Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181765-85-5, name is Methyl 4-chloro-2-iodobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: 181765-85-5

Synthesized in an analogous manner to Intermediate 143a using Intermediate 033a (0.080 g, 0.195 mmol) and methyl 4-chloro-2-iodobenzoate (0.0694 g, 0.234 mmol) to yield Intermediate 145a (0.050 g, 0.110 mmol, 57% yield): LC-MS (Method A2) RT = 0.93 min, MS (ESI) m/z: 453.1 (M+H)+. 1H NMR (400MHz, CDCl3) delta 7.80 (d, 7=8.4 Hz, 1H), 7.39 (dd, 7=8.4, 2.2 Hz, 1H), 7.33 (d, 7=2.0 Hz, 1H), 7.29 – 7.24 (m, 2H), 7.21 – 7.16 (m, 2H), 4.73 (s, 2H), 3.63 (s, 3H), 2.37 – 2.29 (m, 2H), 2.06 – 1.91 (m, 6H), 1.88 – 1.77 (m, 2H), 1.65 – 1.54 (m, 2H), 1.34 (dq, 7=14.9, 7.4 Hz, 2H), 0.88 (t, 7=7.4 Hz, 3H).

The synthetic route of 181765-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
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Application of 77317-55-6, The chemical industry reduces the impact on the environment during synthesis 77317-55-6, name is Methyl 2-amino-5-iodobenzoate, I believe this compound will play a more active role in future production and life.

To a solution of methyl 5-iodoanthranilate (1.5 g, 5.3 mmol) and sodium bicarbonate (892 mg, 10.6 mmol) in DCM (29.5 mL) at 0 C. was added methyl 3-chloro-3-oxopropionate (587 muL, 5.3 mmol) dropwise over 2 minutes. The cream-colored mixture was stirred at 0 C. for 19 hours. The reaction mixture was then diluted with DCM (25 mL), water (25 mL) was added and the biphasic mixture stirred vigorously for 15 minutes. The layers were separated and the aqueous extracted with DCM (25 mL). The organics were combined, dried (Na2SO4), filtered and concentrated to dryness to afford a cream-colored solid. The crude material was purified by FCC (0-50% EtOAc/hexanes) to provide the title compound as a cream-colored solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JOHNSON & JOHNSON; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; CUMMINGS, MAXWELL D.; MCCLURE, KELLY; TANIS, VIRGINIA; US2015/111870; (2015); A1;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H9IO2

Compound 20.1. Methyl 4-(bromomethyl)-3-iodobenzoate. Into a 100-mL round- bottom flask, was placed a mixture of methyl 3-iodo-4-methylbenzoate (compound 5.3, 3.00 g, 10.9 mmol) in CCI4 (50 mL), NBS (2.9 g, 16.3 mmol), azobisisobutyronitrile (360 mg, 2.19 mmol) and potassium carbonate (1.65 g, 1 1.9 mmol). The resulting mixture was stirred overnight at 70 C, then cooled to room temperature and concentrated under reduced pressure. The residue was diluted with EtOAc (100 mL) and the mixture was washed with brine (2 x 50 mL), dried (Na2SC>4), filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1 :20) as the eluent to yield 3.0 g (78%) of the title compound as a yellow solid.

The synthetic route of 90347-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; 3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2014/8197; (2014); A1;,
Iodide – Wikipedia,
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Application of 82998-57-0,Some common heterocyclic compound, 82998-57-0, name is 3-Iodo-4-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-iodo-4-methylbenzoic acid (3.2 g, 12.2 mmol) was dispersed in 50 mL of thionyl chloride.The reaction system was heated to 82 C, kept under reflux for 1 hour, and cooled to room temperature.The reaction solution was added to 50 mL of toluene while maintaining slow stirring.Concentrate under reduced pressure to a pale yellow oil.After the concentrate was dissolved in 100 mL of dichloromethane,To this solution was added 3-trifluoromethylaniline (2.3 mL, 18.3 mmol) and diisopropylethylamine (9 mL).The reaction system was stirred at room temperature overnight to precipitate a large amount of white solid.The reaction solution was concentrated under reduced pressure and then evaporated.Washed with saturated ammonium chloride solution and saturated brine,The organic phase was dried over anhydrous magnesium sulfate and concentrated.Purification by silica gel column chromatography to obtain compound 8(3.5 g, 71%) was obtained as a white solid.

The synthetic route of 82998-57-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Ruixi Biological Technology Co., Ltd.; Jiao Zhaodong; Li Xitao; Tao Guanyu; Pan Zhengying; (36 pag.)CN109305944; (2019); A;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144550-76-5, name is Methyl 2-amino-4-iodobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-amino-4-iodobenzoate

e. Dimethyl 7-iodo-4-hydroxyquinoline-2,3-dicarboxylate Using a procedure similar to that described in Example 3c. except starting with methyl 2-amino-4-iodobenzoate, the crude title diester was obtained as a green solid (2.6 g, 92%). This material was purified by chromatography over silica gel (eluant: methylene chloride/methanol; 9.5/0.5) to provide the title compound (0.85 g, 30%) as a tan solid, mp 243-244 C.; MS(CI): 388 (M+H). Analysis for C13 H10 INO5: Calculated: C, 40.33; H, 2.60; N, 3.62 Found: C, 40.26; H, 2.77; N, 3.54

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Imperial Chemical Industries, PLC; US5599814; (1997); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Iodo-2-(trifluoromethyl)benzene

General procedure: A mixture of aryl iodide (2 mmol), CuI (0.10 mmol), ligand(1.1 mmol), and S8 (1.1 mmol) were added to an oven-driedreaction tube equipped with a septum. The reaction tube wasevacuated and back-filled with argon. Under a counterflowof argon, EIPA (0.258 g, 2 mmol) and DMSO (2 mL) wereadded, and the mixture stirred at r.t. for 8 h. After completedisappearance of aryl iodide (monitored by TLC), H2O (5mL) was added, and the mixture was extracted with CH2Cl2(3 ¡Á 5 mL). The combined organic phases were dried (onMgSO4) and filtered before evaporation of the solvent. Theresidue was purified on silica gel, eluting with PE?EtOAc(20:1), to give product 2. Analytical and spectroscopic datafor all derivatives, except 2g?i have been reported previously.19

The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yavari, Issa; Ghazanfarpour-Darjani, Majid; Solgi, Yazdan; Synlett; vol. 25; 8; (2014); p. 1121 – 1123;,
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Related Products of 340825-13-0,Some common heterocyclic compound, 340825-13-0, name is 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, molecular formula is C10H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 8B: (S)-N-(6-Iodo-3,4-dihydronaphthalen-1(2H)-ylidene)-2-(methoxymethyl) pyrrolidin-1-amine To a stirred mixture of 6-iodo-3,4-dihydronaphthalen-1(2H)-one (I-8A, 20.90 g, 77 mmol), p-toluenesulfonic acid monohydrate (0.584 g, 3.07 mmol), and cyclohexane (40 mL) was added (S)-2-(methoxymethyl)pyrrolidin-1-amine (10 g, 77 mmol) dropwise at room temperature under nitrogen. The mixture was heated with azeotropic removal of water for 5 h. The reaction mixture was diluted with ethyl acetate (20 mL) and mixed with saturated aqueous sodium bicarbonate solution (15 mL). The aqueous layer was separated and extracted with ethyl acetate (2*30 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated under reduced pressure. Flash chromatography purification (330 g silica gel column, gradient elution from 0% to 20% EtOAc in hexanes) afforded (S)-N-(6-iodo-3,4-dihydronaphthalen-1(2H)-ylidene)-2-(methoxymethyl)pyrrolidin-1-amine (29.1 g, 76 mmol) as a yellow liquid. LC/MS M+1=385.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, its application will become more common.

Reference:
Patent; Dhar, T. G. Murali; Xiao, Hai-Yun; Dyckman, Alaric J.; Chan, Eric J.; Dabros, Marta; Roberts, Daniel Richard; US2014/235591; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 54413-93-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54413-93-3, name is 2-Iodo-5-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: NaIO4 (6.7 g, 31 mmol, 1.0 equiv) and2-iodobenzoic acid (7.4 g, 30 mmol, 1.0 equiv) were suspended in 30% (v:v) aqueousacetic acid (45 mL). The reaction mixture was vigorously stirred and refluxed for 3 hprotecting from light. Cold water (120 mL) was then added and allowed to cool toroom temperature. After 1 h, the crude product was collected by filtration, washedwith ice water (3 x 30 mL) and acetone (3 x 30 mL). After air-drying in the dark,hydroxybenziodoxole 2 was yielded as a white solid.

The synthetic route of 2-Iodo-5-methoxybenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Yue; Jia, Kunfang; Chen, Yali; Chen, Yiyun; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1215 – 1221;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6940-76-7, name is 1-Chloro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Chloro-3-iodopropane

335 mg (1.30 mmol) of 4-(3,4-difluorophenyl)phthalazin-1(2H)-one (8n) was dissolved in 10 ml of N,N-dimethylformamide, and 62 mg (1.56 mmol) of sodium hydride were added at 0oC. After being stirred for 30 min, 0.21 ml (1.95 mmol) 3-iodo-1-chloropropane was then added to reaction mixture. After being stirred for 1 h, the reaction mixture was combined with 50 ml of water and extracted with ethylacetate (50 ml X 2) being washed with water and a sodium hydroxide solution, and then the combined organic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was removed from the filtrate under a reduced pressure, and the resulting residue was refined by silica gel column chromatography (ethyl acetate : n-hexane = 1 : 3) to obtain 400 mg (yield 92%) of the title compound.

The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lim, Chae Jo; Kim, Soo Hee; Lee, Byung Ho; Oh, Kwang-Seok; Yi, Kyu Yang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 427 – 430;,
Iodide – Wikipedia,
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Reference of 21304-38-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21304-38-1, name is 4-Iodobenzene-1,2-diamine belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-iodo-1,2-phenylenediamine (2 g, 1 eq), 4-dimethylaminonitrozoaniline (1.26 g, 1 eq) and NaOH (340 mg, 1 eq) were mixed neat and heated at 70 C. for 20 min with constant triturating. The resulting paste was extracted with toluene, concentrated in vacuum and purified by flash chromatography (SiO2, hexane/AcOEt, 8/2) giving a mixture of two isomers (3 and 4 iodo) as a red solid in 32% yield; 4-iodo-1,2-phenylenediamine (2 g, 1 eq), 4-dimethylaminonitrozoaniline (1.26 g, 1 eq) and NaOH (340 mg, 1 eq) were mixed neat and heated at 70 C. for 20 min with constant triturating. The resulting paste was extracted with toluene, concentrated in vacuum and purified by flash chromatography (SiO2, hexane/AcOEt, 8/2) giving a mixture of two isomers (3 and 4 iodo) as a red solid in 32% yield.

The synthetic route of 4-Iodobenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tamagnan, Gilles D.; Alagille, David; Costa, Herve Da; US2007/258887; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com