Some common heterocyclic compound, 51839-15-7, name is Dimethyl 5-iodoisophthalate, molecular formula is C10H9IO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 51839-15-7
General procedure: A 5 mL microwave glass vial (Biotage) sealable with a septum held in place by a metal crimp cap was charged with a diaryliodonium triflate (0.3 mmol, 1 equiv), an aryl iodide (1.5 mmol, 5 equiv.), and 1,2-dicholoroethane (3 mL, 0.1 M iodonium triflate concentration). The tube was sealed (crimp cap) and submitted to microwave irradiation with a target temperature of 100 C in high absorption mode. After the indicated time, the tube was retrieved and cooled to rt and the contents were concentrated under reduced pressure. The crude material was purified by silica gel flash chromatography (gradient 10 ? 50% acetone/CH2Cl2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51839-15-7, its application will become more common.
Reference:
Article; Racicot, Leanne; Ciufolini, Marco A.; Tetrahedron; vol. 73; 50; (2017); p. 7067 – 7072;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com