Month: March 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32024-15-0, name is 3-Iodo-4,5-dimethoxybenzaldehyde, A new synthetic method of this compound is introduced below., Computed Properties of C9H9IO3

General procedure: 3-Iodo-4,5-dimethoxybenzaldehyde (1.5 mmol) and 2,4-dimethyl-3-ethylpyrrole (3.3 mmol) were dissolved in absolute CH2Cl2 (30 mL) under N2 atmosphere, 10 drops of TFA were added and the solution was stirred at rt overnight or until TLC analysis showed complete consumption of the aldehyde. At this time of DDQ (2.5 mmol) were added and stirring continued for 20 min. Then, Et3N (4 mL) and BF3¡¤OEt2 (4 mL) were added. The mixture was stirred for 12 h then the organic layer containing the crude product was subsequently washed three times with water; the organic solution was dried over Na2SO4, and evaporated to dryness. The raw material was chromatographed (SiO2, petroleum ether/CH2Cl2, 6:4) affording 280 mg (yield: 33%) of 1a in the form of orange needles

The synthetic route of 32024-15-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Banfi, Stefano; Nasini, Gianluca; Zaza, Stefano; Caruso, Enrico; Tetrahedron; vol. 69; 24; (2013); p. 4845 – 4856;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 6293-83-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6293-83-0, name is 2-Iodo-4-nitroaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 20 mL dehydrated deoxygenated Schlenk tube, acetophenone p-toluenesulfonylhydrazone(0.30 mmol, 86.4 mg), 2-iodo-4-nitroaniline (0.2 mmol, 52.8 mg), bis triphenylphosphine palladium(0.02 mmol, 14.0 mg), sodium tert-butoxide (1.2 mmol, 115.2 mg) 3.0 mL diethylene glycol dimethyl ether (diglyme), and finally 0.1 MPa of CO2 was injected into the reaction tube. The sealed reaction tube was heated and stirred in an oil bath at 140 C for about 24 hours Rear. The reaction solution was acidified with 1.5 mL of a 1 M hydrochloric acid solution and extracted with ethyl acetate (4 mL x 5) The organic phases were combined and finally the product was purified by column chromatography and then dried to give 23.9 mg of a white solid powder as a solid45%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-4-nitroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changzhou University; Sun, Song; Cheng, Jiang; Hu, Weiming; Gu, Ning; Wang, Bingbing; (12 pag.)CN106432074; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.

Method B): R-lipoyl chloride (10.0g, 44.5mmol) and tetrahydrofuran (200mL) were added to the reaction flask, stirringN, N-dimethylaniline (16.2 g, 133.5 mmol) was added to the solution. The mixture was cooled in an ice bath and 2-iodoethanol (17.6 g, 102.3 mmol)The reaction mixture was reacted at 50 C for 3h. After treatment and purification, the crude product was recrystallized from a mixed solvent of ethyl acetate and n-hexane,R-lipoic acid was 2-iodoethyl ester, light yellow solid (14.1 g), yield 88%, the reaction formula is:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Suzhou Fushilai Pharmaceutical Co., Ltd.; Mo Guoning; (9 pag.)CN107089967; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H5IO2

[00212] 8.1 mg of Pd(OAc)2 (0.036 mmol) and 16 mg (0.033 mmol) of bis(1,2-diphenylarsino)ethane were placed in a reaction tube under nitrogen together with 4 ml of dioxane and 0.45 ml of triethylamine. The tube was heated in an oil bath at 80 C. for 15.5 h and the yellow solution became brown in colour. Then added at room temperature 262 mg (1.06 mmol) of 1-iodo-3,4-methylenedioxybenzene and 0.22 ml (1.5 mmol) of pinacolborane. The reaction mixture was then warmed to 80 C. After 3 h, 45% of the total peak areas was due to the desired product. This increased to 73% after 24 h.

The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Commonwealth Scientific and Industrial Research Organisation; US6680401; (2004); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Computed Properties of C8H9IO2

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd (II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 ¡Á 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product was subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Csuk, Rene; Albert, Sabrina; Siewert, Bianka; Schwarz, Stefan; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 669 – 678;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 216393-67-8, name is 4-Chloro-2-fluoro-6-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H4ClFIN

General procedure: To a 50 mL oven-dried flask containing a magnetic stirring bar, Pd(PPh3)2Cl2 (14.0 mg, 0.02 mmol, 1.0 mol %), CuI (2.0 mg, 0.01 mmol, 0.5 mol %), 4-(tert-butyl)-2-iodoaniline (550.0 mg, 2.0 mmol), 2 (317.0 mg,2.2 mmol) [26], and Et3N (10 mL) were added in sequence under argon atmosphere at room temperature. The resulting reaction mixture was stirred for 5 h, then the reaction mixture was filtered through a shortpad of celite, and the solid was washed with EtOAc (20 mL). The combined organic phase was concentrated under reduced pressure, andthe residue was purified by column chromatography on silica gel(eluent: petroleum ether/ethyl acetate=10:1) to afford pure product4c in 75% yield.

The synthetic route of 216393-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chang, Sai-Lan; Qiu, Li-Hua; Sun, Ru; Yang, Ling; Ge, Jian-Feng; Dyes and Pigments; vol. 160; (2019); p. 58 – 63;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 31599-61-8,Some common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An appropriate phenylacetamide (0.12 mmol, 1 equiv), an appropriate iodo compound (0.48 mmol, 4 equiv), Pd(OAc)2 (2.7 mg, 10 mol%), and AgOAc (50 mg, 0.3 mmol, 2.5 equiv) in anhydrous toluene (3 mL) was heated at 110 C for 24 h under a nitrogen atmosphere. After the reaction period, the solvent was evaporated in vacuo to afford a crude reaction mixture. Purification of the crude reaction mixture by column chromatography furnished the corresponding arylated products 4a-q/7a-f (bis arylation products), 3o,r/6a,b/8e,f/9a,b (mono arylation products) (see corresponding Tables/Schemes for specific examples and reaction conditions).

The synthetic route of 31599-61-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bisht, Narendra; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 72; 39; (2016); p. 5886 – 5897;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 7681-82-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7681-82-5, name is Sodium iodide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of propionic acid (10 ml), sodium iodide (3.0 g, 20 mmol) and Fe3+- montmorillonite catalyst (0.5 g) were stirred in a round-bottomed flask at 25 C for 6 h. The reaction mixture was filtered off to separate the catalyst. The resultant filtrate was titrated with 0. 1M sodium thiosulphate solution using starch as an indicator to know the amount of iodine present in the solution. The amount of iodine liberated in the reaction is 0.998 g (3.7 mmol)

The synthetic route of Sodium iodide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; WO2004/50622; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

2401-21-0, name is 1,2-Dichloro-3-iodobenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 1,2-Dichloro-3-iodobenzene

G. 17alpha-Chloro-17beta-(3′,4′-Dichlorobenzylsulfinyl)-1,4-Androstadiene-3,11-Dione In a manner similar to that described in Example 2A, react 0.238 gms. of 17alpha-(3′,4′-dichlorobenzylthio)-1,4-androstadiene-3,11-dione, 8 ml. of pyridine, 2 ml. of water and 0.411 gm. of iodobenzene dichloride. Purify the residue utilizing thin layer silica gel chromatography, developing with ethyl acetate/chloroform (1:4) and eluding with ethyl acetate. Crystallize the major band from ether to obtain the title compound; m.p.=249¡ã-251¡ã C.

The synthetic route of 2401-21-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Corporation; US4183924; (1980); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41252-96-4, name is 2-Chloro-1-iodo-4-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chloro-1-iodo-4-nitrobenzene

General procedure: 4-acryloyloxy-2,2,6,6-tetramethylpiperidin-1-oxyl (3, 0.113 g,0.5 mmol), aryl iodide (4a-i, 0.5 mmol), Bu4N+AcO- (hygroscopic)(0.3 g), PdEnCatTOTP30 (0.0625 g, 0.025 mol,5 mol %), and toluene (2 mL) were placed in a flask, stirred and heated at 80-100 C for 20-27 h under argon. The particular temperatures and times of the reactions are summarized in Table 1. After approximately 6 h, a second portion of a catalyst(0.0625 g, 0.025 mol, 5 mol %) was added. The progress of the reaction was monitored by TLC (silica, hexane/ethyl acetate9:1). Upon completion of the reaction, the solids were filtered off, the dark filtrate was concentrated under reduced pressureand subjected to column chromatography (hexane/ethyl acetate 9:1, benzene/ethyl acetate 95:5, benzene/methanol 95:5 aspossible mobile phases). The red zone was collected, the eluate was evaporated under reduced pressure to yield red oils (solidifiedin a refrigerator), or directly red crystals of 5a-i.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41252-96-4.

Reference:
Article; Zakrzewski, Jerzy; Huras, Bogumila; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 1155 – 1162;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com