A common compound: 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, belongs to iodides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 31599-61-8
General procedure: Under an ambient atmosphere, Pd(PPh3)4 (116 mg, 5 mol%), K2CO3 (552 mg, 4.0 mmol), and the corresponding aryl iodide (2.0 mmol) were suspended in MeOH (5 mL) and toluene (5 mL) in a 25 mL flask. Dimethyl (1-diazo-2-oxopropyl)phosphonate (499 mg, 1.3 equiv) was then added, and the resulting solution was stirred at r.t. for 5 h. The mixture was filtered through a short pad of silica gel eluting with EtOAc and the filtrate was evaporated in vacuo to remove the volatile materials. The crude residue was purified by column chromatography (silica gel, EtOAc-PE, 1:1) to afford the respective final product 3; yield: 50-90%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 31599-61-8, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wu, Chenggui; Ye, Fei; Wu, Guojiao; Xu, Shuai; Deng, Guisheng; Zhang, Yan; Wang, Jianbo; Synthesis; vol. 48; 5; (2016); p. 751 – 760;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com