Tag: M.W=300-400

Adding a certain compound to certain chemical reactions, such as: 199850-56-1, name is Methyl 2-amino-4-chloro-5-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 199850-56-1, Recommanded Product: 199850-56-1

Intermediate 92 : Methyl 4-chloro-5-iodo-2-(2-(phenylsulfonyl)acetamido)benzoateTo a solution of 2-(phenylsulfonyl) acetic acid (Lancaster Synthesis Ltd., 0.771 mg, 3.85 mmol) in dichloromethane (50 mL) was added oxalyl chloride (4.17 mL, 4.17 mmol) and few drops of DMF. The reaction mixture was stirred 2 hours at room temperature. To a solution of methyl 2-amino-4-chloro-5-iodobenzoate (Intermediate 2) (1 g, 3.21 mmol) and triethylamine (1.074 mL, 7.70 mmol) in dichloromethane (50 mL) at RT was added dropwise the acid chloride prepared above. The reaction mixture was stirred at room temperature overnight then quenched with aqueous solution of NaHC03. The organic layer was and washed with saturated NaHC03, water and brine. The organic layer was dried over anhydrous Na2S04, filtered and concentrated in vacuo to give the title compound methyl 4- chloro-5-iodo-2-(2-(phenylsulfonyl)acetamido)benzoate (1.1 g, 2.228 mmol, 69.4 % yield) as pale yellow powder. LCMS: (M+H)+ = 494 ; Rt = 3.58 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-chloro-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE LLC; DAUGAN, Alain Claude-Marie; LAMOTTE, Yann; MIRGUET, Olivier; WO2012/119978; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 82777-09-1,Some common heterocyclic compound, 82777-09-1, name is 2′-Iodo-1,1′:3′,1”-terphenyl, molecular formula is C18H13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3 Synthesis of Exemplified Compound BOl[0107] [Chem. 14] [0108] The following reagents and solvents were charged into a 100-mL recovery flask. 2 , 8-Dibromodibenzothiophene : 600 mg (1.75 mmol) ( 1 , 3-Bis (diphenylphosphino) propane ) dichloronickel ( II ) : 380 mg (0.70 mmol)Toluene: 24 mLTriethylamine : 1.46 mL After this reaction solution was heated to 90C and was then added with 1.53 mL (10.5 mmol) of 4 , 4 , 5, 5-tetramethyl- 1, 3, 2-dioxaborolane, heating was performed for 6.5 hours. After the reaction solution was cooled to room temperature, the reaction was quenched by addition of water, and an insoluble matter was removed by filtration of the reaction solution. After a reaction product in the filtrate was extracted using toluene, this extracted solution was washed with water and was then dried over sodium sulfate, followed by concentration, so that a crude product was obtained. The obtained crude product was refined by a silica gel column chromatography (eluent: toluene), and 124 mg of intermediate S-Bpin2 was obtained (yield: 16%) . [0109] Then, the following reagents and solvents were charged into a 50-mL recovery flask. 2 ‘ -Iodo-m-terphenyl: 245 mg (0.688 mmol) S-Bpin2:120 mg (0.275 mmol) Tetrakis ( triphenylphosphine ) palladium ( 0 ) : 25 mg (22 umol) Toluene: 6 mLEthanol: 3 mL 30-wt% cesium carbonate aqueous solution: 3 mL This reaction solution was heat-refluxed for 4.5 hours while being stirred in a nitrogen atmosphere. After the reaction was completed, the reaction solution was washed with water and was then dried over sodium sulfate, followed by concentration, so that a crude product was obtained.Next, this crude product was refined by a silica gel column chromatography (eluent: heptane/chloroform=3/l ) , and heating dispersion washing was further performed using a mixed solvent containing hexane and ethanol. After a crystal thus obtained was vacuum dried at 150C, sublimation refining was performed at a pressure of 10~4 Pa and a temperature of 340C, so that 120 mg of a high-purity exemplified compound B01 was obtained (yield: 68%). [0110] The result of identification of the obtainedcompound is shown below. [MALDI-TOF-MS] Observed value:[1H-N R (400 MHz, CDC13) ]delta 7.75-7.42 (m, 6H) , 7.35 (d, 2H) , 7.16-7.01 (m, 22H) , 6.85 (dd, 2H) . In addition, the Tl energy (equivalent wavelength) of the exemplified compound B01 was 423 nm measured by a method similar to that of Example 1. [0111] When the energy gap of the exemplified compound B01 was further measured by a method similar to that of Example 1, the absorption edge of the absorption spectrum was 322 nm, and the energy gap of the exemplified compound B01 was 3.85 eV. [0112] In addition, when the ionization potential of the exemplified compound B01 was measured by a method similar to that of Example 1, 6.49 eV was obtained. [0113] Furthermore, when the LUMO level of the exemplified compound B01 was estimated by a method similar to that of Example 1, it was estimated to be -2.64 eV.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2′-Iodo-1,1′:3’,1”-terphenyl, its application will become more common.

Reference:
Patent; CANON KABUSHIKI KAISHA; KOSUGE, Tetsuya; KAMATANI, Jun; KISHINO, Kengo; TOMONO, Hiroyuki; WO2011/132624; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 51560-21-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51560-21-5, name is 1,4-Diiodo-2,5-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of PdCl2(PPh3)2 (28mg, 0.04mmol), CuI (15.2mg, 0.08mmol), and 2,5-diidodimethoxybenzene (0.78g, 2mmol) in toluene (100ml), was added trimethylsilyacetylene (0.68ml, 4.8mmol) under nitrogen. Triethylamine (0.56ml, 8mmol) was later added dropwise and the reaction mixture was stirred for 24 hours at room temperature. On completion of the reaction (TLC), the solvent was evaporated and the resulting solid residue taken up with dichloromethane. The solution was filtered, concentrated and recrystallized from methanol to give a white-yellowish paste which solidified on standing (0.59g, 90%).

The chemical industry reduces the impact on the environment during synthesis 1,4-Diiodo-2,5-dimethoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Tsakama, Madalitso; Shang, Yuting; He, Yonghuang; Fan, Bei; Wang, Fengzhong; Chen, Weihua; Dai, Xiaofeng; Tetrahedron Letters; vol. 57; 16; (2016); p. 1739 – 1742;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 63131-30-6, These common heterocyclic compound, 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The reaction was as follows: In a nitrogen atmosphere, palladium trifluoroacetate (0.33 mg, 2 mumol) and L3 (1.1 mg, 2.4 mumol) were mixed in a glove box, 1 mL of degassed acetone was added, and the mixture was stirred at room temperature for 1 hour, and the solvent was drained to obtain The in-situ generated metal complex was dissolved with 0.5 mL of pentafluoropropanol, added to a hydrogenation bottle, and 4i (20 mg, 0.1 mmol) was added, and the hydrogenated bottle was transferred to an autoclave. After the reaction vessel was closed, hydrogen was replaced three times, hydrogen gas was charged to 30 atm, and the reaction was carried out at 0 C. for 20 hours and then returned to room temperature. The hydrogen was vented and the reactor was opened. The crude reaction solution was filtered through a microporous membrane to remove metal ions. After diluting with isopropanol, the conversion rate and the product (R)-3-hydroxyl were directly determined by HPLC with a chiral AD-H column. Ethyl-3-(4-iodophenyl)propionate [(R)-5i] has an ee value of 97%.

Statistics shows that Ethyl 3-(4-iodophenyl)-3-oxopropanoate is playing an increasingly important role. we look forward to future research findings about 63131-30-6.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Tang Wenjun; Jiang Wenhao; (37 pag.)CN107827929; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid

EXAMPLE 5 R3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENVLAM INO)-PHENYLL-(4-METHYL-OXAZOL-2-YL) methanone Step A: Synthesis of 314-DIFLUORO-2-(2-FLUORO-4-IODO-PHENVLAMINO)-BENZOYL CHLORIDE A solution of 3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYLAMINO)-BENZOIC acid (5.0 g, 12.7 MMOL) in thionyl chloride (75 mL) containing 10 drops of dimethylformamide was heated at reflux for 15 min. The solvent was removed in vacuo affording 3, 4-DIFLUORO-2- (2-FLUORO-4-IODO- phenylamino)-benzoyl chloride (5.3 g, which can be prepared according to the procedure of WO 02/06213) as a yellow solid

The synthetic route of 391211-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/7616; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 182056-39-9, name is 2-Bromo-4-iodo-1-methoxybenzene, molecular formula is C7H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromo-4-iodo-1-methoxybenzene

A flask was charged with 2-bromo-4-iodoanisole (1.0 g, 3.0 mmol), methanesulfonamide (1.4 g, 15 mmol), cuprous iodide (590 mg, 3.03 mmol), NN- dimethylglycine (319 mg, 3.03 mmol) and potassium phosphate tribasic (1.3 g, 6.1 mmol) and the flask was purged with nitrogen. X.X- Di methyl acetami de (10 mL) was then added and the reaction was stirred at 100 C for 2 hours. The reaction mixture was diluted with water (10 mL) and 10% aqueous glycine (10 mL) and acidified to pH = 1 with 1N HC1, extracted with z-PrOAc (3 x 10 mL), dried with anhydrous MgSCf. concentrated and purified by silica gel column chromatography (0% to 100% z-PrOAc in heptane) to give the title compound as a white solid (598 mg, 70% yield). LCMS (ESI+) m/z 280 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 182056-39-9, its application will become more common.

Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; CUNNINGHAM, Christian; BEROZA, Paul Powell; CRAWFORD, James John; LEE, Wendy; RENE, Olivier; ZBIEG, Jason Robert; LIAO, Jiangpeng; WANG, Tao; YU, Chen; (208 pag.)WO2020/51099; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 31827-94-8, The chemical industry reduces the impact on the environment during synthesis 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: The appropriate carbonyl compound (50 mmol) was dissolved in 50 mL of ethanol and magnetically stirred with an equimolar quantity of thiosemicarbazide for 24 h at room temperature with catalytic amounts of acetic acid. The desired thiosemicarbazone precipitated from reaction mixture, was filtered, crystallized from suitable solvent, and dried. Equimolar quantities of 4-iodo-acetophenone and bromine, both dissolved in chloroform, were stirred for 4 h at room temperature until the presence of HBr disappeared. The solution was evaporated under vacuum and the obtained pale yellow solid was washed with petroleum ether to give alpha-bromo-4-iodo-acetophenone in good yield (94%). Equimolar amounts of the prepared thiosemicarbazone (50 mmol) and alpha-bromo-4-iodo-acetophenone (50 mmol), both suspended in 50 mL of ethanol, were reacted at room temperature under magnetic stirring for 10 h. The precipitate was filtered and purified by chromatography to give compounds 1-25 in high yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-(4-iodophenyl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Secci, Daniela; Bizzarri, Bruna; Bolasco, Adriana; Carradori, Simone; D’Ascenzio, Melissa; Rivanera, Daniela; Mari, Emanuela; Polletta, Lucia; Zicari, Alessandra; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 246 – 253;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 640280-28-0, name is 1-Bromo-2-iodo-4-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C7H3BrF3I

Intermediate P: (2-(Pyridin-4-yl)-4-(trifluoromethyl)phenyl)boronic acid Step 1 : 4-(2-bromo-5-(trifluoromethyl)phenyl)pyridine A solution of pd(ph3p)4 (1.410 g, 1.220 mmol), l-bromo-2-iodo-4- (trifluoromethyl)benzene (3.94 ml, 24.41 mmol), pyridin-4-ylboronic acid (3.00 g, 24.41 mmol), and potassium carbonate (13.49 g, 98 mmol) in 32mL dioxane and 6mL water was heated to 120C overnight. Additional portions of pyridin-4-ylboronic acid (3.00 g, 24.41 mmol) and potassium carbonate (13.49 g, 98 mmol) were added and the reaction mixture was heated to 120C for 3 hours. The reaction mixture was then poured into water and was extracted with DCM. The organics were then concentrated. Purification of the crude residue by silica gel column chromatography (0-100% EtOAc/heptane) gave 4-(2-bromo-5-(trifluoromethyl)phenyl)pyridine (3.054 g, 10.1 1 mmol, 41.4 % yield) as a white solid. [M+H]+ = 303.9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 811842-30-5, The chemical industry reduces the impact on the environment during synthesis 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, I believe this compound will play a more active role in future production and life.

To a flask containing 2-bromo-1-fluoro-4-iodo-benzene (4.0 g, 13.3 mmol) and 1,4-dioxa-8-azaspiro[4.5]decane (2.09 g, 14.6 mmol) in N-methyl-2-pyffolidone (50 mL) was addedK2C03(3.67 g, 26.6 mmol), CuT (128 mg, 0.67 mmol) and L-proline (77 mg, 0.67 mmol) under N2. After being heated with stuffing at 120 C overnight, the resulting mixture was cooled to rt, diluted with H20 (50 mL) and extracted with EA (50 mL) for three times. The combined organic layer was washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo.The residue was purified by flash chromatography to give 8-(3-bromo-4-fluoro-phenyl)-1,4- dioxa-8-azaspiro[4.5]decane (1.4 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 31827-94-8,Some common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, molecular formula is C8H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a solution of the compound from step A1d (1.94 mmol at most) in acetonitrile (5 mL) and DIPEA (3 mL) was added 2-bromo-1-(4′-iodophenyl)ethanone (700 mg, 2.15 mmol). It was stirred at rt for 4 hours before concentration to a dark red oil, which was chromatographed (silica, EtOAc-hexanes) to afford the desired compound as a light yellow oil (643 mg, 66% over three steps). ESIMS m/z=400.03 [M-Boc+2H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-1-(4-iodophenyl)ethanone, its application will become more common.

Reference:
Patent; Qiu, Yao-Ling; Wang, Ce; Cao, Hui; Peng, Xiaowen; Tang, Datong; Or, Yat Sun; US2011/300104; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com