Month: October 2022

Quality Control of 1-IodonaphthaleneIn 2021 ,《Single-molecule junction formation in break-junction measurements》 was published in Journal of Physical Chemistry Letters. The article was written by Fu, Tianren; Frommer, Kathleen; Nuckolls, Colin; Venkataraman, Latha. The article contains the following contents:

The scanning tunneling microscope-based break-junction (STM-BJ) technique is the most common method used to study the electronic properties of single-mol. junctions. It relies on repeatedly forming and rupturing a Au contact in an environment of the target mols. The probability of junction formation is typically very high (∼70-95%), prompting questions relating to how the nanoscale structure of the Au electrode before the metal point contact ruptures alters junction formation. Here we analyze conductance traces measured with the STM-BJ setup by combining correlation anal. and multiple machine learning tools, including gradient-boosted trees and neural networks. We show that two key features describing the Au-Au contact prior to rupture determine the extent of contact relaxation (snapback) and the probability of junction formation. Importantly, our data strongly indicate that mol. junctions are formed prior to the rupture of the Au-Au contact, explaining the high probability of junction formation observed in room-temperature solution measurements. The results came from multiple reactions, including the reaction of 1-Iodonaphthalene(cas: 90-14-2Quality Control of 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 1774-47-6In 2021 ,《Lewis acid-catalyzed [3 + 2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes with ynamides》 was published in Organic & Biomolecular Chemistry. The article was written by Zhang, Dongxin; Cheng, Qihang; Chen, Lvjia; Deng, Huiqing; Cai, Hu; Zhang, Qian-Feng. The article contains the following contents:

The [3 + 2] annulations of oxindole based spirocyclic donor-acceptor cyclopropanes and ynamides catalyzed by copper triflate was developed for the synthesis of biol. important spirocyclopenteneoxindoles. These reactions tolerated a wide scope of substrates and provided the desired products in good to high yields (up to 90%) with up to >40 : 1 diastereoselectivities under mild conditions.Trimethylsulfoxonium iodide(cas: 1774-47-6Related Products of 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Related Products of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 589-87-7In 2021 ,《On-Surface Formation of Cyano-Vinylene Linked Chains by Knoevenagel Condensation》 was published in Chemistry – A European Journal. The article was written by Au-Yeung, Kwan Ho; Kuehne, Tim; Becker, Daniel; Richter, Marcus; Ryndyk, Dmitry A.; Cuniberti, Gianaurelio; Heine, Thomas; Feng, Xinliang; Moresco, Francesca. The article contains the following contents:

The rapid development of on-surface synthesis provides a unique approach toward the formation of carbon-based nanostructures with designed properties. Herein, we present the on-surface formation of CN-substituted phenylene vinylene chains on the Au(111) surface, thermally induced by annealing the substrate stepwise at temperatures between 220°C and 240°C. The reaction is investigated by scanning tunneling microscopy and d. functional theory. Supported by the calculated reaction pathway, we assign the observed chain formation to a Knoevenagel condensation between an aldehyde and a methylene nitrile substituent. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-iodobenzene(cas: 589-87-7SDS of cas: 589-87-7)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..SDS of cas: 589-87-7 It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Molecular Bending: An Important Factor Affecting the Packing of Self-Assembled Monolayers of Triptycene-Based Molecular Rods on a (111) Gold Surface》 was written by Roncevic, Igor; Kaletova, Eva; Varga, Katarina; Cisarova, Ivana; Bastl, Zdenek; Jiang, Jyh-Chiang; Kaleta, Jiri. Formula: C5H4INThis research focused ontriptycene mol rod bending self assembled monolayer gold surface. The article conveys some information:

The present study has identified mol. bending as an important factor that has a profound effect on the self-assembly of originally rod-shaped organic mols. on a (111) gold surface. This was demonstrated on three specifically designed rigid mol. rods carrying archetypal anchoring groups (pyridyl units and thiols) on one terminus. These rods were used to prepare corresponding self-assembled monolayers (SAMs), and a combination of various anal. techniques revealed that originally straight mol. rods that were bent once adsorbed on a metallic surface, acquiring a characteristic “”J-shape””. Extensive d. functional theory calculations, including in silico reconstruction of such SAMs on (111) gold, clearly confirmed exptl. observations. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthaleneOn March 6, 1998, Huang, Wei-Sheng; Hu, Qiao-Sheng; Pu, Lin published an article in Journal of Organic Chemistry. The article was 《A Highly General Catalyst for the Enantioselective Reaction of Aldehydes with Diethylzinc》. The article mentions the following:

An optically active 1,1′-binaphthyl mol., (R)-3,3′-bis(2”,4”-dihexyloxyphenyl)-1,1′-bi-2-naphthol[(R)-I], is found to be the most general catalyst for the enantioselective reaction of aldehydes with diethylzinc. This compound catalyzes the reaction of diethylzinc with a very broad range of aldehydes including ortho-, para- or meta-substituted aromatic aldehydes, linear or branched aliphatic aldehydes, and aryl or alkyl-substituted α,β-unsaturated aldehydes in 91 – <99% ees. The extremely general and high enantioselectivity of (R)-I and its easy preparation make this mol. a very practical catalyst for the synthesis of chiral alcs. After reading the article, we found that the author used (R)-3,3'-Diiodo-2,2'-bis(methoxymethoxy)-1,1'-binaphthalene(cas: 189518-78-3Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Lal, Nand; Jangir, Santosh; Bala, Veenu; Mandalapu, Dhanaraju; Sarswat, Amit; Kumar, Lalit; Jain, Ashish; Kumar, Lokesh; Kushwaha, Bhavana; Pandey, Atindra K.; Krishna, Shagun; Rawat, Tara; Shukla, Praveen K.; Maikhuri, Jagdamba P.; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L. published 《Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology》.European Journal of Medicinal Chemistry published the findings.Recommanded Product: 624-73-7 The information in the text is summarized as follows:

Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole resp. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their use as topical microbicidal contraceptives. Bis(dialkylaminethiocarbonyl)disulfides were designed as dually active, non-surfactant mols. capable of eliminating Trichomonas vaginalis and Candida strains as well as irreversibly immobilizing 100% human sperm instantly, at doses non-cytotoxic to human cervical epithelial cells and vaginal microflora in vitro. Compounds bis(4-butyl-1-piperazinylthiocarbonyl) disulfide (12), bis(4-allyl-1-piperazinylthiocarbonyl) disulfide (16), bis[4-(3-cyanoproyl)-1-piperazinylthiocarbonyl] disulfide (17) were fifty times more active than nonoxynol-9, OTC vaginal spermicide, and compounds 12 and 17 have shown remarkable in vivo activity in rabbit model. Most promising compound 17 has shown promise for further development as a double-edged vaginal microbicide due to their improved activity and safety along with notable in vivo trichomonicidal activity. Role of disulfide group was established by loss of spermicidal activity on chem. modifications. These disulfides might be targeting thiol groups present over cell membrane of human sperm and Trichomonas as shown by fluorescence labeling of free thiols.1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,del Aguila-Sanchez, Miguel A.; Navarro, Yolanda; Garcia Lopez, Jesus; Guedes, Guilherme P.; Lopez Ortiz, Fernando published 《Synthesis of P-stereogenic diarylphosphinic amides by directed lithiation: transformation into tertiary phosphine oxides via methanolysis, aryne chemistry and complexation behaviour toward zinc(II)》.Dalton Transactions published the findings.Name: 1,2-Diiodoethane The information in the text is summarized as follows:

The highly diastereoselective synthesis of P-stereogenic phosphinic amides via directed ortho lithiation (DoLi) of (SC)-P,P-diphenylphosphinic amides with t-BuLi followed by electrophilic quench reactions is described. Functionalized derivatives containing a wide variety of ortho substituents (Cl, Br, I, OH, N3, SiMe3, SnMe3, P(O)Ph2, Me, allyl, tBuOCO) have been prepared in high yields with diastereomeric ratios up to 98:2. The X-ray diffraction structure of the ortho-stannylated and ortho-iodo compounds showed that the pro-S P-Ph ring was stereoselectively ortho-deprotonated by the organolithium base. The usefulness of the method is supported by two key transformations, the synthesis of P-stereogenic Me phosphinates through replacement of the chiral auxiliary by a methoxy group and the first example of the insertion of benzyne into the P-N bond of a P-stereogenic phosphinic amide. A DFT study of this reaction showed that the insertion proceeds through a [2+2] cycloaddition and a subsequent ring-opening with retention of the P-configuration. Explorative coordination chem. of the new P-stereogenic ligands provided access to a chiral phosphinic amide-phosphine oxide Zn(II) complex, the crystal structure of which is reported.1,2-Diiodoethane(cas: 624-73-7Name: 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Pramanick, Pranab K.; Zhou, Zhibing; Hou, Zhen-Lin; Yao, Bo. Application In Synthesis of 1-Bromo-4-iodobenzene. The article was titled 《Free Amino Group-Directed γ-C(sp3)-H Arylation of α-Amino Esters with Diaryliodonium Triflates by Palladium Catalysis》. The information in the text is summarized as follows:

Free amino group-directed C(sp3)-H functionalization of aliphatic amines is a fundamental challenge in synthetic organic chem. Also, the NH2-directed C(sp3)-H functionalization of α-amino acids and their derivatives remains barely explored. With palladium as the catalyst and Ag2O as the additive, the authors developed the first NH2-directed γ-C(sp3)-H arylation of α-amino esters with diaryliodonium triflates for the construction of synthetically useful γ-aryl-α-amino esters, and the result of the KIE study suggested that the catalytic reaction involved an irreversible C-H cleavage as the rate-determining step. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-iodobenzene(cas: 589-87-7Application In Synthesis of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesApplication In Synthesis of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Chowdhury, Sushobhan; Vaishnav, Roopal; Panwar, Namita; Haq, Wahajul. Related Products of 625-99-0. The article was titled 《Regioselective β-Csp3-arylation of β-alanine: An approach for the exclusive synthesis of diverse β-aryl-β-amino acids》. The information in the text is summarized as follows:

An approach for the synthesis of a variety of new β-aryl-β-amino acids has been developed via a palladium-catalyzed auxiliary-directed regioselective Csp3-H arylation of the unactivated β-methylene bond of β-alanine. The use of 8-aminoquinoline amide as an auxiliary efficiently directs the desired regioselective β-Csp3-H functionalization. The developed protocol enables the easy and straightforward access to several high-value β-aryl-β-amino acids useful for peptide engineering, starting from inexpensive and readily available β-alanine precursors in moderate to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Related Products of 625-99-0 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chinese Journal of Structural Chemistry included an article by Hui, Jia; Zhong, Han-Yu; Zhang, Jing-Yi. COA of Formula: C3H9IOS. The article was titled 《Synthesis, crystal structure and bioactivity of ethyl 1 1-((2 2-Bromophenyl)carbamoyl) carbamoyl)-2-(3,4,5 3,4,5- trimethoxyphenyl)cyclopropanecarboxylate》. The information in the text is summarized as follows:

Many small-mol. compounds were reported as microtubule-inhibitor with potential anticancer activities, such as combretastatin-A4 (CA-4) analog. The title compound which is one novel cyclopropylamide analog of CA-4, namely as Et 1-((2-bromophenyl)car- bamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 8.8002 ( 6), b = 11.4525(8), c = 21.7870(16) Å, beta = 93.810(3)°, V = 2190.9(3) Å3, Z = 4, C22H23BrNO6, Mr = 477.32477.32, Dc = 1. 447 Mg /cm3, F(000) = 980, (CuKa) = 1.54178 Å, mu = 2.883 mm-1, R = 0.0691 and wR = 0.1958 for 6420 observed reflections (I > 2s(I)). Importantly, the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro, indicating that the small-mol. could be selected as a lead compound for the development of microtubule stimulator. In the experiment, the researchers used many compounds, for example, Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.COA of Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com