Month: October 2022

Novoa, Nestor; Manzur, Carolina; Roisnel, Thierry; Kahlal, Samia; Saillard, Jean-Yves; Carrillo, David; Hamon, Jean-Rene published an article in 2021. The article was titled 《Nickel(II)-Based Building Blocks with Schiff Base Derivatives: Experimental Insights and DFT Calculations》, and you may find the article in Molecules.HPLC of Formula: 15854-87-2 The information in the text is summarized as follows:

We have recently reported a series of neutral square planar tridentate Schiff base (L) complexes of the general formula [(L)M(py)], showing relatively high first-order hyperpolarizabilities and NLO redox switching behavior. In the present study, new members of this family of compounds have been prepared with the objective to investigate their potential as building blocks in the on-demand construction of D-π-A push-pull systems. Namely, ternary nickel(II) building blocks of general formula [(LA/D)Ni(4-pyX)] (4-7), where LA/D stands for an electron accepting or donating dianionic O,N,O-tridentate Schiff base ligand resulting from the monocondensation of 2-aminophenol or its 4-substituted nitro derivative and β-diketones R-C(=O)CH2C(=O)CH3 (R = Me, anisyl, ferrocenyl), and 4-pyX is 4-iodopyridine or 4-ethynylpyridine, were synthesized and isolated in 60-78% yields. Unexpectedly, the Sonogashira cross-coupling reaction between the 4-iodopyridine derivative 6 and 4-ethynylpyridine led to the formation of the bis(4-pyridyl) acetylene bridged centrosym. dimer [{(LD)Ni}2(μ2-py-CΞC-py)] (8). Complexes 4-8 were characterized by elemental anal., FT-IR and NMR spectroscopy, single crystal X-ray diffraction and computational methods. In each compound, the four-coordinate Ni(II) metal ion adopts a square planar geometry with two nitrogen and two oxygen atoms as donors occupying trans positions. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Ke; Li, Zhi; Liu, Chong; Li, Yunjian; Hu, Qingyue; Elsaid, Mazen; Li, Bijin; Das, Jayabrata; Dang, Yanfeng; Maiti, Debabrata; Ge, Haibo published an article in 2022. The article was titled 《Ligand-promoted palladium-catalyzed β-methylene C-H arylation of primary aldehydes》, and you may find the article in Chemical Science.Product Details of 591-18-4 The information in the text is summarized as follows:

The development of a direct Pd-catalyzed methylene β-C-H arylation of linear unmasked aldehydes were synthesized using 3-amino-3-methylbutanoic acid as a TDG (Transient Directing Group) and 2-pyridone as an external ligand. D. functional theory calculations provided insights into the reaction mechanism and shed light on the roles of the external and transient directing ligands in the catalytic transformation. In the experimental materials used by the author, we found 1-Bromo-3-iodobenzene(cas: 591-18-4Product Details of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Product Details of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Bisht, Narendra; Singh, Prabhakar; Babu, Srinivasarao Arulananda published an article in Synthesis. The title of the article was 《Pd(II)-Catalyzed, Picolinamide-Aided γ-(sp2)-C-H Functionalization of Racemic and Enantiopure α-Methylbenzylamine and Phenylglycinol Scaffolds》.Recommanded Product: 1-Chloro-3-iodobenzene The author mentioned the following in the article:

In this paper, the Pd(II)-catalyzed, picolinamide DG-aided sp2γ-C-H functionalization and expansion of the library of enantiopure α-methylbenzylamine and phenylglycinol scaffolds RCH(CH2R1)NHC(O)R2 (R = Ph, 4-methylphenyl, 2-chlorophenyl, 4-chlorophenyl; R1 = H, OAc; R2 = Ph, pyridin-2-yl, 5-methyl-1,2-oxazol-3-yl, etc.) were reported. The synthesis of a wide range of racemic and enantiopure ortho-C-H arylated, alkylated, brominated, and iodinated α-methylbenzylamine and phenylglycinol scaffolds e.g., N-(1-(4,4”-dimethoxy-[1,1′:3′,1”-terphenyl]-2′-yl)ethyl)picolinamide was shown. Various racemic and Rand S(chiral) sp2γ-C-H functionalized α-methylbenzylamine and phenylglycinol scaffolds were synthesized with good enantiopurities. Racemic and enantiopure α-methylbenzylamine and phenylglycinol derivatives are important building blocks in organic synthesis and medicinal chem. Accordingly, this work contributes to the expansion of the libraries of α-methylbenzylamine and phenylglycinol motifs and substrate scope development through the Pd(II)-catalyzed bidentate directing group picolinamide-aided site-selective C-H activation and functionalization method. The experimental process involved the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 1-Chloro-3-iodobenzene)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1-Chloro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Li, Lin; Liu, Xin-Lian; Qi, Zhuang; Yang, Ai-Hua; Ma, Ai-Jun; Peng, Jin-Bao published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Carbonylative Sonogashira/Annulation Reaction: Synthesis of Indolo[1,2-b]isoquinolines》.Related Products of 63069-48-7 The author mentioned the following in the article:

A palladium-catalyzed carbonylative Sonogashira/annulation reaction for the synthesis of indolo[1,2-b]isoquinolines I [Ar = Ph, 4-MeC6H4, 3,4-di-MeOC6H3, etc.; R1 = H, 3-F, 2-F, 2-Cl, 3-Cl, 3-Me; R2 = H, 8-F, 9-Me ] was developed. Tetracyclic 6/5/6/6 indoline skeletons I were synthesized in moderate to good yields from easily available 2-bromo-N-(2-iodophenyl)benzamides and terminal alkynes. Notably, this efficient methodol. established three C-C bonds and a C-N bond through a one-step transformation and provided a new method for the synthesis of indolo[1,2-b]isoquinoline derivatives I. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Related Products of 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Related Products of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yang, Tao; Zhang, Lei; Shang, Yicun; Zhu, Zhenzhu; Jin, Suxing; Guo, Zijian; Wang, Xiaoyong published an article in Chemical Science. The title of the article was 《Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer′s disease》.Computed Properties of C7H5IO2 The author mentioned the following in the article:

Alzheimer′s disease (AD) is a neurodegenerative illness accompanied by severe memory loss, cognitive disorders and impaired behavioral ability. Amyloid β-peptide (Aβ) aggregation and nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome play crucial roles in the pathogenesis of AD. Aβ plaques not only induce oxidative stress and impair neurons, but also activate the NLRP3 inflammasome, which releases inflammatory cytokine IL-1β to trigger neuroinflammation. A bifunctional mol., 2-[2-(benzo[d]thiazol-2-yl)phenylamino]benzoic acid (BPBA), with both Aβ-targeting and inflammasome-inhibiting capabilities was designed and synthesized. BPBA inhibited self- and Cu2+- or Zn2+-induced Aβ aggregation, disaggregated the already formed Aβ aggregates, and reduced the neurotoxicity of Aβ aggregates; it also inhibited the activation of the NLRP3 inflammasome and reduced the release of IL-1β in vitro and vivo. Moreover, BPBA decreased the production of reactive oxygen species (ROS) and alleviated Aβ-induced paralysis in transgenic C. elegans with the human Aβ42 gene. BPBA exerts an anti-AD effect mainly through dissolving Aβ aggregates and inhibiting NLRP3 inflammasome activation synergistically. In addition to this study using 2-Iodobenzoic acid, there are many other studies that have used 2-Iodobenzoic acid(cas: 88-67-5Computed Properties of C7H5IO2) was used in this study.

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Computed Properties of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Xu; Fang, Wan-Yin; Qin, Hua-Li published an article in Organic Letters. The title of the article was 《Regio- and Stereoselective Installation of Bromide onto Vinyl Sulfonyl Fluorides: Construction of a Class of Versatile Sulfur Fluoride Exchange Hubs》.Related Products of 591-18-4 The author mentioned the following in the article:

A convenient protocol for the exclusively regio- and stereoselective installation of a bromine atom on the 2-arylvinylsulfonyl fluorides using lithium bromide (LiBr) as the bromine source was described, providing (Z)-1-bromo-2-arylethene-1-sulfonyl fluorides (Z-BASF) with versatile reactive handles (bromide, vinyl, and sulfonyl fluoride) in ≤88% yield. Meanwhile, Z-BASF mols. displayed various reactivities in a series of chem. transformations. The results came from multiple reactions, including the reaction of 1-Bromo-3-iodobenzene(cas: 591-18-4Related Products of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Related Products of 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Huang, Yuanjing; Zhang, Jing published an article in Synthesis. The title of the article was 《Potassium tert-Butoxide Facilitated Amination of Carboxylic Acids with N,N-Dimethylformamide》.Computed Properties of C7H5IO2 The author mentioned the following in the article:

A practical and efficient potassium tert-butoxide (KOtBu)-facilitated amination of carboxylic acids with N,N-dimethylamine was described. In the presence of catalytic amount of KOtBu, a variety of aliphatic and aromatic carboxylic acids were transformed to N,N-dimethylamides using DMF as the dimethylamine reagent with the assistance of trimethylacetic anhydride. The applicability of this protocol was demonstrated by late-stage dimethylamidation of complex drug mols. A plausible reaction mechanism involving KOtBu-facilitated in-situ amine generation from formamide decomposition and anhydride-mediated condensation was proposed on the basis of mechanistic investigations. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Computed Properties of C7H5IO2)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Computed Properties of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Pan, Pan; Liu, Shihan; Lan, Yu; Zeng, Huiying; Li, Chao-Jun published an article in Chemical Science. The title of the article was 《Visible-light-induced cross-coupling of aryl iodides with hydrazones via an EDA-complex》.Electric Literature of C6H4ClI The author mentioned the following in the article:

A visible-light-induced, transition-metal and photosensitizer-free cross-coupling of aryl iodides RI (R = Ph, naphthalen-1-yl, thiophen-3-yl, 4-phenylmorpholine, etc.) with hydrazones R1CH=NNH2 (R1 = Ph, naphthalen-1-yl, pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) was developed. In this strategy, hydrazones were used as alternatives to organometallic reagents, in the absence of a transition metal or an external photosensitizer, making this cross-coupling mild and green. The protocol was compatible with a variety of functionalities, including Me, methoxy, trifluoromethyl, halogen, and heteroaromatic rings. Mechanistic investigations showed that the association of the hydrazone anion with aryl halides formed an electron donor-acceptor complex, which when excited with visible light generated an aryl radical via single-electron transfer. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0Electric Literature of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Electric Literature of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Grzanka, Marlena; Smolen, Sylwester; Skoczylas, Lukasz; Grzanka, Dominik published an article in Molecules. The title of the article was 《Synthesis of Organic Iodine Compounds in Sweetcorn under the Influence of Exogenous Foliar Application of Iodine and Vanadium》.Safety of 2-Iodobenzoic acid The author mentioned the following in the article:

A human′s diet should be diverse and rich in vitamins, macro- and microelements essential for the proper functioning of the human body. Globally, a high percentage of the human population suffers from malnutrition, deficiencies of nutrients and vitamins also known as the problem of hidden hunger. This problem it is not only common in poor countries, but also occurs in developed countries. Iodine is a nutrient crucial for the proper functioning of the human and animal body. For plants, it is referred to as a beneficial element or even a microelement. The design of the biofortification experiment was determined on the basis of the interaction of iodine and vanadium (synergistic interaction in marine algae), where vanadium-dependent iodoperoxidase catalyzes apoplastic oxidation of iodine, resulting in high efficiency of iodine uptake and accumulation in brown algae (Laminaria digitate). Three independent experiments (Exp.) were carried out with the foliar application of vanadium (V) and iodine (I) compounds The main differences between the experiments with the adapted proper corn biofortification method were the different application stage between the individual experiments, the application intervals and the dose of the iodine-vanadium compound In each experiment, the accumulation of iodine and vanadium in the grain was several times lower than in the leaves. The combination iodine and vanadium significantly increased the accumulation of iodine in the grain in the case of applying V with inorganic iodine compounds, and a decrease in the accumulation of I after applying V with organic iodine compound -especially in Exp. Number 3. In grain, the highest content of I-, IO3- was in combination with the application of 2-iodobenzoic acid (products of its metabolism). In most of the tested combinations, vanadium stimulated the accumulation/synthesis of exogenous/endogenous 5-iodosalicylic acid (5ISA) and 2-iodobenzoic acid (2IBeA), resp., and decreased the content of 2,3,5-triiodobenzoic acid (2,3,5-triIBeA) in leaves and grains. The tested compounds I and V and the combinations of their application had a diversified effect on the vitamin C content in the grains. Vanadium in the lower dose of 0.1 μM significantly increased the sugar content in the grain. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 2-Iodobenzoic acid

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of Trimethylsulfoxonium iodideIn 2020 ,《Ru(II)-catalyzed C6-selective C-H acylmethylation of pyridones using sulfoxonium ylides as carbene precursors》 appeared in RSC Advances. The author of the article were Fu, Yangjie; Wang, Zhaohui; Zhang, Qiyu; Li, Zhiyu; Liu, Hong; Bi, Xiaoling; Wang, Jiang. The article conveys some information:

A method was described using sulfoxonium ylides as carbene precursors to achieve C6-selective acylmethylation of pyridones catalyzed by a ruthenium(II) complex. This approach featured mild reaction conditions, moderate to excellent yields, high step economy and had excellent functional group tolerance with good site selectivity. Besides, gram-scale preparation, synthetic utility and mechanistic studies were conducted. It offered a direct and efficient way to synthesize pyridone derivatives After reading the article, we found that the author used Trimethylsulfoxonium iodide(cas: 1774-47-6Quality Control of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Quality Control of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com