Month: October 2022

Name: 1-Bromo-4-iodobenzeneIn 2019 ,《Assembly of a Porous Supramolecular Polyknot from Rigid Trigonal Prismatic Building Blocks》 appeared in Journal of the American Chemical Society. The author of the article were Li, Penghao; Chen, Zhijie; Ryder, Matthew R.; Stern, Charlotte L.; Guo, Qing-Hui; Wang, Xingjie; Farha, Omar K.; Stoddart, J. Fraser. The article conveys some information:

Herein we report a hydrogen-bonded three-dimensional porous supramol. polyknot assembled from a rigid trigonal prismatic triptycene building block with six extended peripheral aryl-carboxyl groups. Within this superstructure, three arrays of undulated 2D rhombic subnets, which display an inclined polycatenation, are interconnected to give an unprecedented uninodal six-connected net with a point symbol of (3.44.610). Such an entanglement results in a trefoil knot motif, which, as the basic repeating unit, is fused and interlocked with itself three-dimensionally to afford a supramol. polyknot. This example highlights the ability of supramol. systems to form topol. complex architectures using geometrically simple building blocks. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-4-iodobenzene(cas: 589-87-7Name: 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Name: 1-Bromo-4-iodobenzene It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C6H4BrIIn 2020 ,《Synthesis, Structure, and Optical Properties of Di-m-benzihexaphyrins (1.1.0.0.0.0) and Di-m-benziheptaphyrins (1.0.1.0.0.0.0): Blackening of m-Phenylene-Linked Dicarbaporphyrinoids by Simple π-Expansion》 appeared in Journal of Organic Chemistry. The author of the article were Sulfikarali, Thondikkal; Ajay, Jayaprakash; Suresh, Cherumuttathu H.; Bijina, Padinjare V.; Gokulnath, Sabapathi. The article conveys some information:

Acid catalyzed condensation of newly prepared di-m-benzipentapyrrane with appropriate mono- and diheterocyclic dialcs. selectively produced stable di-m-benzihexaphyrins and di-m-benziheptaphyrins with only two meso-carbon bridges. Single-crystal X-ray diffraction analyses reveal planar conformation with slight distortion of bridged phenylene rings. Despite the presence of m-phenylene units interrupting the global delocalization, the presence of bithiophene unit in di-m-benziheptaphyrins 3a-b exhibit altered optical features covering the entire visible region (∼250-720 nm) exhibiting black dye property as a “”metal-free”” porphyrinoid. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Formula: C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Formula: C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 619-58-9In 2021 ,《A Strategy for Site- and Chemoselective C-H Alkenylation through Osmaelectrooxidative Catalysis》 appeared in Angewandte Chemie, International Edition. The author of the article were Choi, Isaac; Messinis, Antonis M.; Hou, Xiaoyan; Ackermann, Lutz. The article conveys some information:

Osmaelectrocatalyzed C-H activations that set the stage for electrooxidative alkynes e.g., 1-methoxy-4-[2-(4-methoxyphenyl)ethynyl]benzene annulations by benzoic acids e.g., 2-methylbenzoic acid were described. The osmium electrocatalysis enables site- and chemoselective electrooxidative C-H activations with unique levels of selectivity. The isolation of unprecedented osmium(0) I and osmium(II) intermediates [OsCl2(p-cymene)]2, along with crystallog. characterization and analyses by spectrometric and spectroscopic in operando techniques delineate a synergistic osmium redox catalyst regime. Detailed mechanistic studies revealed a facile C-H cleavage, which allows for an ample substrate scope, providing provide robust and user-friendly access to annulated heterocycles II. In the experiment, the researchers used 4-Iodobenzoic acid(cas: 619-58-9SDS of cas: 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. SDS of cas: 619-58-9 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 301673-14-3In 2022 ,《A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor》 was published in Journal of Medicinal Chemistry. The article was written by Griffith, David A.; Edmonds, David J.; Fortin, Jean-Philippe; Kalgutkar, Amit S.; Kuzmiski, J. Brent; Loria, Paula M.; Saxena, Aditi R.; Bagley, Scott W.; Buckeridge, Clare; Curto, John M.; Derksen, David R.; Dias, Joao M.; Griffor, Matthew C.; Han, Seungil; Jackson, V. Margaret; Landis, Margaret S.; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M.; Patel, Jayesh C.; Piotrowski, David W.; Price, David A.; Ruggeri, Roger B.; Tess, David A.. The article contains the following contents:

Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection. Herein, we describe the discovery of the orally bioavailable, small-mol., GLP-1R agonist PF-06882961 (danuglipron). A sensitized high-throughput screen was used to identify 5-fluoropyrimidine-based GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nanomolar potency. Incorporation of a carboxylic acid moiety provided considerable GLP-1R potency gains with improved off-target pharmacol. and reduced metabolic clearance, ultimately resulting in the identification of danuglipron. Danuglipron increased insulin levels in primates but not rodents, which was explained by receptor mutagenesis studies and a cryogenic electron microscope structure that revealed a binding pocket requiring a primate-specific tryptophan 33 residue. Oral administration of danuglipron to healthy humans produced dose-proportional increases in systemic exposure (NCT03309241). This opens an opportunity for oral small-mol. therapies that target the well-validated GLP-1R for metabolic health. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Computed Properties of C6H3ClINO2On September 30, 2019 ,《Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd-Cu》 was published in Journal of Chemical Research. The article was written by Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein. The article contains the following contents:

An efficient method was developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature Excellent yields of the products were obtained in reaction times of 9-11 h. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Computed Properties of C6H3ClINO2)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C6H3ClINO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 83410-16-6On October 25, 1982 ,《Studies on pyrimidine derivatives. XXX. The palladium-catalyzed cross-coupling reactions of iodopyrimidines with terminal olefinic compounds》 was published in Chemical & Pharmaceutical Bulletin. The article was written by Sakamoto, Takao; Arakida, Hiroko; Edo, Kiyoto; Yamanaka, Hiroshi. The article contains the following contents:

The influence of Ph3P, used as a ligand, on the palladium-catalyzed cross-coupling reactions of iodopyrimidines with olefins such as H2C:CHCO2Et, H2C:CHCN, H2C:CHPh was investigated. The effect of Ph3P in the monoazine series is also discussed. Thus, coupling of 2-iodo-4,6-dimethylpyrimidine with N2C:CHCO2Et in presence of Pd(OAc)2 gave 57% pyrimidine I. Using Pd(OAc)2-2Ph3P as a catalyst gave no I.4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6Recommanded Product: 83410-16-6) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 83410-16-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Organic & Biomolecular Chemistry included an article by Camacho-Garcia, J.; Montoro-Garcia, C.; Lopez-Perez, A. M.; Bilbao, N.; Romero-Perez, S.; Gonzalez-Rodriguez, D.. Synthetic Route of C4H4IN3O. The article was titled 《Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers》. The information in the text is summarized as follows:

A series of lipophilic nucleosides comprising natural and non-natural bases that are π-conjugated to a short oligo-phenylene-ethynylene fragment has been synthesized. These bases comprise guanosine, isoguanosine, and 2-amino-adenosine as purine heterocycles, and cytidine, iso-cytosine and uridine as complementary pyrimidine bases. The hydrogen-bonding dimerization and association processes between complementary bases were also studied by 1H NMR and absorption spectroscopy in order to obtain the relevant association constants2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Synthetic Route of C4H4IN3O) was used in this study.

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Synthetic Route of C4H4IN3O

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Condensed heteroaromatic ring systems. VII. Synthesis of thienopyridines, thienopyrimidines, and furopyridines from o-substituted N-heteroarylacetylenes》.COA of Formula: C6H6ClIN2 The author mentioned the following in the article:

Alkynylation of iodopyrimidines I (R = H, Me, Me2CH, MeS; R1 = H, Me, OMe; R2 = H) with Me3SiCCH gave 70-83% I (R2 = CCSiMe3), which were cyclized with NaSH to give 53-95% 8 thienopyrimidines II. In addition to this study using 4-Chloro-5-iodo-2,6-dimethylpyrimidine, there are many other studies that have used 4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6COA of Formula: C6H6ClIN2) was used in this study.

4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C6H6ClIN2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simonsen, Klaus B.; Svenstrup, Niels; Roberson, Mark; Jorgensen, Karl Anker published an article on January 31 ,2000. The article was titled 《Development of an unusually highly enantioselective hetero-Diels-Alder reaction of benzaldehyde with activated dienes catalyzed by hyper-coordinating chiral aluminum complexes》, and you may find the article in Chemistry – A European Journal.Reference of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene The information in the text is summarized as follows:

Benzaldehyde and Danishefsky’s diene [(E)-MeOCH:CHC(Me3SiO):CH2] underwent a stereoselective Diels-Alder cycloaddition in Me3COMe in the presence of >2 mol% (R)-binaphthol derivs I [R = H, MeO, Me(CH2)5O, Me(CH2)6] and trimethylaluminum to give the dihydropyran I (R1 = H) in up to 97% yield and 99.4% ee. I [R = Me(CH2)5O] was the most effective catalyst, giving product in high yields and up to 99.4% ee; I [R = MeO, Me(CH2)6] with either similar steric bulk and no oxygens or a methoxy group with coordination capacity but no steric bulk gave II (R1 = R2 = H) in slightly lower yields and enantiomeric excesses (50-95% yields and 82-96% ee), while the unsubstituted I (R = H) gave product in both diminished yield and ee (29% yield, 65% ee). Changes in the aluminum source from trimethylaluminum to either triethylaluminum or to dimethylaluminum chloride significantly decreased the yield and stereoselectivity of the Diels-Alder cycloaddition reactions. Reaction of dimethyl-Danishefsky’s diene [(1E,3Z)-MeOCH:C(Me)C(OSiMe3):CHMe] with benzaldehyde gave the (R,R)-enantiomer of II (R1 = R2 = Me), indicating that the stereoselectivity of the Diels-Alder cycloaddition is based on an endo-transition state. Based on the exptl. results the mechanism for the hetero-Diels-Alder reaction is discussed and it is postulated that hypercoordination to the chiral aluminum Lewis acid center is of importance for the reaction. In the part of experimental materials, we found many familiar compounds, such as (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3Reference of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthaleneIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of 5-/8-Halogenated or Ethynylated Lipophilic Nucleobases as Potential Synthetic Intermediates for Supramolecular Chemistry》 were Bilbao, Nerea; Vazquez-Gonzalez, Violeta; Aranda, M. Teresa; Gonzalez-Rodriguez, David. And the article was published in European Journal of Organic Chemistry in 2015. Product Details of 3993-79-1 The author mentioned the following in the article:

A series of lipophilic nucleobases that are substituted at the 5- (pyrimidines) or 8- (purines) position with either a halogen atom or a terminal triple bond have been synthesized. The sequences and reactions studied in this work, which mainly comprise halogenation, alkylation, Sonogashira coupling, and trimethylsilylacetylene deprotection, have been carefully optimized, to reach the final compounds in the most straightforward and convenient way, with the highest possible purity and yield. These compounds include cytosine, isocytosine, and uracil derivatives as pyrimidine heterocycles, and guanine, isoguanine, and 2-aminoadenine derivatives as complementary purine bases. Variability was introduced at the N-1/N-9 positions of these pyrimidine/purine nucleobases, which were functionalized with alkyl or benzyl groups, as well as with protected amine or carboxylic acid substituents. The mols. prepared constitute a useful collection of synthetic intermediates for the field of chem. self-assembly. In the experimental materials used by the author, we found 2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1Product Details of 3993-79-1)

2-Amino-5-iodopyrimidin-4(1H)-one(cas: 3993-79-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 3993-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com