Month: October 2022

In 2022,Zeng, Minfeng; Yang, Shuai; Chen, Yuli; Xu, Mengdie; Zhao, Jing; Zhang, Taojun; Sun, Kailang; Yang, Zhen; Zhang, Peng; Cao, Xingzhong; Wang, Baoyi published an article in Applied Clay Science. The title of the article was 《Porous chitosan-derived activated N-doped carbon-supported Pd nanoparticles encaged in Al, Fe pillared montmorillonite as novel heterogeneous catalysts》.Electric Literature of C6H4BrI The author mentioned the following in the article:

Novel pillared montmorillonite encaging porous chitosan derived activated N-doped carbon-supported Pd nanoparticles catalyst (Pd@Al, Fe-Mt/N-C) was synthesized by ion-exchange of the chitosan/Pd precursors into the layered-nanospaces of Al, Fe-pillared montmorillonite and subsequent confinement carbonization. N2 adsorption-desorption study indicated that the resulting nanocomposites have rich mesoporous structures. Effective encagement and in-situ reduction of Pd species led to a decrease in surface area and N2 adsorption, resp. TEM images of the prepared showed that most of the Pd species with a size of 1-3 nm were well dispersed in the interlayer spaces of the pillared montmorillonite. The catalysts showed high catalytic efficiency for the Sonogashira reactions of aryl iodides or bromides with terminal aryl alkynes, and can be recycled 20 runs with no significant loss of activities. The unique encagement of the porous carbon-supported metal catalysts in the layered nanospaces of pillared montmorillonite was further elucidated by the positron annihilation spectroscopy anal. and other structural characterization methods. This layered-nanospace confinement strategy achieves a perfect combination of the advantages of activated carbon and montmorillonite as metal nanoparticle carrier. In addition to this study using 1-Bromo-3-iodobenzene, there are many other studies that have used 1-Bromo-3-iodobenzene(cas: 591-18-4Electric Literature of C6H4BrI) was used in this study.

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Electric Literature of C6H4BrI Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Gugkaeva, Zalina T.; Mardiyan, Zorayr Z.; Smolyakov, Alexander F.; Poghosyan, Artavazd S.; Saghyan, Ashot S.; Maleev, Victor I.; Larionov, Vladimir A. published an article in Organic Letters. The title of the article was 《Sequential Heck Cross-Coupling and Hydrothiolation Reactions Taking Place in the Ligand Sphere of a Chiral Dehydroalanine Ni(II) Complex: Asymmetric Route to β-Aryl Substituted Cysteines》.HPLC of Formula: 90-14-2 The author mentioned the following in the article:

A practically useful protocol for the asym. synthesis of artificial β-aryl-substituted cysteine derivatives was developed through sequential Pd(II)-catalyzed Heck cross-coupling with aryl iodides and hydrothiolation reaction with various alkyl thiols in the presence of triethylamine taking place in the ligand sphere of a robust and bench-stable chiral dehydroalanine Ni(II) complex. The subsequent acidic decomposition of the single diastereomeric Ni(II) complexes led to the target enantiopure cysteine derivatives The experimental part of the paper was very detailed, including the reaction process of 1-Iodonaphthalene(cas: 90-14-2HPLC of Formula: 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.HPLC of Formula: 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Kumar, Rajesh; Sayala, Kapil Dev; Tang, Houliang; Tsarevsky, Nicolay V. published an article in Polymer International. The title of the article was 《Hypervalent iodine-based initiators and efficient chain transfer agents for the synthesis of branched polymers from crosslinkers》.Quality Control of 2-Iodobenzoic acid The author mentioned the following in the article:

The synthesis of hyperbranched polymers with alkyl chloride-type chain ends was accomplished by the copolymerization of Me methacrylate and a crosslinker, ethylene glycol dimethacrylate, in the presence of 1-chloro-1,2-benziodoxol-3(1H)-one (BIO-Cl), which served as both a radical initiator and an efficient chain transfer agent. The polymerizations were carried out under thermal (80°C) and photochem. (irradiation with visible light) conditions. As a result of the transfer of Cl atoms from BIO-Cl to the propagating radicals, gelation was delayed to high monomer conversions and, until that point, soluble branched polymers were formed. Even pure crosslinker could be polymerized to moderate conversions (>15%, depending on the amount of added BIO-Cl), yielding branched polymers prior to formation of networks. The effect of the concentrations of crosslinker and hypervalent iodine(III) compound on the outcome of the (co)polymerizations as well as the kinetic features of Cl transfer and decomposition of BIO-Cl were studied in detail. 2022 Society of Industrial Chem. The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5Quality Control of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Quality Control of 2-Iodobenzoic acidHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Schmalz, Veronika; Koert, Ulrich published an article in Organic Letters. The title of the article was 《Visible-Light Induced Photoannulation of α-Naphthyl Cyclopropane Carboxylic Esters to Functionalized Dihydrophenalenes》.Synthetic Route of C3H9IOS The author mentioned the following in the article:

A general synthetic entry to functionalized dihydrophenalenes was founded using naphthyl-cyclopropane esters as starting materials. The desired annulation were possible with visible light, Ir(Fppy)3 as photocatalyst and BnNMe2 or DABCO as electron donor, HAT-catalyst and proton source. A broad scope of substituted naphthyl and azanaphthyl derivatives provided the photoannulation products in high yield. Deuteration studies supported a photoredox-mechanism involved the photoreductive cyclopropane opening to an enolate radical followed by an aryl radical trapping. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Synthetic Route of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Huang, Long-Ling; Lin, Peng-Peng; Li, Yu-Xin; Feng, Si-Xin; Tu, Fang-Hai; Yang, Shuang; Zhao, Gui-Yang; Huang, Zhi-Shu; Wang, Honggen; Li, Qingjiang published an article in Organic Letters. The title of the article was 《Oxidative Fluoroarylation of Benzylidenecyclopropanes with HF·Py and Aryl Iodides via Iodonio-[3,3]-Rearrangement》.Application In Synthesis of 4-Iodobenzaldehyde The author mentioned the following in the article:

Reported herein is an in situ-generated hypervalent iodine-incorporating fluoroarylation of benzylidenecyclopropanes using com. available HF·Py and aryl iodides as fluorine and aryl sources, resp. The reaction proceeds via regioselective 1,2-fluoroiodination of a double bond followed by an iodonio-[3,3]-rearrangement of the formed cyclopropyl-I(III) species. The protocol offers facile access to valuable monofluorinated 1,1-bis-benzyl-alkenes with mild reaction conditions and moderate to good yields. The synthetic utility of the products was demonstrated by further transformations. Preliminary mechanistic studies were conducted. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Application In Synthesis of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Application In Synthesis of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Javed; Khanam, Ariza; Mandal, Pintu Kumar published an article in Journal of Organic Chemistry. The title of the article was 《Glycosyl 3-Phenyl-4-pentenoates as Versatile Glycosyl Donors: Reactivity and Their Application in One-Pot Oligosaccharide Assemblies》.Product Details of 516-12-1 The author mentioned the following in the article:

Both glycoconjugates and oligosaccharides are important biomols. having significant roles in several biol. processes, and a new strategy for their synthesis is crucial. Here, we report a versatile N-iodosuccinimide/trimethylsilyl triflate (NIS/TMSOTf) promoted glycosidation approach with shelf-stable 3-phenyl-4-pentenoate glycosyl as a donor for the efficient synthesis of O/C-glycosides with free alcs., silylated alcs., and C-type nucleophile acceptors in good to excellent yields. The mild activation conditions and outstanding reactivity of Ph substituted pentenoate donors analogous to 4-pentenoate glycosyl donors enhance their applicability to various one-pot strategies for the synthesis of oligosaccharides, such as single-catalyst one-pot and acceptor reactivity-controlled one-pot strategies. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Product Details of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Product Details of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Meng, Fan-Yi; Chen, I-Han; Shen, Jiun-Yi; Chang, Kai-Hsin; Chou, Tai-Che; Chen, Yi-An; Chen, Yi-Ting; Chen, Chi-Lin; Chou, Pi-Tai published an article in Nature Communications. The title of the article was 《A new approach exploiting thermally activated delayed fluorescence molecules to optimize solar thermal energy storage》.SDS of cas: 589-87-7 The author mentioned the following in the article:

We propose a new concept exploiting thermally activated delayed fluorescence (TADF) mols. as photosensitizers, storage units and signal transducers to harness solar thermal energy. Mol. composites based on the TADF core phenoxazine-triphenyltriazine (PXZ-TRZ) anchored with norbornadiene (NBD) were synthesized, yielding compounds PZDN and PZTN with two and four NBD units, resp. Upon visible-light excitation, energy transfer to the triplet state of NBD occurred, followed by NBD → quadricyclane (QC) conversion, which can be monitored by changes in steady-state or time-resolved spectra. The small S1-T1 energy gap was found to be advantageous in optimizing the solar excitation wavelength. Upon tuning the mol.′s triplet state energy lower than that of NBD (61 kcal/mol), as achieved by another composite PZQN, the efficiency of the NBD → QC conversion decreased drastically. Upon catalysis, the reverse QC → NBD reaction occurred at room temperature, converting the stored chem. energy back to heat with excellent reversibility. The results came from multiple reactions, including the reaction of 1-Bromo-4-iodobenzene(cas: 589-87-7SDS of cas: 589-87-7)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..SDS of cas: 589-87-7 It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 1,2-DiiodoethaneIn 2016 ,《A fast controlled synthesis of poly(p-phenyleneethynylene)s under transition-metal-free conditions》 appeared in Polymer Chemistry. The author of the article were Motoshige, Asahi; Kakinuma, Junko; Iyoda, Tomokazu; Sanji, Takanobu. The article conveys some information:

A transition-metal-free polymerization of an AB-type monomer for the synthesis of well-defined poly(p-phenyleneethynylene)s is described. The polymerization of 1-pentafluorophenylethynyl-4-[(trimethylsilyl)ethynyl]benzene with a catalytic amount of tetrabutylammonium fluoride or potassium t-butoxide in the presence of cryptand[2.2.2] affords polymers within a few minutes. When monitoring the polymerization, the mol. weight as a function of monomer conversion shows a linear relationship, where the polydispersity indexes are around 1.6. The polymerization proceeds predominantly via intramol. fluoride anion transfer to the polymer end. End capping of the active polymerization end is also demonstrated. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Recommanded Product: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 63069-48-7In 2021 ,《Palladium-catalyzed carbonylative synthesis of quinazolines: Silane act as better nucleophile than amidine》 appeared in Molecular Catalysis. The author of the article were Lu, Jia-Ming; Huo, Yong-Wang; Qi, Xinxin; Wu, Xiao-Feng. The article conveys some information:

A palladium-catalyzed reductive carbonylation reaction has been developed for the synthesis of quinazolines I (R = Ph, 3-fluorophenyl, 4-methylphenyl, naphthalen-2-yl, etc.; R1 = H, Me, F, Cl; R2 = H, Me, F). With N-(2-iodophenyl)benzimidamides 2-I-3-R14-R2-C6H2NHC(=NH)R as starting materials, a series of quinazolines I were obtained through the aromatic aldehyde intermediates in moderate to good yields with good functional group compatibilities. In this system, silane act as better nucleophile than amidine. The experimental part of the paper was very detailed, including the reaction process of 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C5H4INIn 2022 ,《Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications》 was published in Nature Communications. The article was written by Xu, Yuling; Li, Chonglu; Lu, Shuai; Wang, Zhizheng; Liu, Shuang; Yu, Xiujun; Li, Xiaopeng; Sun, Yao. The article contains the following contents:

Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com