In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Formula: C5H4IN.
Herbert, Jack;Edwards, Kelsey;Sridharan, Visuvanathar research published 《 Palladium catalysed, three-component cascade reaction for the efficient synthesis of diverse small molecules》, the research content is summarized as follows. A palladium catalyzed, three-component cascade reaction was employed for the regiospecific and stereoselective synthesis of novel substituted (Z)-2-butene 1,4-diamine analogs (Z)-RCH2C(=CHCH2R1)R2 [R = piperidin-1-yl, morpholin-4-yl, 8-fluoro-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl, 4-(4-fluorophenyl)piperidin-1-yl, 4-benzylpiperidin-1-yl; R1 = 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl, 5,6-dichloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl; R2 = 4-CH3C6H4, 2-thienyl, 3-pyridyl, etc.] and substituted 4-aryloxy but-2-enyl amine analogs (Z)-RCH2C(=CHCH2R1)R2 [R = morpholin-4-yl; R1 = 4-bromophenoxy, 4-methoxyphenoxy; R2 = 3-F3CC6H4, 4-CH3OC6H4, 4-ClC6H4]. Allenes R1CH2CH=C=CH2 were first synthesized from the corresponding alkynes R1CH2CCH using the Crabbe reaction and then reacted with a large range of com. available aryl iodides R2I and amines like piperidine, morpholine and 4-(4-fluorophenyl)piperidine, etc. to generate a library of small mols. The reaction is compatible with aryl iodides containing both electron-donating and electron-withdrawing groups. Amines of different sizes can also be utilized with no noticeable effect on the yield, regiospecificity or stereoselectivity.
Formula: C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com