Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52548-63-7, name is 5-Fluoro-2-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 52548-63-7
To a solution of 5-fluoro-2-iodobenzoic acid (17 g) obtained in Step A of Reference Example 1, copper(I) iodide (2.434 g), potassium carbonate (26.5 g) and N,N,N?,N?tetramethylethylene diamine (3.83 mE) in N,N-dimethylformamide (200 mE) was added 1H-1,2,3-triazole (11.11 mE), and the mixture was stirred overnight at 1000 C. The reaction mixture was filtered through Celite, to the filtrate was added 6N aqueous hydrochloric acid solution at 0 C., and the mixture was extracted with ethyl acetate. The obtained organic layer was washed successively with saturated aqueous sodium thiosulfate solution and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ ethyl acetate) to give the title compound (5.6 g). 1H NMR (300 MHz, DMSO-d6) delta 7.52-7.69 (2H, m), 7.81 (1H, dd, J=8.7, 4.9 Hz), 8.08 (2H, s), 13.35 (1H,brs).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52548-63-7.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAMEI, Taku; ARIKAWA, Yasuyoshi; OHASHI, Tomohiro; IMAEDA, Toshihiro; FUJIMORI, Ikuo; MIKI, Takashi; YONEMORI, Jinichi; OGURO, Yuya; SUGIMOTO, Takahiro; SETO, Masaki; NISHIDA, Goushi; KAMATA, Makoto; IMOTO, Hiroshi; (132 pag.)US2018/155333; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com