Reference of 19094-56-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The polyphosphoric acid (113 mL) was added to the three-necked flask, and the compound of formula 1b (28.25 g, 100 mmol) was added and heated to an inner temperature of about 50 C and stirred,Phenol (18.82 g, 200 mmol) was added,After heating, the temperature was raised to 80 to 85 C for 3 to 4 hours. After the reaction was cooled to 50 C, the reaction was slowly added dropwise (283 m), followed by addition of dichloromethane (169 mL)After the separation of the organic phase, the aqueous phase was extracted twice with methylene chloride (84 mL) and the combined organic phase saturated sodium bicarbonate (169 mL)The solution was washed once, washed twice with saturated brine (84 mL), dried over sodium sulfate, concentrated with a mixed solvent of dichloromethane ethanol Crystallization gave compound 2b (29.76 g, 83%).
The synthetic route of 2-Chloro-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.