Month: October 2022

《Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques》 was published in Molecular Pharmaceutics in 2020. These research results belong to Jia, Jianhua; Zhang, Longfei; Song, Jia; Dai, Jiapei; Cui, Mengchao. Category: iodides-buliding-blocks The article mentions the following:

The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki < 100 nM) for Aβ1-42 aggregates, and some ligands even showed values of Ki less than 10 nM. Structure-activity relationship anal. revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.3-Iodophenol(cas: 626-02-8Category: iodides-buliding-blocks) was used in this study.

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Category: iodides-buliding-blocks In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Nickel-Catalyzed trans-Carboamination across Internal Alkynes to Access Multifunctionalized Indoles》 was written by Tambe, Shrikant D.; Iqbal, Naeem; Cho, Eun Jin. Synthetic Route of C6H5ClIN And the article was included in Organic Letters in 2020. The article conveys some information:

A Ni-catalyzed reaction was developed for the synthesis of multifunctionalized indoles. The reaction proceeded through oxidative cyclization of the Ni(0)/bidentate P-N complex with an enyne system, 2-alkynyl anilinoacrylate, to provide a nickelacycle intermediate. The trans-carboamination around the internal alkyne was achieved by syn/anti-rotation of the Ni-carbenoid intermediate formed by C-N bond cleavage of the nickelacycle, and 3-alkenylated indoles were formed by C-N bond-forming reductive elimination. Notably, the synthesized indoles could be successfully transformed to functionalized carbazoles. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Efficient Nondoped Pure Blue Organic Light-Emitting Diodes Based on an Anthracene and 9,9-Diphenyl-9,10-dihydroacridine Derivative》 was written by He, Xin; Ren, Shenghong; Liu, Hui; Zhao, Shiyuan; Liu, Futong; Du, Chunya; Min, Jiarui; Zhang, Haiquan; Lu, Ping. Related Products of 589-87-7 And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

Organic light-emitting diodes (OLEDs) have been greatly developed in recent years owing to their abundant advantages for full-color displays and general-purpose lightings. Blue emitters not only provide one of the primary colors of the RGB (red, green and blue) display system to reduce the power consumption of OLEDs, but are able to generate light of all colors, including blue, green, red, and white by energy transfer processes in devices. However, it remains a challenge to achieve high-performance blue electroluminescence, especially for nondoped devices. In this paper, we report a blue light emitting mol., DPAC-AnPCN, which consists of 9,9-diphenyl-9,10-dihydroacridine and p-benzonitrile substituted anthracene moieties. The asym. decoration on anthracene with different groups on its 9 and 10 positions combines the merits of the resp. constructing units and endows DPAC-AnPCN with pure blue emission, high solid-state efficiency, good thermal stability and appropriate HOMO and LUMO energy levels. Furthermore, DPAC-AnPCN can be applied in a nondoped device to effectively reduce the fabrication complexity and cost. The nondoped device exhibits pure blue electroluminescence (EL) locating at 464 nm with CIE coordinates of (0.15, 0.15). Moreover, it maintains high efficiency at relatively high luminescence. The maximum external quantum efficiency (EQE) reaches 6.04% and still remains 5.31% at the luminance of 1000 cd m-2 showing a very small efficiency roll-off. In addition to this study using 1-Bromo-4-iodobenzene, there are many other studies that have used 1-Bromo-4-iodobenzene(cas: 589-87-7Related Products of 589-87-7) was used in this study.

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Related Products of 589-87-7 It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zu, Bing; Ke, Jie; Guo, Yonghong; He, Chuan published their research in Chinese Journal of Chemistry in 2021. The article was titled 《Synthesis Of Diverse Aryliodine(III) Reagents By Anodic Oxidation》.Reference of 2-Iodobenzoic acid The article contains the following contents:

An anodic oxidation enabled synthesis of hypervalent iodine(III) reagents from aryl iodides is demonstrated. Under mild electrochem. conditions, a range of aryliodine(III) reagents, including iodosylarenes, e.g., PhI(OAc)2, (difunctional-iodo)arenes, e.g., PhI(OH){OP(O)Ph2}, diaryliodonium salts, e.g., I, and benziodoxoles, e.g., II, were efficiently synthesized and derivatized in good to excellent yields with high selectivity. As only electrons serve as the oxidation reagents, this method offers a more straightforward and sustainable manner that avoids the use of expensive or hazardous chem. oxidants. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Reference of 2-Iodobenzoic acid)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 2-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Yuting; Tao, Jiayu; Wang, Yi; Cai, Zhengchun; Fang, Xianying; Wang, Shifa; Xu, Haijun published an article in 2021. The article was titled 《A novel dual-responsive fluorescent probe for the detection of copper(II) and nickel(II) based on BODIPY derivatives》, and you may find the article in Inorganica Chimica Acta.Related Products of 516-12-1 The information in the text is summarized as follows:

A novel dual-responsive fluorescence probe 6 was constructed by introducing a dipicolyamine moiety on the BODIPY-based skeleton via Sonogashira coupling reaction and confirmed by 1H NMR, 13C NMR, elemental anal. and high-resolution mass spectroscopy (HRMS). The present probe 6 exhibited high selectivity and sensitivity toward Cu2+ and Ni2+ detection over other competitive metal ions by fluorescence quenching phenomena, resp. In addition, the detection limits (DLs) for Cu2+ and Ni2+ were calculated to be as low as both 0.1 μM resp., which were lower than the maximum allowable level of the World Health Organization (WHO) limit for the drinking water. The stoichiometric ratio of the probe 6 toward the Cu2+ or Ni2+ ions was determined to be 1:1 according to the result of the Job′s plot and HRMS anal. These results indicated that probe 6 can be used as a selective ′′turn-off′′ fluorescent sensor for the detection of Cu2+ and Ni2+. In the experiment, the researchers used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Related Products of 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Related Products of 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Jianling; Wang, Qiang; Duan, Ruomeng; Li, Huadeng; Zheng, Ke; Wang, Xiaoxia; Xie, Guanqun published an article in 2022. The article was titled 《A facile electrosynthesis of N-acyl benzotriazoles from aldehydes and benzotriazole》, and you may find the article in Tetrahedron Letters.Category: iodides-buliding-blocks The information in the text is summarized as follows:

An electrochem. synthesis of N-acylbenzotriazoles I [R = Ph, 4-ClC6H4, 2-naphthyl, etc.] had been developed under mild conditions with good to excellent yields using aldehydes and benzotriazole as starting materials. In addition, a one-pot reaction of aldehyde, benzotriazole and phenol had been achieved affording phenolic esters II [R1 = Ph, 4-MeC6H4, 4-BrC6H4, etc.] in moderate yields under the combination of electricity-on/off conditions, where N-acyl benzotriazole acted as the benign acylating reagent. It was noteworthy the research provided environmental friendly syntheses in that no superstoichiometric hazardous chem. oxidants were required, corrosive/toxic reagents had been avoided and waste production had significantly been reduced. The key of the electrochem. synthesis involved the oxidation of benzotriazole-aldehyde adduct by phthalimido-N-oxy (PINO), which was generated by N-hydroxyphthalimide (NHPI) as a redox mediator. The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Category: iodides-buliding-blocks)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dutta, Shubham; Shandilya, Shashank; Yang, Shengwen; Gogoi, Manash Protim; Gandon, Vincent; Sahoo, Akhila K. published an article in 2022. The article was titled 《Cationic-palladium catalyzed regio- and stereoselective syn-1,2-dicarbofunctionalization of unsymmetrical internal alkynes》, and you may find the article in Nature Communications.Safety of 4-Iodobenzoic acid The information in the text is summarized as follows:

The discovery of a regio- and stereoselective syn-1,2-dicarbofunctionalization of unsym. internal alkynes was reported. A cationic Pd-catalyzed three-component coupling of aryl diazonium salts, aryl boronic acids (or olefins) and yne-acetates enables access to all-carbon substituted unsym. olefins. The transformation features broad scope with labile functional group tolerance, building broad chem. space of structural diversity (94 mols.). The value of this synthetic method was demonstrated by the direct transformation of natural products and drug candidates containing yne-acetates, to enable highly substituted structurally complex allyl acetate analogs of biol. important compounds Synthetic versatility of the carboxylate bearing highly substituted olefins was also presented. The reaction outcome was attributed to the in situ formation of stabilized cationic aryl-Pd species, which regulated regioselective aryl-palladation of unsym. yne-acetates. Control experiments reveal the synergy between the carboxylate protecting group and the cationic Pd-intermediate in the regioselectivity and reaction productivity; d. functional theory (DFT) studies rationalize the selectivity of the reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzoic acid(cas: 619-58-9Safety of 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Safety of 4-Iodobenzoic acid Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Maiti, Sudip; Li, Yingzi; Sasmal, Sheuli; Guin, Srimanta; Bhattacharya, Trisha; Lahiri, Goutam Kumar; Paton, Robert S.; Maiti, Debabrata published an article in Nature Communications. The title of the article was 《Expanding chemical space by para-C-H arylation of arenes》.Electric Literature of C7H5IO The author mentioned the following in the article:

A robust catalytic system that displayed unique efficacy toward para-arylation of highly functionalized substrates such as drug entities, giving access to structurally diversified biaryl scaffolds, e.g., I was developed. This diversification process provided access to an expanded chem. space for further exploration in drug discovery. Further, the applicability of the transformation was realized through the synthesis of drug mols. bearing a biphenyl fragment. Computational and exptl. mechanistic studies further provided insight into the catalytic cycle operative in this versatile C-H arylation protocol. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Electric Literature of C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Electric Literature of C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Nallagonda, Rajender; Musaev, Djamaladdin G.; Karimov, Rashad R. published an article in ACS Catalysis. The title of the article was 《Light-Promoted Dearomative Cross-Coupling of Heteroarenium Salts and Aryl Iodides via Nickel Catalysis》.Safety of 4-Iodobenzaldehyde The author mentioned the following in the article:

Herein, the coupling of aryl iodides, e.g., Ph iodide with pyridinium and related heteroarenium salts, e.g., I catalyzed by Ni/bpp and an Ir photocatalyst using Zn as a terminal reductant was reported. This methodol. tolerates a wide range of functional groups and allows the coupling of aryl and heteroaryl iodides, thus significantly expanding the scope of nitrogen heterocycle scaffolds, e.g., II that could be prepared through dearomatization of heteroarenes. The reaction products have been further functionalized to prepare various nitrogen heterocycles. Initial mechanistic studies indicate that the reaction described herein goes through a unique mechanism involving dimers of dihydroheteroarenes. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0Safety of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Safety of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 624-31-7In 2022 ,《Trans-ferulic acid valorization into stilbene derivatives via tandem decarboxylation/Heck coupling using Pd/Al-SBA-15 materials》 was published in Materials Today Chemistry. The article was written by Maties, G.; Gonzalez-Arellano, C.; Luque, R.; Montejano-Nares, E.; Ivars-Barcelo, F.; Pineda, A.. The article contains the following contents:

Pd-containing Al-SBA-15 materials were prepared and characterized in view of their utilization in the two-step valorization of trans-ferulic acid into stilbenes via tandem decarboxylation/Mizoroki-Heck coupling. Materials were found to be highly active and selective in the proposed chemistries, with quant. conversion to target products under mild reaction conditions. Relevant insights on catalyst deactivation via sintering (Pd nanoparticles agglomeration) were also observed for the synthesized materials. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Recommanded Product: 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com