Month: October 2022

In 2017,Bogomolov, Alexandr S.; Goldort, Veniamin G.; Kochubei, Sergei A.; Baklanov, Alexey V. published 《Photodissociation of van der Waals complexes of iodine X-I2 (X = I2, C2H4) via charge-transfer state: velocity map imaging investigation》.Journal of Chemical Physics published the findings.Application of 624-73-7 The information in the text is summarized as follows:

The photodissociation of van der Waals complexes of iodine X-I2 (X = I2, C2H4) excited via Charge-Transfer (CT) band has been studied with the velocity map imaging technique. Photodissociation of both complexes gives rise to translationally “”hot”” mol. iodine I2 via channels differing by kinetic energy and angular distribution of the recoil directions. These measured characteristics together with the anal. of the model potential energy surface for these complexes allow us to infer the back-electron-transfer (BET) in the CT state to be a source of observed photodissociation channels and to make conclusions on the location of conical intersections where the BET process takes place. The BET process is concluded to provide an I2 mol. in the electronic ground state with moderate vibrational excitation as well as X mol. in the electronic excited state. In the case of X = I2, the BET process converts anion I2- of the CT state into the neutral I2 in the repulsive excited electronic state which then dissociates promptly giving rise to a pair of I atoms in the fine states 2P1/2. In the case of C2H4-I2, the C2H4 mols. appear in the triplet T1 electronic state. Conical intersection for corresponding BET process becomes energetically accessible after partial twisting of C2H4+ frame in the excited CT state of complex. The C2H4(T)-I2 complex gives rise to triplet ethylene as well as singlet ethylene via the T-S conversion. (c) 2017 American Institute of Physics. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Wisniewski, Steven R.; Stevens, Jason M.; Yu, Miao; Fraunhoffer, Kenneth J.; Romero, Evan O.; Savage, Scott A.. SDS of cas: 591-18-4. The article was titled 《Utilizing Native Directing Groups: Synthesis of a Selective IKur Inhibitor, BMS-919373, via a Regioselective C-H Arylation》. The information in the text is summarized as follows:

BMS-919373 (I) is a highly functionalized quinazoline under investigation as a selective, potent Ikur current blocker. By utilizing the aminomethylpyridine side chain at C-4, a selective C-H functionalization at C-5 was invented, enabling the efficient synthesis of this mol. The strategy of leveraging this inherent directing group allowed the synthesis of this complex heterocycle in only six steps from commodity chems. The scope of the C-H activation was further investigated, and the generality of the transformation across a series of bicyclic aromatic heterocycles was explored. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4SDS of cas: 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.SDS of cas: 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Wisniewski, Steven R.; Savage, Scott A.; Romero, Evan O.; Eastgate, Martin D.; Tan, Yichen; Simmons, Eric M.; Plata, R. Erik; Sowa, John R.; Blackmond, Donna G.. Related Products of 591-18-4. The article was titled 《Utilizing Native Directing Groups: Mechanistic Understanding of a Direct Arylation Leads to Formation of Tetracyclic Heterocycles via Tandem Intermolecular, Intramolecular C-H Activation》. The information in the text is summarized as follows:

A mechanistic study on a direct arylation using a native picolylamine directing group is reported. Kinetic studies determined the concentration dependence of substrates and catalysts, as well as catalyst degradation, which led to the development of a new set of reaction conditions capable of affording a robust kinetic profile. During reaction optimization, a small impurity was observed, which was determined to be a dual C-H activation product. A second set of conditions were found to flip the selectivity of the C-H activation to form this tetracycle in high yield. A catalytic cycle is proposed for the intermol./intramol. C-H activation pathway. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-iodobenzene(cas: 591-18-4Related Products of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Related Products of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《R-Benzylidenehydrazides of NH-Furoyl-5-Iodoanthranilic Acids: Synthesis, Properties, and Analgesic and Antibacterial Activity》 were Gazizova, A. F.; Kurbatov, E. R.; Makhmudov, R. R.; Bobyleva, A. A.; Korkodinova, L. M.; Kurbatova, A. A.. And the article was published in Pharmaceutical Chemistry Journal in 2019. Synthetic Route of C7H5IO The author mentioned the following in the article:

A series of R-benzylidenehydrazides of NH-furoyl-5-iodoanthranilic acid were synthesized by condensing NH-furoyl-5-iodoanthranilic acid hydrazide with aromatic aldehydes. Their structures were confirmed using IR and PMR spectroscopy. Their analgesic and antibacterial activities were studied. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Intestinal electrogenic sodium-dependent glucose absorption in tilapia and trout reveal species differences in SLC5A-associated kinetic segmental segregation》 were Subramaniam, Marina; Weber, Lynn P.; Loewen, Matthew E.. And the article was published in American Journal of Physiology in 2019. Safety of 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Electrogenic sodium-dependent glucose transport along the length of the intestine was compared between the omnivorous Nile tilapia (Oreochromis niloticus) and the carnivorous rainbow trout (Oncorhynchus mykiss) in Ussing chambers. In tilapia, a high-affinity, high-capacity kinetic system accounted for the transport throughout the proximal intestine, midintestine, and hindgut segments. Similar dapagliflozin and phloridzin dihydrate inhibition across all segments support this homogenous high-affinity, high-capacity system throughout the tilapia intestine. Genomic and gene expression anal. supported findings by identifying 10 of the known 12 SLC5A family members, with homogeneous expression throughout the segments with dominant expression of sodium-glucose cotransporter 1 (SGLT1; SLC5A1) and sodium-myoinositol cotransporter 2 (SMIT2; SLC5A11). In contrast, trout’s electrogenic sodium-dependent glucose absorption was 20-35 times lower and segregated into three significantly different kinetic systems found in different anatomical segments: a high-affinity, low-capacity system in the pyloric ceca; a super-high-affinity, low-capacity system in the midgut; and a low-affinity, low-capacity system in the hindgut. Genomic and gene expression anal. found 5 of the known 12 SLC5A family members with dominant expression of SGLT1 (SLC5A1), sodium-glucose cotransporter 2 (SGLT2; SLC5A2), and SMIT2 (SLC5A11) in the pyloric ceca, and only SGLT1 (SLC5A1) in the midgut, accounting for differences in kinetics between the two. The hindgut presented a low-affinity, low-capacity system partially attributed to a decrease in SGLT1 (SLC5A1). Overall, the omnivorous tilapia had a higher electrogenic glucose absorption than the carnivorous trout, represented with different kinetic systems and a greater expression and number of SLC5A orthologs. Fish differ from mammals, having hindgut electrogenic glucose absorption and segment specific transport kinetics. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pd@GO/Fe3O4/PAA/DCA: a novel magnetic heterogeneous catalyst for promoting the Sonogashira cross-coupling reaction》 were Daraie, Mansoureh; Heravi, Majid M.; Kazemi, Shaghayegh Sadat. And the article was published in Journal of Coordination Chemistry in 2019. Synthetic Route of C10H7I The author mentioned the following in the article:

A hybrid system involving graphene oxide (GO), magnetic oxide (Fe3O4), acrylamide and dicyandiamide was prepared via amine functionalization of GO/Fe3O4 by covalent bonding with acrylamide and subsequent reaction with dicyandiamide to provide a multinitrogen containing polymer on the surface of GO. This hybrid system was used as a heterogeneous catalyst support for immobilizing Pd nanoparticles to provide the hybrid, Pd@GO/Fe3O4/PAA/DCA. This nano-Pd composite was characterized using FTIR, TEM, SEM, vibrating sample magnetometer, TGA, x-ray diffraction, and ICP techniques and used for promoting Sonogashira cross-coupling under mild reaction conditions. This heterogeneous and magnetic catalyst was easily separated by external magnet and was reused in a model reaction, efficiently up to six times with slight loss of catalytic activity and Pd leaching, showing the suitability of GO/Fe3O4/PAA/DCA for embedding Pd nanoparticles. To check the effect of the number of surface nitrogens of the polymeric chain on the catalytic performance, the activity of the catalyst was compared with Pd@GO/Fe3O4/PAA; increased number of the surface nitrogens on the chain polymer leads to higher loading of Pd and lower the Pd leaching. In the experimental materials used by the author, we found 1-Iodonaphthalene(cas: 90-14-2Synthetic Route of C10H7I)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Synthetic Route of C10H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Rational design of cyclopenta[2,1-b;3,4-b’]dithiophene-bridged hole transporting materials for highly efficient and stable perovskite solar cells》 were Lin, Yan-Duo; Lee, Kun-Mu; Ke, Bo-Yu; Chen, Kai-Shiang; Cheng, Hao-Chien; Lin, Wei-Juih; Chang, Sheng Hsiung; Wu, Chun-Guey; Kuo, Ming-Chung; Chung, Hsin-Cheng; Chou, Chien-Chun; Chen, Heng-Yu; Liau, Kang-Ling; Chow, Tahsin J.; Sun, Shih-Sheng. And the article was published in Energy Technology (Weinheim, Germany) in 2019. Quality Control of 1-Bromo-4-iodobenzene The author mentioned the following in the article:

A series of small-mol.-based hole-transporting materials (HTMs) featuring a 4H-cyclopenta[2,1-b : 3,4-b]dithiophene as the central core with triphenylamine- and carbazole-based side groups was synthesized and evaluated for perovskite solar cells. The correlations of the chem. structure of the HTMs on the photovoltaic performance were explored through different combinations of the central π-bridge moieties. The optical and electrochem. properties, energy levels, and hole mobility were systematically investigated, revealing the significant influence of the central core planarity and packing structure on their photovoltaic performance. The optimized device based on CT1 exhibited a PCE (power conversion efficiency) of 17.71% with a device architecture of FTO/TiO2 compact layer/TiO2 mesoporous/CH3NH3PbI3/HTM/MoO3/Ag, which was found to be on par with that of a cell fabricated based on state-of-the-art spiro-OMeTAD (16.97%) as HTM. Moreover, stability assessment showed an improved stability for CPDT-based HTMs in comparison with spiro-OMeTAD over 1300 h. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-iodobenzene(cas: 589-87-7Quality Control of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Quality Control of 1-Bromo-4-iodobenzene It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ligand-Controlled Direct γ-C-H Arylation of Aldehydes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Li, Bijin; Lawrence, Brianna; Li, Guigen; Ge, Haibo. Product Details of 624-31-7 The article mentions the following:

The first example of PdII-catalyzed γ-C(sp3)-H functionalization of aliphatic and benzoheteroaryl aldehydes was developed using a transient ligand and an external ligand, concurrently. A wide array of γ-arylated aldehydes were readily accessed without preinstalling internal directing groups. The catalytic mechanism was studied by performing deuterium-labeling experiments, which indicated that the γ-C(sp3)-H bond cleavage is the rate-limiting step during the reaction process. This reaction could be performed on a gram scale, and also demonstrated its potential application in the synthesis of new mechanofluorochromic materials with blue-shifted mechanochromic properties. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Product Details of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Product Details of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ring Opening of Donor-Acceptor Cyclopropanes with Cyanide Ion and Its Surrogates》 was written by Boichenko, Maksim A.; Andreev, Ivan A.; Chagarovskiy, Alexey O.; Levina, Irina I.; Zhokhov, Sergey S.; Trushkov, Igor V.; Ivanova, Olga A.. Computed Properties of C3H9IOS And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A straightforward method for ring opening of donor-acceptor cyclopropanes with trimethylsilyl cyanide as a surrogate of cyanide ion in the presence of B(C6F5)3 or trifluoromethanesulfonic acid as a catalyst has been developed. The methodol. provides a short route to gamma-cyanoesters that can be useful synthetic intermediates for the synthesis of diverse bioactive mols. such as glutaric and delta-aminovaleric acid derivatives, 3-arylpiperidines or other substituted phenethylamines. Oppositely, the attempts to synthesize these gamma-cyanoesters by direct reaction of cyclopropanes with sodium cyanide under typical SN2 conditions led to the formation of 2-arylsuccinonitriles. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Computed Properties of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Computed Properties of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Novel D-π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates》 was written by Lv, Guanglei; Xu, Yunze; Yang, Jiajia; Li, Wenhui; Li, Chunxia; Sun, Anyang. Synthetic Route of C7H5IO And the article was included in Analyst (Cambridge, United Kingdom) in 2020. The article conveys some information:

Aberrant accumulation of Amyloid-β (Aβ) peptide is closely related to Alzheimer′s disease. Thus, it is important to develop featured probes for the specific detection of Aβ species. Herein, the authors designed and synthesized a novel near-IR fluorescent probe SDPY based on the D-π-A architecture for the detection of Aβ aggregates. The probe SDPY displayed higher affinity for Aβ40 aggregates over Aβ42 aggregates in solution (Kd = 164 nM vs. 2.1 μM). In addition, SDPY showed excellent anti-interference against a wide range of other substances. Furthermore, SDPY was capable of labeling Aβ40 aggregates better than Aβ42 aggregates in the brain sections of AD transgenic mouse models.4-Iodobenzaldehyde(cas: 15164-44-0Synthetic Route of C7H5IO) was used in this study.

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Synthetic Route of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com