Tag: M.W=200-300

Reference of 19099-54-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19099-54-8, name is 1-Iodo-2-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

In a dry 25 mL Schlenk reaction tube, 74 mg of 2-isopropyl iodobenzene, 203 mg of benzoic anhydride, 71 mg of benzoxazole, 5.3 mg of palladium chloride,14 mg of tris(2-furyl)phosphine, 43 mg of copper bromide, 56 mg of norbornene, 124 mg of potassium carbonate, and 3 mL of acetonitrile.Under nitrogen atmosphere, stirring was performed at 100C for 16 hours.After the reaction was completed, the mixture was cooled to room temperature and insoluble material was removed by filtration and passed through a silica gel column (volume ratio of ethyl acetate to petroleum ether was 1:10) to obtain 136 mg of a product in a yield of 40%. The reaction process was as shown in the following formula:

The chemical industry reduces the impact on the environment during synthesis 1-Iodo-2-isopropylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zhejiang University; Chen Wanzhi; Zhang Pingshun; Pan Shanfei; (24 pag.)CN107382894; (2017); A;,
Iodide – Wikipedia,
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Reference of 696-41-3,Some common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, molecular formula is C7H5IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of substrate 1g (100.9 mg, 0.3 mmol), 2 (0.6 mmol), Pd(TFA)2 (10.0 mg, 10 mol%), TBHP (67.6 mg, 2.5 equiv) in DCE (2.0 mL) was charged in a glass sealed-tube and stirred under N2 atmosphere at 100 0C for 12 h. Upon completion of the reaction, saturated brine (15 mL) and dichloromethane (15 mL) were added to the mixture, then the aqueous layer was extracted with dichloromethane (15 mL ¡Á 2). The combined organic layer was dried over anhydrous MgSO4. Finally, the solution was concentrated in vacuo to provide a crude product, which was further purified via a column chromatography on silica gel (eluents: petroleum ether/ethyl acetate = 10:1) to supply the product 4.

The synthetic route of 696-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Miao-Miao; Shao, Ling-Yan; Lun, Li-Jun; Wu, Yu-Liang; Fu, Xiao-Pan; Ji, Ya-Fei; Chinese Chemical Letters; vol. 30; 3; (2019); p. 702 – 706;,
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Adding a certain compound to certain chemical reactions, such as: 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2401-21-0, Recommanded Product: 2401-21-0

EXAMPLE 35 Benzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2beta-carboxylate STR77 A solution of benzyl 3alpha-ethylthio-7-oxo-1azabicyclo[3.2.0]heptane-2beta-carboxylate (16) (0.050 g) in methylene chloride (5 ml) was stirred in an ice bath under argon and treated with water (1 drop), pyridine (0.040 g) and iodobenzene dichloride (0.091 g). The ice-bath was removed and the reaction mixture stirred at room temperature for 3 hours. The solution was then concentrated and chromatographed on silica gel 60 (<230 mesh) eluding with ethyl, acetate/60¡ã-80¡ã petroleum ether 7:3 to give benzyl 3-chloro-3-ethylsulphinyl-7-oxo-1-azabicyclo[3.2.0]heptane-2beta-carboxylate (56) (0.037 g) as a gum; tau(CDCl3) 2.61 (5H, s, phenyl), 4.75 (2H, s, benzyl CH2), 5.55 (1H, s, C2-H), 5.6-5.9 (1H, m, C5-H), 6.5-8.0 (6H, m, C4-H2, C6 -H2, SCH2) and 8.64 (3H, t J 7 Hz, CH3). This material was unstable and had to be progressed immediately as shown in example 17. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it. Reference:
Patent; Beecham Group Limited; US4223038; (1980); A;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 354574-31-5, name is 2-Iodo-6-methoxyaniline, A new synthetic method of this compound is introduced below., Formula: C7H8INO

EXAMPLE 2 Total Synthesis of Azagalanthamine 2.1 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-N-(2′-iodo-6′-methoxyphenyl)acetamide (16); A solution of (1,4-dioxaspiro[4.5]dec-7-en-8-yl) acetic acid (567 mg; 2.86 mmol; 1 eq) (7) and 2-iodo-6-methoxyaniline (1 g; 2.86 mmol; 1 eq) in anhydrous dichloromethane (30 mL) is admixed with 2-chloro-1-methylpyridinium iodide (1.46 g; 5.73 mmol; 2 eq) and triethylamine (3.98 mL; 28.65 mmol; 10 eq). The reaction mixture is heated at reflux for 20 hours. After cooling and acidification with iN HCl solution to pH=5-6, the mixture is extracted with dichloro-methane. The organic phases are washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate and evaporated under vacuum. Purification by flash chromatography on silica gel (eluent: heptane/ethyl acetate 4/6) gives 1.10 g of 2-(1,4-di-oxaspiro[4.5]dec-7-en-8-yl)-N-(2′-iodo-6′-methoxy-phenyl)acetamide (16) in the form of a yellow foam (yield: 90%). Elemental analysis calculated for C17H20INO4 (m.p.: 429.25) C, 47.57; H, 4.70; N, 3.26; O, 14.91; found C, 47.39; H, 4.59; N, 3.01; O, 15.16. IR (CHCl3) nu (cm-1): 3382 (N-H); 1687 (CO) MS (ES) m/z: 429.8 [M+H]+. 1H NMR (CDCl3; 300 MHz) delta (ppm): 7.43 (dd, J=8.0, J=1.2; 1H; H3′); 7.18 (broad s; 1H; NH); 6.98 (t, J=8.0; 1H; H4′); 6.91 (dd, J=8.0, J=1.2; 1H; H5′); 5.72 (broad s; 1H; H4); 3.99 (s; 4H; Hdioxolane); 3.80 (s; 3H; OCH3); 3.15 (s; 2H; H2); 2.45 (broad s; 1H; H8); 2.37 (broad s; 1H; H5); 2.37 (broad s; 2H; H6); 1.85 (t, J=6.4; 2H; H7). 13C NMR (CDCl3; 62.9 MHz) delta (ppm): 169.2 (C(O)NH); 155.5 (C6′); 132.9 (Cl’); 130.8 (C3′); 129.6 (C4′); 128.1 (C8); 124.9 (C7); 111.7 (C5′); 107.7 (C5); 99.8 (C2′); 64.8 (Cdioxolane); 56.1 (OCH3); 45.7 (C2); 35.9 (C6); 38.2 (C4); 35.0 (C3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Thal, Claude; Guillou, Catherine; Beunard, Jean-Luc; Gras, Emmanuel; Potier, Pierre; US2005/65338; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 645-00-1,Some common heterocyclic compound, 645-00-1, name is 1-Iodo-3-nitrobenzene, molecular formula is C6H4INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: TAPEHA-Pd (0.015 g) was added to a solution of nitroarenes (1.0 mmol) in EtOH/water (1/1) (20 mL). After NaBH4 (4.0 mmol) was slowly added to the mixture, the color of the reaction mixture turned gradually black in a few minutes, resulting in the formation of palladium nanoparticles (TAPEHA-PdNPs). 42 After being stirredfor 1.5 h at room temperature and atmospheric pressure, the catalyst was removed by ltering and the fitrate was extracted with 3 30 mL of EtOAc. The combined organic layers were dried over MgSO4 and concentrated in a vacuum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Iodo-3-nitrobenzene, its application will become more common.

Reference:
Article; Genc, Hayriye; Zengin, Mustafa; Kuecuekislamo?lu, Mustafa; Imamoglu, Mustafa; Toplan, Hueseyin Oezkan; Arslan, Mustafa; Turkish Journal of Chemistry; vol. 41; 5; (2017); p. 784 – 792;,
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5458-84-4, name is 1-Iodo-2-methoxy-4-nitrobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1-Iodo-2-methoxy-4-nitrobenzene

Step 1 2-Methoxy-1-methylsulfanyl-4-nitro-benzene 2-Iodo-5-nitroanisole (5.58 g, 20.0 mmol), Pd2(dba)3 (0.025 eq, 457 mg), Xantphos (0.05 eq, 578 mg), Hunigs Base (1 eq, 3.48 ml) and sodium methanethiolate (1 eq, 1.40 g) were dissolved in THF. The mixture was heated to reflux overnight. Upon cooling the mixture was filtered through celite. The filtrate was concentrated in vacuo. The residue was purified by flash chromatography (4:1 Hexanes/Ethyl Acetate) to give 2-methoxy-1-methylsulfanyl-4-nitro-benzene (2.72 g, 68.3%) as a yellow crystalline solid.

The synthetic route of 5458-84-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Brotherton-Pleiss, Christine E.; Caroon, Joan Marie; Lopez-Tapia, Francisco Javier; US2010/160388; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40400-15-5, name is 2-(2-Iodophenyl)acetonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H6IN

isatin(1.0 mmol) was added to a 50 mL dry round bottom flask in turn.O-iodophenylacetonitrile (1.0 mmol), 4-hydroxycoumarin (1.0 mmol),Catalyst 3e (5 mol%), palladium dichloride (5 mol%),KOH (20mol%), DMSO 3mL, mix well, 110 C,Stir the reaction, after the reaction is finished (TLC tracking), add appropriate amount of water,Extract with ethyl acetate, combine the organic phases, and distill off the excess solvent in the system under reduced pressure.The crude product was separated by column chromatography (V petroleum ether: V ethyl acetate = 1:1 gradient elution) to give the title compound 12d, yield 82%

The synthetic route of 40400-15-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangsu Normal University; Chen Wen; Yuan Rui; Cui Hao; Ren Xuanxuan; Zhou Shengliang; Wan Yu; Wu Hui; (19 pag.)CN109305970; (2019); A;,
Iodide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29289-13-2, name is 2-Iodo-4-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

A) A mixture of K2CO3 (1.78 g, 12.9 mmol), CuI (61 mg, 5 mol %), 2-iodo-4-methylaniline (1.50 g, 6.44 mmol), N,N’-dimethylethylendiamine (0.14 mL, 20 mol%) and diethyl phosphite (1.04 mL, 8.11 mmol) in toluene (20 mL) was heated unter nitrogen atmosphere for 14h at 110 C. After cooling to room temperature, insolubles were separated by filtration and the residue washed with small portions of toluene. The major part of the solvent was removed in vacuum and the residue purified by column chromatography on silica gel using hexane / 5% ethyl acetate for elution yielding 1.02 g (65%) pale yellow oil. B) A mixture of Pd(PPh3)4 (149 mg, 2 mol %), 2-bromo-4-methyl-aniline (1.20 g, 6.45 mmol), Et3N (1.1 mL, 7.89 mmol) and diethyl phosphite (1.10 mL, 8.60 mmol) in toluene (20 mL) was heated under nitrogen atmosphere for 14h at 100 C and worked up as described in A) to give 1.19 g (76 %) pale yellow oil. 1H NMR (CDCl3): d 1.30 (t, 3J = 7.0 Hz, 6 H, CH3), 2.19 (s, 3 H, 5-CH3), 4.06 (m, 4 H, OCH2), 4.95 (br s, 2 H, NH2), 6.56 (dd, 3J = 8.1, 4JPH = 6.9 Hz, 1 H, H-3), 7.06 (dt, 3J = 8.3, 4J + 5JPH = 1.8 Hz, 1 H, H-4), 7.23 (dd, 3JPH = 14.7, 4J = 1.9 Hz, 1 H, H-6). 13C{1H} NMR (CDCl3): d 16.16 (d, 3J = 6.6 Hz, CH3), 20.09 (s, 5-CH3), 61.77 (d, 2J = 4.0 Hz, OCH2), 107.80 (d, 1J = 183.1 Hz, Cq-1), 116.35 (d, 3J = 13.3 Hz, C-3), 125.84 (d, 3J = 13.3 Hz, Cq-5), 132.80 (d, 2J = 6.6 Hz, C-6), 134.72 (d, 4J = 2.7 Hz, C-4), 148.79 (d, 2J = 8.0, Cq-2). 31P{1H} NMR (CDCl3): d 21.5. HRMS (ESI in MeOH+FA): C11H18NO3P (243.24), calcd. for [M+H]+ 244.1097; found: 244.1099.

According to the analysis of related databases, 29289-13-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ghalib, Mohammed; Niaz, Basit; Heinicke, Joachim W.; Jones, Peter G.; Tetrahedron Letters; vol. 53; 37; (2012); p. 5012 – 5014,3;,
Iodide – Wikipedia,
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Related Products of 20555-91-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 1.00 mmol arylhalide, 1.30 mmol furfural-boronic acid and 0.05 mmolBis(triphenylphosphine)palladium(II) dichloride were treated with 0.30 mLdimethoxyethane, 0.50 mL ethanol and 0.30 mL aqueous 2M sodium carbonate solution.The reaction was heated to 65C for 1h or until the TLC showed no remaining startingmaterial. The mixture was evaporated and extracted three times with ethyl acetate. Thecombined organic layers were washed with brine, dried over MgSO4, filtered andconcentrated. The crude product was purified by column chromatography usinghexanes/ethyl acetate (9:1).

The synthetic route of 1,2-Dichloro-4-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Krake, Susann H.; Martinez, Pablo David G.; McLaren, Jenna; Ryan, Eileen; Chen, Gong; White, Karen; Charman, Susan A.; Campbell, Simon; Willis, Paul; Dias, Luiz Carlos; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 929 – 936;,
Iodide – Wikipedia,
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Application of 19230-28-5, A common heterocyclic compound, 19230-28-5, name is 1,3-Dichloro-2-iodobenzene, molecular formula is C6H3Cl2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (S)-3-((R)-Hydroxyphenylmethyl)pyrrolidine-1-carboxylic acid t-butyl ester 11a (250 mg, 0.9 mmol), copper(I) iodide (51 mg, 270 mumol), 1,10-phenanthroline (97 mg, 540 mumol) and 2,4-difluoro-1-iodobenzene (216 muL, 1.8 mmol) were combined in a vial under air. Toluene (1.4 mL, 14 mmol) was added, followed by the addition of cesium carbonate (587 mg, 1.8 mmol). Air was bubbled through the mixture, the vial was sealed, and the mixture was heated at 105C for 48 hours. The mixture was filtered through Celite. The Celite was then rinsed with DCM (2 x 15 ml), and the resultant filtrate was concentrated. The resultant oil was treated with 1.25 M of HCl in EtOH (5.8 mL, 7.2 mmol) and stirred overnight. The mixture was concentrated and purified by reverse phase preparative HPLC (10 to 70% CH3CN in water with 0.5% TFA) to yield 76 mg (97% purity, 26% yield) of the title compound as the mono-TFA salt.

The synthetic route of 19230-28-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Van Orden, Lori Jean; Van Dyke, Priscilla M.; Saito, D. Roland; Church, Timothy J.; Chang, Ray; Smith, Jacqueline A.M.; Martin, William J.; Jaw-Tsai, Sarah; Stangeland, Eric L.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1456 – 1461;,
Iodide – Wikipedia,
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