These common heterocyclic compound, 2401-21-0, name is 1,2-Dichloro-3-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1,2-Dichloro-3-iodobenzene
D. 17alpha-Chloro-17beta-Methylsulfinyl-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 2.4 gm. of 17alpha-methylthio-1,4-androstadiene-3,11-dione, 55.6 ml. of pyridine, 14.4 ml. of water and 5.76 gm. of iodobenzene dichloride. Pass the concentrated residue through a 250 gm. silica gel column, eluding first with chloroform and then with ethyl acetate. Evaporate the ethyl acetate eluates and crystallize from acetone/hexane to obtain the title compound; nmr (CDCl3) delta 1.21 (C13 –CH3, s), 1.45 (C10 –CH3, s), 2.55 (S–CH3, s), 6.10 (C4 –H, d), 6.20 (C2 –H, dd), 7.68 (C1 –H, d).
The synthetic route of 1,2-Dichloro-3-iodobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com