Month: October 2022

Xiang, Cen; Kong, Xiangshun; Gao, Feng; Zhao, Yufan; Liu, Jiang; Yuan, Yuan; Teng, Yuou published an article in 2021. The article was titled 《Design, synthesis and antioxidant activity of chalcone derivative CMZ-3-5》, and you may find the article in Journal of the Chemical Society of Pakistan.Name: 1-Iodopyrrolidine-2,5-dione The information in the text is summarized as follows:

Excessive accumulation of free radicals can cause a variety of diseases. According to reports, chalcone has the activity of scavenging free radicals. In this study, we synthesized a chalcone derivative CZM-3-5 and evaluated its antioxidant activity using a chem. assessment method (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS.+) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH.) assay and total reducing antioxidant power (FRAP) assay) and a cell model of oxidative damage induced by hydrogen peroxide (H2O2). The chem. evaluation results show that the compound CZM-3-5 has good antioxidant capacity and free radical scavenging ability. MTT anal. showed that the compound has cytoprotective activity in H2O2-induced PC12 cells, and the mechanism may be related to the cytoprotective substance superoxide dismutase (SOD) is related to the level of glutathione (GSH). Overall, our findings indicate that compound CZM-3-5 has potential antioxidant activity in vitro. In addition to this study using 1-Iodopyrrolidine-2,5-dione, there are many other studies that have used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Name: 1-Iodopyrrolidine-2,5-dione) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Name: 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Carrillo, Michael J.; Lin, Wei; Endo, Yasuki published an article in 2021. The article was titled 《Microwave spectrum and iodine nuclear quadrupole coupling constants of 1,1-diiodoethane》, and you may find the article in Journal of Molecular Spectroscopy.Computed Properties of C2H4I2 The information in the text is summarized as follows:

The high resolution rotational spectroscopic observation of 1,1-diiodoethane is investigated using a pulsed jet, cavity Fourier transform microwave (FTMW) spectrometer over the frequency range 11.5-18 GHz for the first time. The rotational constants, the centrifugal distortion constants, the nuclear spin-rotation coupling constants, and the complete tensor components of the nuclear quadrupole coupling for both iodine nuclei have been determined and reported. The fitted rotational constants are A = 4548.320446(47), B = 625.629141(55), C = 558.798939(43) MHz and the nuclear quadrupole coupling constants are χaa = -1089.8125(7), χbb – χcc = -542.3162(13), |χab| = 1215.7505(10), χbc = 340.8983(14), and |χac| = 562.4206(19) MHz. No A-E splittings due to the Me group internal rotation were observed Many dipole-forbidden/elec. quadrupole coupling allowed transitions were observed in the spectrum due to the large iodine quadrupole coupling effect. Quantum chem. calculations were performed at the CCSD(T)/aug-cc-pVTZ-pp level of theory. The calculated rotational constants, centrifugal distortion constants, and hyperfine constants were used to guide the data anal. In the experiment, the researchers used 1,2-Diiodoethane(cas: 624-73-7Computed Properties of C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zurakowski, Joseph A.; Austen, Brady J. H.; Dufour, Maeve C.; Spasyuk, Denis M.; Nelson, David J.; Drover, Marcus W. published an article in 2021. The article was titled 《Lewis Acid-Promoted Oxidative Addition at a [Ni0(diphosphine)2] Complex: The Critical Role of a Secondary Coordination Sphere》, and you may find the article in Chemistry – A European Journal.Electric Literature of C5H4IN The information in the text is summarized as follows:

Oxidative addition represents a critical elementary step in myriad catalytic transformations. Here, the importance of thoughtful ligand design cannot be overstated. In this work, we report the intermol. activation of iodobenzene (PhI) at a coordinatively saturated 18-electron [Ni0(diphosphine)2] complex bearing a Lewis acidic secondary coordination sphere. Whereas alkyl-substituted diphosphine complexes of Group 10 are known to be unreactive in such reactions, we show that [Ni0(P2BCy4)2] (P2BCy4=1,2-bis(di(3-dicyclohexylboraneyl)-propylphosphino)ethane) is competent for room-temperature PhI cleavage to give [NiII(P2BCy4)(Ph)(I)]. This difference in oxidative addition reactivity has been scrutinized computationally – an outcome that is borne out in ring-opening to provide the reactive precursor – for [Ni0(P2BCy4)2], a “”boron-trapped”” 16-electron κ1-diphosphine Ni(0) complex. Moreover, formation of [NiII(P2BCy4)(Ph)(I)] is inherent to the P2BCy4 secondary coordination sphere: treatment of the Lewis adduct, [Ni0(P2BCy4)2(DMAP)8] with PhI provides [NiII(P2BCy4)2(DMAP)8(I)]I via iodine-atom abstraction and not a [NiII(Ph)(I)(diphosphine)] compound – an unusual secondary sphere effect. Finally, the reactivity of [Ni0(P2BCy4)2] with 4-iodopyridine was surveyed, which resulted in a pyridyl-borane linked oligomer. The implications of these outcomes are discussed in the context of designing strongly donating, and yet labile diphosphine ligands for use in a critical bond activation step relevant to catalysis. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2Electric Literature of C5H4IN) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Electric Literature of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Murashkina, A. V.; Averin, A. D.; Panchenko, S. P.; Abel, A. S.; Maloshitskaya, O. A.; Savelyev, E. N.; Orlinson, B. S.; Novakov, I. A.; Correia, C. R. D.; Beletskaya, I. P. published an article in 2022. The article was titled 《Comparison of the Catalytic Activities of Copper(I) Iodide and Copper Nanoparticles in the N-Arylation of Adamantane-Containing Amines》, and you may find the article in Russian Journal of Organic Chemistry.COA of Formula: C6H4ClI The information in the text is summarized as follows:

N-Arylation of n-octylamine and adamantane-containing amines with iodobenzene and its derivatives was performed in DMSO using copper(I) iodide and copper nanoparticles in the presence of various ligands as catalysts. In all cases, 2-isobutyrylcyclohexanone turned out to be the most efficient ligand, and higher yields of the arylation products were obtained in the presence of copper nanoparticles. The nanocatalyst could be recycled 9 times without significant loss of yield. In the experimental materials used by the author, we found 1-Chloro-3-iodobenzene(cas: 625-99-0COA of Formula: C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.COA of Formula: C6H4ClIHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xiaoshuang; Sun, Lei; Wang, Miaomiao; Maestri, Giovanni; Malacria, Max; Liu, Xiang; Wang, Yanlan; Wu, Lingang published an article in 2022. The article was titled 《C-I Selective Sonogashira and Heck Coupling Reactions Catalyzed by Aromatic Triangular Tri-palladium》, and you may find the article in European Journal of Organic Chemistry.Computed Properties of C6H4BrI The information in the text is summarized as follows:

Aromatic triangular tri-palladium cations, abbreviated as [Pd3]+, have shown interesting photoelec. properties, Lewis basic character, and excellent activities in catalytic hydrogenation. Herein, authors report the highly efficient and C-I selective Sonogashira and Heck coupling reactions catalyzed by these tri-palladium complexes. Benefiting from the moderate C-I bond association energy, these tri-palladiums presented exclusive reactivities to aryl iodides over the brominated aromatics in coupling reactions. In the Sonogashira pathway, good to excellent isolated yields (71-95%) were achieved. Gram-scale reaction reached 93% of yield with palladium loading as few as 0.06 mol %. Authors also explored the electronic and steric effects for Ph alkynes and aryl iodides including heteroaromatics like thiophene, pyridine, pyrazole, and pyrazine. Similarly, yields of 71-96% were obtained for palladium loading of 1.5 mol% through catalyzed Heck coupling of aryl iodides and alkenes. The HRMS monitoring revealed that [Pd3]+ maintained as whole entity during the catalytic process due to its robusness. In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Gravatt, Christopher S.; Johannes, Jeffrey W.; King, Eric R.; Ghosh, Avipsa published an article in Journal of Organic Chemistry. The title of the article was 《Photoredox-Mediated, Nickel-Catalyzed Trifluoromethylthiolation of Aryl and Heteroaryl Iodides》.Reference of 4-Iodopyridine The author mentioned the following in the article:

Herein, a method employing a bench-stable Ni(II) salt and an iridium photocatalyst that was mediated the trifluoromethylthiolation of a wide range of electronically diverse aryl and heteroaryl iodides, likely via a Ni(I)/Ni(III) catalytic cycle was reported. The reaction was broad functional group tolerance and potential for application in medicinal chem., as demonstrated by a late-stage functionalization approach to access (racemic)-Monepantel. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Reference of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sabourin, Axel; Dufour, Jeremy; Vors, Jean-Pierre; Bernier, David; Montchamp, Jean-Luc published an article in European Journal of Organic Chemistry. The title of the article was 《Synthesis of Carbon- and Nitrogen-Substituted 5- and 6-Membered Benzophostams》.Quality Control of 4-Iodopyridine The author mentioned the following in the article:

Previously, the synthesis of the novel 6-membered and a series of P-substituted 5-membered benzophostams was accomplished. Here, the synthesis of N- and C-substituted benzophostams is presented. For N-substitution, alkylation was accomplished using the heterocycle, LiHMDS and an alkyl halide, or alternatively by copper-catalyzed cyclization of the N-alkyl phosphonamide. N-Arylation could similarly be accomplished on the preformed heterocycle or on the phosphonamide precursor via copper-catalyzed cross-coupling. Dimethylation at the benzylic position could be conducted with LiHMDS and Me iodide. However, due to the significant cost of LiHMDS, a much less expensive and more efficient alternative approach was developed relying on a palladium-catalyzed reductive Heck reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Quality Control of 4-Iodopyridine)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Roemer, Max; Gillespie, Angus; Jago, David; Costa-Milan, David; Alqahtani, Jehan; Hurtado-Gallego, Juan; Sadeghi, Hatef; Lambert, Colin J.; Spackman, Peter R.; Sobolev, Alexandre N.; Skelton, Brian W.; Grosjean, Arnaud; Walkey, Mark; Kampmann, Sven; Vezzoli, Andrea; Simpson, Peter V.; Massi, Massimiliano; Planje, Inco; Rubio-Bollinger, Gabino; Agrait, Nicolas; Higgins, Simon J.; Sangtarash, Sara; Piggott, Matthew J.; Nichols, Richard J.; Koutsantonis, George A. published an article in Journal of the American Chemical Society. The title of the article was 《2,7- and 4,9-Dialkynyldihydropyrene Molecular Switches: Syntheses, Properties, and Charge Transport in Single-Molecule Junctions》.SDS of cas: 15854-87-2 The author mentioned the following in the article:

This paper described the syntheses of several functionalized dihydropyrene (DHP) mol. switches with different substitution patterns. Regioselective nucleophilic alkylation of a 5-substituted di-Me isophthalate allowed the development of a workable synthetic protocol for the preparation of 2,7-alkyne-functionalized DHPs. Synthesis of DHPs with surface-anchoring groups in the 2,7- and 4,9-positions was described. The mol. structures of several intermediates and DHPs were elucidated by X-ray single-crystal diffraction. Mol. properties and switching capabilities of both types of DHPs were assessed by light irradiation experiments, spectroelectrochem., and cyclic voltammetry. Spectroelectrochem., in combination with d. functional theory (DFT) calculations, shows reversible electrochem. switching from the DHP forms to the cyclophanediene (CPD) forms. Charge-transport behavior was assessed in single-mol. scanning tunneling microscope (STM) break junctions, combined with d. functional theory-based quantum transport calculations All DHPs with surface-contacting groups form stable mol. junctions. Experiments showed that the mol. conductance depends on the substitution pattern of the DHP motif. The conductance was found to decrease with increasing applied bias. After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2SDS of cas: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Li, Jia; Li, Yu-An; Wu, Ge; Zhang, Xu published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Metal-free aminohalogenation of quinones with alkylamines and NXS at room temperature》.Recommanded Product: 516-12-1 The author mentioned the following in the article:

A simple and practical strategy for intermol. aminohalogenation of quinone with alkyl amines and NXS was developed for preparation of halo(amino)naphthalenediones I [X = H, Cl, Br, I; R1 = Me; R2 = 2-cyanoethyl, (4-bromophenyl)methyl, phenethyl, (3S)-3-(2-methylphenoxy)-3-phenyl-propyl; R1 = R2 = (CH2)2O(CH2)2, (CH2)2CH(OH)(CH2)2, (CH2)2CH(CO2Me)(CH2)2], in which haloamines generated in situ were employed as bifunctional reagents. The reaction system was reliable, efficient and wide in substrate range, which was suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals. The results came from multiple reactions, including the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Hepan; Zheng, Purui; Wu, Xiaoqiang; Li, Yuqiang; Xu, Tao published an article in Journal of the American Chemical Society. The title of the article was 《Modular and Facile Access to Chiral α-Aryl Phosphates via Dual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling》.Reference of 4-Iodobenzaldehyde The author mentioned the following in the article:

Chiral phosphine-containing skeletons are important motifs in bioactive natural products, pharmaceuticals, chiral catalysts, and ligands. Herein, the authors report a general and modular platform to access chiral α-aryl P compounds via a Ni/photoredox-catalyzed enantioconvergent reductive cross-coupling between α-bromophosphates and aryl iodides. This dual catalytic regime exhibited high efficiency and good functional group capacity. A wide variety of substrates bearing a diverse set of functional groups could be converted into chiral phosphates in good to excellent yields and enantioselectivities. The utility of the method was also demonstrated by the development of a new phosphine ligand and the synthesis of enzyme inhibitor derivatives The detailed mechanistic studies supported a radical chain process and revealed a unique distinction compared with traditional reductive cross-coupling. The experimental process involved the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com