In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 645-00-1, name is 1-Iodo-3-nitrobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1-Iodo-3-nitrobenzene
General procedure: Under air atmosphere, around-bottomed flask was charged with an aryl halide (1.0mmol), a terminal alkyne (1.0mmol), a base (1.0mmol), and the catalyst 2 (1mol%). The mixture was stirred at room temperature for 3h under aerobic conditions. After completion of the reaction, the mixture was filtered to recover the catalyst. The polymer was washed with water, methanol, and acetonitrile, vacuum-dried, and stored for a new run. After GC analysis, the solvent was removed under vacuum, and the crude product was subjected to silica gel column chromatography using CHCl3-CH3OH (97:3) as eluent to afford the pure product.
The synthetic route of 645-00-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bakherad, Mohammad; Keivanloo, Ali; Samangooei, Shahrzad; Omidian, Mina; Journal of Organometallic Chemistry; vol. 740; (2013); p. 78 – 82;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com