Month: October 2022

On December 21, 2018, Liu, Can; Zhu, Xianjin; Zhang, Pengxiang; Yang, Haijun; Zhu, Changjin; Fu, Hua published an article.Electric Literature of 70931-59-8 The title of the article was Axially Chiral Cyclic Diphosphine Ligand-Enabled Palladium-Catalyzed Intramolecular Asymmetric Hydroarylation. And the article contained the following:

In transition metal-catalyzed asym. synthesis, enantioselectivity strongly depends on the structures of chiral ligands, so the development of new chiral ligands is crucial. Here, an efficient and highly enantioselective palladium-catalyzed intramol. hydroarylation has been developed, and a new kind of N-heterocycles, 1H-pyrazolo[5,1-a]isoindol-2(8H)-ones containing a quaternary stereocenter, was prepared in high yields and excellent enantiomeric excess values. The reaction was effectively catalyzed by palladium-diphosphine complexes with numerous functional group tolerance, in which the newly developed axially chiral cyclic diphosphine ligands played key roles in the reactivity and enantioselectivity of the substrates. These cyclic diphosphine ligands with adjustable dihedral angles have wide application in asym. synthesis. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Electric Literature of 70931-59-8

The Article related to pyrazoloisoindolone preparation enantioselective, iodobenzyl pyrazolone intramol hydroarylation palladium catalyst cyclic diphosphine ligand, axial chiral cyclic diphosphine ligand preparation, catalysis, chemistry, organic chemistry, stereochemistry and other aspects.Electric Literature of 70931-59-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On January 22, 2009, Wacker, Dean A.; Rossi, Karen A.; Wang, Ying published a patent.Formula: C7H3BrF3I The title of the patent was Preparation of pyridones as GPR119 G protein-coupled receptor agonists. And the patent contained the following:

The invention is related to pyridones I and II [G = CH, N; Q = C, N; X = CH, N, provided that Q and X are not both N; Y = CH2, NH and derivatives, CO, O, OCH2 and derivatives, S(O)0-2; U = (CH2)n; V = (CH2)m; n, m = independently 0-2; Z = (CH2)q; q = 1-2; R1 = (un)substituted 6-membered monocyclic (hetero)/aryl, 5-membered monocyclic heteroaryl; R2 = (un)substituted cycloalkyl, (hetero)/aryl, heterocyclyl, etc.; R20, R21 = independently H, halo, CN, CO2H, OCF3, haloalkyl, etc.] which are GPR119 G protein-coupled receptor modulators, especially GPR119 G agonists, and are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy. Thus, arylation of 4-benzyloxy-2(1H)-pyridone with 4-bromophenyl Me sulfone, debenzylation, alkylation of the hydroxypyridinone with tert-Bu 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (preparation given) gave III. The in vivo modulation of recombinant human GPR119 was determined in a HIT-T15 cAMP assay, human Tet-inducible CAMP assay and luciferase assay (some data given). I, alone, or in combination with another therapeutic agent, are useful for treating diabetes, hyperglycemia, impaired glucose tolerance, obesity, metabolic syndrome, etc. The experimental process involved the reaction of 5-Bromo-2-iodobenzotrifluoride(cas: 364-12-5).Formula: C7H3BrF3I

The Article related to pyridone preparation gpr119 g protein coupled receptor agonist diabetes, pyrimidinylpiperidinyloxy pyridone preparation g protein coupled receptor agonist hyperglycemia, oxadiazolylcyclohexyloxy pyridone preparation g protein coupled receptor agonist obesity and other aspects.Formula: C7H3BrF3I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On June 8, 2021, Gao, Ke; Zhang, Yidan; Liu, Yuanyang; Yang, Meigui; Zhu, Tong published an article.Category: iodides-buliding-blocks The title of the article was Screening of imidazoles in atmospheric aerosol particles using a hybrid targeted and untargeted method based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. And the article contained the following:

The method for identification and quantification of imidazoles in atm. aerosol particles with an aerodynamic diameter up to 2.5μm (PM2.5) is scarce, and the existing method focus on only a few imidazoles. With the goal of measuring more imidazoles, especially some previously unidentified ones, we developed a screening workflow based on data-dependent acquisition (DDA) auto MS/MS with a preferred targeted list containing 421 imidazoles using ultra-performance liquid chromatog.-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). To enable our method to effectively and accurately detect as many imidazoles as possible, we optimized and validated the method based on specificity, limit of detection (LOD), limit of quantification (LOQ), linearity, accuracy, precision and matrix effects using 20 imidazole standards with different functional groups. The method exhibited excellent performance with LOD and LOQ of 0.5-2 ng/mL and 1.5-6 ng/mL, resp., and spiked recoveries ranging from 64.7 to 98.7% with standard deviations less than 16.0%, and with relatively shorter anal. time. The established method was then used to screen imidazoles in 37 ambient PM2.5 samples. Ten targeted imidazoles were identified and quantified using imidazole standards, while five suspected imidazoles were identified without standards, and three imidazoles have not been reported before. Concentrations of the 10 targeted imidazoles ranged from 0.13 to 0.42 ng/m3. The established method enabled us to identify a wide range of imidazoles in ambient aerosol particles with and without using standards The experimental process involved the reaction of 2-Bromo-5-iodo-4-nitro-1H-imidazole(cas: 862895-48-5).Category: iodides-buliding-blocks

The Article related to imidazole atm aerosol particle liquid chromatog tof mass spectrometry, a preferred targeted list, data-dependent acquisition auto ms/ms, hybrid targeted and untargeted method, imidazoles, liquid chromatography-quadrupole time-of-flight mass spectrometry, pm(2.5) and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On July 3, 2002, Galoppini, Elena; Guo, Wenzhuo; Zhang, Wei; Hoertz, Paul G.; Qu, Ping; Meyer, Gerald J. published an article.Recommanded Product: 144970-30-9 The title of the article was Long-range electron transfer across molecule-nanocrystalline semiconductor interfaces using tripodal sensitizers. And the article contained the following:

Four tripodal sensitizers, Ru(bpy)2(Ad-tripod-phen)2+ (1), Ru(bpy)2(Ad-tripod-bpy)2+ (2), Ru(bpy)2(C-tripod-phen)2+ (3), and Ru(bpy)2(C-tripod-bpy)2+ (4) (bpy = 2,2′-bipyridine; phen = 1,10-phenanthroline; Ad-tripod-bpy (phen) and C-tripod-bpy (phen) = tripod-shaped bpy (phen) ligands based on 1,3,5,7-tetraphenyladamantane and tetraphenylmethane, resp.), have been synthesized and characterized. The tripodal sensitizers consist of a rigid-rod arm linked to a RuII-polypyridine complex at one end and three COOR groups on the other end that bind to metal oxide nanoparticle surfaces. The excited-state and redox properties of solvated and surface-bound 1-4 have been studied at room temperature The absorption spectra, emission spectra, and electrochem. properties of 1-4 in acetonitrile solution are preserved when 1-4 are bound to nanocrystalline (anatase) TiO2 or colloidal ZrO2 mesoporous films. This behavior is indicative of weak electronic coupling between TiO2 and the sensitizer. The kinetics for excited-state decay are exponential for 1-4 in solution and are nonexponential when 1-4 are bound to ZrO2 or TiO2. Efficient and rapid (kcs > 108 s-1) excited-state electron injection is observed for 1-4/TiO2. The recombination of the injected electron with the oxidized RuIII center is well described by a second-order kinetic model with rate constants that are independent of the sensitizer. The sensitizers bound to TiO2 were reversibly oxidized electrochem. with an apparent diffusion coefficient ∼1 × 10-11 cm2-s-1. Caution preparation of diazomethane (in synthesis of reactant for preparation tripodal ligand) was done in special glassware with smooth joints following safety precautions. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Recommanded Product: 144970-30-9

The Article related to electron transfer across mol nanocrystalline semiconductor interface tripodal photosensitizer, safety photoinduced electron transfer titania tripodal ruthenium complex sensitizer, zirconia tripodal ruthenium complex sensitizer interfacial photoinduced electron transfer and other aspects.Recommanded Product: 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On February 3, 2016, Patil, Komal M.; Dickinson, Michelle E.; Tremlett, Thomas; Moratti, Stephen C.; Hanton, Lyall R. published an article.Category: iodides-buliding-blocks The title of the article was Synthesis of Diamondoid and Lonsdaleite Networks from the Same Ag(I)-Ligand Combination, with Lonsdaleite the Softer Network. And the article contained the following:

The design and synthesis of a Lonsdaleite (lon) network is an attractive and challenging supramol. target. The authors’ reticular synthesis strategy of slow diffusion of solutions of a simple rigid tetrahedral ligand and a Ag(I) metal ion, at room temperature and atm. pressure, resulted in both lon-MOFs and diamondoid (dia-MOFs) and associated 2D honeycomb networks. The prepared complexes are {[AgL]X.nCH3NO2} [X = CF3SO3-, n = 4 (1a, 1); BF4-, n = 3 (1b, 2); CF3CO2-, n = 5.5 (1c, 3); BF4-, n = 4 (1d, 4)] and interpenetrated dia {[AgL]X.nH2O} [X = PF6-, n = 2 (2a, 5); BF4-, n = 3 (2b, 6); ClO4-, n = 2 (2c, 7), CF3SO3- (2d, 8)] networks along with their associated 2D honeycomb (hcb) networks {[AgL](CF3SO3).2CH3NO2.H2O} (3a, 9) and {[AgL(NO3)].4CH3NO2.H2O} (3b, 10) (where L = tetrakis(4-cyanophenyl)adamantane). Solvent appeared to play a key role in templating the formation of these related networks. Nanoindentation studies show that a dia-MOF was 42% harder than a lon-MOF counterpart. The lon-MOFs were thermally stable and retained integrity until 370° while dia-MOFs exhibited stepwise collapse after initial loss of solvents. As lon networks are often only qual. identified, Cremer-Pople ring puckering anal. was used to quantify the degree of distortion in the lon and related 4-connected 66 networks. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

The Article related to preparation diamondoid lonsdaleite network silver cyanophenyladamantane network complex, crystal structure diamondoid lonsdaleite network silver cyanophenyladamantane network complex, thermal decomposition diamondoid lonsdaleite network silver cyanophenyladamantane network complex and other aspects.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On December 31, 2020, Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan published an article.Quality Control of Ethyl 5-chloro-2-iodobenzoate The title of the article was Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. And the article contained the following:

A palladium-catalyzed asym. tandem Heck/carbonylation desymmetrization of cyclopentenes I (R = COMe, CO2Et; R1 = H, F, Cl, Me, OMe; X = I, Br) has been described. Alcs., (such as., n-propanol, isopropanol, cyclohexanol, etc.) phenols (such as., 4-methylphenol, biphenyl-4-ol, naphthol, etc.) and amines (such as., pyrrolidine, morpholine, benzylamine, etc.) are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes II (R2 = OMe, OEt, OPh, pyrrolidino, morpholino, thiomorpholino, etc.) with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asym. tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Quality Control of Ethyl 5-chloro-2-iodobenzoate

The Article related to bicyclooctane preparation diastereoselective enantioselective, cyclopentene alc heck carbonylation desymmetrization palladium catalyst, phenol cyclopentene heck carbonylation desymmetrization palladium catalyst, amine cyclopentene heck carbonylation desymmetrization palladium catalyst and other aspects.Quality Control of Ethyl 5-chloro-2-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On July 5, 2004, Tohma, Hirofumi; Maruyama, Akinobu; Maeda, Akihisa; Maegawa, Tomohiro; Dohi, Toshifumi; Shiro, Motoo; Morita, Tetsuichiro; Kita, Yasuyuki published an article.Name: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Preparation and reactivity of 1,3,5,7-tetrakis[4-(diacetoxyiodo)phenyl]adamantane, a recyclable hypervalent iodine(III) reagent. And the article contained the following:

A wide range of oxidative reactions are mediated by novel, nonpolymeric, and recyclable hypervalent IIII reagents [e.g. I, R = I(OAc)2]. In all cases, tetraiodide I (R = I) was recovered nearly quant. in pure form after a simple workup. Reoxidation of I (R = I) to I [R = I(OAc)2] with m-chloroperbenzoic acid also proceeded quant., without loss of oxidative activity. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Name: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to tetrakisdiacetoxyiodophenyladamantane recyclable oxidizing agent preparation, recyclable hypervalent iodine reagent preparation, diacetoxyiodophenyladamantane tetrakis recyclable oxidizing agent preparation, adamantane tetrakisdiacetoxyiodophenyl recyclable oxidizing agent preparation and other aspects.Name: 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On November 21, 1994, Reichert, Veronica R.; Mathias, Lon J. published an article.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane The title of the article was Expanded Tetrahedral Molecules from 1,3,5,7-Tetraphenyladamantane. And the article contained the following:

The goal of this paper was to investigate the effects of rigid tetrahedral cores (such as adamantane) on the properties of aramid and poly(phenylene) dendrimers as well as dendrimers that form single mol. micelles. This paper deals with model compound studies dealing with generating tetrasubstituted derivatives of adamantane. A previously reported procedure (for making tetraphenyladamantane) using tert-Bu bromide-AlCl3 catalyzed arylation of 1-bromoadamantane was found not to be a general synthetic method for the preparation of other substituted adamantane derivatives Adamantane derivatives with multiple Ph substituents were isolated only when benzene and bromobenzene were used in the Friedel-Crafts reaction. Tetraphenyl-substituted adamantane derivatives were formed, however, by the traditional Friedel-Crafts arylation of 1,3,5,7-tetrabromoadamantane with bromobenzene and 1,3-dibromobenzene. A lack of regioselectivity for these reactions (isolated mixtures of the meta/para isomers or ortho/meta isomers) was observed Large quantities (50-100 g) of 1,3,5,7-tetraphenyladamantane (1) were prepared from 1-bromoadamantane using a slightly modified literature procedure. This organic insoluble compound was iodinated with [bis(trifluoroacetoxy)iodo]benzene to give the all-para-substituted compound, 5. Compound 5 was further reacted to give numerous derivatives and used as a core in the synthesis of first generation dendrimers. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

The Article related to tetraphenyladamantane derivative preparation dendrimer preparation modeling, polyphenylene dendrimer preparation model tetramethyladamantane derivative, core tetraphenyladamantane derivative polyamide polyphenylene dendrimer, polyamide dendrimer preparation model tetramethyladamantane derivative and other aspects.Application In Synthesis of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

On August 2, 2018, Morales, Guilermo A.; Garlich, Joseph R.; Durden, Donald L. published a patent.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate The title of the patent was Preparation of thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors. And the patent contained the following:

The title compounds I-VI [M = (independently) S or O; R1 = H, halo, alkyl, etc.; R2 = VII, VIII (wherein X = C, N, P, P(O), SiRb; n = 0-2; Y = CR1, O, S, NRa, etc.; Z = O or S; R1 = H or independently at each instance any group defined in R1; Rb = H or independently at each instance any group defined in R1; and wherein R2 in III excludes morpholine; Cyc = (un)substituted aryl, heterocycle, carbocycle); R3 = R1; R4 = R1; Rc = a hydrolyzable linker group which is optionally substituted with a targeting agent; Ar = an aryl, heterocycle, or heteroaryl group unsubstituted beyond the attachment to thiophene (or furan) ring; and the R3 substituent is in the meta- or para-positions], useful for treating diseases including but not limited to, cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, type 1 or 2 diabetes, obesity, inflammatory disease, or Myc-dependent disorder by modulating biol. processes by the inhibition of cell cycle checkpoint targets CDKs, and/or PI3 kinase, and/or bromodomain protein binding to substrates, were prepared E.g., a multi-step synthesis of IX, starting from 6-chloro-1-cyclopentyl-1,5,7-triaza-1H-indene-2-carboxylic acid and dimethylamine hydrochloride salt, was described. Representative compounds I were tested for their affinity toward CDK6, PI3K and BRD4 (data given). Pharmaceutical composition comprising compound I-VI was disclosed. The experimental process involved the reaction of Ethyl 5-chloro-2-iodobenzoate(cas: 1012882-90-4).Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

The Article related to thienopyranone furanopyranone preparation kinase bromodomain checkpoint inhibitor antitumor antiviral, proliferative autoimmune disease sepsis treatment antiatherosclerotic thienopyranone furanopyranone preparation, antidiabetic antiobesity antiinflammatory thienopyranone furanopyranone preparation and other aspects.Application In Synthesis of Ethyl 5-chloro-2-iodobenzoate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fyfe, James W. B.; Valverde, Elena; Seath, Ciaran P.; Kennedy, Alan R.; Redmond, Joanna M.; Anderson, Niall A.; Watson, Allan J. B. published an article in 2015, the title of the article was Speciation control during Suzuki-Miyaura cross-coupling of haloaryl and haloalkenyl MIDA boronic esters.Application of 1287221-36-6 And the article contains the following content:

Effects of aryl halide, water, base, reaction temperature, catalyst precursor and ligand on chemoselectivity of Suzuki coupling of PhBpin with 4-HalC6H4BMIDA, producing 4-PhC6H4Bpin with up to 92% selectivity, were evaluated. Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives The reaction is contingent upon control of the basic biphase and is thermodynamically driven: temperature control provides highly chemoselective access to either BMIDA adducts at room temperature or boronic acid pinacol ester (BPin) products at elevated temperature Control experiments and solubility analyses have provided some insight into the mechanistic operation of the formal homologation process. The experimental process involved the reaction of 4-Iodophenylboronic acid MIDA ester(cas: 1287221-36-6).Application of 1287221-36-6

The Article related to suzuki coupling chemoselectivity pinacol mida boronate preparation biaryl, aryl halide solvent base temperature effect chemoselectivity suzuki coupling, homologation boronate arylene insertion chemoselective suzuki coupling pinacol mida, boron, chemoselectivity, cross-coupling, palladium, speciation and other aspects.Application of 1287221-36-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com