Month: October 2022

Safety of 3-IodophenolIn 2021 ,《Magnetic covalently immobilized nickel complex: A new and efficient method for the Suzuki cross-coupling reaction》 appeared in Applied Organometallic Chemistry. The author of the article were Keyhaniyan, Mahdi; Khojastehnezhad, Amir; Eshghi, Hossein; Shiri, Ali. The article conveys some information:

An efficient procedure is reported to prepare Fe3O4@SiO2 magnetic nanoparticles (MNPs) with immobilized nickel NPs. In order to increase the activity of this catalyst, creatine as a ligand with high content of nitrogen atoms was linked onto the magnetic core-shell structure. Then, Ni(II) ions were coordinated on the surface of the silica-coated MNPs and reduced to Ni(0) NPs to obtain the final catalyst. The catalytic activity of the prepared catalyst was studied for the synthesis of biaryl derivatives via the Suzuki-Miyaura cross-coupling reaction in high yields. The catalyst could also be recovered and reused with no loss of activity over five successful runs. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Safety of 3-Iodophenol

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 624-73-7In 2018 ,《Mechanism of SmI2 Reduction of 5-Bromo-6-oxo-6-phenylhexyl Methanesulfonate Studied by Spin Trapping with 2-Methyl-2-nitrosopropane》 was published in Journal of Organic Chemistry. The article was written by Aretz, Christopher D.; McPeak, Joseph E.; Eaton, Gareth R.; Eaton, Sandra S.; Cowen, Bryan J.. The article contains the following contents:

The radical formed by reduction of 5-bromo-6-oxo-6-phenylhexyl methanesulfonate, an α-bromoketone, with SmI2 was spin trapped with 2-methyl-2-nitrosopropane. ESR spectra of the spin adduct and the adduct formed in the analogous reaction with selectively deuterated substrate identify the radical intermediate in this SmI2 reduction as a carbon-centered radical. This result supports the proposal that the formation of reactive Sm-enolates arises from reduction of the carbon-bromine bond rather than a ketyl radical anion. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application In Synthesis of 1-IodonaphthaleneIn 2019 ,《Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide》 was published in European Journal of Organic Chemistry. The article was written by Ishida, Seima; Suzuki, Hiroyuki; Uchida, Seiichiro; Yamaguchi, Eiji; Itoh, Akichika. The article contains the following contents:

In this study, we develop a nickel-catalyzed carbonyl arylation reaction employing aldehydes with aryl and allyl halides. Various aryl, α,β-unsaturated aldehyde and aliphatic aldehydes can be converted into their corresponding secondary alcs. in moderate-to-high yields. In addition, we extended this approach to develop an asym. reductive coupling reaction that combines nickel salts with chiral bisoxazoline ligands to give secondary alcs. with moderate enantioselectivity. In the experimental materials used by the author, we found 1-Iodonaphthalene(cas: 90-14-2Application In Synthesis of 1-Iodonaphthalene)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application In Synthesis of 1-Iodonaphthalene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 516-12-1In 2020 ,《Synthesis of β-Glucosides with 3-O-Picoloyl-Protected Glycosyl Donors in the Presence of Excess Triflic Acid: A Mechanistic Study》 was published in Chemistry – A European Journal. The article was written by Mannino, Michael P.; Demchenko, Alexei V.. The article contains the following contents:

Our previous study showed that picoloylated donors are capable of providing excellent facial stereoselectivity through the H-bond-mediated aglycon delivery (HAD) pathway. Presented herein is a detailed mechanistic study of stereoselective glycosylation with 3-O-picoloylated glucosyl donors. While reactions of glycosyl donors equipped with the 3-O-benzoyl group are typically non-stereoselective because these reactions proceed via the oxacarbenium intermediate, 3-O-picoloylated donors are capable of providing enhanced, but somewhat relaxed, β-stereoselectivity by the HAD pathway. In an attempt to refine this reaction, we noticed that glycosylations are highly β-stereoselective in the presence of NIS and stoichiometric TfOH. The HAD pathway is highly unlikely because the picoloyl nitrogen is protonated under these reaction conditions. The protonation and glycosylation were studied by low-temperature NMR, and the intermediacy of the glycosyl triflate has been observed This article is dedicated to broadening the scope of this reaction in application to a variety of substrates and targets. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Application of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Application of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ex vivo model for elucidating the functional and structural differentiation of the embryonic mouse thyroid》 was written by Carre, Aurore; Gawade, Sanjay; Dertschnig, Simone; Hafen, Kathrin; Polak, Michel; Szinnai, Gabor. Related Products of 516-12-1This research focused onTSH embryonic follicular cell differentiation parathyroid; Culture model; Development; Differentiation; Thyroid. The article conveys some information:

Terminal thyroid gland differentiation – the last developmental step needed to enable thyroid hormone (T4) synthesis – involves profound structural and biochem. changes in the thyroid follicular cells (TFCs). We aimed to develop an ex vivo thyroid model of embryonic mouse thyroid that would replicate the in vivo TFC differentiation program. E13.5 thyroid explants were cultured ex vivo in chem. defined medium for 7 days. Immunostaining and qPCR of thyroid explants showed thyroglobulin production onset, follicle formation, and T4 synthesis onset in 1-, 3-, and 5-day-old cultures, resp. Differentiation was maintained and follicular growth continued throughout the 7-day culture period. Pharmacol. approaches to culture inhibition were performed successfully in the ex vivo thyroids. Our robust and well described ex vivo thyroid culture model replicates the sequence of thyroid differentiation to T4 synthesis seen in vivo. This model can be used to test the effects of pharmacol. inhibitors on thyroid hormone production The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《N-Iodosuccinimide as Bifunctional Reagent in (E)-Selective C(sp2)-H Sulfonylation of Styrenes》 was written by Pramanik, Milan; Choudhuri, Khokan; Mal, Prasenjit. Recommanded Product: 1-Iodopyrrolidine-2,5-dioneThis research focused onvinyl sulfone preparation regioselective stereoselective; styrene sulfonyl hydrazide sulfonylation iodosuccinimide bifunctional reagent. The article conveys some information:

Herein, the use of N-iodosuccinimide (NIS) as a bifunctional reagent for a regio- and (E)-selective C(sp2)-H sulfonylation reaction of styrenes is reported. Styrenes and sulfonyl hydrazides treated with NIS and potassium carbonate in ethanol at 70° resulted in (E)-vinyl sulfones exclusively with good to excellent yields. NIS, plays a dual role to generate sulfonyl radical from sulfonyl hydrazides at an initial stage and finally gives β-iodosulfone intermediate which is further converted to (E)-vinyl sulfones. Overall, a sustainable method for mild, metal free, convenient, one pot and direct synthesis of (E)-vinyl sulfones from styrenes are demonstrated via a C-S coupling reaction. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C24H20I2O4On March 31, 2015, Liu, Xiong-Li; Yu, Zhang-Biao; Pan, Bo-Wen; Chen, Lin; Feng, Ting-Ting; Zhou, Ying published an article in Journal of Heterocyclic Chemistry. The article was 《Synthesis of Novel Chiral Phosphoric Acid-Bearing Two Acidic Phenolic Hydroxyl Groups and its Catalytic Evaluation for Enantioselective Friedel-Crafts Alkylation of Indoles and Enones》. The article mentions the following:

A novel chiral phosphoric acid catalyst bearing two acidic phenolic hydroxyl groups was synthesized. Its catalytic activity as a chiral Bronsted acid has been examined in the enantioselective Friedel-Crafts alkylation of indoles and enones as a model reaction. In comparison with the other chiral phosphoric acid catalysts, the reaction catalyzed by the novel chiral catalyst afforded the desired 3-substituted indoles I (R1 = H, OCH3, Br; R2 = H, CH; R3 = Ph, n-Pr, 2-naphthyl, 2-thienyl, 2-furyl; R4 = Ph, CH3, 2-thienyl, 4-ClC6H4, 4-CH3OC6H4) in a higher enantioselectivity (up to 69% ee). The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3Computed Properties of C24H20I2O4)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Computed Properties of C24H20I2O4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2013,Chemistry – A European Journal included an article by Guetz, Christoph; Hovorka, Rainer; Schnakenburg, Gregor; Luetzen, Arne. HPLC of Formula: 189518-78-3. The article was titled 《Homochiral Supramolecular M2L4 Cages by High-Fidelity Self-Sorting of Chiral Ligands》. The information in the text is summarized as follows:

A 1,1′-binaphthyl-based bis(pyridine) ligand (1) was prepared in racemic and enantiomerically pure form to study the formation of [Pd2(1)4] complexes upon coordination to palladium(II) ions with regard to the degree of chiral self-sorting. The self-assembly process proceeds in a highly selective narcissistic self-recognition manner to give only homochiral supramol. M2L4 cages, which were characterized by ESI-MS, NMR, and electronic CD (ECD) spectroscopy, as well as by single-crystal XRD anal. The prepared complex is [Pd2(1)4](BF4)4 (2). The experimental process involved the reaction of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3HPLC of Formula: 189518-78-3)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.HPLC of Formula: 189518-78-3 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Australian Journal of Chemistry included an article by Poynder, Tiffany B.; Savaliya, Dharmeshkumar P.; Molino, Andrew; Wilson, David J. D.; Dutton, Jason L.. Related Products of 624-73-7. The article was titled 《Elimination of Ethene from 1,2-Diiodoethane Induced by N-Heterocyclic Carbene Halogen Bonding*》. The information in the text is summarized as follows:

The attempted synthesis of N-heterocyclic carbene (NHC)-stabilized dicarbon (C2) fragments via nucleophilic substitution at 1,2-diiodoethane is reported. Rather than the expected SN2 pathway, clean elimination of ethene and formation of an iodoimidazolium cation was observed The resistance towards nucleophilic substitution piqued interest, and subsequent investigation determined NHC-halogen bonding as the source. This is in contrast to reactions between NHCs and other alkyl halides, where substitution or elimination pathways are reported. A detailed theor. study between these cases highlights the importance of iodine as a halogen bond donor compared with other halogens, and shows that NHCs are excellent halogen bond acceptors. This reactivity suggests potential for application of the halogen bonding interaction between NHCs and organic compounds The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Related Products of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Li, Jie; Ren, Qianyi; Cheng, Xinyi; Karaghiosoff, Konstantin; Knochel, Paul. COA of Formula: C10H18INO2. The article was titled 《Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp2-Csp3 Cross-Couplings Using Organomagnesium Reagents》. The information in the text is summarized as follows:

A simple protocol for performing chromium-catalyzed highly diastereoselective alkylations of arylmagnesium halides with cyclohexyl iodides at ambient temperature has been developed. Furthermore, this ligand-free CrCl2 enables efficient electrophilic alkenylations of primary, secondary and tetiary alkylmagnesium halides with readily available alkenyl acetates. Moreover, this chemoselective C-C coupling reaction with stereodefined alkenyl acetates proceeds in a stereoretentive fashion. A wide range of functional groups on alkyl iodides and alkenyl acetates are well tolerated, thus furnishing functionalized Csp2-Csp3 coupling products in good yields and high diastereoselectivity. Detailed mechanistic studies suggest that the in situ generated low-valent chromium(I) species might be the active catalyst for these Csp2-Csp3 cross-couplings. After reading the article, we found that the author used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3COA of Formula: C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com