Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 620621-48-9, name is Methyl 2-chloro-5-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 2-chloro-5-iodobenzoate

Example 106 2-Chloro-N-(1 -hydroxy-cyclohexylmethyl)-5-(pyridin-4-yloxy)- benzamide106.1 Sodium 2-chloro-5-(Dyridin-4-yloxy)benzoateA microwave vial was charged with copper (I) bromide (23 mg), Cs2C03 (2055 mg), 4- hydroxypyridine (300 mg) and methyl-2-chloro-5-iodobenzoate (1 122 mg) and flushed with argon. DMSO (4.7 mL) was added followed by 2-pyridyl acetone (0.043 mL) and the reaction mixture was heated to 100C for 3h in the microwave. It was diluted with EtOAc, filtered and the filtrate was washed with H20. The aqueous phase was basified with a 1 M solution of NaOH and extracted with EtOAc. The crude was purified by CC (RP C18, H20/CH3CN 1/0 to 8/2) to give 1 .2 g of the titled compound as a white powder.LC-MS (B): tR = 0.34 min; [M+H]+: 249.98

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 620621-48-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H3Cl2I

General procedure: A mixture of the corresponding carboxamide ((±)-1a-h or (±)-1iA or 1iB or 1j-(S)) (0.25 mmol), Pd(OAc)2 (2.8 mg, 5 mol %), aryl iodide (1.0 mmol, 4 equiv) and AgOAc (92 mg, 0.55 mmol, 2.2 equiv) in anhydrous toluene (3 mL) was heated at 110 C for 24-70 h (see the respective Tables/Schemes for the reaction time for the specific examples) under nitrogen atmosphere. After the reaction period, the reaction mixture was concentrated in vacuum and purification of the resulting reaction mixture by silica gel column chromatography furnished the corresponding beta-C-H arylated racemic compounds 3a-l, 4a-c, 5a, 6a-f, 8a-c, 8eA-hA, 8eB-hB and enantiomerically enriched 10a-c (see Tables/Schemes for the reaction conditions for the specific examples).

According to the analysis of related databases, 20555-91-3, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 181765-86-6, name: Methyl 5-bromo-2-iodobenzoate

A 500 mL round bottom flask reactor was charged with methyl 5-bromo-2-iodobenzoate (1.7g, 0.15mmol) and potassium carbonate (20.2g, 146.7mmol) were added to a toluene solution (25.0g, 73mmol), 4-dibenzofuranboronic acid (18.7g, 88mmol) 125 mL of tetrahydrofuran, and 50 mL of water. The temperature of the reactor was raised to 80 C and stirred for 10 hours. When the reaction was completed, the temperature of the reactor was lowered to room temperature, extracted with ethyl acetate, and the organic layer was separated. The organic layer was concentrated under reduced pressure and then separated by column chromatography to obtain Intermediate 1-a (75.0 g, 60.1%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 4387-36-4, name is 2-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4387-36-4, name: 2-Iodobenzonitrile

This compound was prepared by following aliterature procedure.2 A solution of o-iodobenzonitrile(0.916 g, 4 mmol) in THF (0.5 mL)was added drop-wise to 1 M LiN(SiMe3)2 in anhydrous THF (4.4 mL, 4.4mmol) at room temperature and the reaction mixture was stirred at sametemperature overnight. i-PrOH (3 mL) was added and thecrude reaction mixture was bubbled with HCl (gas) for 15 min. The mixture waskept at 0 °C overnight. The precipitated product was filtered and washed withdiethyl ether to yield titled product as a white solid (0.961 g, 85percent). Mp291°C; 1H NMR (500 MHz, DMSO-d6) delta 8.90 (s, 4H), 8.01 (dd, J = 8.0, 1.0 Hz, 1H), 7.63 ? 7.49 (m,2H), 7.35 (ddd, J = 7.9, 7.2, 2.0 Hz,1H); 13C NMR (126 MHz, DMSO) delta 167.64, 139.23, 135.90, 132.71,128.92, 128.27, 94.88; IR (neat) 3038, 1664, 1588, 1404 cm-1; HRMScalcd for C7H8IN2 (M++1) + [-HCl]:246.9727, found 246.9719.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

69113-59-3, name is 3-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 3-Iodobenzonitrile

Example 173-Trimethylsilanylethynyl-benzonitrile 3-Iodo-benzonitrile (10.0 g, 43.7 mmol), trilmethylsilane acetylene (5.57 g, 56.8 mmol), palladium tetrakis triphenylphosphine (2.02 g, 1.75 mmol), and copper iodide (1.0 g, 5.24 mmol) in triethylamine (120 mL) was stirred for 12 h. The reaction was concentrated and purified by column chromatography to afford the title product (9.35 g, quantitative yield) as a brown oil.1H NMR (300 MHz, CDCl3): delta (ppm) 7.76 (t, 1H), 7.71 (dd, 1H), 7.63 (dd, 1H), 7.28 (t, 1H), 0.26 (s, 9H).

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71838-16-9 as follows. Recommanded Product: 2-Bromo-1-iodo-4-methylbenzene

Step A. 4-(2′-bromo-4′-methylbiphenyl-4-yl)-1-(2,2,2-trifluoroethyl)piperidine A mixture of 2-bromo-1-iodo-4-methylbenzene (0.764 g, 2.57 mmol), the title compound from Example 60 Step B (1.00 g, 2.71 mmol), dichloro bis(triphenylphosphine)palladium(II) (0.095 g, 0.135 mmol), sodium carbonate (5.42 mL of 1 M solution, 5.42 mmol) and MeCN (5.42 mL) was heated at 110 C. overnight. Organic layer was separated. Aqueous layer was extracted with hexanes-EtOAc. The organic layers were combined and concentrated. Silica gel flash chromatography eluting with hexanes:EtOAc (20:1 to 9:1 v/v) gave the title compound: LCMS m/z 414.0 [M+H+]; 1H NMR (500 MHz, CDCl3) delta 7.54 (s, 1H), 7.40 (d, J=8.1 Hz, 2H), 7.31 (d, J=8.1 Hz, 2H), 7.26 (d, J=7.8 Hz, 1H), 7.20 (d, J=7.8 Hz, 1H), 3.16 (m, 2H), 3.08 (q, J=9.8 Hz, 2H), 2.57 (m, 3H), 2.42 (s, 3H). 1.95-1.88 (m, 4H).

According to the analysis of related databases, 71838-16-9, the application of this compound in the production field has become more and more popular.

Reference of 461-17-6,Some common heterocyclic compound, 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, molecular formula is C4H6F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.4 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl) malononitrile and 1.2 g of 1-iodo-4, 4,4- trifluorobutane were dissolved in 5 ml of dimethyl sulfoxide, 0.83 g of potassium carbonate was added, and the mixture was stirred at room temperature for 5 hours. Thereafter, dilute hydrochloric acid was added to the reaction mixture, followed by extraction with methyl tert- butyl ether. The organic layer was washed successively with water, aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.35 g of 2- (2, 2,3, 3,4, 4,5, 5- octafluoropentyl)-2- (4, 4,4-trifluorobutyl) malononitrile (hereinafter, referred to as the present compound (66)). The present compound (66): lH-NMR (CDCl3, TMS) b (ppm): 2.01-2. 13 (2H, m), 2. 16-2. 32 (4H, m), 2.78 (2H, t), 6.02 (1H, tt).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-4-iodobutane, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 481075-58-5, name is 2-Bromo-1-iodo-4-(trifluoromethyl)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 481075-58-5, Recommanded Product: 481075-58-5

Under the protection of nitrogen, the 2-bromo-1-iodo-4 – (trifluoromethyl) benzene (0.50g, 1 . 42mmol), 4 – (4, 4, 5, 5-tetramethyl -1, 3, 2- two oxygen boron fifth heavenly stem link -2-yl) – 5,6-dihydropyridine -1 (2H)-carboxylic acid tert-butyl (0.48g, 1 . 57mmol), Pd (PPh3)2Cl2(25 mg, 36 mumol) and sodium carbonate (0.23g, 2 . 14mmol) into acetonitrile (10 ml) and water (3 ml) in the mixed solvent. Reaction solution is heated to 90 C stirring for 12 hours, cooling to the room temperature and adding water (20 ml), then with ethyl acetate (20 ml × 3) extraction. Combined organic phase dried with anhydrous sodium sulfate, filter, and concentrating under reduced pressure, the resulting residue by a silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=20/1) to obtain the title compound as a yellow oily liquid (470 mg, 81.0%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-iodo-4-(trifluoromethyl)benzene, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52807-27-9, name is 4-Chloro-2-iodoanisole, A new synthetic method of this compound is introduced below., Product Details of 52807-27-9

EXAMPLE 37A 3′,5-dichloro(1,1′-biphenyl)-2-yl methyl ether A suspension of 4-chloro-2-iodo-1-methoxybenzene (2.5 g, 9.3 mmol) and 3-chlorophenylboronic acid (2.2 g, 13.9 mmol) in a mixture of toluene (10 mL), dioxane (10 mL), and 2N Na2CO3 (10 mL) was treated with tetrakis(triphenylphosphine)-palladium (O) (0.54 g, 0.47 mmol), heated to reflux for 16 hours, cooled to room temperature, and extracted with ethyl acetate. The combined extracts were dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 20:1 hexanes/ethyl acetate to provide 2.5 g (100%) of the desired product. MS (DCI/NH3) m/z 254 (M+H)+; 1H NMR (CDCl3) delta 7.75-7.23 (m, 6H), 6.91 (d, 1H), 3.80 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 25309-64-2, A common heterocyclic compound, 25309-64-2, name is 1-Ethyl-4-iodobenzene, molecular formula is C8H9I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under nitrogen atmosphere, Cu2O (10 mol %), DABCO (25 mol %), and a stirring bar were added into a 10 mL oven-dried sealed glass tube (as shown in Figure S1). Then NMP (0.5 mL), aryl iodides (0.125 mmol, 1.0 equiv.) and PhSiH3 (0.75 mmol, 6 equiv.) were injected by syringe. The tube was then sealed and CO2 (0.67 mmol, 5.4 equiv., 15 mL) as well as NH3 (0.67 mmol, 5.4 equiv., 15 mL) were injected by syringe after N2 was removed under vacuum. Finally, the mixture was stirred for 24 hr in a pre-heated-to-130 C alloyed block. After the reaction was finished, the tube was cooled to room temperature and the pressure was carefully released. The yield of were measured by GC analysis using dodecane as the internal standard or by flash chromatography on silica gel (petroleumether/ethyl acetate).

The synthetic route of 25309-64-2 has been constantly updated, and we look forward to future research findings.