In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1829-28-3 as follows. Recommanded Product: 1829-28-3
In a typical run, 4-isopropylphenylboronic acid (200 mg, 1.22 mmol) was taken up in 4 mL of DMF along with ethyl 2-iodobenzoate, [1,1 ‘-bis(diphenylphosphino)- ferrocene]dichloropalladium (II) complex with CH2Cl2 (149 mg, 15 molpercent) and anhydrous Na2CO3 (194 mg, 1.83 mmol). The reaction mixture was heated in a microwave reactor at 140 0C for 45 min. It was then cooled to room temperature and diluted with EtOAc. The organic layer was washed with water, dried (Na2SO4) and concentrated under reduced pressure to afford crude ethyl 4’-isopropylbiphenyl-2-carboxylate.
According to the analysis of related databases, 1829-28-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2008/100423; (2008); A1;,
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