Synthetic Route of 19099-54-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19099-54-8, name is 1-Iodo-2-isopropylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 7-(2-isopropyl)-phenylamino-9,9-diethylfluorene-2-nitrile (7.6 g, 19.97 mmol), 2-isopropyliodobenzene (24.88 g, 101 m·mol), copper powder (3.13 g, 49.25 mmol), potassium carbonate (12.71 g, 92 mmol), 18-crown-6 (0.34 g, 1.29 mmol) and xylenes (5 mL) was held at 165-175 C. for 19 hours cooled, diluted with toluene and filtered. The filtrate was washed with water, dried and concentrated. The residual liquid (27.15 g) was chromatographed over silica gel, and elution with 3:1 heptane-toluene recovering first the unreacted iodobenzene. The product came out in 1:1 and 65% toluene-heptane eluates, and was recrystallized from isopropanol, 6.82 g (68%), m.p. 179.2-180.4 C. Mass spec: m/z 498 (M+). Analysis: Calcd for C36H38N2: C, 86.70; H, 7.68 and N, 5.62%. Found: C, 86.61; H, 7.68, and N, 5.41%. 1H NMR (CDCl3) delta ppm: 0.27 (t, 6H, 7.32 Hz), 1.04 (d, 12H, 6.36 Hz), 1.89 (m, 4H), 3.26 (q, 2H, 6.6 Hz), 6.67 (m, 2H), 6.97 (d, 2H, 7.64 Hz), 7.17 (m 2H), 7.21 (m, 2H), 7.35 (dd, 2H, 1.28 and 7.72 Hz), 7.49 (t, 2H, 5 Hz), 7.54 (m, 2H). 13C NMR delta ppm: 8.32, 23.48, 27.42, 32.44 and 56.36 (5 sp3C), 108.15, 118.98, 120.14, 121.15, 125.87, 126.07, 126.73, 127.59, 128.36, 131.39, 132.18, 145.37, 146.37, 149.96, 151.91 and 152.55 (16 sp2 and sp C).
The synthetic route of 1-Iodo-2-isopropylbenzene has been constantly updated, and we look forward to future research findings.