture of compound S4 (90.0 mg, 286 lirnol, I equiv), and iodo-diazirine S7 (70.0 mg, 286 imol, 1.00 equiv) was dissolved in DMF (3.0 rnL) at 24 C. To this mixture, was added potassium carbonate (40.0 mg, 286 umol, 100 equiv) and stirred for 12 hours at 24 C. The reaction mixture was partitioned between ethyl acetate (30 mL) and DI water (15 mL) and the organic portion was separated and washed with brine (3 x 15 mL). The combined organic portion was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to afford an off white powder. The powder was purified by flash column chromatography (30—60% ethyl acetate–hexane, three steps) to afford photo-celecoxib (5) as a white powder (92.0 nig, 75Rf = 0.20 (40% ethyl acetate—hexane; UV). ?H NMR (500 MHz, CDCI3): oe 8.05 (d, 21-1, J 8.2 Hz, H3). 8.02 (d, 2H, J 8.1 Hz, Fl4), 5.95 (s, iH, H?), 5.13 (br, 2H, H5), 4.04 (t,21-1, J 7.2 Hz, H2). 2.05—2.03 (in, 51-1, E-16/I-18/H9), i.71—i.69 (in, 21-1. H7). ?3C N]?[R (125 MIz, CDCI3): d 154.6 (C), 143.0 (q, 2JCF = 38.8 Hz, CH), 141.1 (C), 140.4 (C), 127.6 (CH), 122.5 ((1-1), 121.7 (q, IJCF 267.5 Hz CF3), 5.3 (C), 82.4 (C), 69.7 (CH). 67.6 (OCH2),32.4 (CH2), 32.1 (CH2), 26.1 (CN2), 13.2 (CH3). ?9FvR(375 MHz, CDCI3): -63.6. IR (ATR-FT1R), cnf?: 3277 (br), 1590 (s), 1563 (m), 1512 (m), 1490 (w), 1416 (m), 1380 (w), 1335 (w), 1246 (m), 1151 (rn), 1101 (rn), 968 (w), 908 (w), 40 (w), 743 (w), 715 (w), 626 (in), 543 (w). HRMS-ES1 (m/z): [M+F1] calculated for Ci7H,7F3NsO3S, 428,0999; found,428.0949.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1450754-38-7, its application will become more common.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WOO, Christina, M.; GAO, Jinxu; (555 pag.)WO2018/226828; (2018); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 29632-73-3, name is 2-Bromo-4-iodoaniline, A new synthetic method of this compound is introduced below., Computed Properties of C6H5BrIN

To a solution of (10) (570 mg, 1.9 mmol) in dry toluene (8 mL), was added PPh3 (65.5 mg, 0.2 mmol) and Pd(OAc)2 (47.5 %, 60 mg, 0.1 mmol). tert-Butyl Acrylate (370 mu., 2.5 mmol) and NEt3 (420 mu., 3.0 mmol) were added and the flask was stirred at reflux overnight. The reaction was allowed to cool and washed with saturated aqueous NH4C1, brine, extracted with DCM, dried (Na2S04), filtered and concentrated. Purification by column chromatography (Hexane:EtOAc = 12: 1, 9: 1, 4: 1) provided the title compound as a brown oil (238.5 mg, 0.8 mmol, 64 %) Rf : 0.23 (Hexane:EtOAc, 4: 1). 1H NMR (400 MHz; CDC13,): delta 1.51 (9H, s, C(CH3)3), 6.15 (1H, d, J = 15.8 Hz, CH), 6.69 (1H, d, J = 8.1Hz, ArCH), 7.23 (1H, d, J = 8.2 Hz, ArCH), 7.40 (1H, d, J = 15.8 Hz, CH), 7.55 (1H, s, ArCH). 13C NMR (100 MHz; CDC13,): delta 28.2, 80.2, 109.0, 115.3, 117.0, 126.0, 128.4, 132.4, 142.3, 145.7, 166.6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; TEXAS TECH UNIVERSITY SYSTEM; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; TRIPPIER, Paul; VERMA, Kshitij; PENNING, Trevor, M.; ZHANG, Tianzhu; (204 pag.)WO2018/148721; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

The reference gathers the precedent 11 the obtained 1 – [trans-4 – (hydroxy methyl) cyclohexyl] – 3,7-bis-{ [2 – (trimethyl silicon alkyl) ethoxy] methyl} – 1H-pyrrolo [3 ‘, 2’ : 5,6] pyrido [4,3-d] pyrimidine -2,4 (3H, 7H)-dione (1.35g, 2 . 35mmol) bis methyl chloride (14 ml) is added in the solution 1, 1, 1-trifluoro-3- propyl iodide (1.34 ml, 11 . 8mmol), 2,6-di-tert-butyl pyridine (2.38 ml, 10 . 8mmol) and trifluoro methane sulfonic acid silver (2.60g, 10 . 1mmol), stirring 113 hours. Furthermore, filter the reaction mixture, added to the resulting filtrate extraction of chloroform and water. The resulting organic layer after drying with anhydrous sodium sulfate, concentrated under reduced pressure. Residues to silica gel column chromatography (section 1 time: hexane/ethyl acetate = 1/0 ? 78/22(v/v), paragraph 2 time: hexane/ethyl acetate = 1/0 ? 4/1(v/v), paragraph 3 time: hexane/ethyl acetate = 1/0 ? 4/1(v/v)) purification of 3 time, to obtain the colorless amorphous title compound (1.34g, yield 85%).

According to the analysis of related databases, 460-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WATANABE, TSUNEO; TAKAHASHI, KEIJI; HAYASHI, KEISHI; NAKAMURA, TAKANORI; MINAMI, MASATAKA; KURIHARA, KAZUNORI; YAMAMOTO, AKIO; NISHIMURA, TAKUYA; UNI, MIYUKI; KAMIYAMA, TOSHIHIKO; IWAMOTO, SHUNSUKE; (96 pag.)TW2016/7947; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com