Month: October 2022

HPLC of Formula: 189518-78-3On October 31, 2001 ,《Photoinduced pitch changes in chiral nematic liquid crystals formed by doping with chiral diarylethene》 appeared in Journal of Materials Chemistry. The author of the article were Yamaguchi, Tadatsugu; Inagawa, Takatoshi; Nakazumi, Hiroyuki; Irie, Setsuko; Irie, Masahiro. The article conveys some information:

Chiral binaphthyl derivatives having two photochromic diarylethene units were synthesized in an attempt to use them as dopants for photoresponsive liquid crystals. These compounds showed thermally irreversible photochromic reactions. The CD (CD) spectra and the optical rotation values of the derivatives reversibly changed in methanol upon alternate irradiation with UV and visible light. Large photostimulated pitch changes of chiral nematic K-15 liquid crystals were observed on addition of the derivatives as dopants. The relation between the optical rotation and the twisting power force was discussed. The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3HPLC of Formula: 189518-78-3)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.HPLC of Formula: 189518-78-3Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bakherad, Mohammad; Bahramian, Bahram; Nasr-Isfahani, Hossein; Keivanloo, Ali; Doostmohammadi, Nesa published an article on January 31 ,2009. The article was titled 《Polystyrene-supported palladium(II) ethylenediamine complex: a highly active and recyclable catalyst for the synthesis of 2-benzylimidazo[2,1-b]pyridines through heteroannulation of acetylenic compounds》, and you may find the article in Journal of Heterocyclic Chemistry.HPLC of Formula: 41252-95-3 The information in the text is summarized as follows:

The polymer-supported palladium(II) ethylenediamine [PS-en-Pd(II)] complex is a highly active catalyst for the heterocyclization that takes place during the Sonogashira reaction between an aryl iodide and 2-amino-1-(2-propynyl)pyridinium bromide. This heterogeneous palladium catalyst can readily be recovered from the reaction medium by simple filtration and reused without a significant loss in its activity. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3HPLC of Formula: 41252-95-3)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 41252-95-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Duan, Meng; Diaz-Oviedo, Christian David; Zhou, Yang; Chen, Xiangyang; Yu, Peiyuan; List, Benjamin; Houk, Kendall N.; Lan, Yu published an article on February 21 ,2022. The article was titled 《Chiral Phosphoric Acid Catalyzed Conversion of Epoxides into Thiiranes: Mechanism, Stereochemical Model, and New Catalyst Design》, and you may find the article in Angewandte Chemie, International Edition.SDS of cas: 189518-78-3 The information in the text is summarized as follows:

Computations and experiments leading to new chiral phosphoric acids (CPAs) for epoxide thionations are reported. D. functional theory calculations reveal the mechanism and origin of the enantioselectivity of such CPA-catalyzed epoxide thionations. The calculated mechanistic information was used to design new efficient CPAs that were tested exptl. and found to be highly effective. Bulky ortho-substituents on the 3,3′-aryl groups of the CPA are important to restrict the position of the epoxide in the key transition states for the enantioselectivity-determining step. Larger para-substituents significantly improve the enantioselectivity of the reaction. In the experimental materials used by the author, we found (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3SDS of cas: 189518-78-3)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.SDS of cas: 189518-78-3 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Fash, David M.; Peer, Cody J.; Li, Zhenwu; Talisman, Ian J.; Hayavi, Sima; Sulzmaier, Florian J.; Ramos, Joe W.; Sourbier, Carole; Neckers, Leonard; Figg, W. Douglas; Beutler, John A.; Chain, William J. published 《Synthesis of a stable and orally bioavailable englerin analogue》.Bioorganic & Medicinal Chemistry Letters published the findings.Quality Control of 1,2-Diiodoethane The information in the text is summarized as follows:

Synthesis of analogs of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound (I) which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Angewandte Chemie, International Edition included an article by Cheng, Ying; Mueck-Lichtenfeld, Christian; Studer, Armido. Computed Properties of C10H18INO2. The article was titled 《Metal-Free Radical Borylation of Alkyl and Aryl Iodides》. The information in the text is summarized as follows:

A metal-free radical borylation of alkyl and aryl iodides with bis(catecholato)diboron (B2cat2) as the B source under mild conditions is introduced. The borylation reaction is operationally easy to conduct and shows high functional group tolerance and broad substrate scope. Radical clock experiments and d. functional theory calculations provide insights into the mechanism and rate constants for C-radical borylation with B2cat2 are disclosed. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Computed Properties of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of the American Chemical Society included an article by Yang, Qi-Liang; Xing, Yi-Kang; Wang, Xiang-Yang; Ma, Hong-Xing; Weng, Xin-Jun; Yang, Xiang; Guo, Hai-Ming; Mei, Tian-Sheng. Application of 625-99-0. The article was titled 《Electrochemistry-Enabled Ir-Catalyzed Vinylic C-H Functionalization》. The information in the text is summarized as follows:

Herein, the development of electrochem. vinylic C-H functionalization of acrylic acids with alkynes is reported. In this reaction an iridium catalyst enables C-H/O-H functionalization for alkyne annulation, affording α-pyrones with good to excellent yields in an undivided cell. Preliminary mechanistic studies show that anodic oxidation is crucial for releasing the product and regeneration of a Ir(III) intermediate from a diene-Ir(I) complex, which is a coordinatively saturated, 18-electron complex. Importantly, common chem. oxidants such as Ag(I) or Cu(II) did not give significant amounts of the desired product in the absence of elec. current under other-wise identical conditions.1-Chloro-3-iodobenzene(cas: 625-99-0Application of 625-99-0) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Application of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Angewandte Chemie, International Edition included an article by Clare, Daniel; Dobson, Benjamin C.; Inglesby, Phillip A.; Aissa, Christophe. HPLC of Formula: 1774-47-6. The article was titled 《Chemospecific Cyclizations of α-Carbonyl Sulfoxonium Ylides on Aryls and Heteroaryls》. The information in the text is summarized as follows:

The functionalization of aryl and heteroaryls using α-carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides (safety: an α-diazo ketone was potentially explosive, whereas an α-carbonyl sulfoxonium ylide was not). Described herein are the cyclizations of α-carbonyl sulfoxonium ylides onto benzenes, benzofurans and N-p-toluenesulfonyl indoles in the presence of a base in HFIP [e.g., I → II (91%) in presence of K2CO3 in HFIP], whereas pyrroles and N-Me indoles undergo cyclization in the presence of an iridium catalyst. Significantly, these two sets of conditions are chemospecific for each groups of substrates. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6HPLC of Formula: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.HPLC of Formula: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Asymmetric Three-Component Heck Arylation/Amination of Nonconjugated Cyclodienes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zhu, Daoyong; Jiao, Zhiwei; Chi, Yonggui Robin; Goncalves, Theo P.; Huang, Kuo-Wei; Zhou, Jianrong Steve. Product Details of 15164-44-0 The article mentions the following:

Substituted cyclohexylamines are becoming increasingly important in drug discovery. Asym. Heck insertion/amination of nonconjugated cyclodienes proceeds to give 5-aryl cyclohexenylamines with good enantioselectivity and exclusive trans configurations. Primary and secondary anilines, indoline, and benzylamines are suitable amines. The weakly donating diphosphite Kelliphite forms a deep unsym. pocket, which is essential for stereoselective anti attack of amines. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Product Details of 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Product Details of 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Electrophilic Vinylation of Thiols under Mild and Transition Metal-Free Conditions》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Castoldi, Laura; Di Tommaso, Ester Maria; Reitti, Marcus; Graefen, Barbara; Olofsson, Berit. Name: 2-Iodobenzoic acid The article mentions the following:

The iodine(III) reagents vinylbenziodoxolones (VBX) were employed to vinylate a series of aliphatic and aromatic thiols, providing E-alkenyl sulfides with complete chemo- and regioselectivity, as well as excellent stereoselectivity [e.g., PhSH + VBX I → II (87%, >20:1 E/Z) + PhSSPh (7%) in THF solvent using tBuOK as base]. The methodol. displays high functional group tolerance and proceeds under mild and transition metal-free conditions without the need for excess substrate or reagents. Mercaptothiazoles could be vinylated under modified conditions, resulting in opposite stereoselectivity compared to previous reactions with vinyliodonium salts. Novel VBX reagents with substituted benziodoxolone cores were prepared, and improved reactivity was discovered with a dimethyl-substituted core. In the experimental materials used by the author, we found 2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Name: 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Enantioselective Carboetherification/Hydrogenation for the Synthesis of Amino Alcohols via a Catalytically Formed Chiral Auxiliary》 was published in Journal of the American Chemical Society in 2020. These research results belong to Buzzetti, Luca; Purins, Mikus; Greenwood, Phillip D. G.; Waser, Jerome. Product Details of 625-99-0 The article mentions the following:

Chiral auxiliaries and asym. catalysis are the workhorses of enantioselective transformations, but they still remain limited in terms of either efficiency or generality. Herein, we present an alternative strategy for controlling the stereoselectivity of chem. reactions. Asym. catalysis is used to install a transient chiral auxiliary starting from achiral precursors, which then directs diastereoselective reactions. We apply this strategy to a palladium-catalyzed carboetherification/hydrogenation sequence on propargylic amines, providing fast access to enantioenriched chiral amino alcs., important building blocks for medicinal chem. and drug discovery. All stereoisomers of the product could be accessed by the choice of ligand and substituent on the propargylic amine, leading to a stereodivergent process. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Product Details of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Product Details of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com