Adding a certain compound to certain chemical reactions, such as: 626-44-8, name is 1,3,5-Triiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-44-8, Product Details of 626-44-8
Ethynyl-dC was synthesized following the procedure of Dodd et ah, Org. Biomol. Chem. (2010) 8:663-6665. Ethynyl-dC (0.2 g, 0.796 mmol) was then dissolved in DMF (10 mL) and maintained under nitrogen atmosphere. To this solution NEt (0.1.12 mL, 7.96 mmol), 1,3,5-triiodobenzene (1.11 g, 2.39 mmol), Pd(Ph P)4 (92 mg, 0.080 mmol) and Cul (31 mg, 0.16 mmol) were added sequentially with stirring under nitrogen. The reaction was continued at rt for 2 h and TLC (10percent MeOH in DCM) and LCMS (ES+) indicated complete disappearance of starting material. After removing the solvent under reduced pressure, the residue was chromatographed on silica gel column using 0 – 20percent MeOH gradient over DCM) to get pure product (0.324 g, 70percent). TLC:(10percent MeOH in DCM): Rf = 0.52. LCMS (ES+): (M+H) calculated mass: 579.14 and observed mass: 579.31. 1H-NMR (DMSO-d6): delta 8.82 (bs, 2H, 4-NH2), 8.38 (s, 1H, 6-H), 8.06 (t, 1H, Ar-H), 8.00 (d, 2H, Ar-H), 6.10 (t, 1H, l’-H), 5.22 (d, 1H, 2′-OH), 5.13 (t, 1H, 5′- OH), 4.22 (m, 1H, 4H), 3.80 (m, 1H, 3′-H), 3.63 – 3.68 (m, 1H, 5′-H), 3.55 – 3.61 (m, 1H, 5″-H), 2.15 – 2.22 (m, 1H, 2′-H), 1.98 – 2.04 (m, 1H, 2″-H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Triiodobenzene, and friends who are interested can also refer to it.