Month: October 2022

The author of 《Rhodium-Catalyzed Reaction of Sulfoxonium Ylides and Anthranils toward Indoloindolones via a (4 + 1) Annulation》 were Wu, Xiaopeng; Xiao, Yan; Sun, Song; Yu, Jin-Tao; Cheng, Jiang. And the article was published in Organic Letters in 2019. SDS of cas: 1774-47-6 The author mentioned the following in the article:

A rhodium-catalyzed annulation between aroyl sulfoxonium ylides and anthranils has been developed to synthesize 10H-indolo[1,2-a]indol-10-one derivatives This reaction started with an unprecedented (4 + 1) annulation toward N-(2-formylphenyl) indolones, proceeding with the sequential ortho-amination of the C-H bond in aroyl sulfoxonium ylides by anthranils and the insertion of N-H to carbene. Finally, the Aldol condensation constructed the second indole ring. This procedure features the formation of two C-N bonds and one C=C bond in one pot. The results came from multiple reactions, including the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of α-heterosubstituted ketones through sulfur mediated difunctionalization of internal alkynes》 were Zhang, Zhong; Luo, Yuzheng; Du, Hongguang; Xu, Jiaxi; Li, Pingfan. And the article was published in Chemical Science in 2019. Computed Properties of C6H4ClI The author mentioned the following in the article:

Synthesis of α-heterosubstituted ketones was achieved through sulfur mediated difunctionalization of internal alkynes in one-pot. The reaction design involved Ph substituted internal alkyne attacking triflic anhydride activated di-Ph sulfoxide to give a sulfonium vinyl triflate intermediate hydrolysis to give an α-sulfonium ketone and then substitution with various nucleophiles. This method provided a unified route to accessed α-amino ketones, α-acyloxy ketones, α-thio ketones, α-halo ketones, α-hydroxy ketones and related heterocyclic structures in a rapid fashion. The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Computed Properties of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Computed Properties of C6H4ClI In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction》 were Shen, Zuyuan; Zhang, Shilei; Geng, Huihui; Wang, Jiarui; Zhang, Xinyu; Zhou, Anqi; Yao, Cheng; Chen, Xiaobei; Wang, Wei. And the article was published in Organic Letters in 2019. Product Details of 1774-47-6 The author mentioned the following in the article:

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a “”one-pot”” operation. The preparative power of the new versatile reagent and the “”one-pot”” protocol is demonstrated by its use to install the -CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D). In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Product Details of 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Product Details of 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Photoinduced Transition-Metal-Free Cross-Coupling of Aryl Halides with H-Phosphonates》 were Zeng, Huiying; Dou, Qian; Li, Chao-Jun. And the article was published in Organic Letters in 2019. Formula: C7H7I The author mentioned the following in the article:

Preparation of arylphosphonates and phosphine oxides ArP(O)X2 (Ar = substituted Ph, naphthyl, biphenyl; X = OMe, OEt, OiPr, aryl) by photoinduced transition-metal- and photosensitizer-free cross-coupling of aryl halides (including Ar-Cl, Ar-Br, and Ar-I) with H-phosphonates (including dialkyl phosphonates and diarylphosphine oxides) is reported. Various functional groups were tolerated, including ester, methoxy, dimethoxy, alkyl, Ph, trifluoromethyl, and heterocyclic compounds This simple and green strategy provides a practical pathway to synthesize arylphosphine oxides. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Formula: C7H7I)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Formula: C7H7I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides》 was published in Organic Letters in 2020. These research results belong to Ding, Ting-Hui; Qu, Jian-Ping; Kang, Yan-Biao. Related Products of 90-14-2 The article mentions the following:

A simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides to afford aromatic compounds The combined visible light and base system was used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds were tolerated.1-Iodonaphthalene(cas: 90-14-2Related Products of 90-14-2) was used in this study.

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1》 was published in Molecules in 2020. These research results belong to Vorobyeva, Anzhelika; Bezverkhniaia, Ekaterina; Konovalova, Elena; Schulga, Alexey; Garousi, Javad; Vorontsova, Olga; Abouzayed, Ayman; Orlova, Anna; Deyev, Sergey; Tolmachev, Vladimir. Formula: C7H5IO2 The article mentions the following:

Efficient treatment of disseminated triple-neg. breast cancer (TNBC) remains an unmet clin. need. The epithelial cell adhesion mol. (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic target. Radionuclide mol. imaging of EpCAM expression might permit selection of patients for EpCAM-targeting therapies. In this study, we evaluated a scaffold protein, designed ankyrin repeat protein (DARPin) Ec1, for imaging of EpCAM in TNBC. DARPin Ec1 was labeled with a non-residualizing [125I]I-para-iodobenzoate (PIB) label and a residualizing [99mTc]Tc(CO)3 label. Both imaging probes retained high binding specificity and affinity to EpCAM-expressing MDA-MB-468 TNBC cells after labeling. Internalization studies showed that Ec1 was retained on the surface of MDA-MB-468 cells to a high degree up to 24 h. Biodistribution in Balb/c nu/nu mice bearing MDA-MB-468 xenografts demonstrated specific uptake of both [125I]I-PIB-Ec1 and [99mTc]Tc(CO)3-Ec1 in TNBC tumors. [125I]I-PIB-Ec1 had appreciably lower uptake in normal organs compared with [99mTc]Tc(CO)3-Ec1, which resulted in significantly (p < 0.05) higher tumor-to-organ ratios. The biodistribution data were confirmed by micro-Single-Photon Emission Computed Tomog./Computed Tomog. (microSPECT/CT) imaging. In conclusion, an indirectly radioiodinated Ec1 is the preferable probe for imaging of EpCAM in TNBC. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C7H5IO2Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Lewis Acid-Free Ynoate-Mediated Chemoselective Reduction of Carboxylic Acids to Primary Alcohols》 was published in ChemistrySelect in 2020. These research results belong to Sun, Feixiang; Feng, Huangdi; Huang, Liliang; Liu, Weiping. Formula: C7H5IO2 The article mentions the following:

Economical and facile catalytic reduction process of carboxylic acids for the synthesis of alcs was reported. This pyridine-catalyzed strategy operates through addition of carboxylic acids with Me propiolate followed by NaBH4 reduction or unexpected ester exchange, provided the corresponding primary alcs. and esters, resp. A range of carboxylic acids bearing other reductive groups (e. g., halogen, cyano, nitro, ester and double bond) were accessed with uniformly high chemoselectivity. The use of environmentally benign, convenient and safe procedure also makes this catalytic protocol attractive for practical application. In addition to this study using 4-Iodobenzoic acid, there are many other studies that have used 4-Iodobenzoic acid(cas: 619-58-9Formula: C7H5IO2) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Formula: C7H5IO2 Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《When Gold Meets Perfumes: Synthesis of Olfactive Compounds via Gold-Catalyzed Cycloisomerization Reactions》 was written by Laher, Romain; Marin, Christophe; Michelet, Veronique. Name: 1-Bromo-3-iodobenzene And the article was included in Organic Letters in 2020. The article conveys some information:

An efficient, and mild synthetic route for the preparation of functionalized volatile oxa-bicyclo[4.1.0]-hept-4-enes I [R1 = H, Me, Bn; R2 = H, Me, Ph; R3 = Me, Ph, 4-tolyl, etc.] was developed relying on the association of IPrAuCl with NaBArF. The remarkable selectivity was demonstrated on a 1 g and 25 g scale with low catalyst loadings. The synthetic utility of these low-mol.-weight enols was further demonstrated by the derivatization of some adducts and by the unprecedented olfactory evaluation of all bicyclic derivatives In the experiment, the researchers used 1-Bromo-3-iodobenzene(cas: 591-18-4Name: 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Name: 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Flower-like NiCo2S4 nanosheets with high electrochemical performance for sodium-ion batteries》 was written by Miao, Yongqiang; Zhao, Xiaosen; Wang, Xin; Ma, Chenhui; Cheng, Lu; Chen, Gang; Yue, Huijuan; Wang, Lei; Zhang, Dong. Related Products of 516-12-1 And the article was included in Nano Research in 2020. The article conveys some information:

A three-dimensional flower-like NiCo2S4 formed by two-dimensional nanosheets is synthesized by a facile hydrothermal method and utilized as the anode for sodium-ion batteries. Studies have shown that materials can achieve the best performance under the ether-based electrolyte system with voltage ranging from 0.3 to 3 V, which could effectively avoid the dissolution of polysulfides and over-discharge of the material. Here, sodium storage mechanism and charge compensation behaviors of this ternary metal sulfide are comprehensively investigated by ex situ X-ray diffraction. Moreover, ex situ Raman spectra, ex situ XPS and transmission electron microscopy measurements are used to related tests for the first time. Addnl., quant. kinetic anal. unravels that sodium storage partially depends on the pseudocapacitance mechanism, resulting in good specific capacity and excellent rate performance. The initial discharge capacity is as high as 748 mAh·g-1 at a c.d. of 0.1 A·g-1 with the initial coulomb efficiency of 94%, and the capacity can still maintain at 580 mAh·g-1 with the Coulomb efficiency close to 100% after following 50 cycles. Moreover, by the long cycle test at a high c.d. of 2 A·g-1, the capacity can still reach at 376 mAh·g-1 after over 500 cycles. [graphic not available: see fulltext]. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Planje, Inco J.; Davidson, Ross J.; Vezzoli, Andrea; Daaoub, Abdalghani; Sangtarash, Sara; Sadeghi, Hatef; Martin, Santiago; Cea, Pilar; Lambert, Colin J.; Beeby, Andrew; Higgins, Simon J.; Nichols, Richard J. published their research in ACS Sensors in 2021. The article was titled 《Selective Anchoring Groups for Molecular Electronic Junctions with ITO Electrodes》.Computed Properties of C5H4IN The article contains the following contents:

Indium tin oxide (ITO) is an attractive substrate for single-mol. electronics since it is transparent while maintaining elec. conductivity Although it has been used before as a contacting electrode in single-mol. elec. studies, these studies have been limited to the use of carboxylic acid terminal groups for binding mol. wires to the ITO substrates. There is thus the need to investigate other anchoring groups with potential for binding effectively to ITO. With this aim, we have investigated the single-mol. conductance of a series of eight tolane or “”tolane-like”” mol. wires with a variety of surface binding groups. We first used gold-mol.-gold junctions to identify promising targets for ITO selectivity. We then assessed the propensity and selectivity of carboxylic acid, cyanoacrylic acid, and pyridinium-squarate to bind to ITO and promote the formation of mol. heterojunctions. We found that pyridinium squarate zwitterions display excellent selectivity for binding to ITO over gold surfaces, with contact resistivity comparable to that of carboxylic acids. These single-mol. experiments are complemented by surface chem. characterization with XPS, quartz crystal microbalance, contact angle determination, and nanolithog. using an at. force miscroscope. Finally, we report the first d.-functional theory calculations involving ITO electrodes to model charge transport through ITO-mol.-gold heterojunctions. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Computed Properties of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com