Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51411-81-5, name is 3-Amino-4-iodobenzoic acid, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Amino-4-iodobenzoic acid

Step 3 Reaction with 1-Hexyne and Trifluoroacetylation To a mixture of 3-amino-4-iodobenzoic acid on Wang resin (loading 0.6 mmol/g; 3.0 g, 1.8 mmol) and 1-hexyne (0.74 g, 9.0 mmol) in DMF (40 mL) was added bis(triphenylphosphine)palladium(II) chloride (0.20 g, 0.28 mmol) and CuI (0.1 g, 0.52 mmol). The mixture was stirred magnetically for 2 h, filtered, and washed with CH2 Cl2. The resin was suspended in CH2 Cl2 (40 mL), cooled (0 C.), and pyridine (1.5 mL) and trifluoroacetic anhydride (2.6 mL) were added. After 2 h, the mixture was filtered, washed with CH2 Cl2, and dried. To confirm that the reactions occured, 100 mg of resin was treated with 50% TFA/CH2 Cl2 for 3 h, filtered, and the filtrate was concentrated to give 9.8 mg of 4-(1-hexynyl)-3-trifluoroacetamidobenzoic acid; 1 H NMR (DMSO-d6) delta 0.95 (t, 3 H), 1.50 (m, 4 H), 2.95 (m, 2 H), 7.60 (d, 1 H), 7.85 (d, 1 H), 7.90 (s, 1 H), 11.20 (s, 1 H). Anal. calc’d for C15 H14 F3 NO3: C, 57.51; H, 4.50; N, 4.47; Found: C, 57.20; H, 4.38; N, 4.46.

The synthetic route of 51411-81-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Home Products Corporation; US5932743; (1999); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6828-35-9, name is 5-Chloro-2-iodoaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloro-2-iodoaniline

1 mmol of 5-chloro-2-iodoaniline was added to the reaction vessel, 3 mL of aqueous ammonia at 12 mol / L and 1 mmol of benzaldehyde were added 0.1 mmol of copper chloride, 0.1 mmol of proline lithium (proline lithiumas) Sodium hydroxide 3 mmol, water 3 mL. Placed in a microwave reactor at 150 w of power heated to 100 C for 15 min continuous reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The product was purified by column chromatography to give a white solid in 86% yield.

The synthetic route of 6828-35-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujian Medical University; Ke Fang; Zhang Peng; Xu Jianhua; Wu Wen; Zheng Yu; Wu Lixian; (9 pag.)CN106866543; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 217314-45-9, name is Methyl 3-amino-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 217314-45-9

Step C: To a 0C solution of aniline from step B (21.7 g, 78.3 mmol) in 3:1 DCM:pyridine (75 mL) wasadded methanesulfonyl chloride (6.36 mL, 82.2 mmol). The ice bath was removed after 15 min and thesolution was stirred overnight at rt. The reaction mixture was extracted several times with IN HC1. Theorganic phase was dried, concentrated, and cliromatographed (1:1 EtOAc:Hex) to afford the desiredsulfonamide as a white solid.

The synthetic route of 217314-45-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2006/2004; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 116632-39-4, name is 5-Bromo-2-iodotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Bromo-2-iodotoluene

[0001074] To a mixture of Compound 298A (2.96 g, 0.01 mol), 4-fluorophenylboronic acid (2 g, 1.32 mol), and K3PO4 (6.4 g, 0.03 mol) in 1 ,2-dimethoxyethane (80 mL) was added Pd(dppf)Cl2 (733 mg, 1.0 mmol). The reaction mixture was stirred under nitrogen at room temperature overnight. The resulting mixture washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 10% to 50% v/v) to furnish Compound 298B.

The synthetic route of 5-Bromo-2-iodotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; BRIDGES, Alexander, James; WO2015/42397; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, A new synthetic method of this compound is introduced below., SDS of cas: 103962-05-6

A solution of 3-(4-bromophenyl)-lH-l,2,4-triazole (10.9 g, 48.5 mmol), l-iodo-4-(trifluoromethoxy)benzene (13.2 g, 45.8 mmol), copper(I) iodide (2.38 g, 12.5 mmol), and cesium carbonate (30.3 g, 93.0 mmol) in dimethylsulfoxide (85 mL) was degassed with nitrogen for 5 minutes. The mixture was heated at 100 ¡ãC for 60 hours. After cooling, ethyl acetate (200 mL) was added and the mixture was filtered through Celite?. The filtrate was added to a solution of saturated ammonium chloride (200 mL) and stirred for one and a half hours. The layers were separated and the aqueous layer was extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were dried over anhydrous magnesium sulfate, filtered, and adsorbed onto Celite?. Purification by flash column chromatography using 0-40percent ethyl acetate/hexanes as eluent provided the title molecule as an off-white solid (9.65 g, 52percent) : mp 109-112 ¡ãC; XH NMR (400 MHz, CDCI3) delta 8.56 (s, 1H), 8.10-8.03 (m, 2H), 7.83-7.75 (m, 2H), 7.64-7.57 (m, 2H), 7.42-7.35 (m, 2H); ESIMS m/z 384 ([M + H]+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DOW AGROSCIENCES LLC; GIAMPIETRO, Natalie C.; BAUM, Erich W.; FISCHER, Lindsey G.; GOLDSMITH, Miriam E.; CROUSE, Gary D.; RENGA, James M.; SPARKS, Thomas C.; (234 pag.)WO2016/99929; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 6828-35-9, The chemical industry reduces the impact on the environment during synthesis 6828-35-9, name is 5-Chloro-2-iodoaniline, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of 2-iodo aniline/2-iodo phenol (0.25 mmol), Pd-NHC (5 mg, 2 mol%), Mo(CO)6 (0.50 mmol, 132 mg) was taken in round bottomed flask and backfilled with nitrogen three times. Alkyne (0.50 mmol), DMF (2 ml) and Me2NH (4 equiv) were added to the reaction mixture via syringe. The reaction mixture was heated at 95 C until the completion of the reaction. Afterwards, the reaction mixture was poured into the water and extracted with ethyl acetate (3¡Á10 ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified through column chromatography using ethyl acetate and petroleum ether as eluents.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ghosh, Prasanjit; Nandi, Aritra Kumar; Das, Sajal; Tetrahedron Letters; vol. 59; 21; (2018); p. 2025 – 2029;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 6940-76-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6940-76-7, name is 1-Chloro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows.

4-(3-Chloropropyl)-5,7-difluoro-4H-benzo[1,4]oxazin-3-one 5,7-Difluoro-4H-benzo[1,4]oxazin-3-one (0.24 g, 1.3 mmol), Cs2CO3 (1.08 g, 3.3 mmol), and 1-chloro-3-iodopropane (0.296 g, 1.45 mmol) were mixed according to GP2. Purified by column chromatography (SiO2; heptanes/EtOAc, gradient 0 to 30% EtOAc) to give the title compound (0.17 g, 49%). Rf=0.66 (heptanes/EtOAc 1:1); 1H NMR (CDCl3) d 6.67-6.58 (m, 2H), 4.55 (s, 2H), 4.16-4.10 (m, 2H), 3.59-3.52 (m, 2H), 2.21-2.10 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 1-Chloro-3-iodopropane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Skjaerbaek, Niels; Koch, Kristian Norup; Mikael Friberg, Bo Lennart; Tolf, Bo-Ragnar; US2005/209226; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 364-75-0, name is 1-Fluoro-4-iodo-2-nitrobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Fluoro-4-iodo-2-nitrobenzene

General procedure: A mixture of benzenesulfonamides (1, 1.0 mmol), halogenated nitrobenzene(2, 1.0 mmol) and K2CO3 (1.1 mmol) were dissolved in DMF in a microwave tube. Then, the reaction mixture was irradiated in a microwave apparatus at 140 C for 12 minutes. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by column chromatography on silica gel to the desired products 3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Huang, Zhi-You; Liu, Min; Mao, Yi-Jun; Chen, Yu-De; Wang, Yan-Ping; Liu, Chong; Tetrahedron Letters; vol. 60; 8; (2019); p. 626 – 629;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1878-94-0, name is 2-(4-Iodophenoxy)acetic acid, A new synthetic method of this compound is introduced below., COA of Formula: C8H7IO3

A mixture of 5 (846 mg, 3.0 mmol), 11 (869 mg, 5.2 mmol), EDCI (997 mg, 5.2 mmol), HOBt (796 mg, 5.2 mmol), DIPEA (0.89 mL, 5.2 mmol) was dissolved DMF (5 mL) and stirred at room temperature overnight. The reaction was quenched by 1 N of HCl solution and the reaction mixture was extracted with ethyl acetate, neutralized with saturated aqueous NaHCO3 solution, washed with saturated aqueous NaCl solution, dried over anhydrous Na2SO4, and concentrated. The resulting solid was washed with cold methanol to afford 6 (939 g, 2.2 mmol, 73%) as a white solid. This solid compound was pure enough to perform the next step: 1H NMR (400 MHz; CDCl3): delta 9.50 (s, 1H), 8.53 (s, 1H), 7.85 (d, J = 8.2 Hz, 1H), 7.78 (s, 1H), 7.67 (d, J = 8.4 Hz, 2H), 7.07 (d, J = 8.2 Hz, 1H), 6.80 (d, J = 8.4 Hz, 2H), 4.67 (s, 2H), 3.90 (s, 3H); 13C NMR (100 MHz; DMSO) delta 166.5, 166.2, 157.7, 152.0, 138.3, 126.8, 125.7, 122.3, 120.5, 117.7, 114.9, 84.4, 67.2, 52.0; MS (ESI) m/z 428 [M + H]+, 450 [M + Na]+, 466 [M + K]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Nakamura, Hiroyuki; Yasui, Yuka; Ban, Hyun Seung; Journal of Organometallic Chemistry; vol. 747; (2013); p. 189 – 194;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20555-91-3, HPLC of Formula: C6H3Cl2I

Step C: To 3,4-dichloro-1-iodobenzene (9.00 g, 41.0 mmol) in tetrahydrofuran (80 mL) at room temperature, was added isopropylmagnesium bromide (40.5 mL of a 2.0 M solution in THF, 82.0 mmol) dropwise. After 2 h, a solution of 1-(3-methoxybenzyl)piperidin-4-one (9.0 g, 41.0 mmol) from Step B above in tetrahydrofuran (10 mL) was added dropwise at 0 C. The reaction mixture was warmed to ambient temperature and stirred for 2 h. After 1 h, the reaction mixture was quenched with saturated ammonium chloride (5 mL). The mixture was diluted with ethyl acetate (50 mL) and washed with saturated ammonium chloride (80 mL), water (80 mL), brine (80 mL), dried over anhydrous sodium sulfate and concentrated in vacuo. Purification by silica gel chromatography (dichloromethane to 10% ethyl acetate in dichloromethane) gave 4-(3,4-dichlorophenyl)-1-(3-methoxybenzyl)piperidin-4-ol (13.0, 86%) as a colorless oil: 1H NMR (CDCl3, 400 MHz) delta 7.62 (d, J=2.0 Hz, 1H), 7.43-7.38 (m, 1H), 7.36-7.30 (m, 1H), 7.25-7.21 (m, 1H), 6.96-6.90 (m, 2H), 6.84-6.77 (m, 1H), 3.82 (s, 3H), 3.55 (s, 2H), 2.84-2.76 (m, 2H), 2.47-2.37 (m, 2H), 2.10 (dt, J=4.5, 13.1 Hz, 2H), 1.72-1.65 (m, J=11.5 Hz, 2H); ESI MS (m/z) 366 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dichloro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ALBANY MOLECULAR RESEARCH, INC.; US2012/46271; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com