Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148870-57-9, name is 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C15H18INO3

Example 11Charge 21.0 g of [N-[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-l,3,5-trien-7-yl]methyl]-N- methylamine (V), 43.15 g of 3-(3-iodopropyl)-7,8-dimethoxy-l,3-dihydro-2H-3- benzazepine-2-one (XII), 60.0 g of K2CO3 and 315 ml of DMF in a RB flask equipped with mechanical stirrer and thermometer pocket at 25C. Heat the reaction mixture to 40-450C and maintain at the same temperature for 12 hours. Monitor the reaction by HPLC. (if starting material i.e. compound (V) remains, add compound (XII) and continue heating with stirring till compound (V) comes to less than 1.0%). If HPLC complies, cool the reaction mixture to 25C. Charge 1500 ml of IN HCl (pH should be acidic), 1500 ml of ethyl acetate (3 x 500 ml) and stir for 10 minutes and separate the layers. Charge 10% NaOH solution to aqueous layer till pH of the solution becomes basic (pH ~ 7.0 – 8.0). Charge ethyacetate (2 x 500.0 ml), stir for 10 minutes and separate the layers. Wash the ethyl acetate layer with 500 ml of water. Dry ethyl acetate layer over anhydrous Na2SO4 and evaporate ethyl acetate under vacuum at below 50C to result a brown colored residue (XIII). Weight: 43.0 gYield: 91.0 %HPLC purity (Reverse phase): >98.5%

According to the analysis of related databases, 148870-57-9, the application of this compound in the production field has become more and more popular.

103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Iodo-4-(trifluoromethoxy)benzene

Example 19; Preparation of 4-bromo-1-(4-trifluoromethoxyphenyl)-1H-imidazole A round bottom flask was charged with 4-bromoimidazole (1.15 g, 7.81 mmol), CuI (0.07 g, 0.36 mmol), 8-hydroxyquinoline (0.05 g, 0.36 mmol), cesium carbonate (3.39 g, 10.4 mmol) and 4-trifluoromethoxyiodobenzene (1.50 g, 5.21 mmol). A 10:1 mixture of DMF (15 mL) and H2O (1.5 mL) were added to the reaction mixture, and the solution was heated to 130° C. for 4 h. The reaction mixture was then diluted with EtOAc and washed sequentially with water, ammonium chloride (saturated), water and sodium bicarbonate. The organics were dried over MgSO4, filtered and purified on a reverse phase column to give 820 mg of imidazole as a white solid. MS 308.0 (M+H); mp 139-141° C.

The synthetic route of 103962-05-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1643-29-4,Some common heterocyclic compound, 1643-29-4, name is 3-(4-Iodophenyl)propanoic acid, molecular formula is C9H9IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-(4-iodophenyl)propanoic acid (Atlantic Research Chemicals Ltd.) (2.76 g, 10.00 mmol) were dissolved In tetrahydrofuran (100 mL) and added slowly to a suspension of lithium aluminium hydride (0.23 g, 6.00 mmol) in 100 mL tetrahydrofuran. The reaction was stirred for 3h, then 1 N aqueous sodium hydrogen carbonate (150 mL) were added slowly and the resulting mixture was extracted with ethyl acetate (3 x 400 mL), the organic extracts were dried over magnesium sulfate and concentrated in vacuo. The crude product was purified on silica gel using a hexane/ethyl acetate gradient, and the appropriate fractions were combined and concentrated. Yield: 1.30 g (49.8%) 1H-NMR (300MHz, CHLOROFORM-d): delta [ppm]= 1.88 (m, 2H), 2.62 – 2.72 (m, 2H), 3.64 – 3.70 (m, 2H), 6.97 (d, 2H), 7.61 (d, 2H). ESI+ m/z 263.2 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(4-Iodophenyl)propanoic acid, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89459-38-1, name is 2-Iodo-4-nitrobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H4INO4

A flame-dried 3 E 3-necked flask was charged with Example 2.12310 (51.9 g) and tetrahydrofuran (700 mL). The mixture was cooled in an ice bath to 0.5 C and borane-tetrahydrofuran complex (443 mL, 1M in THF) was added dropwise (gas evolution) over 50 minutes, reaching a final internal temperature of 1.3 C. The reaction mixture was stirred for 15 minutes, and the ice bath was removed. The reaction was left to come to ambient temperature over 30 minutes. A heating mantle was installed, and the reaction was heated to an internal temperature of 65.5 C. for 3 hours, and then allowed to cool to room temperature while stirring overnight. The reaction mixture was cooled in an ice bath to 0 C. and quenched by dropwise addition of methanol (400 mL). Afier a brief incubation period, the temperature rose quickly to 2.5 C. with gas evolution. After the first 100 mE are added over 30 minutes, the addition was no longer exothermic, and the gas evolution ceased. The ice bath was removed, and the mixture was stirred at ambient temperature under nitrogen overnight. The mixture was concentrated to a solid, dissolved in dichloromethane/methanol and adsorbed on to silica gel (.-150 g). The residue was loaded on a plug of silica gel (3000 mE) and eluted with dichloromethane to give the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 89459-38-1.

Electric Literature of 460-37-7, These common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 91Preparation of Compound 496Step A – synthesis of compound 9JBCompound 91 A (5.Og, 22mol) was added to Mg turnings (0.7Og, 29mga) and catalytic iodine in ether (3OmL). After Ih, the reaction was cooled to 0 0C and treated with benzaldehyde (2.08g, 20mmol). After Ih , satd. NH4Cl was added (10OmL). The ether was concentrated to leave a yellow oil, taken up in CH2Cl2 (4OmL), and treated with PCC (12.0g, 56mmol) for 4h. Hexane (30ml) was added, the solid filtered and concentrated to give crude compound 91B as a yellow solid.

Statistics shows that 1,1,1-Trifluoro-3-iodopropane is playing an increasingly important role. we look forward to future research findings about 460-37-7.

Electric Literature of 108078-14-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108078-14-4, name is 2-Iodo-3-methylbenzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

2-iodo-3-methyl benzoic acid (1310 mg, 5 mmol) and thionyl chloride (730 uL, 10 mmol) were dissolved into THF (10 mL) and stirred at RT for 4 days. The solvents were removed IN VACUO and the resulting residue was dissolved into EtOAc, washed with brine. The combined organic layers were dried (MGS04) and the solvents were removed in vacuo resulting in an oil that was used without further purification or characterization.

The chemical industry reduces the impact on the environment during synthesis 2-Iodo-3-methylbenzoic acid. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 811842-30-5, name is 2-Bromo-1-fluoro-4-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 811842-30-5, Application In Synthesis of 2-Bromo-1-fluoro-4-iodobenzene

2-Bromo-l-fluoro-4-iodobenzene (890 mg, 7.6 mmol), dichlorobis(triphenylphosphine)palladium (27 mg, 0.038 mmol) and copper(I) iodide (7 mg, 0.038 mmol) were dissolved in anhydrous tetrahydrofuran (30 mL) and triethylamine (15 mL). 4-Ethynyl-2-methylpyridine (890 mg, 7.6 mmol) was added, the reaction stirred at room temperature for 3 h and then neutralized using hydrochloric acid (2 M). The solution was extracted with dichloromethane and the combined organic phases were concentrated in vacuo. Purification by column chromatography, using a gradient of ethyl acetate (0 to 40%) in «-heptane as the eluent, gave 1.4 g (63% yield) of the title compound: MS (ESI) m/z 426 [M+l]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-4-iodobenzene, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 76801-93-9, These common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-1,3-N,N’-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophtalamide (40.0 g, 56.7 mmol) was suspended in pyridine (80 ml). With effective stirring and cooling in an ice/water bath, acetic anhydride (70 ml) was added dropwise. After addition the mixture was stirred at ambient temperature over night. The clear solution was evaporated to an oil, which was dissolved in ethyl acetate (450 ml). This solution was washed with diluted hydrochloric acid (0.05 M, 100 ml), water (200 ml), diluted solution of sodium hydrogen carbonate (5 %, 2 × 100 ml) and at last a saturated solution of sodium chloride (70 ml). The organic phase was dried (NaSO4) and the solvent evaporated to a white crystalline substance. Yield 49.5 g (= quantitative). 1H NMR (CDCl3): 6.71 & 6.38 (two t:s, 2H), 5.24 (br. s, 2H), 5.09 (s, 2H), 4.37 – 4.48 & 4.22 – 4.35 (m:s, 4H), 3.71 – 3.85 & 3.50 – 3.65 (m:s, 4H), 2.06 (s, 12H).

Statistics shows that 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide is playing an increasingly important role. we look forward to future research findings about 76801-93-9.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13194-69-9, name is 2-Iodo-5-methylaniline, A new synthetic method of this compound is introduced below., Product Details of 13194-69-9

General procedure: The corresponding pyrazinoic acid (5.0 mmol) was dispersed in dry toluene (20 mL) and mixed with 1.5eq. of thionyl chloride (0.55 mL, 7.5 mmol). The reaction mixture was heated to reflux for approximately 1 h. Next, the excess of thionyl chloride was removed by repeated evaporation with dry toluene under vacuum.The crude acyl chloride was dissolved in dry acetone(20 mL) and added drop-wise to a stirred solution of the corresponding aniline (5.0 mmol) with triethylamine(5.0 mmol) in dry acetone (30 mL). The reaction mixture was stirred at ambient temperature for up to 6 h. The completion of the reaction was monitored by TLC (eluent: hexane/ethyl acetate; r =2 : 1). The crude product adsorbed on silica gel by solvent evaporation was purified by flash chromatography(hexane/ethyl acetate gradient elution).The analytical data of the prepared compounds were fully consistent with the proposed structures and are available in the Supplementary Data.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 626-01-7, A common heterocyclic compound, 626-01-7, name is 3-Iodoaniline, molecular formula is C6H6IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 10-ml round-bottom flask equipped with a condenser, a mixture of the aromatic amine (2 mmol), ethyl acetoacetate (1 mmol), and [Pyridinium-SO3H]HSO4 (0.0,385 g, 15 mol %) was stirred at 100 C for 10 min. Afterwards, the aromatic aldehyde (2 mmol) was added, and the resulting mixture was kept under stirring for the specified time in Table 3, the progress of the reaction was followed by TLC. After completion of the reaction, the reaction mixture was cooled to room temperature, extracted by the warm EtOAc (10 ml) to separate the catalyst. EtOAc was removed and the crude product was recrystallized from aqueous ethanol (96 %) to afford the pure product, which required no further purification. The recovered catalyst was washed with EtOAc (2 x 10 ml), dried, and reused, without considerable catalytic activity decrease.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.