Month: October 2022

In 2019,Green Chemistry included an article by Lang, Xian-Dong; You, Fei; He, Xing; Yu, Yi-Chen; He, Liang-Nian. Quality Control of 1-Bromo-4-iodobenzene. The article was titled 《Rhodium(I)-catalyzed Pauson-Khand-type reaction using formic acid as a CO surrogate: an alternative approach for indirect CO2 utilization》. The information in the text is summarized as follows:

Formic acid was found to be an ideal CO surrogate for the rhodium(I)-catalyzed Pauson-Khand-type (PK-type) reaction of various substituted 1,6-enynes to afford bicyclic cyclopentenones I [R = Ph, 2-MeOC6H4, 4-BrC6H4, etc.] and II [R1 = Ph, 4-FC6H4 2-ClC6H4, etc.] in moderate to good yields. High TON value up to 263 and good results in the gram-scale experiment were also obtained. In addition, heterocyclic mols. of pharmaceutical importance were also furnished via inter- or intra-mol. hetero-PK-type reactions, further broadening the application of current strategy. Formic acid was utilized as a bridging mol. for the conversion of CO2 to CO, since formic acid was manufactured via catalytic hydrogenation of CO2 and released CO in the presence of acetic anhydride readily. Therefore, this methodol. represented a green and indirect approach for chem. valorization of CO2 in the preparation of value-added compounds In addition to this study using 1-Bromo-4-iodobenzene, there are many other studies that have used 1-Bromo-4-iodobenzene(cas: 589-87-7Quality Control of 1-Bromo-4-iodobenzene) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesQuality Control of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic Letters included an article by Chen, Yanchi; Su, Lei; Gong, Hegui. Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate. The article was titled 《Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO》. The information in the text is summarized as follows:

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Halogen-containing BODIPY derivatives for photodynamic therapy》 were Gorbe, Monica; Costero, Ana M.; Sancenon, Felix; Martinez-Manez, Ramon; Ballesteros-Cillero, Rafael; Ochando, Luis E.; Chulvi, Katherine; Gotor, Raul; Gil, Salvador. And the article was published in Dyes and Pigments in 2019. Related Products of 516-12-1 The author mentioned the following in the article:

Two iodinated (1 and 2) and two brominated (3 and 4) BODIPY-based photosensitizers are prepared and characterized using slightly modified synthetic procedures previously described. 1-4 present intense absorption bands in the 510-540 nm interval and very weak emissions due to the presence of halogen atoms in their structure. Irradiation of aqueous solutions of 1-4 with visible light (wavelength > 475 nm) induce the generation of singlet oxygen with quantum yields of ca. 0.62-0.66 for the photosensitizers containing iodine atoms (1 and 2) and of ca. 0.16-0.21 for the brominated counterparts (3 and 4). In vitro studies carried out with HeLa, SCC-13 and HaCaT cell lines and the four photosensitizers show marked reductions in cell viability with lower IC50 values for the iodinated derivatives (in the 0.82-2.51 range) than those found for the brominated compounds (in the 0.91-8.26 range) suggesting that these compounds could be used in photodynamic therapy protocols. Subcellular localization studies carried out using confocal microscopy show that photosensitizers accumulated in the endoplasmic reticulum.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1) was used in this study.

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Iodophenylsulfonates and iodobenzoates as redox-active supporting electrolytes for electrosynthesis》 were Roesel, Arend F.; Broese, Timo; Majek, Michal; Francke, Robert. And the article was published in ChemElectroChem in 2019. Formula: C7H5IO2 The author mentioned the following in the article:

Hypervalent iodine compounds constitute a popular class of reagents in organic chem. Regardless of whether they are generated in situ from an iodoarene precursor with a terminal oxidant or used in stoichiometric amounts, the resulting separation and waste issues are major challenges en route to sustainable and scalable processes. The electrochem. generation of iodine(III) compounds represents an attractive alternative, since elec. current is used as traceless oxidant and unstable or hazardous species are conveniently generated in situ. In this context, we have explored the possibility for the use of iodoarene sulfonates and iodobenzoates as ex-cell mediators for electrosynthesis in 1,1,1,3,3,3-hexafluoroisopropanol. While 2-, 3- and 4-iodobenzoate salts proved to be impractical for various reasons, 2- and 4-iodobenzenesulfonates salts can be selectively oxidized to the iodine(III) species and used for synthetic applications. The ionic tag on the mediator allows for electrolysis without supporting electrolyte additives and enables a straightforward recovery from the product mixture The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Phosphorus corrole complexes: from property tuning to applications in photocatalysis and triplet-triplet annihilation upconversion》 were Mahammed, Atif; Chen, Kepeng; Vestfrid, Jenya; Zhao, Jianzhang; Gross, Zeev. And the article was published in Chemical Science in 2019. Reference of 1-Iodopyrrolidine-2,5-dione The author mentioned the following in the article:

Efficient triplet photosensitizers are important for fundamental photochem. studies and applications such as triplet-triplet annihilation upconversion (TTA UC), photoredox catalytic organic reactions and photovoltaics. We now report a series of phosphorus corrole compounds as efficient visible light-harvesting metal-free triplet photosensitizers. While the heavy-atom-free phosphorus corroles show absorption in the visible spectral region (centered at 573 nm) and have a decent triplet state quantum yield (ΦΔ = 49%), iodo-substitution on the corrole core induces red-shifted absorption (589 nm) and improves intersystem crossing significantly (ΦΔ = 67%). Nanosecond transient absorption spectra confirm triplet state formation upon photoexcitation (τT = 312 μs) and the iodinated derivatives also display near IR phosphorescence in fluid solution at room temperature (λem = 796 nm, τp = 412 μs). Both singlet oxygen (1O2) and superoxide radical anions (O2- ·) may be produced with the phosphorus corroles, which are competent photocatalysts for the oxidative coupling of benzylamine (the Aza Henry reaction). Very efficient TTA UC was observed with the phosphorus corroles as triplet photosensitizers and perylene as the triplet acceptor, with upconversion quantum yields of up to ΦUC = 38.9% (a factor of 2 was used in the equation) and a very large anti-Stokes effect of 0.5 eV. In the experimental materials used by the author, we found 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Reference of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Reference of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of (het)aryl 2-(2-hydroxyaryl)cyclopropyl ketones》 was published in Molecules in 2020. These research results belong to Fadeev, Alexander A.; Chagarovskiy, Alexey O.; Makarov, Anton S.; Levina, Irina I.; Ivanova, Olga A.; Uchuskin, Maxim G.; Trushkov, Igor V.. Electric Literature of C3H9IOS The article mentions the following:

A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes I [R = 5-F, 5-NO2, 3-OMe, etc.; Ar = Ph, 4-OMeC6H4, 2-thienyl], which belong to the donor-acceptor cyclopropane family, was developed. This method, based on the Corey-Chaykovsky cyclopropanation of 2-hydroxychalcones, allowed for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which could serve as promising building blocks for the synthesis of various bioactive compounds In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Electric Literature of C3H9IOS) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Electric Literature of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides》 was published in Organic Letters in 2020. These research results belong to Huang, Wenyi; Wang, Yun; Weng, Yangyang; Shrestha, Mohini; Qu, Jingping; Chen, Yifeng. Name: tert-Butyl 4-iodopiperidine-1-carboxylate The article mentions the following:

Herein, disclosed a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, e.g., I, which proceeded via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction featured wide functional group tolerance under mild conditions. Addnl., the selective, one-pot hydrolysis of reaction mixture under acid conditions allowed for expedient synthesis of the corresponding alkyl carboxylic acid. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Name: tert-Butyl 4-iodopiperidine-1-carboxylate)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Name: tert-Butyl 4-iodopiperidine-1-carboxylate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Binuclear Palladium Complex Immobilized on Mesoporous SBA-16: Efficient Heterogeneous Catalyst for the Carbonylative Suzuki Coupling Reaction of Aryl Iodides and Arylboronic Acids Using Cr(CO)6 as Carbonyl Source》 was published in Catalysis Letters in 2020. These research results belong to Niakan, Mahsa; Asadi, Zahra; Emami, Mohammad. Application of 624-31-7 The article mentions the following:

A binuclear palladium complex immobilized on organo-functionalized SBA-16 was prepared and structurally characterized by routine techniques. Characterizations indicated that the mesostructure of SBA-16 was maintained after the immobilization of palladium complex. Then, the prepared nanomaterial was applied as a heterogeneous catalyst in the carbonylative Suzuki coupling reaction of aryl iodides RI with arylboronic acids R1B(OH)2 using Cr(CO)6 as carbonyl source to afford diaryl ketones RC(O)R1 [R = Ph, 4-MeC6H4, 4-ClC6H4, 2-H2NC6H4, etc.; R1 = Ph, 4-EtC6H4, 4-F3CC6H4] in excellent yields. Moreover, the catalyst was readily recovered by filtration and could be reused for seven cycles without losing its structural integrity and catalytic activity. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Application of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Application of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Estimated Survival and Major Comorbidities of Very Preterm Infants Discharged Against Medical Advice vs Treated With Intensive Care in China.》 was written by Jiang, Siyuan; Huang, Xiangyuan; Zhang, Lan; Han, Junyan; Yang, Yi; Wang, Weiping; Lee, Shoo K; Yan, Weili; Cao, Yun; Reduction of Infection in Neonatal Intensive Care Units Using the Evidence-Based Practice for Improving Quality (REIN-EPIQ) Study Group. Safety of 1,2-Diiodoethane And the article was included in JAMA network open in 2021. The article conveys some information:

Importance: A significant proportion of very preterm infants (<32 weeks' gestation) are discharged against medical advice (DAMA) from neonatal intensive care units in China. There is minimal information available on the potential outcomes of providing complete care before discharge in these infants. Objective: To describe potential neonatal outcomes of DAMA in very preterm infants if they receive complete care based on estimates derived from a group of propensity score-matched infants who are not DAMA. Design, Setting, and Participants: This cohort study enrolled all infants born at between 24 and 31 weeks' gestation from May 1, 2015, to April 30, 2018, and admitted to 25 tertiary neonatal intensive care units across China within 7 days of birth. A multilevel mixed-effects logistic regression model was constructed to estimate the propensity score for the likelihood of DAMA for each infant. Infants who were not DAMA were then matched to DAMA infants with the closest propensity score on a 1:1 ratio by using a nearest neighbor greedy matching algorithm without replacement. Incidences of neonatal outcomes were then calculated among the matched non-DAMA infants to simulate the outcomes of DAMA infants. Statistical analyses were performed from August 16, 2020, to September 26, 2020. Exposures: Discharge against medical advice, which was defined as termination of treatment and discharge before the treating physicians recommended discharge. Main Outcomes and Measures: Survival and survival without major morbidity. Results: The study enrolled a total of 14 083 infants (8141 boys [57.8%]) with a median gestational age of 30.1 weeks (interquartile range [IQR], 29.0-31.1 weeks) and a median birth weight of 1400 g (IQR, 1170-1600 g). Overall, 1876 of 14 083 very preterm infants (13.3%; 95% CI, 12.8%-13.9%) were DAMA, of whom 1367 of 1876 (72.9%; 95% CI, 70.8%-74.8%) required intensive care on discharge. A total of 1473 DAMA infants were successfully matched to 1473 non-DAMA infants. Overall, 1211 of 1473 matched non-DAMA infants (82.2%; 95% CI, 80.2%-84.1%) survived to discharge. The survival rates were 68.3% (95% CI, 62.4%-73.7%) for infants at 26 to 27 weeks' gestation, 84.1% (95% CI, 80.7%-87.0%) for infants 28 to 29 weeks' gestation, and 92.4% (95% CI, 90.0%-94.2%) for infants at 30 to 31 weeks' gestation. A total of 872 of 1473 matched non-DAMA infants (59.2%; 95% CI, 56.7%-61.7%) survived without any major morbidity. Conclusions and Relevance: The results of this cohort study suggest that very preterm infants who are DAMA from neonatal intensive care units may have intact survival if complete care is provided. Efforts to reduce DAMA may be associated with improved outcomes of very preterm infants in China. After reading the article, we found that the author used 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jia, Xiangqing; Zhang, Ziyan; Gevorgyan, Vladimir published their research in ACS Catalysis in 2021. The article was titled 《Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes》.HPLC of Formula: 301673-14-3 The article contains the following contents:

A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeded via the in situ formation of a reactive ketenimine intermediate, allowed for a rapid construction of a broad range of valuable amides I [Ar = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R1 = n-Bu, i-Bu, 2,2-dimethylpropyl, etc.; R2 = t-Bu, 1-adamantyl, 1,1,3,3-tetramethylbutyl] and nitriles II [Ar1 = Ph, 4-FC6H4, 4-ClC6H4, 4-MeOC6H4, (6-methoxy-3-pyridyl); R3 = n-Bu, cyclohexyl, 2,2-dimethylpropyl, trimethylsilylmethyl, phenethyl] from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated. In addition to this study using tert-Butyl 4-iodopiperidine-1-carboxylate, there are many other studies that have used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3HPLC of Formula: 301673-14-3) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.HPLC of Formula: 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com