Tag: M.W=300-400

Related Products of 811842-30-5, These common heterocyclic compound, 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-bromo-1-fluoro-4-iodobenzene (3.01 g, 10 mmol), Example 35a (1.472 g, 10.50 mmol), and cesium carbonate (3.42 g, 10.50 mmol) in dimethylsulfoxide (20 mL) was heated at 110 C overnight. After cooling to ambient temperature, the reaction mixture was partitioned between water and ethyl acetate. The aqueous layer was extractedwith additional ethyl acetate twice. The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated. The residue was purified by column chromatography on silica gel eluting with heptanes to give the title compound (3.21 g, 76% yield) as a white solid.

The synthetic route of 811842-30-5 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 672-57-1, name is 1-Chloro-2-iodo-4-(trifluoromethyl)benzene, molecular formula is C7H3ClF3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks

Methyl-4-iodosalycilate 1 or 4-Chloro-3-iodobenzotrifluoride 2 (1.00 mmol) and 5-formyl-2-furan boronic acid 3 were dissolved in 10 mL of DMF and 15 mL of EtOH. The reaction mixture was stirred for 10 min under N2, then Pd(PPh3)2Cl2 (0.10 mmol) was added and finally Na2CO3 2M (6.00 mmol). The reaction mixture (light-orange) was stirred under N2 at room temperature. After 1h the reaction went to completion and was quenched with H2O and 2N HCl; then EtOAc was added and the mixture was stirred until the two layers became clear. The aqueous layer was extracted three times with EtOAc, then the organic phase was washed several times with H2O and brine, dried over Na2SO4, filtered and evaporated under reduced pressure. 5-(2-chloro-5-(trifluoromethyl)phenyl)furan-2-carbaldehyde (4). The crude product was purified by flash chromatography using PE/EtOAc = 4:1 as eluent to yield the wished product 4 as a brown solid (yield: 20%); mp = 157 C (decomposition); 1H NMR (400 MHz, CDCl3) delta 9.73 (s, 1H), 8.23 (s, 1H), 7.76-7.45 (m, 2H), 7.42-7.28 (m, 2H)ppm. MS (ESI): m/z 273.0 [M-H]-;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 672-57-1, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 289039-83-4, name is Methyl 2-amino-5-bromo-3-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289039-83-4, COA of Formula: C8H7BrINO2

[0323] Pent-4-yn-l-ol (35.4 mg, 0.42 mmol), methyl 2-amino-5-bromo-3-iodobenzoate (100 mg, 0.28 mmol) ,PdCl2(PPh3)2 (45.9 mg, 0.06 mmol), DIEA (0.098 mL, 0.56 mmol)and copper(I) iodide (10.70 mg, 0.06 mmol) were suspended in THF (2 mL) under nitrogen. The reaction was stirred at rt for 2 hours. The solvent was removed. The crude product was purified by flash silica chromatography, elution gradient 0 to 80% EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford methyl 2-amino-5-bromo-3-(5-hydroxypent-l-yn-l-yl)benzoate (0954) (80 mg, 91 %) as a brown solid (80 mg, 91%). XH NMR (300 MHz,CDCl3-d6) delta ppm 1.67 – 1.76 (2H,m), 2.50 – 2.57 (2H, m), 3.50 – 3.82 (2H, m), 3.82 (3H, s), 4.58 (1H, tr), 6.76 (2H, brs), 7.52 (1H, d), 7.79(1H, d). LC-MS (Method A): m/z (ES+), [M+H]+ = 312.2; acid, HPLC tR = 1.54 mm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-5-bromo-3-iodobenzoate, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 689291-89-2 as follows. Safety of 5-Bromo-2-iodobenzaldehyde

Intermediate 21; N-[(l£)-(5-bromo-2-iodophenyI)methylidene]-2-methyl-2- ropanamine; To a solution of 2-1, 4-Br benzaldehyde (2.0 g, 6.4 mmol) in anhydrous THF (10 mL) was added tert-butylamine (2.0 mL, 19.3 mmol) and the reaction stirred at room temperature under a nitrogen atmosphere for 4 days. The reaction was concentrated in vacuo and partitioned between dichloromethane and water. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to afford the desired compound as a pale yellow solid in quantitative yield.

According to the analysis of related databases, 689291-89-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 98-61-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 98-61-3 as follows.

General procedure: To a solution of pyrrolidine (0.5 mL) and DIPEA (0.5 mL) in 5 mL THF was added dropwise at 0 C a solution of 4-iodobenzenesulfonyl chloride (300 mg, 1 mmol) in THF (2 mL). The mixture was stirred overnight, diluted with ethyl acetate, washed with 1 N HCl solution and water, concentrated, and dried under vacuum. 1-(4-iodobenzenesulfonyl)pyrrolidine (310 mg, 92%) was obtained.

According to the analysis of related databases, 98-61-3, the application of this compound in the production field has become more and more popular.

199850-56-1, name is Methyl 2-amino-4-chloro-5-iodobenzoate, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: iodides-buliding-blocks

Methyl 2-acetamido-4-chloro-5-iodobenzoate A mixture of methyl 2-amino-4-chloro-5-iodobenzoate (8.4 g, 0.027 mol), pyridine (6.4 g, 0.081 mol) in dichloromethane (250 mL) at 0 oC, acetyl chloride (2.5 g, 0.032 mol) was added. The mixture was stirred at RT for 16 h. The reaction mixture was washed with brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (ethyl acetate/petroleum ether = 1:5) to afford the desired product (7.6 g, 80% yield). ESI-MS m/z:353.9 [M + H]+.

The synthetic route of 199850-56-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628-21-7, name is 1,4-Diiodobutane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H8I2

Example 1: Synthesis of dimethyl 3,3′-(3,3′-(butane-l,4-diyl)bis(5-methyl-2,4-dioxo- 3,4-dihydropyrimidine-3,l(2H)-diyl))dipropanoate or butyl- linked bis-(thymine propanoate).[70] The title compound was synthesized according to the reaction scheme depicted in Figure 2. Thymine propanoate (1.4 g, 6.8 mmol) was dissolved in anhydrous DMF (10 mL) at 70 C. K2CO3 (1.1 g, 8.2 mmol) was added, and the mixture was stirred for 5 min before the addition of diiodobutane (0.84 g, 2.7 mmol). After 48 hours, the insoluble white material was collected by filtration. The solids were suspended in distilled H20 to dissolve K2C03, and precipitate the products. The insoluble material was collected by filtration, washed with distilled H20, and recrystallised from hot EtOH. Mp. 189 C; Yield: 0.72 g (89 %). MS (ESI): calculated for [C22H23N408]+: m/z 478.2; Found: m/z 479.1 (M+l), 501.1 (M+Na). 1H- NMR (400 MHz, CDC13): deltaEta 7.14 (d, J = 1.2 Hz 2H, CH), 3.96 (t, J = 6.4 Hz, 8H, 2 x N3- CH2, 2 x NI-CH2), 2.77 (t, J = 6.4 Hz, 4H, N1-C-CH2), 1.90 (d, J = 1.2 Hz, 6H, C-CH3), 1.68 (m, J = 3.2 Hz, 4H, (CH2)2). 13C-NMR (200 MHz, CDC13): 5C 151.47, 139.52, 109.66, 61.17 (C-CH3), 52.16 (O-CH3), 45.96 (CH2), 41.22 (CH2), 33.11 (CH2), 25.42 ((CH2)2), 13.15 (C- CH3). IR (KBr, cm”1): 1730 (v COOR

The synthetic route of 628-21-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 629-09-4, name is 1,6-Diiodohexane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1,6-Diiodohexane

A suspension of sodium hydride (60%, 0.48 g, 12 mmol) in 20 ml of DMF was prepared. 1-(2-Chloro-5-thiazolylmethyl)-2-nitroiminoimidazolidine (2.61 g, 10 mmol) was added to this suspension. The resulting mixture was then stirred for 1 hour at room temperature. 1,6-Diiodohexane (1.64 g, 5 mmol) was added dropwise to this reaction mixture over the course of 30 minutes while cooling the reaction mixture with ice. Following completion of dropping, the mixture was stirred for 4 hours at room temperature. The DMF was distilled off from the reaction mixture under reduced pressure. The residue was then shaken with a mixture of water and chloroform. After separating the chloroform layer and drying, the solvent was distilled off under reduced pressure. The semi-solid residue was subjected to silica gel column chromatography with a mixture (15:1 (v/v)) of ethyl acetate and ethanol as the eluate. The crude product was recrystallized from methanol. The yield of crystalline product was 0.22 g (70%), and the melting point was 204 to 206 C. The results of elementary analysis and NMR analysis are shown below. [0117] Elementary Anal., Found (Calc.): C 36.80 (36.67), H 4.51 (4.33), N 23.50 (23.13). [0118] NMR (CDCl3, delta, ppm): 1.34 (4H, m), 1.60 (4H, m), 3.32 (4H, t, J=7.3), 3.66 (4H, m) , 3.77 (4H, m) , 4.57 (4H, s), 7.49 (2H, s). [0119] Based on the results of analysis, the compound of Example 14 was determined to be 1,6-bis[1-(2-chloro-5-thiazolylmethyl)-2-nitroiminoimidazolidin-3-yl]hexane having the structural formula indicated below.

The synthetic route of 629-09-4 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Iodo-2-(2-iodoethoxy)ethane

Butyllithium (2.5 M in hexanes, 3.76 mL, 9.39 mmol) was added to a solution of oxindole (500 mg, 3.76 mmol) at -78 0C in TEtaF (40 mL). After complete addition, NJSfJSf1N- tetramethylethane-l,2-diamine (1.48 mL, 9.76 mmol) was added, maintaining the internal temperature < 70 0C. After 1 h at -78 0C, 2-iodoethyl ether (4.90 g, 15.0 mmol) was added and the reaction warmed to ambient temperature. After 48 h the reaction was quenched with H2O (5 mL) and the mixture was partitioned between EtOAc (100 mL) and H2O (100 mL). The aqueous solution was extracted with EtOAc (3 x 50 mL) and the combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography, eluting with a gradient of CH2Cl2MeOH- 100:0 to 97:3, gave the title compound. MS: m/z = 204 (M + 1). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34270-90-1. Reference:
Patent; MERCK & CO., INC.; WO2006/31610; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 791642-68-7, These common heterocyclic compound, 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-bromo-l-iodo-2-methoxy-benzene (642 mg, 2.05 mmol) in anhydrous tetrahydrofuran (5 mL) was added n-BuLi (2.5 M, 820 uL) at -70C under a nitrogen for 30 min. Then, (¡À)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (360 mg, 2.05 mmol) in anhydrous tetrahydrofuran (5 mL) was added at -70C under a nitrogen for 30 min. The reaction mixture was stirred at 25C for 30 min. On completion, the reaction was quenched with saturated ammonium chloride (8 mL) and concentrated in vacuo to remove tetrahydrofuran. The residue was extracted with ethyl acetate (3 X 20 niL), dried over anhydrous sodium sulfate and concentrated in vacuo. The yellow oil was purified by silica gel chromatography (petroleum ether: ethyl acetate = 3 : 1 to 1 : 1) to give the title compound. LCMS: (ES+) m/z (M+l) + = 362.1, tR = 0.777.

The synthetic route of 791642-68-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com