Month: October 2022

Li, Haoyu; Tang, Xinxin; Pang, Jia Hao; Wu, Xiangyang; Yeow, Edwin K. L.; Wu, Jie; Chiba, Shunsuke published their research in Journal of the American Chemical Society in 2021. The article was titled 《Polysulfide anions as visible light photoredox catalysts for aryl cross-couplings》.Electric Literature of C10H18INO2 The article contains the following contents:

Polysulfide anions are endowed with unique redox properties, attracting considerable attentions for their applications in alkali metals-sulfur batteries. However, the employment of these anionic species in redox catalysis for small mol. synthesis remains underdeveloped due to their moderate-poor electrochem. potential in the ground state, whereas some of them are characterized by photoabsorptions in visible spectral regions. Herein, we disclose the use of polysulfide anions as visible light photoredox catalysts for aryl cross-coupling reactions. The reaction design enables single-electron reduction of aryl halides upon the photoexcitation of tetrasulfide dianions (S42-). The resulting aryl radicals are engaged in (hetero)biaryl cross-coupling, borylation, and hydrogenation in a redox catalytic regime involving S4• -/S42- and S3• -/S32- redox couples. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Electric Literature of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Electric Literature of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saha, Debarshi; Maajid Taily, Irshad; Banerjee, Prabal published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones》.Reference of Trimethylsulfoxonium iodide The article contains the following contents:

An unprecedented external oxidant-free electrochem. protocol for 1, 3-oxohydroxylation of donor-acceptor cyclopropanes is disclosed. The strategy encompasses the activation of the labile π-electron cloud of the aryl ring to cleave the strained Csp3-Csp3 bond of cyclopropane to afford the β-hydroxy ketones via insertion of mol. oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed. The experimental part of the paper was very detailed, including the reaction process of Trimethylsulfoxonium iodide(cas: 1774-47-6Reference of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Reference of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Nemr, Ahmed; Eleryan, Ahmed; Mashaly, Mohammad; Khaled, Azza published their research in Polymer Bulletin (Heidelberg, Germany) in 2021. The article was titled 《Comparative study of synthesis of cellulose propionate from different sources using NIS as a new catalyst》.Name: 1-Iodopyrrolidine-2,5-dione The article contains the following contents:

Propylation of cellulose from different sources with propionic anhydride using N-iodosuccinimide (NIS) under solvent-free condition was tested. It was done in the presence of NIS as a new catalyst for propylation using three different amounts of catalyst under mild reaction conditions. The degree of substitution by propionate was exptl. calculated and confirmed by FTIR and 1H NMR analyses. The propylation yields varied from 71.54 to 88.37% with the degree of substitution (DS) ranged from 1.32 to 2.80 for com. cotton cellulose, 1.76-3.00 for rice husk cellulose, and 1.60-3.0 for wheat straw cellulose. The DS were easily controlled by changing the reaction duration (2-6 h) and the amount of the NIS catalyst (50, 75, and 100 mg for each 1.0 g of cellulose) in 25 mL of propionic anhydride. Prolonging the reaction’s duration has no favorable effect on the propylation process and led to decrease in the cellulose propionate (CP). Also, increasing the amount of NIS catalyst results in decrease the DS and CP yield. NIS was recognized as a novel and more successful catalyst for propylation of the hydroxyl groups of cellulose from different sources in high degree of substitution. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Name: 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Name: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ayer, Maxime; Bolli, Rico S.; Chesman, Anthony S. R.; Forsyth, Craig M.; Jeffery, Justine L.; Liepa, Andris J.; Morawska, Karolina M.; Ozga, Theo; Francis, Craig L. published their research in ARKIVOC (Gainesville, FL, United States) in 2021. The article was titled 《Some new 2,8-disubstituted-1,7-dicyano-3,9-diazaperylenes》.Reference of 3-Iodophenol The article contains the following contents:

Concise synthetic protocols for a range of new 2,8-disubstituted-1,7-dicyano-3,9-diazaperylenes, starting from com. available 1,5-diaminoanthraquinone, have been developed, which enable the introduction of various tertiary-amino, substituted-ethynyl, and aryl groups at the C2 and C8 positions, as well as incorporation of aryl-amino groups at the C4 and C10 positions, of the rare 3,9-diazaperylene system. This methodol. should enable tuning of phys. and optoelectronic properties and may find use in the discovery of new materials for organic photovoltaic devices or other organic electronic applications. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Reference of 3-Iodophenol)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Reference of 3-IodophenolIodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ni, Shengjun; Hribersek, Matic; Baddigam, Swarna K.; Ingner, Fredric J. L.; Orthaber, Andreas; Gates, Paul J.; Pilarski, Lukasz T. published an article in 2021. The article was titled 《Mechanochemical Solvent-Free Catalytic C-H Methylation》, and you may find the article in Angewandte Chemie, International Edition.Application of 626-02-8 The information in the text is summarized as follows:

The mechanochem., solvent-free, highly regioselective, rhodium-catalyzed C-H methylation of (hetero)arenes is reported. The reaction shows excellent functional-group compatibility and is demonstrated to work for the late-stage C-H methylation of biol. active compounds The method requires no external heating and benefits from considerably shorter reaction times than previous solution-based C-H methylation protocols. Addnl., the mechanochem. approach is shown to enable the efficient synthesis of organometallic complexes that are difficult to generate conventionally. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Application of 626-02-8Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huang, Weibo; Tong, Zhouyu; Bi, Yuxin; Ma, Mingliang; Liao, Zijian; Wu, Guanglei; Ma, Yong; Guo, Siyu; Jiang, Xiaoyu; Liu, Xueping published an article in 2021. The article was titled 《Synthesis and microwave absorption properties of coralloid core-shell structure NiS/Ni3S4@PPy@MoS2 nanowires》, and you may find the article in Journal of Colloid and Interface Science.Quality Control of 1-Iodopyrrolidine-2,5-dione The information in the text is summarized as follows:

Herein, coralloid core-shell structure NiS/Ni3S4@PPy@MoS2 nanowires were elaborately designed and successfully synthesized through a three-step route to obtain exceptional microwave absorption (MA) properties. Ni nanowires were first fabricated, and then used as the substrate to be coated with a layer of PPy. Ni chalcogenides were obtained by using Ni nanowire as sacrificial templates while growing MoS2 nanorods by hydrothermal method. Both the one-dimensional (1D) core-shell structure and the coralloid surface generated by MoS2 nanorods were beneficial for the attenuation of microwaves. After investigating the electromagnetic properties of different loading content absorbers (30 weight%, 40 weight% and 50 weight%), it is found that the 50 weight% loading absorber has the optimal MA performance. The min. reflection loss (RLmin) value can reach -51.29 dB at 10.1 GHz with a thickness of 2.29 mm, and the corresponding effective absorption bandwidth (EAB, RL < -10 dB) can be up to 3.24 GHz. This research provides a reference for exploiting novel high-efficient 1D absorbers in the field of MA. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Quality Control of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Quality Control of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shukla, Satyendra Nath; Gaur, Pratiksha; Bagri, Sanjay Singh; Mehrotra, Ripul; Chaurasia, Bhaskar; Raidas, Mohan Lal published an article in 2021. The article was titled 《Pd(II) complexes with ONN pincer ligand: Tailored synthesis, characterization, DFT, and catalytic activity toward the Suzuki-Miyaura reaction》, and you may find the article in Journal of Molecular Structure.Recommanded Product: 3-Iodophenol The information in the text is summarized as follows:

A pincer type ONN tridentate Schiff base ligand, 2-(((pyridin-2-yl)methylimino)methyl)-6-methoxyphenol (L1) synthesized by the condensation of 4-hydroxy-3-methoxy-benzaldehyde and (pyridin-2-yl)methanamine. The ligand L1 and the new Pd(II) heteroleptic complexes of the composition [Pd(L1)(L2)]Cl, where L2 = benzimidazole, imidazole, benzooxazol or pyridine were synthesized and characterized by a set of chem., spectrometric and spectroscopic analyses. These complexes were named 1 to 4, resp. The FT-IR and DFT have suggested that ligand is coordinated with metal through azomethine-N and phenolic-O and arranged in square planar fashion around the metal. Correlation coefficients value between 0.995 – 0.993 shows satisfactory agreement in theor. and exptl. 1H-NMR and 13C-NMR. Benzimidazole anchored complex 1 exhibits an excellent catalytic activity. DFT calculated the energy profile diagram of the Suzuki-Miyaura reaction. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Recommanded Product: 3-Iodophenol) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Recommanded Product: 3-Iodophenol In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huber-Gedert, Marina; Nowakowski, Michal; Kertmen, Ahmet; Burkhardt, Lukas; Lindner, Natalia; Schoch, Roland; Herbst-Irmer, Regine; Neuba, Adam; Schmitz, Lennart; Choi, Tae-Kyu; Kubicki, Jacek; Gawelda, Wojciech; Bauer, Matthias published an article in 2021. The article was titled 《Fundamental Characterization, Photophysics and Photocatalysis of a Base Metal Iron(II)-Cobalt(III) Dyad》, and you may find the article in Chemistry – A European Journal.Name: 4-Iodopyridine The information in the text is summarized as follows:

A new base metal iron-cobalt dyad has been obtained by connection between a heteroleptic tetra-NHC iron(II) photosensitizer combining a 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine with 2,6-bis(3-methyl-imidazol-2-ylidene)-4,4′-bipyridine ligand, and a cobaloxime catalyst. This novel iron(II)-cobalt(III) assembly has been extensively characterized by ground- and excited-state methods like X-ray crystallog., X-ray absorption spectroscopy, (spectro-)electrochem., and steady-state and time-resolved optical absorption spectroscopy, with a particular focus on the stability of the mol. assembly in solution and determination of the excited-state landscape. NMR and UV/Vis spectroscopy reveal dissociation of the dyad in acetonitrile at concentrations below 1 mM and high photostability. Transient absorption spectroscopy after excitation into the metal-to-ligand charge transfer absorption band suggests a relaxation cascade originating from hot singlet and triplet MLCT states, leading to the population of the 3MLCT state that exhibits the longest lifetime. Finally, decay into the ground state involves a 3MC state. Attachment of cobaloxime to the iron photosensitizer increases the 3MLCT lifetime at the iron center. Together with the directing effect of the linker, this potentially makes the dyad more active in photocatalytic proton reduction experiments than the analogous two-component system, consisting of the iron photosensitizer and Co(dmgH)2(py)Cl. This work thus sheds new light on the functionality of base metal dyads, which are important for more efficient and sustainable future proton reduction systems. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Name: 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Name: 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koothradan, Fathima Febin; Suresh Babu, Anusree; Pushpakaran, Krishnendu P.; Jayarani, Arumugam; Sivasankar, Chinnappan published an article in 2022. The article was titled 《Carboxylic Acid Functionalization Using Sulfoxonium Ylides as a Carbene Source》, and you may find the article in Journal of Organic Chemistry.Reference of 2-Iodobenzoic acid The information in the text is summarized as follows:

Functionalization of carboxylic acids using sulfoxonium ylides in the presence of [VO(acac)2] as a catalyst was reported. The usual carbene source, diazo compounds, failed to produce α-carbonyloxy esters I [R1 = Ph, 4-ClC6H4, 2-furyl, etc.; R2 = Me, Et, i-Pr, Bn; R3 = H, 2-Cl, 3-Cl, 4-Cl, 2-Br, 2-I] in good yield when compared to sulfoxonium ylides. Various standard spectroscopic and anal. techniques were used to characterize the products formed. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Reference of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Reference of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Keylor, Mitchell H.; Gulati, Anmol; Kattar, Solomon D.; Johnson, Rebecca E.; Chau, Ryan W.; Margrey, Kaila A.; Ardolino, Michael J.; Zarate, Cayetana; Poremba, Kelsey E.; Simov, Vladimir; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Yan, Xin; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa; Lesburg, Charles A.; Adpressa, Donovon; Lin, Shishi; Neelamkavil, Santhosh; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Faltus, Robert; Xiong, Tina; Ciaccio, Paul J.; Piesvaux, Jennifer; Otte, Karin M.; Wood, Harold B.; Kennedy, Matthew E.; Bennett, David Jonathan; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H. published an article in 2022. The article was titled 《Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors》, and you may find the article in Journal of Medicinal Chemistry.Formula: C10H18INO2 The information in the text is summarized as follows:

The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson′s disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. In this report, we describe a rigorous hit-to-lead optimization campaign supported by structural enablement, which culminated in the discovery of brain-penetrant, candidate-quality mols. as represented by compounds 22 and 24. These compounds exhibit remarkable selectivity against the kinome and offer good oral bioavailability and low projected human doses. Furthermore, they showcase the implementation of stereochem. design elements that serve to enable a potency- and selectivity-enhancing increase in polarity and hydrogen bond donor (HBD) count while maintaining a central nervous system-friendly profile typified by low levels of transporter-mediated efflux and encouraging brain penetration in preclin. models. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com