Month: October 2022

Xu, Kang; Yang, Ruiqi; Yang, Shuang; Jiang, Cheng; Ding, Zhenhua published the artcile< Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles>, Quality Control of 1391728-13-4, the main research area is vinyl acetamide preparation fluoro dimethylbenziodoxole boron trifluoride etherate heterocyclization; aryl methyloxazole preparation; acetamido phenylacrylate preparation nitrile fluoro dimethylbenziodoxole zinc fluoroborate cyclocondensation; phenyl imidazolyl carboxylate preparation.

A hypervalent iodane reagent used for the intramol. cyclization of N-acetyl enamines and intermol. cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles resp., in moderate to excellent yields. This transformation exhibited good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermol. reaction was depended on the structure of N-acetyl enamines.

Organic & Biomolecular Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Quality Control of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhao, Lulu; Dong, Yanan; Xia, Qiangqiang; Bai, Jianfei; Li, Yuehui published the artcile< Zn-Catalyzed Cyanation of Aryl Iodides>, Application In Synthesis of 2265-92-1, the main research area is aryl cyanide preparation; formamide aryl iodide cyanation zinc catalyst.

An efficient method for the synthesis of cyanides such as ArCN [Ar = 4-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.] via zinc-catalyzed cyanation of aryl iodides with formamide as cyanogen source was reported. The transformation was promoted by bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into the nitrile products ArCN in good to excellent yields. This approach was an exceedingly simple and benign method for the synthesis of aryl nitriles ArCN and was likely to proceed via a dinuclear-Zn concerted catalysis.

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Application In Synthesis of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lin, Wenwei; Chen, Ling; Knochel, Paul published the artcile< Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates>, Name: 4-Iodopyridin-3-ol, the main research area is pyridyne preparation Diels Alder cycloaddition furan nucleophilic addition; pyridine arylsulfonyloxy halo preparation magnesiation elimination; oxaazatricycloundecatetraene preparation.

The preparation of functionalized 3,4-pyridynes as highly reactive intermediates has been achieved by the controlled elimination of readily generated magnesiated diaryl sulfonates obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halopyridines I (Ar = 4-ClC6H4; X = Br, iodo; R1 = H, Br, Me; R2 = Cl, iodo, MeO, H2C:CHCH2, PhS, 4-ClC6H4S, 4-EtO2CC6H4). After trapping with furan, moderate to good yields of the desired functionalized cycloadducts II were obtained. The addition of an (arylthio)magnesium chloride or (arylselenyl)magnesium chloride to 3,4-pyridyne followed by quenching with an electrophile is also described.

Tetrahedron published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Name: 4-Iodopyridin-3-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Waldvogel, S. R.; Wehming, K. M. published the artcile< Product subclass 2: iodoarenes>, HPLC of Formula: 2265-92-1, the main research area is review iodoarene preparation iodination organic synthesis.

A review of methods to prepare iodoarenes.

Science of Synthesis published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation) (iodo). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Prakash, G. K. Surya; Mathew, Thomas; Hoole, Dushyanthi; Esteves, Pierre M.; Wang, Qi; Rasul, Golam; Olah, George A. published the artcile< N-Halosuccinimide/BF3-H2O, Efficient Electrophilic Halogenating Systems for Aromatics>, SDS of cas: 2265-92-1, the main research area is halosuccinimide trifluoroborane monohydrate electrophile halogenation aromatic.

N-Halosuccinimides (NXS, 1) are efficiently activated in trifluoromethanesulfonic acid and BF3-H2O, allowing the halogenations of deactivated aromatics Because BF3-H2O is more economic, easy to prepare, nonoxidizing, and offers sufficiently high acidity (-H0 ≈ 12, only slightly lower than that of trifluoromethanesulfonic acid), an efficient new electrophilic reagent combination of NXS/BF3-H2O has been developed. DFT calculations at the B3LYP/6-311++G**//B3LYP/6-31G* level suggest that protonated N-halosuccinimides undergo further protosolvation at higher acidities to reactive superelectrophilic species capable either in the transfer of X+ from the protonated forms of NXS to the aromatic substrate or in forming a highly reactive and solvated X+ which would readily react with the aromatic substrates. Structural aspects of the BF3-H2O complex have also been investigated.

Journal of the American Chemical Society published new progress about Acid catalysis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, SDS of cas: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

D’Auria, Maurizio; Piancatelli, Giovanni; Ferri, Tommaso published the artcile< Photochemical reactivity of halofuran and halothiophene derivatives in the presence of arylalkenes and arylalkynes>, Name: Methyl 5-iodothiophene-2-carboxylate, the main research area is photochem substitution iodothiophene vinylarene ethynylarene; halofuran photochem substitution vinylarene; ethylene furyl thienyl.

Photochem. reactions of 5-iodo-2-thiophenecarboxaldehyde, 2-acetyl-5-iodothiophene (I), and 5-bromo- and 5-iodo-2-furancarboxaldehyde with styrene, 2-vinylthiophene and -furan (II), 4-methyl-5-vinyl-1,3-thiazole, and benzofuran are described. All the reactions give the substitution products as cis-trans mixtures E.g., I and II give a 1:1 cis-trans mixture of furylthienylethylene III. Reactions of iodothiophenes with ethynylarenes are also described; products resulting from substitution on the CCH group or on the thiophene ring are both obtained. The mechanism of the reactions is discussed in terms of an electron-transfer process.

Journal of Organic Chemistry published new progress about Photosubstitution reaction. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Name: Methyl 5-iodothiophene-2-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Devine, Shane M.; Challis, Matthew P.; Kigotho, Jomo K.; Siddiqui, Ghizal; De Paoli, Amanda; MacRaild, Christopher A.; Avery, Vicky M.; Creek, Darren J.; Norton, Raymond S.; Scammells, Peter J. published the artcile< Discovery and development of 2-aminobenzimidazoles as potent antimalarials>, Synthetic Route of 188057-20-7, the main research area is aminobenzimidazole derivative chemoselective preparation SAR antimalarial; 2-Aminobenzimidazole; Malaria; Plasmodium falciparum; Structure-activity relationships.

The design, synthesis and antimalarial activity of a series of 2-aminobenzimidazoles I [R = H, NH2, NHEt, NHBn, etc.; Ar = 2-HOC6H4, 2-NH2C6H4, benzofuran-7-yl, etc.], featuring a phenol moiety that was crucial to the pharmacophore. Two potent mols. exhibited IC50 values against P. falciparum 3D7 strain of 42 ± 4 I [R = NH2; Ar = 5-Me-2-HOC6H3] and 43 ± 2 nM [R = NH2; Ar = 5-MeO-2-HOC6H3] and high potency against strains resistant to chloroquine (Dd2), artemisinin (Cam3.IIC580Y) and PfATP4 inhibitors (SJ557733), while demonstrating no cytotoxicity against human cells (HEK293, IC50 > 50μM). The most potent mol., possessing a 4,5-di-Me substituted phenol I [R = NH2; Ar = 4,5-(MeO)2-2-HOC6H2] displayed an IC50 value of 6.4 ± 0.5 nM against P. falciparum 3D7, representing a 12-fold increase in activity from the parent mol. The 2-aminobenzimidazoles containing a N1-substituted phenol represented a new class of mols. that had high potency in vitro against P. falciparum malaria and low cytotoxicity. They possessed attractive pharmaceutical properties, including low mol. weight, high ligand efficiency, high solubility, synthetic tractability and low in vitro clearance in human liver microsomes.

European Journal of Medicinal Chemistry published new progress about Antimalarials. 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Synthetic Route of 188057-20-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sviripa, Vitaliy M.; Zhang, Wen; Kril, Liliia M.; Liu, Alice X.; Yuan, Yaxia; Zhan, Chang-Guo; Liu, Chunming; Watt, David S. published the artcile< Halogenated diarylacetylenes repress c-myc expression in cancer cells>, Recommanded Product: 1,4-Difluoro-2-iodobenzene, the main research area is halogenated diarylacetylene preparation cmyc inhibitor cancer; Antineoplastic agents; Colon cancer; Diarylacetylenes; c-myc.

Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiproliferative agents. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Recommanded Product: 1,4-Difluoro-2-iodobenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cortes Gonzalez, Miguel A.; Jiang, Xingguo; Nordeman, Patrik; Antoni, Gunnar; Szabo, Kalman J. published the artcile< Rhodium-mediated 18F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent>, Electric Literature of 1391728-13-4, the main research area is alpha fluoro ether preparation; diazoketone trimethyl orthoformate oxyfluorination rhodium catalyst.

Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium catalyst and hypervalent iodine-based [18F]fluoro-benziodoxole reagent to get various α-[18F]fluoro ethers I [R = Ph, 2-furyl, 4-MeC6H4, etc.] in high radiochem. yield (up to 98%) and molar activity (216 GBq μmol-1).

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Benniston, Andrew C.; Harriman, Anthony; Li, Peiyi; Rostron, James P.; Harrington, Ross W.; Clegg, William published the artcile< A spectroscopic study of the reduction of geometrically restrained viologens>, COA of Formula: C5H4INO, the main research area is spectroscopy reduction geometry restrained viologen.

A small series of N,N’-dimethyl-4,4′-bipyridinium dication derivatives (commonly known as viologens) has been synthesized and fully characterized; a short dialkoxy tether attached at the 3,3′-positions is used to alter the central dihedral angle. These angles were determined by both single-crystal X-ray diffraction and by computational studies made for the dication, radical cation, and neutral species in a solvent reservoir. The dihedral angle derived for the dication controls the first reduction potential, whereas the geometry of the resultant π-radical cation determines the magnitude of the second reduction potential. The optical absorption spectra recorded for the various species, and especially those of the radical cations, and the EPR spectral parameters of the π-radical cations also depend on the mol. geometry. In particular, the central dihedral angle influences the spin d. distribution around the aromatic nucleus and, by way of comparison to the parent viologen, it has been possible to resolve the angle dependence from the inherent inductive effect of the strap. These results are considered in terms of the degree of electronic communication between the two aromatic rings, as controlled by the length of the tether.

Chemistry – A European Journal published new progress about Crystal structure. 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, COA of Formula: C5H4INO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com