Month: October 2022

Formula: C3H9IOSIn 2020 ,《Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes》 was published in Angewandte Chemie, International Edition. The article was written by Tobiesen, Henriette N.; Leth, Lars A.; Iversen, Marc V.; Naesborg, Line; Bertelsen, Soeren; Joergensen, Karl Anker. The article contains the following contents:

The first stereoselective, near-equimolar, and metal-free oxidative bioconjugation of amino acids and oligopeptides to aldehydes is presented. Based on a newly developed organocatalytic oxidative concept, the C-terminal and side-chain carboxylic acid functionalities of amino acids and oligopeptides are shown to couple in a stereoselective manner to α-branched aldehydes catalyzed by a chiral primary amine and a quinone as oxidizing agent. The oxidative coupling generally proceeds in high yield. For aspartic acid, selective coupling of the side-chain, or the C-terminal carboxylic acid, is demonstrated depending on the protection strategy. The stereoselective, oxidative bioconjugation concept is extended to a series of oligopeptides where coupling to carboxylic acid functionalities is presented. Bioorthogonal linker mols. for further functionalization are obtained by merging the oxidative coupling strategy with the click concept. It is demonstrated that the configuration of the new stereocenter is determined exclusively by the organocatalyst. The results came from multiple reactions, including the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Formula: C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Formula: C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 301673-14-3In 2021 ,《Site-Selective C-H alkylation of Complex Arenes by a Two-Step Aryl Thianthrenation-Reductive Alkylation Sequence》 was published in Journal of the American Chemical Society. The article was written by Lansbergen, Beatrice; Granatino, Paola; Ritter, Tobias. The article contains the following contents:

Herein, an undirected para-selective two-step C-H alkylation of complex arenes e.g., I useful for late-stage functionalization is presented. The combination of a site-selective C-H thianthrenation with palladium-catalyzed reductive electrophile cross-coupling grants access to a diverse range of synthetically useful alkylated arenes e.g., II which cannot be accessed otherwise with comparable selectivity, diversity, and practicality. The robustness of this transformation is further demonstrated by thianthrenium-based reductive coupling of two complex fragments. The results came from multiple reactions, including the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed Asymmetric Synthesis of α-Arylbenzamides》 was written by Cuesta-Galisteo, Sergio; Schoergenhumer, Johannes; Wei, Xiaofeng; Merino, Estibaliz; Nevado, Cristina. Computed Properties of C7H7IThis research focused onvinyl amide aryliodide nickel catalyst regioselective enantioselective reductive hydroarylation; chiral arylbenzamide preparation; asymmetric synthesis; hydroarylation; nickel; vinyl amides; α-aryl amides. The article conveys some information:

A nickel-catalyzed asym. reductive hydroarylation of vinyl amides to produce enantioenriched α-arylbenzamides is reported. The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables the regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center α to the N atom. The use of neutral reagents and mild reaction conditions provides simple access to pharmacol. relevant motifs present in anticancer, SARS-CoV PLpro inhibitors, and KCNQ channel openers. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Computed Properties of C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application》 were Nie, Ruifang; Lai, Ruizhi; Lv, Songyang; Xu, Yingying; Guo, Li; Wang, Qiantao; Wu, Yong. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application of 1774-47-6 The author mentioned the following in the article:

A water-mediated C-H activation using sulfoxonium ylides was reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Three series of aryl-alkylketones RCOCH2R1 [R = t-Bu, 1-adamantanyl, Ph; R1 = 2-(2-pyridyl)phenyl, 2-(2-pyridyl)-3-thienyl, 2-pyrazol-1-ylphenyl, etc.], benzothiazines I [R2 = Me, i-Pr, Ph, Bn; R3 = i-Pr, t-Bu, Ph; R4 = H, 6-Me, 6-OMe, 6-F, 8-OMe] and isoquinolines II [R5 = H, 8-F, 6-Br, etc.; R6 = H, Me; R7 = 2,6-di-MeOC6H3, 2-naphthyl, 2-thienyl, etc.] were synthesized via rhodium-catalyzed coupling of arenes/sulfoximines/benzylamines with sulfoxonium ylides. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Application of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Application of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach》 was published in Journal of Chemical Information and Modeling in 2020. These research results belong to de Souza, Mariana L.; de Oliveira Rezende, Celso Junior; Ferreira, Rafaela S.; Espinoza Chavez, Rocio Marisol; Ferreira, Leonardo L. G.; Slafer, Brian W.; Magalhaes, Luma G.; Krogh, Renata; Oliva, Glaucius; Cruz, Fabio Cardoso; Dias, Luiz Carlos; Andricopulo, Adriano D.. Related Products of 626-02-8 The article mentions the following:

A virtual screening conducted with nearly 4,000,000 compounds from lead-like and fragment-like subsets enabled the identification of a small-mol. inhibitor I of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. Subsequent comprehensive structure-based drug design and structure-activity relationship studies led to the discovery of carbamoyl imidazoles as potent, reversible, and competitive cruzain inhibitors. The most potent carbamoyl imidazole inhibitor II exhibited high affinity with a Ki value of 20 nM, presenting both in vitro and in vivo activity against T. cruzi. Furthermore, the most promising compounds reduced parasite burden in vivo and showed no toxicity at a dose of 100 mg/kg. These carbamoyl imidazoles are structurally attractive, nonpeptidic, and easy to prepare and synthetically modify. Finally, these results further advance our understanding of the noncovalent mode of inhibition of this pharmaceutically relevant enzyme, building strong foundations for drug discovery efforts. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Related Products of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Related Products of 626-02-8 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides》 was written by Yao, Tuanli; Wang, Bo; Ren, Beige; Qin, Xiangyang; Li, Tao. Recommanded Product: 4-Chloro-2-iodoaniline And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021. The article conveys some information:

The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides I (R = t-Bu, cyclohexyl, 2,6-dimethylphenyl, etc.; R1 = H, OMe, Cl, F, etc.; R2 = H, Cl, C(O)OMe; R3 = H, F, Cl; R4 = Me, Ph, thiophen-3-yl, etc.) from isocyanides RNC, 2-iodoanilines 2-I-4-R1-5-R2-6-R3C6HNH2 and carboxylic acids R4C(O)OH has been developed. This method provides expeditious and highly efficient access to structurally diverse N-acyl anthranilamides I from readily available starting materials with good functional group compatibility. The utility of this method has been demonstrated by the late stage functionalization of two com. drugs: Flurbiprofen and Loxoprofen. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Jun-An; Peng, Hai; Liang, Jin-Shao; Meng, Ru-Fang; Su, Wei; Xiao, Qi; Yang, Hua published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Gold/scandium bimetallic relay catalysis of formal [5+2]- and [4+2]-annulations: access to tetracyclic indole scaffolds》.Related Products of 1774-47-6 The article contains the following contents:

Regiodivergent formal [5+2]- and [4+2]-annulation reactions of indole derivatives with 2-(2-alkynyl)aryl cyclopropane-1,1-diesters (ACPs) was developed. A series of tetracyclic indole derivatives were delivered in a 77% average yield with excellent regioselectivities enabled by Au(I)/Sc(III) bimetallic relay catalysis. A gram-scale reaction and further transformation of the resulting tetracyclic indoles demonstrated the practical utility of this protocol. Moreover, the photophys. properties of the obtained multicyclic compounds were also investigated.Trimethylsulfoxonium iodide(cas: 1774-47-6Related Products of 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Related Products of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tanaka, Yuki; Bai, Shiqiang; Wang, Xizu; Tee, Si Yin; Lim, Siew Lay; Ke, Lin; Dolmanan, Surani B.; Lee, Coryl Jing Jun; Lim, Poh Chong; Yao, Xiang; Wu, Jishan; Han, Ming-Yong published an article in 2021. The article was titled 《Synthesis and optical and electronic properties of one-dimensional sulfoxonium-based hybrid metal halide (CH3)3SOPbI3》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Electric Literature of C3H9IOS The information in the text is summarized as follows:

The authors report the synthesis and optical and electronic properties of a one-dimensional sulfoxonium-based hybrid metal halide in an orthorhombic crystal system with a Pnma space group. To provide direct insights, a method is developed to calculate tolerance factors with the ionic radii of non-spherical cations from x-ray crystallog. data.Trimethylsulfoxonium iodide(cas: 1774-47-6Electric Literature of C3H9IOS) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Electric Literature of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xinchao; Wang, Hang; Zhou, Chunlin; Yang, Lei; Fu, Lei; Li, Gang published an article in 2022. The article was titled 《Native carboxyl group-assisted C-H acetoxylation of hydrocinnamic and phenylacetic acids》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Application In Synthesis of 1-Bromo-3-iodobenzene The information in the text is summarized as follows:

A method of native carboxyl-assisted, Pd(II)-catalyzed ortho-C-H acetoxylation of both hydrocinnamic and phenylacetic acids 2-R-3-R1-4-R2C6H2CH(R3)CH2C(O)OH (R = H, Me, Cl, OCF3, etc.; R1 = Me, Br, CF3, etc.; R2 = Me, F, COOMe, etc.; R3 = H, Me, Et)/2-R4-3-R5-4-R6-5-R7C6HC(R8)(R9)C(O)OH (R4 = H, Me, I, etc.; R5 = H, OMe, CF3, etc.; R6 = F, OMe, COOMe, etc.; R7 = R8 = R8 = H, Me) that can be found in many biol. active mols. as the key moieties was reported. Based on the broad scope and the application potential showcased with drug mols., such as (ibuprofen, ketoprofen, and flurbiprofen) it is anticipated that this C-H acetoxylation reaction will find attractive applicability in future synthetic endeavors. In the experiment, the researchers used 1-Bromo-3-iodobenzene(cas: 591-18-4Application In Synthesis of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Application In Synthesis of 1-Bromo-3-iodobenzene Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Safety of 1-Bromo-3-iodobenzeneIn 2019 ,《Rhodium catalyzed synthesis of seleno-ketals via carbene transfer reactions of diazoesters》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Jana, Sripati; Aseeva, Polina; Koenigs, Rene M.. The article contains the following contents:

Herein, rhodium catalyzed carbene transfer reactions of diazoesters with diselenides that result in the formal insertion reaction of the carbene fragment into the Se-Se bond to give seleno-ketals in up to 96% yield (35 examples) via an ionic mechanism is described. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Safety of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Safety of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com