Tag: M.W=300-400

Related Products of 31827-94-8, The chemical industry reduces the impact on the environment during synthesis 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, I believe this compound will play a more active role in future production and life.

General procedure: The appropriate carbonyl compound (50 mmol) was dissolved in 50 mL of ethanol and magnetically stirred with an equimolar quantity of thiosemicarbazide for 24 h at room temperature with catalytic amounts of acetic acid. The desired thiosemicarbazone precipitated from reaction mixture, was filtered, crystallized from suitable solvent, and dried. Equimolar quantities of 4-iodo-acetophenone and bromine, both dissolved in chloroform, were stirred for 4 h at room temperature until the presence of HBr disappeared. The solution was evaporated under vacuum and the obtained pale yellow solid was washed with petroleum ether to give alpha-bromo-4-iodo-acetophenone in good yield (94%). Equimolar amounts of the prepared thiosemicarbazone (50 mmol) and alpha-bromo-4-iodo-acetophenone (50 mmol), both suspended in 50 mL of ethanol, were reacted at room temperature under magnetic stirring for 10 h. The precipitate was filtered and purified by chromatography to give compounds 1-25 in high yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-(4-iodophenyl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Secci, Daniela; Bizzarri, Bruna; Bolasco, Adriana; Carradori, Simone; D’Ascenzio, Melissa; Rivanera, Daniela; Mari, Emanuela; Polletta, Lucia; Zicari, Alessandra; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 246 – 253;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 640280-28-0, name is 1-Bromo-2-iodo-4-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C7H3BrF3I

Intermediate P: (2-(Pyridin-4-yl)-4-(trifluoromethyl)phenyl)boronic acid Step 1 : 4-(2-bromo-5-(trifluoromethyl)phenyl)pyridine A solution of pd(ph3p)4 (1.410 g, 1.220 mmol), l-bromo-2-iodo-4- (trifluoromethyl)benzene (3.94 ml, 24.41 mmol), pyridin-4-ylboronic acid (3.00 g, 24.41 mmol), and potassium carbonate (13.49 g, 98 mmol) in 32mL dioxane and 6mL water was heated to 120C overnight. Additional portions of pyridin-4-ylboronic acid (3.00 g, 24.41 mmol) and potassium carbonate (13.49 g, 98 mmol) were added and the reaction mixture was heated to 120C for 3 hours. The reaction mixture was then poured into water and was extracted with DCM. The organics were then concentrated. Purification of the crude residue by silica gel column chromatography (0-100% EtOAc/heptane) gave 4-(2-bromo-5-(trifluoromethyl)phenyl)pyridine (3.054 g, 10.1 1 mmol, 41.4 % yield) as a white solid. [M+H]+ = 303.9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 811842-30-5, The chemical industry reduces the impact on the environment during synthesis 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, I believe this compound will play a more active role in future production and life.

To a flask containing 2-bromo-1-fluoro-4-iodo-benzene (4.0 g, 13.3 mmol) and 1,4-dioxa-8-azaspiro[4.5]decane (2.09 g, 14.6 mmol) in N-methyl-2-pyffolidone (50 mL) was addedK2C03(3.67 g, 26.6 mmol), CuT (128 mg, 0.67 mmol) and L-proline (77 mg, 0.67 mmol) under N2. After being heated with stuffing at 120 C overnight, the resulting mixture was cooled to rt, diluted with H20 (50 mL) and extracted with EA (50 mL) for three times. The combined organic layer was washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo.The residue was purified by flash chromatography to give 8-(3-bromo-4-fluoro-phenyl)-1,4- dioxa-8-azaspiro[4.5]decane (1.4 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 199850-56-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 199850-56-1, name is Methyl 2-amino-4-chloro-5-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

LODINATION of aniline containing compounds: LODINATION was accomplished using a procedure similar to that set forth in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: J. Med. Chem. 2001,44, 6,917-922. The ANTHRANILIC ester in EtOH was added to a mixture of silver sulfate (1 equivalent) and 12 (1 equivalent). The reaction was typically done after 3 hours at room temperature. The reaction was filtered through Celite and concentrated. The residue was taken up in EtOAc and washed with aqueous saturated NAHC03 (3x), water (3x), brine (1X), dried (MGS04), filtered, and concentrated. The crude product (-5 g) was dissolved in MeOH (60-100 mL), NAOH 6 N (25 mL), and water (250 mL). The reactions were typically done after heating at 70-80 C for 4 hours. The reaction mixture was extracted with EtOAc (2x), neutralized with aqueous HCI, filtered to collect the solids, and the solid products were washed with water. The products were dried in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-chloro-5-iodobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 98-61-3,Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 7 (1.0 eq) and triethylamine (3.5 eq) in dichloromethane (10 volume), substituted sulphonyl chloride (1.2 eq) was added at 5-10 C and stirred overnight at room temperature.The completion of the reaction was confirmed by TLC. The reaction mixture was poured into separating funnel washed with water followed by brine solution, dried over anhydrous sodium sulphate and concentrated to syrup. Crude syrup was purified by crystallization using dichloromethane and petroleum ether to yield the oxadiazole substituted sulfonamide as white to white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodobenzenesulfonyl chloride, its application will become more common.

Reference:
Article; Harish, Kikkeri P.; Mohana, Kikkeri N.; Mallesha, Lingappa; Prasanna Kumar, Basavapatna N.; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 276 – 283;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Product Details of 148836-41-3

Step B: Preparation of l -Bromo-4-chloro-2-(3,3,3-triethoxyprop- l -ynyl)benzene; [08941 lambda mixture of l -bromo-4-chloro-2-iodoben/cne ( 1 0 g. 32 mmol) in 100 mL degassed ACN and TEA (29 g. 284 mmol), was treated with 3.3,3- triethoyprop- l -ync (6.0 g, 35 mmol), copper(l) iodide (0.60 g. 3.2 mmol), and dichltheta.Obis(triphenylphosphine)palladium(H) ( 1. 1 g, 1 .6 mmol). The mixture was stirred at room temperature for 2 hours at room temperature (the mixture turned dark green after 5 minutes). TLC showed that all starting material was converted, and a new spot was produced. The mixture was concentrated in vacuo. The residue was diluted with 100 ml. ether, washed with H2O (2 20 mL), 5% ammonia water (2 x 20 ml.), brine (20 ml.), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography pretreated with TEA and eluted with 0-15 % EtOAc/hexane to give 7.6 g of the product as a pale yellow oil. The oil solidified after it was stored in the refrigerator.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6BrIO

General procedure: All 1-substituted 2-hydroxy-2-aryl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts were synthesized by using previously described protocols.41 A general procedure is described below (with compound 79 as an example): In a 30 mL microwave vial were successively brought acetonitrile (15 mL), N-(1,3-benzodioxol-5-ylmethyl)pyrimidin-2-amine (1.15 g, 5 mmol), 4-fluorophenacylbromide (1.3 g, 6 mmol, 1.2 equiv), and a catalytic amount of4-dimethylaminopyridine (6 mg, 0.05 mmol). The reaction tube was sealed and irradiated in a microwave reactor at a ceiling temperature of 80 C at 150 W maximum power for 30 min. After the reaction mixture was cooled with an air flow for 15 min, the precipitate was washed with acetone (25 mL), ether (20 mL) and dried in vacuum to afford 79 (1.98 g, 89% yield) as a white powder.

The synthetic route of 2-Bromo-1-(4-iodophenyl)ethanone has been constantly updated, and we look forward to future research findings.

Reference:
Article; Steenackers, Hans P.L.; Ermolat’Ev, Denis S.; Savaliya, Bharat; Weerdt, Ami De; Coster, David De; Shah, Anamik; Van Der Eycken, Erik V.; De Vos, Dirk E.; Vanderleyden, Jozef; De Keersmaecker, Sigrid C.J.; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3462 – 3473;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 450412-29-0

To a stirred solution of 1-bromo-3-fluoro-2-iodobenzene (2.0 g, 6.7 mmol) in 1,4-dioxane (15 mL), were added dimethylphosphine oxide (0.62 g, 8.0 mmol), and K3PO4 (1.6 g, 7.3 mmol). The reaction mixture was purged with nitrogen for 5 min and charged with Xantphos (0.39 g, 0.67 mmol) and Pd2(dba)3 (0.30 g, 0.33 mmol). The reaction mixture was again purged with nitrogen for 3 min and heated at 100 C. for 9 h. The reaction mixture was filtered through Celite and concentrated under reduced pressure. The crude material was purified by column chromatography (0-100% EtOAc-Hexane, followed by 3% MeOH-CHCl3) to give Intermediate 16 (0.33 g, 1.3 mmol, 20% yield) as a yellow solid. MS(ESI) m/z: 250.9 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta=7.63 (d, J=8.0 Hz, 1H), 7.52 (td, J=8.0, 6.0 Hz, 1H), 7.43-7.28 (m, 1H), 1.87 (d, J=16.6 Hz, 3H), 1.86 (d, J=16.6 Hz, 3H).

The synthetic route of 450412-29-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; Shirude, Pravin Sudhakar; Baligar, Vishweshwaraiah; Seshadri, Balaji; Chattopadhyay, Amit Kumar; Wurtz, Nicholas R.; Kick, Ellen K.; (91 pag.)US2019/270704; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-chloro-2-iodobenzene

The starting material 1-bromo-4-chloro-2-iodobenzene (1.58 g, 5.0 mmol), 4-chloro-1-ethynyl-2-methoxybenzene (916 g, 5.5 mmol), PdCl2(PPh3)2(70 mg, 0.1 mmol), CuI (19 mg, 0.05 mmol) and Et3N (20 mL) were stirred at room temperature for 24 hours under nitrogen. When the reaction is complete, extract the organic layer three times with diethyl ether. The extracted organic layer was dried over magnesium sulfate, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography to obtain Intermediate A-1 (1.60 g, 4.5 mmol, 90% yield). The resulting compound was identified via MS / FAB. C15H9BrCl2O cal. 356.04, found 353.92.

The synthetic route of 148836-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung Display Co., Ltd.; Kim Hae-jin; Go Su-byeong; Jeon Mi-eun; Kim Yeong-guk; Hwang Seok-hwan; (70 pag.)KR2018/21340; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4897-68-1 as follows. SDS of cas: 4897-68-1

Step 40a. 2-(2-Bromo-5-methoxyphenylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine (Compound 0205-53) A mixture of compound 0204 (1.549 g, 5.41 mol), 1-bromo-2-iodo-4-methoxybenzene (Compound 0104-13) (2.54 g, 8.115 mol), neocuproine hydrate (113 mg, 0.541 mmol), CuI (103 mg, 0.541 mmol) and NaOt-Bu (519 mg, 5.41 mmol) in anhydrous DMF (50 mL) was stirred for 24 h at 110 C. (oil bath) under nitrogen atmosphere. The solvent was removed under high vacuum and the crude purified by column chromatography on silica gel (CH2Cl2/MeOH at 100/1) to give the title compound 0205-53 as a brown solid (1.67 g, 65%): LCMS: 471 [M+1]+.

According to the analysis of related databases, 4897-68-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; US2008/234314; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com