Month: October 2022

Li, Hongsheng; Zhao, Junhao; Yi, Songjian; Hu, Kongzhen; Feng, Pengju published their research in Organometallics in 2021. The article was titled 《Consequent Construction of C-C and C-N Bonds via Palladium-Catalyzed Dual C-H Activation: Synthesis of Benzo[c]cinnoline Derivatives》.COA of Formula: C6H5IO The article contains the following contents:

A highly efficient palladium-catalyzed cascade annulation of pyrazolones and aryl iodides to access various benzo[c]cinnoline derivatives has been achieved at 80°C. A pyridine-type ligand could improve the reaction efficiency under current reaction conditions, giving a higher product yield up to 94%. This novel approach provided a one-pot dual C-H activation strategy with good functional group tolerance, such as halogen, methoxy, nitro, ester, phenol, and so forth. The product could readily convert into cinnoline derivatives In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8COA of Formula: C6H5IO) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.COA of Formula: C6H5IOHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Rong-Jia; Zhou, Hou-Gan; Zhang, Zhi-Yin; Ning, Guo-Hong; Li, Dan published their research in CCS Chemistry in 2021. The article was titled 《Copper (I)- organic frameworks for catalysis: networking metal clusters with dynamic covalent chemistry》.COA of Formula: C5H4IN The article contains the following contents:

Metal clusters exhibit diverse structures, emerging functions, and applications; thus, incorporating clus- ters into metal-organic frameworks (MOFs) brings tremendous merits. Although the construction of cluster-based MOFs is sophisticated, the reticular materials constructed from a combination of the chem. of metal clusters and covalent organic frameworks (COFs) remain unexplored. Herein, we prepared two Cu(l) cluster-based MOFs with cyclic trinuclear units (CTUs), termed JNM-1 and JNM-Z, either by a stepwise synthetic approach or by a one-pot reaction, for networking clusters with dy- namic covalent chem., rarely utilized in MOF syn- thesis. The generated JNMs exhibited excellent stability and could be used as recyclable catalysts for palladium-free Sonogashira coupling reactions with high efficiency and tolerance (>90% yield for nine examples), without loss of performance for at least five cycle runs. In addition, conjugated single molec- ular wires with lengths ranging from 1.6 to 2.7 nm were synthesized feasibly using the JNM-1 catalyst. The experimental part of the paper was very detailed, including the reaction process of 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qiu, Jiawei; Sako, Makoto; Tanaka, Tomoyuki; Matsuzaki, Tsuyoshi; Takehara, Tsunayoshi; Suzuki, Takeyuki; Ohno, Shohei; Murai, Kenichi; Arisawa, Mitsuhiro published an article in 2021. The article was titled 《Iridium-Catalyzed Isomerization/Cycloisomerization/Aromatization of N-Allyl-N-sulfonyl-o-(λ1-silylethynyl)aniline Derivatives to Give Substituted Indole Derivatives》, and you may find the article in Organic Letters.Application of 63069-48-7 The information in the text is summarized as follows:

Herein, a one-iridium-catalyst system that transforms N-allyl-N-sulfonyl-2-(silylalkynyl)aniline derivatives, which are 1,7-enynes in which both multiple bonds have a heteroatom, to the corresponding substituted indole derivatives via isomerization/cycloisomerization/aromatization was developed. This strategy provides an atom-economical and straightforward synthetic approach to a series of valuable indoles having vinyl and silylmethyl groups at the 2- and 3-positions.4-Chloro-2-iodoaniline(cas: 63069-48-7Application of 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Taylor, Steven J.; Abeywardane, Asitha; Liang, Shuang; Xiong, Zhaoming; Proudfoot, John R.; Farmer, Bennett Sandy; Gao, Donghong A.; Heim-Riether, Alexander; Smith-Keenan, Lana Louise; Muegge, Ingo; Yu, Yang; Zhang, Qiang; Souza, Donald; Panzenbeck, Mark; Goldberg, Daniel; Hill-Drzewi, Melissa; Margarit, Mariana; Collins, Brandon; Li, John Xiang; Zuvela-Jelaska, Ljiljana; Li, Jun; Farrow, Neil A. published an article in 2021. The article was titled 《Indole Inhibitors of MMP-13 for Arthritic Disorders》, and you may find the article in ACS Omega.Synthetic Route of C5H4IN The information in the text is summarized as follows:

Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochem. properties to qualify as tool compounds suitable for in vivo testing. Optimization of potency was guided by structure-based insights, specifically to replace an ester moiety and introduce polar directional hydrogen bonding interactions in the core of the mol. By introducing polar enthalpic interactions in this series of inhibitors, the overall beneficial physicochem. properties were maintained. These physicochem. properties translated to excellent drug-like properties beyond potency. In a murine model of rheumatoid arthritis, treatment of mice with selective inhibitors of MMP-13 resulted in a statistically significant reduction in the mean arthritic score vs. control when dosed over a 14 day period. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Synthetic Route of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Synthetic Route of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Po-Ting; Yu, Chia-Ling; Shen, Min-Hsiu; Cheng, Mu-Jeng; Wu, Yao-Ting; Hsu, Hsiu-Fu published an article in 2022. The article was titled 《Highly Substituted Acephenanthrylenes and Their π-Extended Derivatives: Syntheses, Structural Analyses, and Properties》, and you may find the article in Organic Letters.Formula: C6H4BrI The information in the text is summarized as follows:

This investigation demonstrates that a series of (highly) substituted acephenanthrylenes (APs) e.g., I, benzo[l]acephenanthrylene II (R1 = 4-methylphenyl) and dicyclopenta[cd,mn]pyrene III (R2 = 4-pentylphenyl) was easily prepared by palladium-catalyzed cycloaromatization of 2,3-diethynylbiphenyls 2,3-(CCAr)2-4-R1-5-R2-6-R3-CR. The first nonpyrolysis synthesis of III by two-fold cycloaromatization was achieved in a high yield. This synthetic protocol has two crucial advantages: facile introduction of various substituents and efficient extension of the AP backbone. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Formula: C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Formula: C6H4BrI Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alterman, Joshua L.; Kraus, George A. published an article in 2022. The article was titled 《A Convenient Procedure for Sonogashira Reactions Using Propyne》, and you may find the article in Synthesis.Recommanded Product: 625-99-0 The information in the text is summarized as follows:

A modified Sonogashira coupling of aryl iodides and propyne was achieved using only two equivalent of propyne in THF from -78°C to room temperature The results came from multiple reactions, including the reaction of 1-Chloro-3-iodobenzene(cas: 625-99-0Recommanded Product: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Elius Hossain, Md.; Guo, Zhifang; Wang, Jun; Deacon, Glen B.; Junk, Peter C. published an article in 2022. The article was titled 《Synthesis and characterization of η6-arene(halogenidoaluminato)lanthanoid(II) and alkaline earth(II) complexes》, and you may find the article in Polyhedron.Electric Literature of C2H4I2 The information in the text is summarized as follows:

η6-Arene(iodidoaluminato)lanthanoid(II) complexes, {[Ln(η6-C6H5Me)(AlI4)2]}n [Ln = Sm, 1, Eu, 2, Yb, 3; C6H5Me = toluene] have been prepared by reactions of in situ generated aluminum triiodide with the corresponding lanthanoid metals and 1,2-diiodoethane in toluene (molar ratio: 2:1:1). Compounds 1-3 are polymeric and the lanthanoid(II) atom of 1 and 2 is coordinated by an η6-arene and three chelating κ (I, I’) tetraiodidoaluminate ligands, two of which are also bridging (LnI2AlI2Ln) and one is terminal. 3 Is coordinated by an η6-arene, one terminal chelating κ (I, I’) and one chelating and bridging (YbI2AlI2Yb) tetraiodidoaluminate ligand, and one monodentate tetraiodidoaluminate ligand, which is also bridging (YbIAl(I)I2Yb). These are the first x-ray crystal structures of arene(tetrakisiodidoaluminato)lanthanoid(II) complexes. The first reported alk. earth(II) (η6-arene)iodidoaluminate complexes, namely [Ca(η6-C6H5Me)(AlI4)2]n (4), {[Sr(η6-C6H5Me)(AlI4)2]n·nPhMe} (5), [Ba(η6-C6H5Me)2(AlI4)2] (6), [Ca(η6-C6H3Me3-1,3,5)(AlI4)2]n (7) and {[Sr(η6-C6H3Me3-1,3,5)(AlI4)2]n·0.5n(PhMe3)} (8) have also been obtained in an arene (toluene or mesitylene) solution by a similar method. Complex 4 is isocoordinate with 3, and 5 is isomorphous with 2. Complex 7 has eight coordinate Ca similar to 4, and complex 8 has nine coordinate Sr as in 5. Mononuclear ten coordinate complex 6 is the first example of a monomeric η6-arene sandwich complex of barium. The EuII bromidoaluminate complex {[Eu(η6-C6H5Me)(AlBr4)2]n·0.5nPhMe} (9) has been prepared from Eu metal, AlBr3, and BrCH2CH2Br in toluene and has a unit cell similar to 8 despite the different metal and arene. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Electric Literature of C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Electric Literature of C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Lee, Jaehee; Ju, Xuan; Lee, Miseon; Jiang, Qi; Jang, Hwanjong; Kim, Wan Shin; Wu, Linglin; Williams, Suja; Wang, Xiao-Jun; Zeng, Xingzhong; Payne, Jenna; Han, Zhengxu S. published an article in Organic Letters. The title of the article was 《Copper Catalyzed Regioselective and Stereospecific Aziridine Opening with Pyridyl Grignard Nucleophiles》.Related Products of 15854-87-2 The author mentioned the following in the article:

Copper catalyzed regioselective and stereospecific coupling between aziridines and in-situ generated pyridine Grignard reagents was reported. This method provided β-pyridylethylamines with diverse structures and functionalities from aziridines and iodopyridines. The β-pyridylethylamines were potential scaffolds for the synthesis of biol. active compounds often found in pharmaceuticals. The synthesis of challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed by nucleophilic cyclization.4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Hu, Weiming; Wang, Xilong; Peng, Yan; Luo, Shuang; Zhao, Jiaji; Zhu, Qiang published an article in Organic Letters. The title of the article was 《Synthesis of 7-Arylthiomethyl Dibenzo[b,d]azepines through Imidoylative Heck Cyclization and CPA-Catalyzed Thio-Michael Addition/Enantioselective Protonation》.SDS of cas: 15164-44-0 The author mentioned the following in the article:

Diversified 7-[(arylthio)methyl]-7H-dibenzo[b,d]azepines I (R1 = Ph, 4-MeO2CC6H4, 3,4-Cl2C6H4, etc.; R2 = Ph, 4-MeC6H4, 2-ClC6H4, 4-pyridinyl, etc.) bearing a benzylic stereocenter and a thermodynamically regulated biaryl axis were produced via chiral phosphoric acid-catalyzed thio-Michael addition/enantioselective protonation of unsaturated imines II with aryl thiols R2SH in good to excellent enantioselectivity and 14-25:1 diastereoisomeric ratios. The compounds II were in turn prepared by palladium-catalyzed heterocyclization of 2-isocyano-2′-vinyl-1,1′-biphenyl with a variety of aryl iodides R1I. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0SDS of cas: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.SDS of cas: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Peng, Dao; Zhang, Yu; Liu, Xiao-Qing; Shang, Hang; Lin, Gang; Jin, Hong-Ying; Liu, Xue-Fen; He, Ran; Shang, Ye-Han; Xu, Yin-Hua; Luo, Shu-Ping published an article in Molecular Catalysis. The title of the article was 《Highly active and reusable copper phthalocyanine derivatives catalyzed the hydroxylation of (hetero)aryl halides》.Product Details of 626-02-8 The author mentioned the following in the article:

Authors have researched and developed a series of copper phthalocyanine derivatives as new highly active and reusable catalysts for the hydroxylation of (hetero)aryl halides. The perfluorinated copper phthalocyanine (CuPcF16) showed the highest activity for the hydroxylation of aryl iodide with an excellent yield (up to 98%) under low catalytic loading (0.5 mol% CuPcF16). Similarly, the hydroxylation of aryl bromides and aryl chlorides catalyzed by CuPcF16 also had high activity with 42-98% yield. Moreover, the recyclability of this catalyst can up to 6 times without significant loss in catalytic activity. In addition to this study using 3-Iodophenol, there are many other studies that have used 3-Iodophenol(cas: 626-02-8Product Details of 626-02-8) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Product Details of 626-02-8 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com