Month: October 2022

The author of 《Reaction-based fluorometric analysis of N-bromosuccinimide by oxidative deprotection of dithiane》 were Lee, Yu Jeong; Choi, Myung Gil; Park, Tae Jung; Chang, Suk-Kyu. And the article was published in Analyst (Cambridge, United Kingdom) in 2019. Electric Literature of C4H4INO2 The author mentioned the following in the article:

In this study, a fluorescent probe is developed for the first time for N-bromosuccinimide (NBS), a synthetically and anal. important compound Pyrene-dithiane-based probe 1 showed prominently selective and sensitive signaling behavior toward NBS owing to the oxidative cleavage of the dithiane protecting group of 1-pyrenecarboxaldehyde. The NBS-selective signaling of the probe was possible under competitive conditions in the presence of common metal ions and anions as a background. The detection limit of the probe for NBS was found to be 5.6 × 10-8 M (10.0 ppb). The signaling product was sufficiently stable under the oxidative stress of NBS in contrast to another tested compound, 6-methoxy-2-naphthaldehyde-based dithiane derivative 2, which showed a gradually decaying response because of the reaction of the signaling product with the residual NBS. In the practical application of the probe, a smartphone was used as a stand-alone device, and the fluorometric assays of the com. NBS reagents could be conducted rapidly and in a convenient manner. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Electric Literature of C4H4INO2)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Electric Literature of C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Metal-Free Electrophilic Alkynylation of Sulfenate Anions with Ethynylbenziodoxolone Reagents》 were Amos, Stephanie G. E.; Nicolai, Stefano; Gagnebin, Alec; Le Vaillant, Franck; Waser, Jerome. And the article was published in Journal of Organic Chemistry in 2019. Product Details of 88-67-5 The author mentioned the following in the article:

Alkynyl sulfoxides are important building blocks with a unique reactivity in organic chem., but only a few reliable methods have been reported to synthesize them. A novel route to access alkynyl sulfoxides is reported herein by using ethynyl benziodoxolone (EBX) reagents to trap sulfenate anions generated in situ, via a retro-Michael reaction. The reaction takes place under metal-free and mild conditions. It is compatible with aryl, heteroaryl, and alkyl sulfoxides with up to 90% yield. This practical access to alkynyl sulfoxides is expected to facilitate the application of these useful building blocks in organic synthesis. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Product Details of 88-67-5Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Ni-Catalyzed Reductive Dicarbofunctionalization of Nonactivated Alkenes: Scope and Mechanistic Insights》 were Shu, Wei; Garcia-Dominguez, Andres; Quiros, M. Teresa; Mondal, Rahul; Cardenas, Diego J.; Nevado, Cristina. And the article was published in Journal of the American Chemical Society in 2019. Safety of 1-Iodo-4-methylbenzene The author mentioned the following in the article:

Olefins devoid of directing or activating groups have been dicarbofunctionalized here with two electrophilic carbon sources under reductive conditions. Simultaneous formation of one C(sp3)-C(sp3) and one C(sp3)-C(sp2) bond across a variety of unbiased π-systems proceeds with exquisite selectivity by the combination of a Ni catalyst with TDAE as sacrificial reductant. Control experiments and computational studies revealed the feasibility of a radical-based mechanism involving, formally, two interconnected Ni(I)/Ni(III) processes and demonstrated the different ability of Ni(I) species (Ni(I)I vs PhNi(I)) to reduce the C(sp3)-I bond. The role of the reductant was also investigated in depth, suggesting that a one-electron reduction of Ni(II) species to Ni(I) is thermodynamically favored. Further, the preferential activation of alkyl vs aryl halides by ArNi(I) complexes as well as the high affinity of ArNi(II) for secondary over tertiary C-centered radicals explains the lack of undesired homo- and direct coupling products (Ar-Ar, Ar-Alk) in these transformations. In addition to this study using 1-Iodo-4-methylbenzene, there are many other studies that have used 1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene) was used in this study.

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Safety of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Novel preparation of poly(arylene ether sulfone amide)s via supported palladium-catalyzed carbonylative polymerization》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Liu, Limin; Li, Jianying; Yan, Tao; Cai, Mingzhong. SDS of cas: 626-02-8 The article mentions the following:

Two new aromatic diiodides with ether-sulfone linkages were synthesized via a 1-step procedure. Poly(arylene ether sulfone amide)s were synthesized by a supported Pd-catalyzed polycondensation of aromatic diiodides having ether-sulfone linkages, aromatic diamines, and CO. Polycondensation reactions were conducted in N,N-dimethylacetamide using a magnetic nanoparticles-bound Pd(II) complex [Fe3O4@SiO2-2P-PdCl2] as the catalyst and 1,8-diazabicycle[5,4,0]-7-undecene as the base at 120°, yielding poly(arylene ether sulfone amide)s having inherent viscosities of 0.43-0.77 dL/g. The resulting polymers were soluble in polar aprotic solvents and showed glass transition temperatures in the 204-265° range, with 10% weight losses occurring at temperatures >456° in N. Most of the polymers afforded transparent and tough films by solution-casting with tensile strengths of 71.8-82.2 MPa, Young’s moduli of 1.77-2.35 GPa, and elongations at break of 9.3-13.4%. More importantly, this supported Pd catalyst can facilely be separated from the product by simply using an external magnetic field and reused at least 7 times with almost consistent activity. In the experiment, the researchers used many compounds, for example, 3-Iodophenol(cas: 626-02-8SDS of cas: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. SDS of cas: 626-02-8 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《A Combination of Biocompatible Room Temperature Ionic Liquid and Palladium Catalyst for Base- and Ligand-free Suzuki Coupling Reactions》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Joo, Seong-Ryu; Kwon, Gyu-Tae; Kim, Seung-Hoi. HPLC of Formula: 626-02-8 The article mentions the following:

A system with mild and versatile reaction conditions for a carbon-carbon bond-forming reaction using arylboronic acids RB(OH)2 (R = Ph, 3,4-dimethoxyphenyl, pyridin-3-yl, etc.) and aryl halides R1X (R1 = 4-methylphenyl, 3-iodophenyl, thiophen-2-yl, etc.; X = I, F, Cl, Br) was developed. A readily available and biodegradable room-temperature ionic liquid, choline hydroxide (ChOH), was combined with a ligand-free Pd(OAc)2-catalyst, providing the corresponding sym. and/or unsym. biaryl products RR1 in satisfactory yields under aerobic conditions. No external base or ligand was required for completion of the cross-coupling reactions. More significantly, the reaction medium showed good recyclability, which is an important characteristic from the viewpoint of sustainable chem. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8HPLC of Formula: 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.HPLC of Formula: 626-02-8Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Biodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Erol, Arzu; Rosberg, Derya B. Hazer; Hazer, Baki; Goncu, Beyza S.. Name: 4-Iodobenzoic acid The article mentions the following:

Some novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Addnl., biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Name: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Name: 4-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Direct synthesis of chain-end-functionalized poly(3-hexylthiophene) without protecting groups using a zincate complex》 was published in Macromolecular Rapid Communications in 2020. These research results belong to Inagaki, Shin; Yamamoto, Takuya; Higashihara, Tomoya. Reference of 4-Iodobenzoic acid The article mentions the following:

Chain-end-functionalized poly(3-hexylthiophene)s (P3HTs) with benzyl alc. (-PhCH2OH), phenol (-PhOH), and benzoic acid (-PhCOOH) groups are directly synthesized based on the Negishi catalyst-transfer polycondensation method utilizing the zincate complex of tBu4ZnLi2. In this system, neither protection nor deprotection steps are required, and also providing a living polymerization system to control the mol. weight while maintaining a low molar mass dispersity (DM) of the obtained P3HT derivatives Indeed, the chain-end-functionalized P3HTs can be synthesized along with controlled number-average mol. weights (Mn = 5100-20 000), low DM (1.06-1.14), and high chain-end functionality (Fn = 46-86%). The Fn values for the alc. and phenol groups are found to be high (86% for-PhCH2OH and 71% for -PhOH based on 1H NMR, resp.), as also confirmed by matrix-assisted laser desorption/ionization time of flight mass spectroscopy. The easily synthesizable chain-end-functionalized P3HTs will be applicable for the facile synthesis of block and branched polymers containing P3HT as well as its related semiconducting polymer segments. In the experiment, the researchers used many compounds, for example, 4-Iodobenzoic acid(cas: 619-58-9Reference of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Reference of 4-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Gallagher, Rory T.; Basu, Souradeep; Stuart, David R.. Formula: C6H4ClI The article mentions the following:

Herein, a synthetic approach for arylation that exploits the in situ formation and reaction of an unsym. diaryliodonium salt is described. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a “”dummy”” group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Transition-Metal-Free Synthesis of Phenanthridinones through Visible-Light-Driven Oxidative C-H Amidation》 was written by Usami, Kaoru; Yamaguchi, Eiji; Tada, Norihiro; Itoh, Akichika. Quality Control of 2-Iodobenzoic acid And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

The treatment of N-aryl biphenylcarboxamide 2-(4-R2C6H4)-4-R1C6H3C(O)NHR (R = Me, Ph, 1,3-benzothiazol-2-yl, etc.; R1 = H, Br, phenyl; R2 = H, OMe, tert-Bu, Ph, trifluoromethyl, Cl), 1-chloroanthraquinone (1-Cl-AQN) catalyst, and K2CO3 in CHCl3 under visible light irradiation affords phenanthridinone I via radical cyclization. This reaction proceeds under transition-metal-free condition, room temperature, and direct C-H amidation. Mechanistic studies indicate that amidyl radical generation proceeds by visible light induced proton coupled electron transfer (PCET) from N-H bond of the amide. The results came from multiple reactions, including the reaction of 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Quality Control of 2-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lauta, Nicholas R.; Williams, Ryan E.; Smith, David T.; Kumirov, Vlad K.; Njardarson, Jon T. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines》.Synthetic Route of C6H5ClIN The article contains the following contents:

A new intramol. oxidative amino-hydroxylation of o-allenyl anilines was reported. Treatment of carbamate-protected anilines with lead(IV) carboxylates in dichloromethane at room temperature resulted in facile tandem C-N (allene cyclization) and C-O bond formation (carboxylate trapping) to form indole products I [R1 = H, Br, MeO, etc.; R2 = Me, H2CCCl3, t-Bu, Bn; R3 = Me, Ph, 4-FC6H4, 4-F3CC6H4, 4-MeOC6H4, HC=CHPh; R4 = H, Me; R5 = H, Me] . Detailed reaction scope, mechanistic and kinetic studies suggested a reaction pathway involving an initial Wessely dearomatization step followed by cyclization and rearomatization. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com