Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Oligonuclear Homoleptic Copper(I) Pyrazolates with Multinucleating Ligand Scaffolds: High Structural Diversity in Solid-State and Solution, published in 2009-11-02, which mentions a compound: 75732-01-3, Name is Mesitylcopper(I), Molecular C9H11Cu, Synthetic Route of C9H11Cu.

The synthesis of three pyrazole-based, potentially binucleating ligands 3,5-bis(R1NMeCH2)-4-R2pyrazole (L1H: R1 = pyridyl-2-methyl-, R2 = Ph; L2H: R1 = 8-quinolyl-, R2 = H; L3H: R1 = 8-quinolyl-, R2 = Ph) is described. Reaction of L1-3H with 1 equiv of mesitylcopper affords oligonuclear homoleptic complexes [CuL]n (1-3). The single crystal x-ray structure of 2 shows a tetranuclear assembly of linear coordinated Cu(I)-centers bridged by pyrazolato ligands that alternate above and below the Cu4 plane, with addnl. weak interactions from some of the ligand side arms. As the single crystal X-ray structure of 3 reveals, Ph substitution at the 4-position of the pyrazolato framework leads to significant structural modification of the Cu4 array, giving a rhombical tetranuclear complex with two linear coordinated Cu(I) centers that exhibit a short intramol. Cu···Cu contact (2.8212(10) Å) and two peripheral Cu(I) centers in a distorted tetrahedral coordination mode. Thus, 3 represents a very rare example of an inorganic pyrazolato cuprate which can also be viewed as a partly rearranged structural isomer of 2. Also, the crystal lattice of 3 shows an extended network of intra- and intermol. π-π stacking interactions between the aromatic rings. In solution, 1-3 each form two types of oligomers a and b that slowly (<1 s-1) equilibrate at room temperature Using Diffusion Ordered Spectroscopy (DOSY) and variable temperature 1H NMR spectroscopy, a and b correspond to a tetrameric and a (planar) trimeric species. Coordination of the pyridyl/quinolyl side arms that is observed in the solid state seems to be only transient in solution There are many compounds similar to this compound(75732-01-3)Synthetic Route of C9H11Cu. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Velisek, Jan; Ledahudcova, Katerina; Hajslova, Jana; Pech, Pavel; Kubelka, Vladislav; Viden, Ivan published the article 《New 3-chloro-1,2-propanediol derived dihydroxypropylamines in hydrolyzed vegetable proteins》. Keywords: hydroxypropylamine vegetable protein hydrolyzate; ammonia chloropropanediol reaction; soybean hydrolyzate hydroxypropylamine.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Formula: C3H7ClO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.

Reaction products of 3-chloro-1,2-propanediol (the main contaminant of protein hydrolyzates produced by HCl hydrolysis and used as food seasonings) with ammonia in model aqueous solutions were analyzed, and in addition to the known compounds (glycerol, 3-amino-1,2-propanediol, 2-amino-1,3-propanediol), bis(2,3-dihydroxypropyl)amine and tris(2,3-dihydroxypropyl)amine were newly identified. A soybean meal hydrolyzate containing >400 mg/kg 3-chloro-1,2-propanediol, and an alkali-treated hydrolyzate containing <1 mg/kg 3-chloro-1,2-propanediol were analyzed, and bis(2,3-dihydroxypropyl)amine (in concentrations of 6 and 3 mg/kg, resp.) and tris(2,3-dihydroxypropyl)amine (2 and 4 mg/kg, resp.) were identified as components of these com. seasonings. Mass spectra of the silyl derivatives and 1H and 13C NMR spectra of these newly found compounds in foods are presented. There are many compounds similar to this compound(60827-45-4)Formula: C3H7ClO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Catalytic behavior of wool-osmium tetroxide complex for asymmetric dihydroxylation of olefins, published in 2004-04-30, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Reference of (2S)-(+)-3-Chloropropane-1,2-diol.

A new chiral polymer-metal complex, wool-osmium tetroxide (wool-OsO4) complex was prepared by a very simple method. This complex was able to catalyze the asym. dihydroxylation of allylamine to (R)-(+)-3-amino-1,2-propanediol and allyl chloride to (S)-(+)-3-chloro-1,2-propanediol. The optical yields amounted to 83.7 and 57.2%, and the product yields were 80.2 and 68.5% resp. The exptl. results showed that OsO4 content in the complex, reaction time, allylamine/OsO4 molar ratio and solvent all have an effect on the product and optical yields. Addnl., wool-OsO4 complex catalyst could be reused without any remarkable change in optical catalytic activity.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Nickel-Catalyzed C-H Heteroarylation of Chiral Oxazolines.SDS of cas: 2058236-52-3.

A nickel-catalyzed C-H heteroarylation at the 2-position of oxazolines e.g., (3aR,8aS)-3a,8a-Dihydro-8H-indeno[1,2-d]oxazole with heteroaryl halides such as 2-bromothiophene, 1-bromoisoquinoline, (E)-(2-bromovinyl)benzene, 2,6-dibromopyridine, etc. was developed. Various oxazoline-containing multidentate chiral ligands e.g., (3aR,8aS)-2-(thiophen-2-yl)-8,8a-dihydro-3aH-indeno[1,2-d]oxazole have been efficiently synthesized.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Mesitylcopper(I)(SMILESS: [Cu]C1=C(C)C=C(C)C=C1C,cas:75732-01-3) is researched.Application In Synthesis of 2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine. The article 《Conjugate addition of diorganozincs to α,β-unsaturated ketones catalyzed by a copper(I)-sulfonamide combined system》 in relation to this compound, is published in Tetrahedron Letters. Let’s take a look at the latest research on this compound (cas:75732-01-3).

In the presence of a Cu(I)-N-monosubstituted sulfonamide combined catalyst system, diorganozincs react with α,β-unsaturated ketones, e.g., 2-cycloheptenone, to generate Zn enolates, which may be hydrolyzed giving the β-substituted ketones, e.g., 3-ethylcycloheptanone, or used for further aldol reaction or Pd(0)-catalyzed reaction with allyl acetate leading to the regiospecific α,β-vicinal condensation products.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of (2S)-(+)-3-Chloropropane-1,2-diol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Spontaneous Resolution of Chiral 3-(2,3-Dimethylphenoxy)propane-1,2-diol under the Circumstances of an Unusual Diversity of Racemic Crystalline Modifications. Author is Bredikhin, Alexander A.; Zakharychev, Dmitry V.; Bredikhina, Zemfira A.; Kurenkov, Alexey V.; Krivolapov, Dmitry B.; Gubaidullin, Aidar T..

Depending on the conditions of crystallization from solutions, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 1 forms 3 relatively stable crystalline modifications. Each of the crystalline forms, namely, 2 polymorphic racemic compounds and a racemic conglomerate, was characterized by single-crystal x-ray diffraction. Two more metastable racemic compounds crystallized from the racemic melt were found by DSC method. Addnl. thermochem. studies allowed to plot the dependence of the free Gibbs energy on temperature for all the phases found. With the help of slurrying experiments, the nature of the transitions between solid phases was specified. Even a slight predominance of 1 of the enantiomers in almost racemic 1 samples ensures the crystallization of the conglomerate. The revealed features of rac-1 crystallization were taken into account during the realization of its resolution into individual enantiomers by the entrainment procedure.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Hao; Zheng, Weiwei; Wang, Xia; Liu, Li; Qu, Weidong researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Category: iodides-buliding-blocks.They published the article 《Inhibitory effect of (s)-chlorohydrin on rat sperm motility and hyperactivation》 about this compound( cas:60827-45-4 ) in Weisheng Yanjiu. Keywords: chlorohydrin sperm motility hyperactivation. We’ll tell you more about this compound (cas:60827-45-4).

The effects of (S)-α-chlorohydrin (SACH) on rat epididymal sperm motility and hyperactivation and the mechanisms of the effects were studied. 20 Adult male Sprague-Dawley rats were divided randomly into 4 groups and dosed orally with 0, 2.5, 5.0, and 10mg/kg BW SACH for 52 days. After the cauda epididymal sperm were incubated under a capacitating condition for 5h, sperm motility and hyperactivation parameters were obtained by computer-assisted sperm anal. (CASA), and sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) activity, ATP (ATP), and cyclic adenosine monophosphate (cAMP) were assayed. The protecting effect of pentoxifylline (PTF) against SACH was also tested. The sperm from the SACH-treated rats showed significant decreases in curvilinear velocity (VCL), average path velocity (VAP), straight line velocity (VSL), and amplitude of lateral head movement (ALH) (P<0.01 of all), and an increase in linearity (LIN) (P<0.01). The SACH-treated rats had much less sperm population with VCL≥400μm/s or LIN≤20% than that of the control (P<0.05 and P<0.01, resp.), indicating that SACH diminishes hyperactivation of rat sperm. GAPDS activities were inhibited by SACH, and decreasing trends of ATP and cAMP levels were observed PTF rescued the cAMP level which was depressed by SACH, and alleviated partly the inhibition of sperm motility and hyperactivation. SACH impairs the motility and hyperactivation of rat sperm, which might be related to inhibition of GAPDS by SACH and subsequent defects of ATP and cAMP. I hope my short article helps more people learn about this compound((2S)-(+)-3-Chloropropane-1,2-diol)Category: iodides-buliding-blocks. Apart from the compound(60827-45-4), you can read my other articles to know other related compounds.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of C9H11Cu. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Cu24O24Si8R8: Organic Soluble 56-Membered Copper(I) Siloxane Cage and Its Use in Homogeneous Catalysis. Author is Tan, Gengwen; Yang, Ying; Chu, Chenhui; Zhu, Hongping; Roesky, Herbert W..

An organic-soluble 56-membered copper(I) siloxane cage compound Cu24O24Si8R8 {R = [2,6-(Me2CH)2C6H3](Me3Si)N}(I) is prepared and structurally characterized; I is a catalyst for Ullmann-Goldberg coupling reactions of imidazole, pyrazole, and 3,5-dimethylpyrazole with bromobenzene, 4-bromotoluene, mesityl bromide, and 2-bromothiophene to give heteroaryl-substituted arenes in 22-93% yields. The structure of I·3.2Me(CH2)4Me is determined by X-ray crystallog.; I forms a copper silica-supported structure, in which the copper ions are two-coordinate and covalently anchored onto the cage surface and with weak copper···copper d10-d10 interactions within the cage. I is a potential analog of species generated from heterogeneous catalysts during reactions.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called 4(2)-Methoxyphenyl glycerol ethers in the synthesis of non-racemic di-O,O-acylglycerols, published in 2008-11-30, which mentions a compound: 60827-45-4, mainly applied to enantioselective hydrolysis epichlorohydrin catalyst glyceride synthesis resolution; methoxyphenyl glyceride ether synthesis glycerol chloropropanediol resolution aryloxypalmitoyl, Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol.

Effective methods for the synthesis of non-racemic 4- and 2-methoxyphenyl glycerol ethers from non-racemic 3-chloropropanediols and by direct resolution of the racemate, resp., were developed. Some existing discrepancies related to the to chiroptical properties of their derivatives were eliminated. Both ethers were used to synthesize non-racemic 3-O-aryloxy-1,2-di-O’,O”-palmitoyl glycerols.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Biodegradation of 3-Chloro-1,2-propanediol with Saccharomyces cerevisiae.Synthetic Route of C3H7ClO2.

A novel enzymic dehalogenating activity of 3-chloro-1,2-propanediol (3-MCPD) with Saccharomyces cerevisiae (baker’s yeast) is reported. All bioconversion assays were carried out under aerobic conditions at 28°, and the kinetics were monitored. The biodegradation was performed at different pH values (6.2, 7.0, and 8.2), in the presence and absence of glucose, using racemic 3-MCPD at two different concentrations (7.3 μmol/L and 27 mmol/L). Optimal conversion (68%) of racemic (R,S)-3-MCPD at a concentration of 27 mmol/L was achieved after 48 h of reaction time, at pH 8.2, and in the presence of glucose. At a concentration of 7.3 μmol/L, 73% degradation was observed after 72 h, at pH 8.2 and in the absence of glucose. Under the same exptl. conditions, the conversion of pure (S)-3-MCPD (85%) was higher than that of the (R)-enantiomer (60%).

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com