Month: October 2022

Quality Control of Trimethylsulfoxonium iodideIn 2020 ,《Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition》 was published in Organic & Biomolecular Chemistry. The article was written by Beck, Kasper M.; Krogh, Marie B.; Hornum, Mick; Ludford, Paul T.; Tor, Yitzhak; Nielsen, Poul. The article contains the following contents:

Xeno nucleic acids (XNAs) are artificial genetic systems based on sugar-modified nucleotides. Herein, we investigate double-headed nucleotides as a new XNA. A new monomer, AT, is presented, and together with previous double-headed nucleotide monomers, new nucleic acid motifs consisting of up to five consecutive A·T base pairs have been obtained. Sections composed entirely of double-headed nucleotides are well-tolerated within a DNA duplex and can condense the genetic information. For instance, a 13-mer duplex is condensed to an 11-mer modified duplex containing four double-headed nucleotides while simultaneously improving duplex thermal stability with +14.0°C. Also, the transfer of information from double-headed to natural nucleotides by DNA polymerases has been examined The first double-headed nucleoside triphosphate was prepared but could not be recognized and incorporated by the tested DNA polymerases. On the other hand, it proved possible for Therminator DNA polymerase to transfer the information of a double-headed nucleotide in a template sequence to natural DNA under controlled conditions. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Quality Control of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Quality Control of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 4-IodopyridineIn 2022 ,《Synthesis of Thioalkynes by Desilylative Sonogashira Cross-Coupling of Aryl Iodides and 1-Methylthio-2-(trimethylsilyl)ethyne》 was published in European Journal of Organic Chemistry. The article was written by Cao, Yang; Huang, Yang; Blakemore, Paul R.. The article contains the following contents:

1-Methylthio-2-arylethynes ArC≡CSMe [Ar = Ph, 1-naphthyl, 4-MeC6H4, etc.] were prepared in typically good to excellent yields from aryl iodides and 1-methylthio-2-(trimethylsilyl)ethyne by a desilylative Sonogashira process employing Pd(PPh3)2Cl2 (1 mol %), CuI (10 mol %) and K2CO3 (6 equiv) in MeOH-Et3N-THF (1:2:2) at rt for 16 h (16 examples, 31-96% yield). Thienyl and pyridyl iodides (all regioisomers) were similarly converted to 1-methylthio-2-heteroarylethynes ArC≡CSMe [Ar = 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl] (5 examples, 54-82% yield). The process was extended with similar results to comparable thioalkynes PhC≡CSR [R = n-Bu, cyclohexyl, 4-MeC6H4] substituted on sulfur. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Safety of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Drug Design, in Vitro Pharmacology, and Structure-Activity Relationships of 3-Acylamino-2-aminopropionic Acid Derivatives, a Novel Class of Partial Agonists at the Glycine Site on the N-Methyl-D-aspartate (NMDA) Receptor Complex》 was written by Urwyler, Stephan; Floersheim, Philipp; Roy, Bernard L.; Koller, Manuel. Quality Control of 1-Chloro-4-iodo-2-nitrobenzene And the article was included in Journal of Medicinal Chemistry on August 27 ,2009. The article conveys some information:

Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in mols. derived from glycine or D-serine has proven to be difficult because in the vicinity of the α-amino acid group little substitution is tolerated. We have solved this problem by replacing the hydroxy group of D-serine with an amido group, thus keeping the hydrogen donor function and allowing for further substitution and exploration of the adjacent space. Heterocyclic substitutions resulted in a series of 3-acylamino-2-aminopropionic acid derivatives, with high affinities in a binding assay for the glycine site. In a functional assay assessing the activation of the glycine site, these compounds displayed a wide range of intrinsic efficacies, from antagonism to a high degree of partial agonism. Structure-activity relationships reveal that lipophilic substituents, presumably filling an addnl. hydrophobic pocket, are accepted by the glycine site, provided that they are separated from the α-amino acid group by a short linker. The experimental process involved the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Quality Control of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ethyl 2-Cyano-2-(2-Nitrophenylsulfonyloximino)Acetate (ortho-NosylOXY) Mediated One-Pot Racemization Free Synthesis of Ureas, Carbamates, and Thiocarbamates via Curtius Rearrangement》 was written by Kalita, Tapasi; Dev, Dharm; Mondal, Sandip; Giri, Rajat Subhra; Mandal, Bhubaneswar. Synthetic Route of C7H5IO2This research focused onurea preparation; carbamate preparation; thiocarbamate preparation; carboxylic acid ethyl cyano nitrophenylsulfonyloximino acetate Curtius rearrangement. The article conveys some information:

A detailed NMR-based mechanism study is incorporated here. Direct conversion of to ureas RNHC(O)NHR1 (R = Ph, 4-methylphenyl, 4-methoxybenzyl, (tert-butoxycarbonylamino)(phenyl)methyl, etc.; R1 = 4-chlorophenyl, tert-Bu, methoxycarbonylmethyl, etc.), carbamates RNHC(O)OR1 (R = 4-methoxyphenyl, 4-bromophenyl; R1 = 4-nitrobenzyl, 4-methoxybenzyl), and thiocarbamate RNHC(O)SR1 (R = Ph, undecan-1-yl, 2-methoxyphenyl; R1 = 4-chlorobenzyl) in a single pot via Curtius rearrangement is accomplished. One recently established coupling reagent, ethyl-2-cyano-2-(2-nitrophenylsulfonyloximino)acetate (ortho-NosylOXY), is successfully used for the racemization free synthesis of ureas, di-peptidyl ureas, and carbamates with moderate to good yield (82-69%). This single-pot hassle-free procedure works with a diverse range of N-protecting groups Fmoc, Boc, and Cbz. Various amines R1NH2, including aromatic, Me esters of amino acids, tert-butylamine, benzyl alcs. (such as 4-nitrobenzyl alc., 4-methoxybenzyl alc.), and (4-chlorophenyl)-methanethiol, are used as nucleophiles. Racemization suppression, easy removal of byproducts, and less waste generation make this methodol. useful. The experimental process involved the reaction of 4-Iodobenzoic acid(cas: 619-58-9Synthetic Route of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy》 was written by Jenni, Sebastien; Sour, Angelique; Bolze, Frederic; Ventura, Barbara; Heitz, Valerie. Synthetic Route of C7H5IO2This research focused ontumor photosensitizer photon excitation photodynamic therapy. The article conveys some information:

Despite the advantages of photodynamic therapy (PDT) over chemotherapy or radiotherapy such as low side effects, lack of treatment resistance and spatial selectivity inherent to light activation of the drug, several limitations especially related to the photosensitizer (PS) prevent PDT from becoming widespread in oncol. Herein, new folic acid- and biotin-conjugated PSs for tumor-targeting PDT are reported, with promising properties related to PDT such as intense absorption following one-photon excitation in the red or two-photon excitation in the near-IR, and also high singlet oxygen quantum yield (close to 70% in DMSO). Cellular studies demonstrated that both targeted PSs induced phototoxicity, the folate-targeted PS being the most effective one with 80% of cell death following 30 min of irradiation and a phototoxicity four times higher than that of the non-targeted PS. This result is in accordance with the uptake of the folate-targeted PS in HeLa cells, mediated by the folate receptors. Moreover, this folate-targeted PS was also phototoxic following two-photon excitation at 920 nm, opening new perspectives for highly selective PDT treatment of small and deep tumors. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Synthetic Route of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Synthetic Route of C7H5IO2 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 1-Chloro-4-iodo-2-nitrobenzeneOn September 30, 2009 ,《Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles》 was published in Journal of Heterocyclic Chemistry. The article was written by Goeker, Hakan; Alp, Mehmet; Ates-Alagoez, Zeynep; Yildiz, Sulhiye. The article contains the following contents:

A series of 47 novel N1-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogs were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that I and II, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogs III (R1 = H, R2 = Br; R1 = Pr, R2 = Br, CN) have no inhibitory activity. The results came from multiple reactions, including the reaction of 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Reference of 1-Chloro-4-iodo-2-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C7H4FIO2On November 26, 2012 ,《Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure-Activity Relationships and Assessment in a Rat Model of Nicotine Dependence》 appeared in Journal of Medicinal Chemistry. The author of the article were Sidique, Shyama; Dhanya, Raveendra-Panickar; Sheffler, Douglas J.; Nickols, Hilary Highfield; Yang, Li; Dahl, Russell; Mangravita-Novo, Arianna; Smith, Layton H.; D’Souza, Manoranjan S.; Semenova, Svetlana; Conn, P. Jeffrey; Markou, Athina; Cosford, Nicholas D. P.. The article conveys some information:

Compounds that modulate metabotropic glutamate subtype 2 (mGlu2) receptors have the potential to treat several disorders of the central nervous system (CNS) including drug dependence. Herein the authors describe the synthesis and structure-activity relationship (SAR) studies around a series of mGlu2 receptor pos. allosteric modulators (PAMs). The effects of N-substitution and substitutions on the aryl ring were identified as key areas for SAR exploration. Investigation of the effects of varying substituents in both the isoindolinone (I) and benzisothiazolone (II) series led to compounds with improved in vitro potency and/or efficacy. In addition, several analogs exhibited promising pharmacokinetic (PK) properties. Furthermore, compound I was shown to dose-dependently decrease nicotine self-administration in rats following oral administration. Our data, showing for the first time efficacy of an mGlu2 receptor PAM in this in vivo model, suggest potential utility for the treatment of nicotine dependence in humans. The results came from multiple reactions, including the reaction of 5-Fluoro-3-iodobenzoic acid(cas: 723294-74-4Computed Properties of C7H4FIO2)

5-Fluoro-3-iodobenzoic acid(cas: 723294-74-4) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C7H4FIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bakherad, Mohammad; Bahramian, Bahram; Nasr-Isfahani, Hossein; Keivanloo, Ali; Sang, Golnaz published an article on February 28 ,2009. The article was titled 《Polystyrene-supported palladium(II) ethylenediamine complex: A recyclable catalyst for the syntheses of 2-benzylimidazo[2,1-b][1,3]benzothiazoles by Sonogashira reaction》, and you may find the article in Chinese Journal of Chemistry.Recommanded Product: 41252-95-3 The information in the text is summarized as follows:

The polymer-supported palladium(II) ethylenediamine complex was used as a catalyst for the heterocyclization by Sonogashira reaction between aryl iodides and 2-amino-3-(2-propynyl)-1,3-benzothiazolium bromide and could readily be recovered from the reaction medium by a simple filtration and reused without a significant loss in its activity. In addition to this study using 1-Chloro-4-iodo-2-nitrobenzene, there are many other studies that have used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Recommanded Product: 41252-95-3) was used in this study.

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 41252-95-3Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bakherad, Mohammad; Keivanloo, Ali; Mohammadi, Marzieh; Jajarmi, Saeideh published an article in Letters in Organic Chemistry. The title of the article was 《Syntheses of 2-benzyl substituted imidazo[1,2-a]pyrimidines via coupling-cyclization under Pd-Cu catalysis》.Product Details of 41252-95-3 The author mentioned the following in the article:

The reaction of 1-(prop-2-yn-1-yl)pyrimidin-2(1H)-imine with various halobenzenes in the presence of a palladium catalyst leads to the production of 2-benzyl substituted imidazo[1,2-a]pyrimidines, e.g. I (R = 4-O2N, 2-O2N-4-Cl, 4-MeCO).1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Product Details of 41252-95-3) was used in this study.

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 41252-95-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Lu, Xi; Wang, Yan; Zhang, Ben; Pi, Jing-Jing; Wang, Xiao-Xu; Gong, Tian-Jun; Xiao, Bin; Fu, Yao published 《Nickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides》.Journal of the American Chemical Society published the findings.COA of Formula: C10H18INO2 The information in the text is summarized as follows:

In the presence of Ni(cod)2 and an imidazolinylpyridine ligand, 1,1-difluoroalkenes such as I underwent chemoselective and diastereoselective reductive defluorinative coupling reactions with secondary alkyl bromides and iodides such as iodocyclohexane mediated by bis(pinacolato)diboron and tripotassium phosphate to yield (Z)-arylfluoroalkenes such as II in 36-95% yields and in 8:1->50:1 Z:E diastereoselectivities; the reaction was also used to couple difluoroalkenes with primary alkyl iodides and 1,1-difluoroalkyl bromides using a catalyst generated from NiBr2(diglyme) and 4,7-dimethoxy-1,10-phenanthroline. In the experimental materials used by the author, we found tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3COA of Formula: C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.COA of Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com