Month: October 2022

Synthetic Route of C5H5IN2OOn September 30, 2013 ,《Methylenepyran based dipolar and quadrupolar dyes: synthesis, electrochemical and photochemical properties》 was published in Tetrahedron. The article was written by Gauthier, Sebastien; Vologdin, Nikolay; Achelle, Sylvain; Barsella, Alberto; Caro, Bertrand; Robin-le Guen, Francoise. The article contains the following contents:

This paper presents the synthesis of a series of push-pull and quadrupolar π-conjugated structures incorporating pro-aromatic methylenepyran electron-donor groups and various electron-attracting groups. Some of the methylenepyran derivatives were oxidized by I2 to give, after reduction by Na2S2O3, bismethylenepyran compounds via successive steps. The electrochem. redox properties of methylenepyrans 5-9 and extended bismethylenepyrans 10, 14, and 15 determined by cyclic voltammetry indicate the formation of redox bistable systems with high bi-stability. Oxidation of the dimers obtained from 5 to 9 was also described. All compounds are colored and slightly fluorescent (except some bismethylenepyran derivatives). Some compound second-order nonlinear optical properties were investigated, and large pos. values of μβ were obtained. A pos. dimer effect was also observed for bispyran derivatives In the experimental materials used by the author, we found 4-Iodo-6-methoxypyrimidine(cas: 161489-05-0Synthetic Route of C5H5IN2O)

4-Iodo-6-methoxypyrimidine(cas: 161489-05-0) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Synthetic Route of C5H5IN2O

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 189518-78-3On September 16, 2011 ,《Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-Appended Enones》 was published in Organic Letters. The article was written by Lundy, Brian J.; Jansone-Popova, Santa; May, Jeremy A.. The article contains the following contents:

An enantioselective addition of alkenylboronic acids and alkynylboronic esters to unprotected indole-appended enones is reported. This transformation proceeds with high enantioselectivity and high product yields via the use of catalytic amounts of 3,3′-bis(pentafluorophenyl)-BINOL and Mg(Ot-Bu)2. A range of α-branched indole derivatives, e.g., I, are available from the transformation.(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3HPLC of Formula: 189518-78-3) was used in this study.

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.HPLC of Formula: 189518-78-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 189518-78-3On March 20, 2020, Osakabe, Hiroto; Saito, Shota; Miyagawa, Masamichi; Suga, Takuya; Uchikura, Tatsuhiro; Akiyama, Takahiko published an article in Organic Letters. The article was 《Enantioselective Dehydroxyhydrogenation of 3-Indolylmethanols by the Combined Use of Benzothiazoline and Chiral Phosphoric Acid: Construction of a Tertiary Carbon Center》. The article mentions the following:

An enantioselective hydrogen transfer reaction of indolylmethanol, I (R = H, Me, Bn; R1 = Me, i-Pr, Ph, t-Bu; Ar = C6H5, 4-ClC6H4, CCC6H5, etc.; X = H, Me, OMe, Br) which is characterized by the combined use of 2,3-dihydro-2-(2-naphthalenyl)benzothiazole and a newly synthesized chiral phosphoric acid II (Y = 4-Ph-2,6-(i-Pr)2C6H2) has been described. The reaction furnished indoles (R)-III bearing a chiral tertiary carbon center at the 3-position in high to excellent yields and with excellent enantioselectivities, most of which are greater than 95% ee. The chiral indole (R)-III (R = Me; R1 = t-Bu; Ar = 4-BrC6H4; X = H) was converted into an inhibitor of leukotriene production while retaining excellent ee.(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3SDS of cas: 189518-78-3) was used in this study.

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.SDS of cas: 189518-78-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Polymer Chemistry included an article by Meng, Fandian; Li, Yunzhi; Zhang, Wenjie; Li, Shuhua; Quan, Yiwu; Cheng, Yixiang. Application In Synthesis of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene. The article was titled 《Circularly polarized luminescence based chirality transfer of the chiral BINOL moiety via rigid π-conjugation chain backbone structures》. The information in the text is summarized as follows:

Three kinds of chiral BINOL-based polymers could be synthesized by polymerization in a Pd-catalyzed cross-coupling reaction. The resulting chiral polymers can exhibit strong mirror image Cotton effects. Interestingly, only P2 and P3 can emit circularly polarized luminescence (CPL) signals, which can be attributed to the chirality transfer of the BINOL moiety via the rigid π-conjugation chain backbone structure system. This work can develop a new strategy for the design of novel CPL materials. The results came from multiple reactions, including the reaction of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3Application In Synthesis of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Application In Synthesis of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Broman, Soeren Lindbaek; Andersen, Cecilie Lindholm; Jevric, Martyn; Tortzen, Christian Gregers; Hammerich, Ole; Nielsen, Mogens Broendsted published 《Metal cation binding to acetylenic tetrathiafulvalene-pyridine conjugates: affinity tuned by preorganization and cavity size》.Tetrahedron published the findings.Electric Literature of C2H4I2 The information in the text is summarized as follows:

A series of three structurally related mono-, bidentate and macrocyclic TTF-pyridine hosts were prepared and titrated with several metal cations including Ag+ and Pb2+ and studied using NMR- and UV-vis spectroscopy and cyclic voltammetry. For Ag+, we found an eightfold increase in binding affinity between the bidentate and macrocyclic host and conversely, for Pb2+, a 100-fold drop. D. functional theory (DFT) calculations support the increased binding affinity for Ag+ is due to an N···N distance for the uncomplexed macrocycle very much suited for binding of Ag+ but being too small for Pb2+. The bidentate host, on the other hand, is of a suitable size for Pb2+.1,2-Diiodoethane(cas: 624-73-7Electric Literature of C2H4I2) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Pick, Fraser S.; Leznoff, Daniel B.; Fryzuk, Michael D. published 《Redox behaviour of ([fc(NPiPr2)2]Fe)2, formation of an iron-iron bond and cleavage of azobenzene》.Dalton Transactions published the findings.Recommanded Product: 1,2-Diiodoethane The information in the text is summarized as follows:

The redox behavior of the dimeric tetrairon complex, ([fc(NPiPr2)2]Fe)2 (where fc(NPiPr2)2 = 1,1′-(C5H4NPiPr2)2Fe) has been investigated. Upon reduction with KC8 an Fe-Fe bond is formed with the complex maintaining a high spin configuration and having the formula [K(THF)6]([fc(NPiPr2)2]Fe)2. In contrast, oxidation of the complex is ligand based; for example, addition of the 1,2-diiodoethane (I2 equivalent) results in the formation of the monomeric iron(II) diiodide [fc(NiPr2I)2]FeI2 wherein the phosphine is oxidized. The dimeric tetrairon complex reacts photolytically with azobenzene, cleaving the N:N double bond and forming the new monomeric bis(phosphoramidate) iron complex. [fc(NP(NPh)iPr2)2]Fe. Characterization of these paramagnetic complexes was accomplished by magnetic susceptibility studies and x-ray analyses. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,New Journal of Chemistry included an article by Li, Ze-Lin; Wu, Peng-Yu; Cai, Chun. COA of Formula: C4H4INO2. The article was titled 《Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes》. The information in the text is summarized as follows:

A straightforward Ni(II)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes such as benzamide, benzenesulfonamide, Me benzoate, etc. with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described. The experimental process involved the reaction of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1COA of Formula: C4H4INO2)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. COA of Formula: C4H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Palladium-catalyzed reductive Heck reaction of α,β-unsaturated alkenes and cycloalkyl iodides》 were Liu, Zhenwei; Wei, Shanshan; Liang, Apeng; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie. And the article was published in Tetrahedron Letters in 2019. Electric Literature of C10H18INO2 The author mentioned the following in the article:

The palladium catalyzed reductive Heck reactions of unactivated cycloalkyl iodides RI [R = cyclopentyl, Ph, 1-[(tert-butoxy)(oxo)methane]azetidin-3-yl, oxolan-3-yl, etc.] with α,β-unsaturated alkenes R1CH=CH2 [R1 = COOMe, CN, COOPh, C(O)Me, etc.] have been developed. A number of hydrocycloalkylated compounds RCH2CH2R1 were obtained in reasonable yields under the optimized conditions. The obvious advantage of this approach is that the hydride source was provided by Et3N and no other reductant or base was required in the reaction. In the experimental materials used by the author, we found tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Electric Literature of C10H18INO2)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Electric Literature of C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light》 was published in Chemical Science in 2020. These research results belong to Liang, Kangjiang; Liu, Qian; Shen, Lei; Li, Xipan; Wei, Delian; Zheng, Liyan; Xia, Chengfeng. Computed Properties of C5H4IN The article mentions the following:

The phenolate anion was discovered as a new photocatalyst with strong reduction potentials. Under visible light irradiation, the phenolate anion enabled the reduction of (hetero)aryl halides (including electron-rich aryl chlorides) to (hetero)aryl radicals through single electron transfer. Based on this new photocatalyst, a novel and efficient photocatalytic protocol for the intermol. oxyarylation of olefins with aryl halides and 1-hydroxy-2,2,6,6-tetramethylpiperidine was developed. The developed three-component coupling reaction proceeded under redox-neutral reaction conditions with stable and readily available synthons and exhibited broad substrate scope. The utility of this process was further highlighted by the diversified chem. manipulation of the resulting oxyarylation products and the late-stage modification of active pharmaceutical ingredients. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Computed Properties of C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Wu, Wei; Han, Xiaoyan; Weng, Zhiqiang. Application of 626-02-8 The article mentions the following:

A new strategy for the construction of pertrifluoromethyl pyridazine derivatives is presented. The tandem reaction starts from the condensation of arenediazonium salts with hexafluoroacetylacetone leading to the formation of pertrifluoromethyl pyridazinols, which readily underwent electrophilic substitution reactions with phenols to afford benzo[5,6]chromeno[3,4-c]pyridazine products in the presence of concd H2SO4. In the experiment, the researchers used 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Application of 626-02-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com