Related Products of 13421-13-1, A common heterocyclic compound, 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Chloro-2-(2H-I ,2,3-triazol-2-yI)benzoic acid (A-I -I)Cs2CO3 (12.0 g, 37 mmol) was added portionwise to a rt solution of commercially available 4-chloro-2-iodobenzoic acid (5.22 g, 18.5 mmol) in DMF (25 mL) followed by 1H-1,2,3-triazole(1.61 mL, 27.8 mmol) and Cu(l)l (210 mg, 1.1 mmol). The resulting blue suspension was stirredat 120C for 30 mm, then the rxn mixture was quenched with 2M aq. HCI and filtered through acelite plug before being extracted with DCM (3x). The combined org. layers were dried (Na2SO4), filtered and evaporated in vacuo to give the crude product that was purified by FC (Biotage SP1: eluting with DCM/MeOH 95:5 + 0.1% AcOH) to give the title compound A-I-I as a brown solid. LC-MSA: tR= 0.66 mm; [M(35Cl)+H]= 224.10.
The synthetic route of 13421-13-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BOLLI, Martin; BOSS, Christoph; BROTSCHI, Christine; HEIDMANN, Bibia; SIFFERLEN, Thierry; WILLIAMS, Jodi T.; WO2014/141065; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com