Tag: M.W=300-400

Application of 31827-94-8,Some common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, molecular formula is C8H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The appropriate carbonyl compound (50 mmol) was dissolved in 50 mL of ethanol and magnetically stirred with an equimolar quantity of thiosemicarbazide for 24 h at room temperature with catalytic amounts of acetic acid. The desired thiosemicarbazone precipitated from reaction mixture, was filtered, crystallized from suitable solvent, and dried. Equimolar quantities of 4-iodo-acetophenone and bromine, both dissolved in chloroform, were stirred for 4 h at room temperature until the presence of HBr disappeared. The solution was evaporated under vacuum and the obtained pale yellow solid was washed with petroleum ether to give alpha-bromo-4-iodo-acetophenone in good yield (94%). Equimolar amounts of the prepared thiosemicarbazone (50 mmol) and alpha-bromo-4-iodo-acetophenone (50 mmol), both suspended in 50 mL of ethanol, were reacted at room temperature under magnetic stirring for 10 h. The precipitate was filtered and purified by chromatography to give compounds 1-25 in high yield.

The synthetic route of 31827-94-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Secci, Daniela; Bizzarri, Bruna; Bolasco, Adriana; Carradori, Simone; D’Ascenzio, Melissa; Rivanera, Daniela; Mari, Emanuela; Polletta, Lucia; Zicari, Alessandra; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 246 – 253;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181765-86-6, Recommanded Product: Methyl 5-bromo-2-iodobenzoate

The intermediate 1 – 2 (4.0 g, 16.8 mmol) and 5 – bromo -2 – iodo benzoic acid methyl ester (6.3 g, 18.5 mmol) dissolved in 50 ml in tetrahydrofuran and then potassium carbonate (4.56 g, 33.6 mmol), 25 ml water mixed together in single-port is added to the flask. Under the protection of argon, and then added to the mixture (triphenylphosphine) palladium four (0.28 g, 0 . 24 mmol), heating reflux for 4 hours. After the reaction, the reaction mixture can be cooled to the room temperature, and steaming and remove the tetrahydrofuran, then washing, dichloromethane extraction three times (each 10 ml). The combined organic phase, anhydrous sodium sulfate drying, the crude product is used good column chromatography purification, get 5.67 g, yield of 82.7%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Shanghai Daoyi Chemical Technology Co., Ltd.; Huang Jinhai; Su Jianhua; (27 pag.)CN107163066; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 791642-68-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5-bromo-2-iodoanisole (0.5 g, 1.6 mmol), morpholine (0.14 mL, 1.6 mmol), Pd2(dba)3 (0.04 g, 0.048 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.08 g, 0.144 mmol) and sodium tert-butoxide (0.46 g, 4.79 mmol) in toluene (10 mL) was heated to 70 C for 20 h. The reaction was diluted with water, extracted with EtOAc, dried and evaporated. The crude product was purified by flash silica chromatography eluting with 0-30% EtOAc/cyclohexane. Pure fractions were evaporated to dryness to give 4-(4-bromo-2- methoxy-phenyl)morpholine, (0.24g, 56%). m/z ES+ [M+H]+ 272/274; 1H NMR (400 MHz, DMSO-d6) d 7.10- 7.04 (m, 2H), 6.82 (d, J = 8.4 Hz, 1H), 3.80 (s, 3H), 3.74- 3.66 (m, 4H), 2.96- 2.89 (m, 4H).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-iodo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ARTIOS PHARMA LIMITED; BLENCOWE, Peter; CHARLES, Mark; CRIDLAND, Andrew; EKWURU, Tennyson; HEALD, Robert; MACDONALD, Ellen; MCCARRON, Hollie; RIGOREAU, Laurent; (200 pag.)WO2020/30925; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1320266-94-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1320266-94-1, name is 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine, This compound has unique chemical properties. The synthetic route is as follows.

1 -(4-(8-amino-3 -isopropylimidazo[ 1 ,5-a]pyrazin- 1 -yl)naphthalen- 1 -yl)-3 -(3- (trifluoromethyl)phenyl)urea (KIRA3). A mixture of compound 1 (12.0 mg, 0.040 mmol), compound 3 (21.9 mg, 0.048 mmol), tetrakis(triphenylphosphine)palladium (1.4 mg, 1.2 muetaiotaomicroniota) and sodium carbonate (9.3 mg, 0.088 mmol) was dissolved in a 3 : 1 mixture of DME/water (160 uL). The mixture was heated overnight at 85 C. The crude mixture was cooled to room temperature, diluted in a mixture of acetonitrile/water and purified by reverse phase chromatography (HPLC) to obtain 12.3 mg of GP146 (61% yield). TLC (CH2C12:MeOH, 95:5 v/v): Rf = 0.4; 1H MR (300 MHz, MeOD): delta 8.27-8.22 (m, 1H), 8.02-7.96 (m, 2H), 7.90-7.86 (m, 1H), 7.83-7.79 (m, 1H), 7.72-7.49 (m, 5H), 7.37-7.32 (m, 1H), 7.04-6.99 (m, 1H), 3.66-3.55 (m, 1H), 1.54-1.48 (m, 6H); 13C NMR (500 MHz, MeOD): delta 154.9, 151.6, 149.8, 140.2, 135.9, 132.9, 129.4, 128.7, 128.7, 127.1, 126.6, 126.6, 125.8, 125.7, 121.9, 121.9, 121.8, 120.2, 1 18.7, 118.7, 1 15.1, 1 14.6, 1 12.9, 108.4, 25.8, 19.6; [M+l]+ found, 505.4. HPLC Purification Conditions: C18 column (250 x 21 mm), CH3CN/H2O-0.1% CF3C02H = 1 :99 to 100:0 over 78 min; 8 mL/min; 220 nm and 254 nm detection for 78 min. The purity of GP146 was determined to be >98% by analytical HPLC in two different solvent systems.

The chemical industry reduces the impact on the environment during synthesis 1-Iodo-3-isopropylimidazo[1,5-a]pyrazin-8-amine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MALY, Dustin J.; BACKES, Bradley, J.; OAKES, Scott, A.; PAPA, Feroz, R.; GHOSH, Rajarshi; WANG, Likun; (220 pag.)WO2016/4254; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 199786-58-8, name is (5-Bromo-2-iodophenyl)methanol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6BrIO

In a 1 L 3 -necked round-bottom flask (5-bromo-2-iodophenyl)methanol (14.0 g, 44.7 mmol) and IH-imidazole (6.09 g, 89.0 mmol) were combined with dichloromethane (150 mL). Then ieri-butylchlorodimethylsilane (10.1 g, 67.1 mmol) was added dropwise at 0-4C. The resulting mixture was stirred at ambient temperature for 16 hours then water (50 mL) was added. The resulting mixture was extracted with ethyl acetate (3 x 50 mL) and the combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue purified on silica, eluting with 5-10% ethyl acetate in petroleum ether to afford the title compound. 1H NMR (400 MHz, CDC13) 57.67- 7.62 (m, 2H), 7.15-7.12 (m, 1H), 4.61 (s, 2H), 1.01 (s, 9H), 0.20 (s, 6H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 199786-58-8.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CHILDERS, Matthew Lloyd; DINSMORE, Christopher; FULLER, Peter; GUERIN, David; KATZ, Jason David; PU, Qinglin; SCOTT, Mark E.; THOMPSON, Christopher F.; ZHANG, Hongjun; FALCONE, Danielle; TORRES, Luis; BRUBAKER, Jason; ZENG, Hongbo; CAI, Jiaqiang; DU, Xiaoxing; WANG, Chonggang; BAI, Yunfeng; KONG, Norman; LIU, Yumei; ZHENG, Zhixiang; WO2014/146490; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 791642-68-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-bromo-2-iodoanisole (533 mg, 1.30 mmol) and oxetan-3-one (0.12 mL, 2.0 mmol) in tetrahydrofuran (5 mL) at -78 C. followed by the addition of n-butyl lithium (2.5M in hexane, 0.56 mL, 1.4 mmol) dropwise over 5 minutes. The reaction mixture was stirred at -78 C. for 2 hours. The reaction mixture was quenched with saturated aqueous ammonium chloride, warmed to room temperature and extracted two times with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and concentrated under reduced pressure yielding 476 mg of crude material. The crude material was purified using the Biotage Isolera One (SNAP 25 g silica gel column) and eluting with a gradient of 0-70% ethyl acetate/heptane yielding 137 mg (41% yield) of the title compound. 1H NMR (500 MHz, CDCl3) delta 7.15 (dd, J=8.1, 1.7 Hz, 1H), 7.13 (d, J=8.1 Hz, 1H), 7.07 (d, J=1.5 Hz, 1H), 4.99 (d, J=7.1 Hz, 2H), 4.84 (d, J=7.3 Hz, 2H), 3.87 (s, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-iodo-2-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; Bhattacharya, Samit; Cameron, Kimberly; Dowling, Matthew; Fernando, Dilinie; Ebner, David; Filipski, Kevin; Kung, Daniel; Lee, Esther; Smith, Aaron; Tu, Meihua; US2013/267493; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is DIRISIO, C, once mentioned the new application about 450412-29-0, Recommanded Product: 450412-29-0.

PREPARATION OF METHYL [I-131] IODIDE

The preparation of methyl iodide labelled with iodine-131, starting from diazomethane and potassium [I-131]iodide, in different solvents, is described.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 450412-29-0. The above is the message from the blog manager. Recommanded Product: 450412-29-0.

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 450412-29-0, 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, belongs to iodides-buliding-blocks compound. In a document, author is Tietze, Sabrina, introduce the new discover.

Formation of organic iodides from containment paint ingredients caused by gamma irradiation

The formation of volatile alkyl iodides other than methyl iodide during a serious nuclear reactor accident may have radiological significance. The hypothesis that radioactive alkyl iodides, other than methyl iodide, could form from paint solvents under the conditions of a serious nuclear accident in light water reactors (under boiling water reactor (BWR) and pressurised water reactor (PWR) conditions) was tested using stable elemental iodine, a gamma irradiator and gas chromatography equipment. It was found that methyl and isopropyl iodides were formed from the texanol ester, which is used in many modern water-based paints. Methyl, ethyl, propyl and butyl iodides were formed from a hydrocarbon solvent (white spirit) commonly used in paint products used in the past. These results suggest that further work on the formation and behaviour of the higher alkyl iodides (containing more than one carbon atom) under the conditions of a serious nuclear accident is justified.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 450412-29-0. Recommanded Product: 450412-29-0.

Chemistry is an experimental science, Name: 1-Bromo-3-fluoro-2-iodobenzene, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, belongs to iodides-buliding-blocks compound. In a document, author is NIAZI, SB.

SPECTROPHOTOMETRIC DETERMINATION OF TRACES OF IODIDE BY LIQUID-LIQUID-EXTRACTION OF BRILLIANT GREEN IODIDE-ION PAIR

Iodide in natural waters at the 10(-6) M level is determined spectrophotometrically as the Brilliant Green-iodide ion pair. Iodide is first oxidized to iodine with hydrogen peroxide-sulphuric acid to separate it from other chemical species and extracted into carbon tetrachloride. It is then extracted back into aqueous medium by its reduction with sodium thiosulphate and stabilized as the ion pair with Brilliant Green. At pH 7 the ion pair is extracted into chloroform and the absorbance is measured at 625 nm against chloroform. A linear calibration graph is obtained over the range 5 x 10(-7) – 3.5 x 10(-6) M iodide with a relative standard deviation of 0.38% at the 2 x 10(-6) M iodide level. The apparent molar absorptivity for iodide is 3.0 x 10(5) mol-1 cm-1.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 450412-29-0. Name: 1-Bromo-3-fluoro-2-iodobenzene.

Chemistry is an experimental science, Application In Synthesis of 1-Bromo-3-fluoro-2-iodobenzene, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 450412-29-0, Name is 1-Bromo-3-fluoro-2-iodobenzene, molecular formula is C6H3BrFI, belongs to iodides-buliding-blocks compound. In a document, author is Yabuta, Tomonori.

Preoperative Administration of Excess Iodide Increases Thyroid Volume of Patients with Graves’ Disease

Preoperative excess iodide administration for patients with Graves’ disease has been widely adopted by surgeons to perform surgery safely, because it decreases blood flow in the thyroid. However, surgeons often encounter the enlargement of thyroid volume after iodide administration, which makes surgery even more difficult. In this study, we retrospectively investigated the change in thyroid volume in Graves’ disease that was evaluated on ultrasonography between before and after iodide administration. Eighty-nine patients who received iodide administered (KI(+) patients) and 24 ill whom iodide was not administrated (KI(-) patients) before surgery for Graves’ disease were enrolled in the study. The level of free T4 (FT4) significantly decreased and that of thyroid stimulating hormone (TSH) significantly increased after iodide administration. Average thyroid volume also significantly increased for KI(+) patients after iodide administration and 17% of these patients showed a 30% or more increase in thyroid volume. In KI(-) patients who were preoperatively treated only by anti-thyroid drugs, thyroid volume did not change before surgery. Preoperative TSH levels remained below measurement sensitivity in 37 of KI(+) patients, but the average thyroid volume also significantly increased after iodide administration. These findings suggest that thyroid volume in Graves’ disease call increase with iodide administration not only due to TSH stimulation but also due to reasons other than TSH. Surgeons should be careful when preoperatively iodide administering to patients with Graves’ disease, especially when the goiter is large.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 450412-29-0, in my other articles. Application In Synthesis of 1-Bromo-3-fluoro-2-iodobenzene.