Month: March 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-61-3, name is 4-Iodobenzenesulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

2-Ethoxyethylamine (2.14g, 24mmol) and diisopropylethylamine (4. 2ml, 24mmol) were dissolved in DCM (sol) and cooled to 0 C. To this was added pipsyl chloride (6.05g, 20mmol) in portions and the reaction stirred for 18 hours. Volatiles were evaporated in vacuo. The residue was dissolved in EtOAc (sol), washed with 0.33M citric acid (2 x 50ml), brine (sol), dried and evaporated in vacuo to yield an oil which solidified on standing to give the title compound as a pale yellow solid (6.97g, 98%). NMR: 1.01 (t, 3H), 2.89 (q, 2H), 3.30 (m, 4H), 7.53 (d, 2H), 7.75 (t, 1H), 7.97 (d, 2H); m/z 354 (M-H)-.

According to the analysis of related databases, 98-61-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76436; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14452-30-3, name is 1-(3-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 14452-30-3

To a stirred solution of l-(3-iodophenyl) ethanone 22-1 (200 mg, 0.81 mmol) in DMF (3 mL) was added allyl alcohol (252 mg, 4.06 mmol), AgOAc (137 mg,0.81 mmol), TPP (21 mg, 0.081 mmol). The mixture was purged with argon for 15 min and Pd(OAc)2 (27 mg, 0.04 mmol) was added at RT. The reaction mixture was warmed to 70 C for 16 hr under nitrogen atmosphere. The reaction mixture was diluted with water (10 mL) extracted with EtOAc (3 X 50 mL), the combined organic layers were washed with brine (2 X 40 mL) and dried over Na2S04 and concentrated. The residue was purified by column chromatography (100-200 silica) using 20-25% EtOAc/Pet. ether to afford 22-2 (100 mg, 0.56, 69.9% yield) as a colorless liquid. MS=177.1 [M+l]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 14452-30-3.

Reference:
Patent; COCRYSTAL PHARMA, INC.; JACOBSON, Irina C.; FEESE, Michael D.; LEE, Sam S.; (169 pag.)WO2016/154241; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 88-82-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88-82-4 name is 2,3,5-Triiodobenzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0251] Several approaches have been used to synthesize iodine-containing X-ray contrast agents. The esterification of the ethanolamide of indomethacin has been accomplished by carbodiimide coupling of indomethacin ethanolamide (Compound 4) and 2,3,5-triiodobenzoic acid (FIG. 7). The product, Compound 5, is a potent and highly selective COX-2 inhibitor (IC50 for COX-2=50 nM, IC50 for COX-1>50 muM). Higher concentrations are required for inhibition of COX-2 in the RAW264.7 macrophage cell line (IC50=3.5 muM), which might be related to the hydrophobicity of the compound (cLogP=8.5). Amide derivatives (Compounds 8 and 9) that correspond to the ester, Compound 5, are generated. Compounds 6 and 7 are synthesized and their coupling to 2,3,5-triiodobenzoic acid is carried out

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3,5-Triiodobenzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; US2005/2859; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 3032-81-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3032-81-3, name is 1,3-Dichloro-5-iodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-picolinoylcyclododecylamine (3) (0.2 mmol, 57.6 mg), aryl iodide4 (0.4 mmol), Ag2CO3 (0.3 mmol, 82.7 mg), and Pd(OAc)2 (0.04 mmol, 9.0 mg)in t-AmOH (1 mL) was stirred for 48 h at 110 C in the dark. After dilution withEtOAc, the mixture was filtered and the filtrate was concentrated in vacuo. Theresidue was purified by preparative TLC (EtOAc/CHCl3/hexane = 1:1:8) to givethe corresponding product. Trans-3-(4-nitrophenyl)-N-picolinoylcyclododecylamine[5a(trans)]

The synthetic route of 1,3-Dichloro-5-iodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Seki, Atsushi; Tetrahedron Letters; vol. 58; 45; (2017); p. 4232 – 4235;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 355-43-1, SDS of cas: 355-43-1

General procedure: A 25 mL tube was charged with the appropriate N-arylacrylamide arylacrylamide1 (0.3 mmol), RFI 2 (0.9 mmol), Cs2CO3 (0.3 mmol), andeosin Y (5% mmol). DMA (2 mL) was added and the tube waspurged with argon. The mixture was stirred and irradiated witha 26 W compact LED lightbulb at 65 C for 16 h until the reactionwas completed. H2O (10 mL) and CH2Cl2 (10 mL) wereadded successively to the cooled reaction mixture, the organicphase was separated, and the aqueous phase was furtherextracted with CH2Cl2 (3 ¡Á 30 mL). The combined organic layerswere dried (Mg2SO4) and concentrated under vacuum. Theresidue was purified performed by flash column chromatography(silica gel).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yang, Zhiyong; Tang, Anjiang; Synlett; vol. 30; 9; (2019); p. 1061 – 1066;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 696-41-3, These common heterocyclic compound, 696-41-3, name is 3-Iodobenzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6(0.6 mmol,220 mg), K2CO3(1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMFwere added and mixture was stirred for appropriate reaction timeat 120C under argon atmosphere. The progress of the reactionwas monitored by GC analysis. After completion of the reaction,reaction mixture was washed with 5 mL water and crude productwas isolated using dichloromethane (5¡Á 1 mL). Organic extractswere combined together, evaporated and purified by flash chro-matography using hexane/EtOAc to give the desired aryl cyanideproducts.

The synthetic route of 696-41-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gholinejad, Mohammad; Aminianfar, Afsaneh; Journal of Molecular Catalysis A: Chemical; vol. 397; (2015); p. 106 – 113;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, name: 4-Bromo-1-iodo-2-nitrobenzene

Under nitrogen atmosphere, 500mL three-necked round flask was added 32.8g (0.1mol) 4- bromo-1-iodo-2-nitrobenzene, 16.3g (0.12mol) 2- methyl-phenylboronic acid, 2.31g (2mol%) Pd (PPh 3) 4, and a mixture of100mL of toluene and 100mL of ethanol was added 35mL concentration 2molL sodium carbonatesolution, an oil-bath at 40-50 C the reaction was stirred for 2h, cooled, separated and the organic phase, afterthe organic phase washed with water 2-3 times and dried over anhydrous MgSO 4, the organic solvent wasremoved by rotary evaporation to give the crude product. Recrystallization from absolute ethanol to give theintermediate 4-bromo-1-(2-methylphenyl)-2-nitrobenzene25.9g. Yield 88.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; KUNSHAN VISIONOX DISPLAY?CO., LTD; Tsinghua University; BEIJING VISIONOX TECHNOLOGY CO.LTD; QIU, YONG; LIU, FEI; LI, YINKUI; (42 pag.)CN103183691; (2016); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 111771-08-5, A common heterocyclic compound, 111771-08-5, name is 2-Fluoro-6-iodobenzoic acid, molecular formula is C7H4FIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

W-Ethyl-2-fluoro-6-iodo-W-[(S)-1 -methyl-2-(5-trifluoromethyl-pyridin-2-yloxy)-ethyn (0350) (0351) D-1.1 (150 mg, 0.56 mmol) is dissolved in dry DCM (3.0 mL). Under stirring oxalylchloride (846 mg, 1 .13 mmol) and a drop of DMF are added and the mixture is stirred for 2 h. The mixture is concentrated and the residue is taken up with dry DCM (3.0 mL). The resulting mixture is added dropwise to a mixture of B-1 (145 mg, 0.51 mmol) and DIPEA (390 mu, 2.30 mmol) in DCM (4.0 mL) at 0C. The cold bath is removed and the mixture is stirred for 2 h. The crude product is diluted with DCM and washed with NH4CI (sat. solution), KHC03 (sat. solution) and water. The organic phase is dried and concentrated. The residue is purified by flash column chromatography (using a solvent gradient from 100% Cyclohexane to Cyclohexane/EA 65/35) to afford 160 mg of compound D-1. ESI-MS: 497 [M+H]+; HPLC (Rt): 1.21 min (Method P).

The synthetic route of 111771-08-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; FERRARA, Marco; HEINE, Niklas; LESSEL, Uta; NICHOLSON, Janet Rachel; PEKCEC, Anton; SCHEUERER, Stefan; (69 pag.)WO2017/178341; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 199786-58-8 as follows. Computed Properties of C7H6BrIO

A solution of oxalyl chloride (1.53 g, 0.012 mol) in CH2Cl2 (15 ML) was cooled to -70 C., and DMSO (1.41 g, 0.018 mol) in CH2Ck (15 ML) was added at -65 to -70 C. The mixture was stirred under nitrogen for 10 minutes at -70 C. and then treated with the product from Example 62B (2.35 g, 7.5 mmol) in 60 ML CH2Cl2.The slurry was stirred at -65 C. for 15 minutes and treated with triethylamine (3.8 g, 0.037 mol).The mixture was allowed to warm to -10 C. over 1 hour.The mixture was treated with 20 ML of water and allowed to warm to room temperature.The organic layer was separated and concentrated to provide the title compound. 1H NMR (CDCl3, 400 MHz) delta 9.97 (s, 1H), 7.97 (d, J=4 Hz, 1H), 7.79 (d, J=8 Hz, 1H), 7.40 (dd, J=4, 8 Hz, 1H). MS (DCl/NH3) [M+NH4]+ at 328.

According to the analysis of related databases, 199786-58-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25245-35-6, name is 2-Iodo-1,4-dimethoxybenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9IO2

(3) Compound C (20.21 g, 98.0 mmol) was dissolved in benzene (150 mL), and 2,5-dimethoxyiodobenzene (27.16 g, 102.9 mmol), Pd (PPh3) was sequentially added at -15 C. 2Cl2 (0.69 g, 0.98 mmol), CuI (0.93 g, 4.9 mmol) and DIPEA (40 mL, 391 mmol),Then it was raised to 20 C to 30 C and stirred for 4 h.The reaction was quenched with EtOAc EtOAc (EtOAc)The combined organic layers were washed with brine (30 mL)After concentration under reduced pressure, the mixture was separated by column chromatography (hexane: ethyl acetate = 16:1).25.16 g of compound D was obtained in a yield of 75%(Rf = 0.38, n-hexane: ethyl acetate = 8:1).Among them, the detection data of compound D is as follows:

The synthetic route of 25245-35-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing University Shenzhen Sheng Yuan; Shao Wenbin; Huang Jun; Guo Kai; Zhang Weibin; Gong Jianxian; Yang Zhen; (47 pag.)CN108484638; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com