Electric Literature of 19821-80-8, A common heterocyclic compound, 19821-80-8, name is 1,3-Dibromo-2-iodobenzene, molecular formula is C6H3Br2I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Place 3-mercaptoindole (25g, 1eq), 1,3-dibromo-2-iodobenzene (60.62g, 1eq), cesium carbonate Cs2CO3(109.18g, 6eq)in a dry two-necked bottleWith a small amount of copper flakes (3.47g, 0.001eq), then add 250mL of dimethylformamide, warmed to 130 for 24 hours, the solvent was distilled off in vacuo, and then dichloromethane and water, the dichloromethane layer After drying with magnesium sulfate, spin-dry it, and then use silica gel column to separate and purify.The solid was obtained as an intermediate (Ir-072-a) with a yield of 83%.
The synthetic route of 19821-80-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Liang Zhiming; Yan Caijuan; Huang Hong; Pan Junyou; Chen Sihang; (52 pag.)CN111039987; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com