October 2022 - Page 22 of 154 - Iodides-buliding-blocks

Saavedra, Oscar Mario et al. published their patent in 2007 |CAS: 70931-59-8

The Article related to thienopyridine preparation pharmaceutical composition, thienopyrimidine preparation vegf hgf receptor signaling inhibitor, thieno pyridine preparation vegf hgf receptor signaling inhibitor, pyridine thieno preparation treatment proliferative disease, pyrimidine thieno preparation treatment proliferative disease and other aspects.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

On May 18, 2007, Saavedra, Oscar Mario; Claridge, Stephen William; Zhan, Lijie; Raeppel, Franck; Vaisburg, Arkadii; Raeppel, Stephane; Deziel, Robert; Mannion, Michael; Zhou, Nancy Z.; Isakovic, Ljubomir published a patent.Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene The title of the patent was Thienopyridine and thienopyrimidine derivatives and their preparation, pharmaceutical compositions, and use as inhibitors of VEGF receptor and HGF receptor signaling for treatment of proliferative diseases. And the patent contained the following:

The invention relates to the inhibition of vascular endothelial growth factor (VEGF) receptor signaling and hepatocyte growth factor (HGF) receptor signaling. The invention provides compounds of formula I and methods for inhibiting VEGF receptor signaling and HGF receptor signaling for treatment of proliferative diseases. Compounds of formula I, wherein T is (un)substituted (hetero)aryl(alkyl), cycloalkyl or heterocyclyl; W is O, S, NH, or NMe; Z is O, S, or NH; X and X1 are independently H, (un)substituted C1-6 alkyl, halo, CN, or NO2; or X and X1 together may form C3-7 cycloalkyl; R1, R2, R3, R4 are independently H, halo, trihalomethyl, CN, NO2, NH2 and derivatives, OH and derivatives, CO2H and derivatives, COH and derivatives, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; R5 is H, CN, (un)substituted (CH2)2-5 (hetero)aryl, (un)substituted C1-6 alkyl, (un)substituted C2-6 alkenyl, C2-6 alkynyl, CH2(CH2)0-4T2, (un)substituted C1-4 alkylcarbonyl, (un)saturated 3- to 7-membered carboxycyclic or heterocyclic group; where T2 is OH, OMe, OEt, NH2, NHMe, or NMe2; Q is CH2, O, S, NH, N(C1-6 alkyl), N(alkyl)aryl, NOMe, NCH2OMe, or NBn; D is C-E or N; L is N or CR where R is H, halo, CN, (un)substituted C1-6 alkyl, (un)substituted C2-4 alkenyl, or (un)substituted C2-6 alkynyl; E is E1, E2 or E3 wherein E1 is H, halo, NO2, azido, (un)substituted C1-6 alkyl, C3-10 cycloalkyl, etc.; E2 is (un)substituted alkynes; E3 is (un)substituted heterocyclyl(ene); and the pharmaceutically acceptable salts and complexes thereof are claimed in this invention. Example compound II was prepared by chlorination of thieno[3,2-b]pyridine-7-ol followed by carboxylation and the resulting lithium carboxylate was converted into the corresponding acid chloride, which reacted with dimethylamine to give compound III; compound III underwent coupling with 2-fluoro-4-nitrophenol, and the resulting 7-(2-fluoro-4-nitrophenoxy)-N,N-dimethylthienopyridinecarboamide was reduced to give the corresponding arylamine, which was reacted with phenylacetyl isocyanate to give example compound II. Addnl. 329 examples were prepared in this invention. The example compounds were tested for their in vitro HGF receptor and VEGF receptor signaling inhibition and solid tumor growth inhibition. The invention compounds showed inhibitory activity and was reported to have IC50 values less than 50 nM, ≥50 but <250 nM, ≥250 but <500 nM, ≥ 500 nM, or no activity in various assays. Example compound II showed and IC50 of >50 nM for inhibition of VEGF receptors, and this compound also showed tumor growth inhibition (TGI) against several types of tumors. Example compound II had greater than 100% TGI against U87MG, which indicated tumor shrinkage. The experimental process involved the reaction of 1-(Bromomethyl)-4-fluoro-2-iodobenzene(cas: 70931-59-8).Reference of 1-(Bromomethyl)-4-fluoro-2-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Katherine M. E. et al. published their research in CrystEngComm in 2006 |CAS: 144970-30-9

The Article related to phosphonophenyladamantane hydrate chloroform crystal self assembly preparation structure, adamantane tetrakisphosphonophenyl diamondoid net hydrogen bonded water cluster preparation, crystal structure phosphonophenyladamantane hydrate chloroform assembly, mol structure phosphonophenyladamantane hydrate chloroform assembly and other aspects.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Jones, Katherine M. E.; Mahmoudkhani, Amir H.; Chandler, Brett D.; Shimizu, George K. H. published an article in 2006, the title of the article was An adamantane-based tetraphosphonic acid that forms an open diamondoid net via a hydrogen-bonded phosphonic acid-water cluster.Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane And the article contains the following content:

An adamantane-based tetraphosphonic acid (1,3,5,7-tetrakis(4-phosphonophenyl)adamantane·4H2O·2CHCl3) H-bonds into unprecedented tetrahedral clusters with H2O to form a 4-fold interpenetrated diamondoid net, incorporating both hydrophobic and hydrophilic domains. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Safety of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Grigg, Ronald et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2012 |CAS: 144970-30-9

The Article related to adamantane z alkene organic tecton stereoselective preparation, adamantanamine iodoarene allene palladium multicomponent catalytic diastereoselective cascade, iodophenyladamantane amine amino acid allene palladium multicomponent diastereoselective cascade, multicomponent catalytic diastereoselective cascade catalyst palladium and other aspects.Application of 144970-30-9

Grigg, Ronald; Elboray, Elghareeb E.; Aly, Moustafa F.; Abbas-Temirek, Hussien H. published an article in 2012, the title of the article was Exploiting adamantane as a versatile organic tecton: multicomponent catalytic cascade reactions.Application of 144970-30-9 And the article contains the following content:

3- And 9-component Pd(0) catalyzed assembly of allenes, aryl iodides and N-nucleophiles with concomitant installation of trisubstituted Z-alkenes is readily achieved. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Application of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Valera, Silvia et al. published their research in Journal of Organic Chemistry in 2014 |CAS: 144970-30-9

The Article related to rigid methylpyrrolinyloxy diradical triradical tetraradical preparation cw epr spectrum, nitroxide rigid diradical triradical tetraradical preparation, esterification polyphenol methylpyrrolinyloxycarboxylic acid modular preparation polyradical, methylpyrrolinyloxycarboxylate resorcinol phloroglucinol ester mol crystal structure and other aspects.Category: iodides-buliding-blocks

On September 5, 2014, Valera, Silvia; Taylor, James E.; Daniels, David S. B.; Dawson, Daniel M.; Athukorala Arachchige, Kasun S.; Ashbrook, Sharon E.; Slawin, Alexandra M. Z.; Bode, Bela E. published an article.Category: iodides-buliding-blocks The title of the article was A Modular Approach for the Synthesis of Nanometer-Sized Polynitroxide Multi-Spin Systems. And the article contained the following:

Rigid sym. poly(tetramethylpyrrolinyloxy) radicals such as I were prepared for studying the effect of distance on interradical interactions; their room temperature continuous wave (CW) EPR spectra are reported. The nitroxide polyradicals were prepared using the esterification of the tetramethylpyrrolinyloxycarboxylic acid II with polyphenols as a key step. Sym. di- and trinitroxides with aromatic cores and a tetranitroxide with an adamantane core were prepared by this method. The structures of I and a bis(tetramethylpyrrolidinecarboxylate) diester of resorcinol were determined by X-ray crystallog. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Vasylyev, Maxym et al. published their research in Journal of Molecular Structure in 2003 |CAS: 144970-30-9

The Article related to structure control organic cation polyoxometalate salt, crystal structure trisdimethylaminoethylbenzenetricarboxamide phosphotungstate, silicotungstate tetrakismethylpyridiniumylvinylphenyladamantane salt preparation, tungstate phospho silico organic cation preparation structure control, microporous polyoxometalate organic cation structure control and other aspects.Synthetic Route of 144970-30-9

On August 27, 2003, Vasylyev, Maxym; Popovitz-Biro, Ronit; Shimon, Linda J. W.; Neumann, Ronny published an article.Synthetic Route of 144970-30-9 The title of the article was Inorganic-organic hybrid materials based on Keggin type polyoxometalates and organic polyammonium cations. And the article contained the following:

Co-crystallization of a triammonium cation with short and somewhat flexible ‘arms’, [N,N,N-tris[2-(dimethylamino)ethyl]-1,3,5-benzenetricarboxamide]3+, with a polyoxometalate trianion, PW12O403-, yielded an insoluble channeled or microporous structure (crystal data reported). The polyoxometalate clusters are arranged in a layered and zigzag fashion along the xy plane. Looking along the x-axis, channels of a dimension of ∼3.5×∼6.5 Å are observed C-H···O bonds aided in determining the crystal packing by providing directionality to the anion-cation interaction. However, the co-crystallization of a tetraammonium cation with an extended and rigid tetrahedral configuration, 1,3,5,7-tetrakis{4-[(E)-2(N-methylpyridinium-4-yl)vinyl]phenyl}adamantane tetraiodide, with a polyoxometalate tetracation, SiW12O404-, yielded a lamellar structure with alternating layers with spacing of 16.6 Å of the inorganic-organic hybrid material. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Synthetic Route of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Chi-Hang et al. published their research in Tetrahedron in 2010 |CAS: 144970-30-9

The Article related to bipyridineethynylphenyladamantane carboxylate derivative preparation ruthenium complex, electrochem ruthenium bipyridineethynylphenyladamantane carboxylic ester complex, fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid complex, quenching fluorescence ruthenium bipyridineethynylphenyladamantane carboxylic acid titanium dioxide and other aspects.Computed Properties of 144970-30-9

On May 29, 2010, Lee, Chi-Hang; Zhang, Yongyi; Romayanantakit, Apiwat; Galoppini, Elena published an article.Computed Properties of 144970-30-9 The title of the article was Modular synthesis of ruthenium tripodal system with variable anchoring groups positions for semiconductor sensitization. And the article contained the following:

The authors describe an improved synthetic approach to access tripodal compounds with variable footprints and anchor groups. Two Ru(II) bipyridine tripodal complexes with three carboxylic acid groups in meta (Ru-m-COOH, 1; I) and para (Ru-p-COOH, 2; II) positions, and with large (180-250 Å2) footprints were synthesized and bound to the surface of nanostructured TiO2. Selected properties of 1 and 2 in solution and bound are reported. The experimental process involved the reaction of 1,3,5,7-Tetrakis(4-iodophenyl)adamantane(cas: 144970-30-9).Computed Properties of 144970-30-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nagai, Seiya team published research in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2021 | 144-48-9

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., SDS of cas: 144-48-9

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. SDS of cas: 144-48-9.

Nagai, Seiya;Koshiishi, Ichiro research published 《 Simple and sensitive quantification of glutathione hydropersulfide alkylated using iodoacetamide by high-performance liquid chromatography with post-column derivatization》, the research content is summarized as follows. A novel anal. method was developed for the quantification of glutathione hydropersulfide (G-SSH) in biol. samples by high-performance liquid chromatog. (HPLC) with post-column derivatization. G-SSH was treated with iodoacetamide as an alkylating agent for 5 min at 37 °C, and the resultant acetamide-labeled G-SSH (G-SS-acetamide) was subjected to HPLC. After separation on a reversed-phase column, G-SS-acetamide was quantified by detection using a post-column reaction with orthophthalaldehyde under alk. conditions. The standard G-SS-acetamide was synthesized through the S-S exchange reaction between oxidized glutathione and 2-mercaptoacetamide. It should be noted that some types of alkylating agents, including N-ethylmaleimide and monobromobimane, cleave the polysulfide chains of polysulfides that consist of glutathione, resulting in the production of alkylated G-SSHs. We confirmed that iodoacetamide did not enhance the cleavage of acetamide-labeled glutathione trihydropersulfide (G-SSS-acetamide). The lowest quantification limit was estimated to be 25 nM for G-SS-acetamide. This method can be useful for studying the dynamics of sulfane sulfur in glutathione-containing matrixes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Naaz, Sanobar team published research in Crystal Growth & Design in 2022 | 1120-90-7

Related Products of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Related Products of 1120-90-7.

Naaz, Sanobar;Debnath, Bhaswati;Islam, Sakhiul;Khan, Samim;Ahmed, Faruk;Dutta, Basudeb;Jana, Atish Dipankar;Mir, Mohammad Hedayetullah research published 《 Carboxylato Bridged Cyclic SBUs as Robust Features in a Series of Cu(II) Coordination Polymers and Halogen···Halogen Interactions in Crystal Packing》, the research content is summarized as follows. Four new meta- substituted halopyridine appended coordination polymers (CPs) {[Cu(i.p.)₆(py)₆]·2CH₃OH}_n (1), [Cu(i.p.)₂(3-Clpy)₂]_n (2), [Cu(i.p.)₂(3-Brpy)₂]_n (3) and [Cu(i.p.)₂(3-Ipy)₂]_n (4) (py = pyridine, 3-Clpy = 3-chloropyridine, 3-Brpy = 3-bromopyridine, 3-Ipy = 3-iodopyridine and H₂i.p. = isophthalic acid) have been synthesized by diffusion method. The compounds are structurally characterized by single crystal x-ray diffraction (SCXRD) technique and supramol. interactions are studied by geometrical and d. functional theory (DFT) calculations The study reveals that the compounds 1–3 form two-dimensional (2D) coordination polymeric structure with carboxylato bridged dimeric Cu(II) cyclic secondary building units (SBUs). However, a cyclic supramol. synthon involving four halogen (X = Cl, Br) atoms has been observed in 2 and 3. This cyclic halogen synthon combined with pyridine ring forms a (π···π)+X···X+(π···π) mega-synthon, which dictates the dimensionality of 2D CP into three-dimensional (3D) network. However, compound 4 with larger I atom does not show such interactions and forms 1D tape structure.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Murphy, EmmaRae L. team published research in Analytical Biochemistry in 2021 | 144-48-9

Application of C2H4INO, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Application of C2H4INO.

Murphy, EmmaRae L.;Joy, Andrew P.;Ouellette, Rodney J.;Barnett, David A. research published 《 Optimization of cysteine residue alkylation using an on-line LC-MS strategy: Benefits of using a cocktail of haloacetamide reagents》, the research content is summarized as follows. Several common reagents for the alkylation of cysteine residues of model intact proteins were evaluated for reaction speed, yield of alkylated product and degree of over-alkylation using an online LC-MS platform. The efficiency of the alkylation reaction is found to be dependent on the (1) reagent, (2) peptide/protein, (3) reagent concentration and (4) reaction time. At high reagent concentrations, iodoacetic acid was found to produce significant levels of over-alkylation products wherein methionine residues become modified. For optimal performance of the alkylation reaction, we found the use of a cocktail of chloroacetamide, bromoacetamide and iodoacetamide worked best. The alkylating efficiency of each haloacetamide is a balance between the characteristics of the halogen leaving group and the steric hindrance of the alkylation site on the peptide or protein. A key aspect of using a cocktail of haloacetamides is that they all produce the same modification (+57.0209 Da) to the cysteine residues of the protein while the alkylation efficiency of each site may differ for each of the three reagents. Over-alkylation effects appear to be lower with the cocktail due to a lower concentration of each reagent. The haloacetamide cocktail could be useful when considering complex mixtures of proteins.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Murashkina, Arina V. team published research in Mendeleev Communications in 2022 | 5029-67-4

5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., Quality Control of 5029-67-4

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Quality Control of 5029-67-4.

Murashkina, Arina V.;Kuliukhina, Daria S.;Averin, Alexei D.;Abel, Anton S.;Savelyev, Evgenii N.;Orlinson, Boris S.;Novakov, Ivan A.;Correia, Carlos R. D.;Beletskaya, Irina P. research published 《 A comparison of homogeneous and heterogeneous copper catalyzed arylation of amines》, the research content is summarized as follows. Comparison of the homogeneous and heterogeneous copper-catalyzed arylation of model primary amines with (hetero)-aryl iodides in DMSO revealed a comparable efficiency of CuI and com. available unsupported copper nanoparticles (25 nm size) in the presence of 2-isobutyryl-cyclohexanone or L-proline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com