Month: October 2022

In 2017,Lovinger, Gabriel J.; Morken, James P. published 《Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy》.Journal of the American Chemical Society published the findings.Computed Properties of C10H18INO2 The information in the text is summarized as follows:

The catalytic enantioselective conjunctive coupling of C(sp3) electrophiles can be accomplished with Ni catalysis. The enantioselectivity of the reaction is dependent on reaction mechanism with many substrates able to engage in an asym. process with Pybox-Ni complexes, whereas other substrates provide racemic product mixtures The link between substrate structure and selectivity is addressed. The results came from multiple reactions, including the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Computed Properties of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Computed Properties of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of indoles and quinazolines via additive-controlled selective C-H activation/annulation of N-arylamidines and sulfoxonium ylides》 were Lai, Ruizhi; Wu, Xiaohua; Lv, Songyang; Zhang, Chen; He, Maoyao; Chen, Yuncan; Wang, Qiantao; Hai, Li; Wu, Yong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: Trimethylsulfoxonium iodide The author mentioned the following in the article:

Selective synthesis of indole I (R1 = 5-OCH3, 6-F, 4,6-(CH3)2, etc.; R2 = CH3, (CH2)2CH3, CH2CH(CH3)2, (CH2)2OCH3, CH2C6H5; R3 = C6H5, 2-naphthyl, 2H-1,3-benzodioxol-5-yl, etc.) and quinazoline products II (R4 = 6-OCH3, 5-Cl, 6-C(O)CH3)was achieved through a precise control of the C-H activation/annulation by changing the additives from NaOAc to CuF2/CsOAc. This strategy constructs indoles I and quinazoline scaffolds II efficiently, and hence it is greatly used in pharmaceutical, agricultural and chem. industries.Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Computational-aided design of a library of lactams through a diversity-oriented synthesis strategy》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Saldivar-Gonzalez, Fernanda I.; Lenci, Elena; Calugi, Lorenzo; Medina-Franco, Jose L.; Trabocchi, Andrea. Recommanded Product: Trimethylsulfoxonium iodide The article mentions the following:

Small mol. libraries for virtual screening are becoming a well-established tool for the identification of new hit compounds As for exptl. assays, the library quality, defined in terms of structural complexity and diversity, is crucial to increase the chance of a successful outcome in the screening campaign. In this context, Diversity-Oriented Synthesis has proven to be very effective, as the compounds generated are structurally complex and differ not only for the appendages, but also for the mol. scaffold. In this work, we automated the design of a library of lactams by applying a Diversity-Oriented Synthesis strategy called Build/Couple/Pair. We evaluated the novelty and diversity of these compounds by comparing them with lactam moieties contained in approved drugs, natural products, and bioactive compounds from ChEMBL. Finally, depending on their scaffold we classified them into β-, γ-, δ-, ε-, and isolated, fused, bridged and spirolactam groups and we assessed their drug-like and lead-like properties, thus providing the value of this novel in silico designed library for medicinal chem. applications. In the experiment, the researchers used many compounds, for example, Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kakuchi, Ryohei; Fukasawa, Kota; Kikuchi, Moriya; Narumi, Atsushi; Kawaguchi, Seigou; Li, Yao; Kim, Hyung; Amii, Hideki published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Computer-aided design of postpolymerization modification reaction based on aminolysis of α,α-difluoroacetate esters》.Electric Literature of C7H5IO The article contains the following contents:

A new postpolymn. protocol based on the reactivity of α,α-difluoroacetate esters is proposed and rationalized via a combined effort of computational and exptl. methods. Reaction systems designed on the basis of computational results are characterized in detail. It is found that aminolysis of polymers featuring α,α-difluoroacetate esters results in a 100% conversion of ester units to α,α-difluoroacetamide derivatives This indicates that the new activated ester-amine chem. reported here offers a promising approach to postpolymn. modifications. After reading the article, we found that the author used 4-Iodobenzaldehyde(cas: 15164-44-0Electric Literature of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Electric Literature of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Luo, Run; Guo, Lina; Su, Meiyun; Liu, Wenjie; Wang, Shaohua published an article in 2021. The article was titled 《Copper-catalyzed three-component ortho-selective selenation of phenols》, and you may find the article in Phosphorus, Sulfur and Silicon and the Related Elements.Quality Control of 1-Bromo-3-iodobenzene The information in the text is summarized as follows:

An efficient and convenient copper-catalyzed three-component reaction has been developed for the arylselenation of phenols RC6H4OH (R = 3-t-Bu, 4-Ph, 2-OMe, etc.) with Se powder and aryl iodides R1I (R1 = Ph, 2,4-dimethylphenyl, 3-bromophenyl, etc.). This one-pot procedure provides a straightforward approach to the synthesis of ortho-arylselenylphenols 2-OHRC6H3SeR1 with high regioselectivity. This practical process shows good functional group tolerance, providing the corresponding products in moderate to good yields. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-iodobenzene(cas: 591-18-4Quality Control of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Quality Control of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 625-99-0In 2022 ,《Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Maji, Kakoli; Thorve, Pradip Ramdas; Rai, Pramod; Maji, Biplab. The article conveys some information:

An enantioselective ortho-C(sp2)-H functionalization of ketones/esters, e.g., I (R1 = Me, Et, Ph, OMe; R2 = H, 4-F, 3-MeO, 3,4-benzo, etc.) with 1,6-enynes II [Ar = Ph, X = NTs, O, C(COOMe)2; Ar = 3-ClC6H4, 4-MeOC6H4, 3,5-Me2C6H3, etc., X = NTs] is demonstrated via photoredox/cobalt dual catalysis. The method provides the corresponding arylmethylene-substituted carbo- and heterocycles III in high yields with functional group tolerance and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramol. cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0SDS of cas: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.SDS of cas: 625-99-0 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 625-99-0In 2022 ,《Diastereoselective palladium-catalyzed C(sp3)-H cyanomethylation of amino acid and carboxylic acid derivatives》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Garai, Sumit; Ghosh, Krishna Gopal; Biswas, Ashik; Chowdhury, Sushobhan; Sureshkumar, Devarajulu. The article conveys some information:

In this study, an efficient protocol for Pd-catalyzed methylene β-C(sp3)-H cyanomethylation of 8-aminoquinoline-directed α-amino acids using inexpensive chloroacetonitrile was reported. Iodoacetonitrile generated in situ from chloroacetonitrile reacts with methylene C(sp3)-H bonds of α-amino acids with excellent diastereoselectivity, enabling access to a wide range of important γ-cyano-α-amino acids. The protocol works well with different amino acid and carboxylic acid derivatives with good chem. yields and high functional group tolerance. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0HPLC of Formula: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com