Chen, Su; Oliva, Monica; Van Meervelt, Luc; Van der Eycken, Erik V.; Sharma, Upendra K. published an article in 2021. The article was titled 《Palladium-Catalyzed Domino Synthesis of 2,3-Difunctionalized Indoles via Migratory Insertion of Isocyanides in Batch and Continuous Flow》, and you may find the article in Advanced Synthesis & Catalysis.Related Products of 63069-48-7 The information in the text is summarized as follows:
Authors report, herein, a palladium-catalyzed cascade comprising carbopalladation, migratory insertion of isocyanide and triple bond activation followed by a nucleophilic attack to construct difunctionalized acyl indoles e.g. I. The process involves multiple bond formations via key palladium-chem. steps, to construct these bis-heterocycles containing two privileged scaffolds (indole and oxindole) in a single operational step, along with attempts to generate enantioselectivity at a quaternary carbon center. The methodol. also demonstrates a continuous-flow process to synthesize aryl isocyanides within minutes and using them in a telescopic manner. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Related Products of 63069-48-7)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Related Products of 63069-48-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com