Tag: M.W=300-400

Related Products of 175278-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 175278-30-5, name is 4-Bromo-2-ethyl-1-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

First, 65 g (209 mmol) of 1-iodo-2-ethyl-4-bromobenzene and 38 g (226 mmol) of 4-n-butylphenylacetylene were introduced into 300 ml of NEt3, 1 g (5.3 mmol) of copper (I) iodide 3.6 g (5.1 mmol) bis (triphenylphosphine) palladium (II) chloride, and the mixture was stirred at room temperature for 2 hours. The batch was cooled, water and heptane were added, and the phases were separated. The organic phase is washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and evaporated on a rotary evaporator. The residue was purified by column chromatography (SiO2, heptane); the product was obtained as a colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-ethyl-1-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; JASPER, CHRISTIAN; BROCKE, CONSTANZE; PAULUTH, DETLEF; REIFFENRATH, VOLKER; MANABE, ATSUTAKA; (37 pag.)TW2017/16378; (2017); A;,
Iodide – Wikipedia,
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Related Products of 289039-83-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 289039-83-4, name is Methyl 2-amino-5-bromo-3-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 2-amino-5-bromo-3-iodobenzoate (7.47 g, 20.99 mmol) in TEA (40 mL, 287 mmol) is added Pd(PPh3)2C12 (0.884 g, 1 .259 mmol), and copper(l) iodide (0.240 g, 1.259 mmol). The mixture is stirred under N2 for about 5 mm, and then trimethylsilylacetylene (3.83 mL, 27.3 mmol) is added. The mixture is stirred at rt for I h. The reaction is followed by LCMS (only 6% product after I h). The mixture is then transferred to a pressure tube and additional Pd(PPh3)2C12 (0.14 g, 0.199 mmol) and copper(l) iodide (0.036 g, 0.189 mmol) are added. The mixture is purged with N2 for 1 mm, and then it is heated at 60 C for 2 h (LCMS shows 54% mono-alkyne and 35% bis-alkyne). The reaction mixture is concentrated under reduced pressure. The residue is taken up in CH2CI2 and filtered through a plug of Celite. The Celite plug is washed with CH2CI2. The filtrate is washed with water (2x) and brine (lx), dried over Na2SO4, filtered and concentrated. The residue is chromatographed over silica gel (120 g ISCO column) eluting with 0-5% EtOAc/hexane gradient to yield a mixture of methyl 2-amino-5- bromo-3-((trimethylsilyl)ethynyl)benzoate and methyl 2-amino-3, 5- bis((trimethylsilyl)ethynyl)benzoate (4.2 to I ratio by I H NMR). LCMS (ES API) MH+ = 326 & 328 for Br isotopes mono-alkyne product; and LCMS (ES API) MH+ = 344 bis-alkyne product.

The chemical industry reduces the impact on the environment during synthesis Methyl 2-amino-5-bromo-3-iodobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; BECHERER, J. David; CADILLA, Rodolfo; DEATON, David Norman; HAFFNER, Curt; HENKE, Brad Richard; PREUGSCHAT, Frank; SCHULTE, Christie; (69 pag.)WO2016/87975; (2016); A1;,
Iodide – Wikipedia,
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Some common heterocyclic compound, 98-61-3, name is 4-Iodobenzenesulfonyl chloride, molecular formula is C6H4ClIO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Iodobenzenesulfonyl chloride

General procedure: To the solution of meridianin G (7) or meridianin C (3) indichloromethane (5 ml) was added DMAP (0.05 equiv.), aryl/heteroarylsulfonyl chloride (1.1 equiv.) and N,N-diisopropylethylamine(1.5 equiv.). The mixturewas stirred at room temperature for20 h. Reaction was then quenched by the addition of 10% HCl. Thisreaction mixture was extracted with dichloromethane (50 ml 3),and combined organic layer was evaporated on rotary evaporator.Purification by silica gel column chromatography (mesh 100e200)using dichloromethane-methanol (99:1 to 97:3) to get the titledproducts 14aead.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 98-61-3, its application will become more common.

Reference:
Article; Yadav, Rammohan R.; Khan, Shabana I.; Singh, Samsher; Khan, Inshad A.; Vishwakarma, Ram A.; Bharate, Sandip B.; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 160 – 169;,
Iodide – Wikipedia,
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Application of 628-21-7,Some common heterocyclic compound, 628-21-7, name is 1,4-Diiodobutane, molecular formula is C4H8I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

With reference to the above reaction formula 12, the ICH2CH2CH2CH2I (309 mg, 0 . 18mmol) containing as added to the starting material of the amine compound (amine compound, 40 mg, 0 . 15mmol), K2CO3(62 mg, 0 . 45mmol) of DMF (10 ml) solution, in 60 C mix 48 hours for reaction. Thus-prepared reaction solution, with the ice water (10 ml) after mixing, using CH2Cl2(2×20 ml) to carry out extraction. Collecting the organic layer, water (2x 10 ml) after washing, the use of non-aqueous sulfuric acid drying, to chromatographic method for the brown residue (CH2Cl2As eluant) is purified, thereby obtaining the chemical formula 27 compound (yield: 17 mg, 35%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Diiodobutane, its application will become more common.

Reference:
Patent; Shuntian Township University-Industry Association; Korea Chemical Research Institute; Song, Honyeon; Jang, Ungsig; Nam, Gungu; Li, Byeongui; Gil, Yeonsig; Li, Qiin; Sadu, Bunjabtab Seopaila; Jo, Huiyeong; (35 pag.)CN106176709; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 628-77-3, name is 1,5-Diiodopentane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 628-77-3

EXAMPLE 1 N, N’-Pentane-1, 5-diyl-bis-pyridinium Diiodide (bPPeI).; 1,5-Diiodopentane (mmol) was added to a solution (30 mL) of dry pyridine, and the solution heated for 24 hours at 65C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting yellow solid was isolated in a 90% yield. ‘H NMR (300 MHz, DMSO-D6) 8 9.14 (2H, d, C2&C6-H), 8.62 (1H, t, C4-H), 8.19 (2H, t, C3&C5-H), 4.62 (2H, t, C’1-CH2), 1.92 (2H, m, C’2-CH2), 1.25 (1H, m, C’3-CH2).

The synthetic route of 1,5-Diiodopentane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WO2005/66129; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 249647-24-3, name is Methyl 3-bromo-4-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 249647-24-3, Recommanded Product: 249647-24-3

A solution of the compound obtained in 81-1 (5.02 g, 29.771 mmol) in THF (35 mL) was added with 9-BBN (0.5M THF solution, 65.5 mL, 32.748 mmol) and stirred at room temprature for 2.5 hours. The mixture was added with DMF (100 mL), methyl 3-bromo-4-iodobenzoate (11.17 g, 32.748 mmol) and K2CO3 (12.34 g, 89.313 mmol), and then substituted with nitrogen for a few minutes. Then, the mixture was added with Pd(dppf)Cl2¡¤MC (1.22 g, 1.489 mmol) and allowed to react at 100C for 16 hours. After cooled to room temperature, the reaction mixture was added with distilled water and brine, and then extracted with EtOAc. The organic layer was collected and dried over MgSO4. The filtrate thus obtained was concentrated under reduced pressure and purified by silica gel chromatography to obtain the title compound (yellow oil, 5.38 g, 47% yield). 1H NMR (300 MHz, CDCl3) delta 8.20 (d, 1H), 7.90 (dd, 1H), 7.29 (d, 1H), 6.98 (s, 1H), 3.92 (s, 3H), 2.90 – 2.74 (m, 4H), 2.50 (s, 3H), 2.17 – 1.99 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SK Chemicals Co., Ltd.; LEE, Ju Young; LEE, Jeong A; AHN, Jaeseung; RYU, Je Ho; HAN, Min-Young; YOO, Taekyung; SA, Joon Ho; KIM, Jae-Sun; (297 pag.)EP2963027; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16355-92-3, name is 1,10-Diiododecane, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H20I2

Example 19: Preparation of C10-bis-L-Lactate Diol (Compound 19b) [0135] 25.0 g 1,10-diiododecane (Compound 18b) was dissolved in 7 ml DCM, and the solution added to 120 g tetrabutylammonium-L-lactate (Compound 17b). The reaction mixture was placed in a 40C rotary evaporator bath, and rotated at top speed for 20 hours. The solution was then diluted with 100ml dichloromethane, and washed with 100 ml water. 750 ml diethyl ether were placed into a 2-liter Erlenmeyer flask and stirred magnetically. The lower organic phase from the separatory funnel was dripped into the diethyl ether with stirring until a precipitate appeared. The precipitated salt (tetrabutylammonium iodide) was vacuum-filtered through a medium porosity frit, and the filtrate was collected in a 1-liter round-bottom flask and washed once with 400 ml 1.25% sodium thiosulfate in water, and twice with 400 ml water. The ether layer was dried over anhydrous magnesium sulfate and the solvent was removed in vacuo to produce 15.5 g of the product. [0136] The structure of the product was confirmed by’H NMR.

According to the analysis of related databases, 16355-92-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; POLYMERIX CORPORATION; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; WO2005/39489; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 188815-32-9, name is 3-Bromo-5-iodobenzoic acid, A new synthetic method of this compound is introduced below., SDS of cas: 188815-32-9

Example 50 Synthesis of 3-Bromo-5-hydroxy-benzoic acid; The title compound was made according to the method described in Org. Proc. Res. Dev. 2002, 6, 591-595. To 5- iodo-3-bromo-benzoic acid (500 mg, 1.53 mmol), NaOH (250 mg, 6.1 mmol), Cu20 (240 mg, 1.68 mmol) was added water (4.0 mL). The mixture was heated for 1.5 h at 140 C in a sealed tube. The cooled mixture was diluted with water and extracted with CH2Cl2. The aqueous layer was acidified (pH-2) with TFA and extracted with EtOAc. The organic layer was dried over Na2S04, filtered, concentrated and purified by reverse-phase HPLC to yield 3-bromo-5-hydroxy-benzoic acid. ?H NMR (400 MHz, DMSO-d6): 10.30 (s, 1H), 7.46 (m, 1H), 7.31 (m, 1H), 7.17 (m, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AMGEN INC.; WO2005/113494; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1219741-79-3, name is 4-Bromo-5-fluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Bromo-5-fluoro-2-iodoaniline

To a mixture of 4-bromo-5-fluoro-2-iodoaniline (step 1) (5.2 g, 16 mmol), Pd(PPh3)2Cl2 (582 mg, 0.83 mmol) and CuI (313 mg, 1.6 mmol) in 50 ml of Et3N was added ethynyltrimethylsilane (2.3 mL, 1.6 mmol) slowly at 0 C. The resulting mixture was degassed and charged with N2 three times. After stirring at 30 C. for 2 hrs, the reaction mixture was filtered over celite. The filtrate was diluted with ethyl acetate (*2), washed with water (*2) and brine (*2). The combined organic layers were dried over anhydrous Na2SO4 and filtered. The filtration was evaporated under reduced pressure to afford the crude product, which was purified by column chromatography on silica gel eluting with 0?5% ethyl acetate in hexanes to afford the title compound as yellow oil. LC-MS: Rt=1.29 mins; MS m/z [M+H]+ 286.0; Method 5-95AB 1.5minLC_v003 1H NMR (400 MHz, CDCl3) delta 7.19 (1H, d), 6.21 (1H, d), 4.11 (2H, s), 0.00 (9H, s).

The synthetic route of 1219741-79-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; CHEN, Shuhui; HE, Haiyang; LAGU, Bharat; QIN, Hua; WU, Chengde; XIAO, Yisong; US2015/183802; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 628-21-7,Some common heterocyclic compound, 628-21-7, name is 1,4-Diiodobutane, molecular formula is C4H8I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 50 mL flask compound 6 (100 mg, 0.43 mmol) and dry K2CO3 (80 mg, 0.50 mmol) were added to anhydrous DMF (3 mL). When the product was completelydissolved, an excess of 1,4-diiodobutane (0.5 mL) was added at room temperature. To the crude product distilled water (10 mL) was added and the solution was extracted three times with diethyl ether (30 mL). Then, the organic phase was washed three times with saturated aqueous NaCl solution(10 mL) and finally dried over Na2SO4. The product was purified by column chromatography(30%-60% CHCl3 in hexane), to give compound 7 was obtained as a white solid (237 mg, 0.39 mmol,91%).

The synthetic route of 628-21-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Altieri, Alessandro; Alvino, Antonello; Ohnmacht, Stephan; Ortaggi, Giancarlo; Neidle, Stephen; Nocioni, Daniele; Franceschin, Marco; Bianco, Armandodoriano; Molecules; vol. 18; 11; (2013); p. 13446 – 13470;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com